Drug Complaints Reach Record High at US Food + Drug Administration; HepaLife Reiterates Expected Rise in Drug-Induced Liver Injury

Drug toxicity to the liver is the most
common cause for withdrawal of approved medications, and drug-induced
liver disease remains the leading cause of acute liver failure in
America. As a result, HepaLife, using the patented PICM-19 cell line,
plans to develop proprietary in vitro toxicological and pre-clinical
drug testing platforms that will more accurately determine the
potential toxicity and metabolism of new pharmacological compounds in
the liver. The statements
contained in this press release regarding ongoing research and
development, and results attained by the Company to-date, have not
been evaluated by the Food and Drug Administration.
ChevronTexaco Corporation (NYSE:CVX) announced earlier this month
that it would acquire Unocal Corporation in a stock and cash
transaction valued at about $18 billion.
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encarta exaggerated

Clearly, when you have more products on
the market, you're likely to have more side effects. The report explains that the first objective is: "To develop
animal models or in vitro systems for the study of different forms of
idiosyncratic drug-induced liver injury, both allergic and
non-allergic.
With the cost to develop an FDA approved drug approaching $1
billion and taking 10 to 15 years, a 10% improvement in predicting
failures before clinical trials could save $100 million in development
costs per drug.
This release contains forward-looking statements within the meaning of
Section 27A of the Securities Act of 1933 and Section 21E of the
Securities Exchange Act of 1934 that are based upon current
expectations or beliefs, as well as a number of assumptions about
future events.
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com

perceptible neoclassical

. Limited treatment options, a low number of donor organs,
the high price of transplants and follow up costs, a growing base of
hepatitis, alcohol abuse, drug overdoses, and other factors that
result in liver disease all clearly indicate a strong need for an
artificial liver device . Read about ConocoPhillips (NYSE:COP),
ChevronTexaco Corporation (NYSE:CVX) and Kerr-McGee Corporation
(NYSE:KMG).

From encarta.

preference moralizing

"After all, only three months earlier, we learned through the
Centers for Disease Control that almost half of all Americans are now
taking at least one prescription drug and one person in every six is
taking three or more. At that time, I announced our assertion that
drug related liver injury and adverse effects would rise as a
consequence of greater prescription drug usage -- this report
certainly supports our expectations," explained Mr."
According to USA Today, the bulk of adverse-event reports are
submitted by drug manufacturers in accordance with FDA requirements to
file such details relating to use of their products. "As a result," states the
USA Today article, "annual totals are believed to cover only a
percentage of the actual number of serious drug reactions and
problems."
Among known adverse-effects, drug-induced liver damage
(hepatotoxicity ) is ranked as one of the most serious complications
from pharmaceutical compounds.now represents the
leading cause of acute liver failure, and is the most common reason
for withdrawal of an approved medication from clinical use.drug induced liver injury
accounts for over half of acute liver failure cases in the United
States," and proposes specific research goals to help deal with the
problem .asp

To view the full HTML text of this release, please visit
http://www.

Business Editors

CHICAGO----Concerns have crept into
the oil industry lately, but the All Stars continue to expect solid
returns for certain companies.

classicism 1750

.zacks.

Neoclassical artists at first sought to replace the sensuality and what they viewed as the triviality of the rococo style with a style that was logical , solemn in tone, and moralizing in character.

preference encarta

Harmel
Rayat, "that even though the number of reports filed with the FDA is
greater than ever before, industry analysts believe these incidents
remain generally under-reported.html

In addition to its potential application for pre-screening toxins
in pharmaceutical and chemical compounds, the PICM-19 cell line is
currently being optimized and tested by HepaLife for eventual use and
integration into the first-ever, artificial liver device of its kind
-- a potentially life-saving solution for patients dying from liver
failure.

For additional information, please visit www. There can be no assurance that further research and
development , and /or whether clinical trial results, if any, will
validate and support the results of our preliminary research and
studies.

Disclaimer: Past performance does not guarantee future results.
Investors should always research companies and securities before
making any investments.

Art and Architecture

Art produced in Europe and North America from about 1750 through the early 1800s, marked by the emulation of Greco-Roman forms.

republics virtue

"It's disturbing to see the number of adverse drug reactions
rising so dramatically, although frankly, this phenomenon isn't
entirely unexpected," commented Mr. Rayat . Despite efforts to develop better methods, most of the
tools used for toxicology and human safety testing are decades old.com/?id=96

What Do The All Stars Recommend:

ConocoPhillips (NYSE:COP ): In late January ConocoPhillips, which
recently announced that 2005 production should be about +3% higher
than 2004, announced fourth quarter income from continuing operations
of $3. In late January, ChevronTexaco announced its fourth quarter
results, which the company said capped off its strongest year in its
125-year history.

neo sensuality

ABOUT HEPALIFE TECHNOLOGIES, INC.

HepaLife Technologies, Inc.

Artificial Liver Device

Presently, through a Cooperative Research and Development
Agreement, HepaLife Technologies is working towards optimizing the
hepatic functionality of the patented PICM-19 cell line.

adopted virtue

.com/Investor/PressReleases/20050222-1.hepalife. The earnings
result marked a solid improvement over the previous year's performance
of $1. They are the select group of
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marked romanticism

Rayat. Most helpful would be
an artificial or bioartificial liver assist device that could be used
to sustain patients and serve as a bridge to liver transplantation,
which is the only effective treatment that is currently available for
fulminant hepatic failure. In fact, about one third of all drugs fail
pre-clinical or clinical trials due to the toxic nature of the
compounds being tested, costing pharmaceutical companies around $2
billion annually on such toxicity-related drug failures.75 million barrels of oil equivalent per
day, and its refineries ran at 94% of capacity , excluding the impact
of LUKOIL. The company posted adjusted after-tax income of $1.

msn.

1800s propagandistic

HepaLife Technologies, Inc.
In a March 14, 2005, article (Drug Complaints Reach Record High),
USA Today states: "Drug side effects and other related health problems
reported to the Food and Drug Administration reached an all-time high
in 2004" and culminated with over 422,500 adverse-event reports, an
increase of nearly 14% from the previous year.

NIH: Drug and Tox-Induced Liver Disease is the Leading Cause of
Acute Liver Failure

In January 2005, the National Institutes of Health (NIH) released
its first-ever, comprehensive plan (Action Plan for Liver Disease
Research) addressing the burden of liver disease in the United States
and directing NIH funding and research resources towards the
prevention, diagnosis, and management of liver and biliary diseases. "In the past few weeks,
we 've announced specific initiatives to expand our research efforts in
this area, and develop novel in vitro testing technologies using the
PICM-19 cell line -- patented, proprietary cells with unique ,
liver-like traits.hepalife.com/Alerts-Index. The
only way to get these powerful insights is with a free subscription to
the "Profit from the Pros" investment newsletter.

When revolutionary movements established republics in France and America, the new governments adopted neoclassicism as the style for their official art, by virtue of its association with the democracy of ancient Greece and republican Rome.

perceptible romanticism

(HepaLife's December 15, 2004 press release can be viewed at:
http://www.hepalife."
"It's particularly important to note however," stated Mr.
According to a subsection of the report (Drug and Tox-Induced
Liver Disease; Chapter 8), "Hepatotoxicity ...

com

Music

A term most often referring to music that was composed between the two world wars and that avoided the exaggerated gestures and complex forms of late romanticism.

adopted virtue

Harmel S. The company expects
oil -equivalent production from the combined portfolios to average
about 3 million barrels per day.
Kerr -McGee Corporation (NYSE:KMG), which recently authorized a
modified "Dutch Action" tender offer for up to $4 billion of its
common stock, reported a strong fourth quarter performance in late
January ." and highlights the
"All Star Portfolio," the exclusive stock list comprised only of
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virtue triviality

In response to the growing number of individuals suffering from
liver disease as a result of drug overdoses or interactions, rampant
alcohol abuse and the worldwide hepatitis epidemic, HepaLife
Technologies is developing the first of its kind artificial liver
device incorporating the PICM-19H cell line, which has now been in
continuous culture for over two years without presenting any
detectable changes in hepatocyte morphology and function, a
significant achievement.html

Legal Notice Regarding Forward-Looking Statements

No statement herein should be considered an offer or a
solicitation of an offer for the purchase or sale of any securities. Visit http://at. Just visit
http://at.

Later, as Napoleon rose to power in France, the style was modified to serve his propagandistic needs.

Instead, such music adopted more clearly perceptible themes and revived forms of earlier periods.

1800s exaggerated

(OTCBB:HPLF) is a development stage
biotechnology company focused on the identification, development and
eventual commercialization of technologies and products for liver
toxicity detection and the treatment of various forms of liver
dysfunction and disease .
The PICM-19 cells grown in vitro synthesize liver specific
proteins such as albumin and transferrin , and display enhanced
liver-specific functions such as ureagenesis and cytochrome P450
activity .
In addition, other factors that could cause actual results to differ
materially are discussed in the Company's most recent Form 10-QSB and
Form 10-KSB filings with the Securities and Exchange Commission. Furthermore, Unocal assets would
provide enhanced presence in several of ChevronTexaco 's core areas of
operations, including Asia Pacific, Gulf of Mexico, and the Caspian
Region.

romanticism preference

(OTCBB:HPLF ), a development stage
biotechnology company focused on the identification, development and
eventual commercialization of technologies and products for liver
toxicity detection and the treatment of various forms of liver
dysfunction and disease, today reiterated its previously forecasted
expectations of increased drug induced liver injuries, in response to
the record number of 'adverse-events' filed with the FDA, according to
findings published by USA Today."

(HepaLife's February 22, 2005 press release can be viewed at:
http://www."
As reported in HepaLife's press release dated December 8, 2004,
results from ongoing research into its proprietary embryonic liver
stem cell line, PICM -19H, have surpassed initial expectations.
Notably, these cells recorded higher growth density than their parent
cell line, while determinations of inducible P-450, ammonia removal,
and urea production similarly yielded markedly positive results, all
highly beneficial attributes towards the development of a
bio-artificial liver device for use by human patients suffering from
liver disease. The
Company undertakes no obligation to publicly release the results of
any revisions to these forward looking statements that may be made to
reflect the events or circumstances after the date hereof or to
reflect the occurrence of unanticipated events.com provides the All Star Top Picks for another
sector followed by Wall Street's top analysts.zacks.com/?id=100
Zacks Investment Research is under common control with affiliated
entities (including a broker-dealer and an investment adviser), which
may engage in transactions involving the foregoing securities for the
clients of such affiliates.

virtue referring

According to the NIH: "In the area of acute liver failure, the
primary goals of research should be in developing means to prevent
acute liver failure and ameliorate its course. Although the Company believes that the expectations
reflected in the forward-looking statements and the assumptions upon
which they are based are reasonable, it can give no assurance that
such expectations and assumptions will prove to have been correct.

Zacks.com Features the Following Top Stocks in the Integrated Oil Industry: ConocoPhillips ChevronTexaco and Kerr-McGee

com
http://at. Its earnings per share in the quarter topped the
consensus by more than +10%.

More than just an antique revival, neoclassicism was linked to contemporary political events.

From encarta.

neo neoclassical

"
"These in vitro testing technologies are critical to ensuring the
industry's success in the battle against drug-induced liver toxicity,
and NIH support for development of such platforms is particularly
timely for HepaLife," explained Mr. The hepatic
characteristics of the PICM-19 cell line have been demonstrated to
have potential application in the production of an artificial liver
device for use by human patients with liver failure. Further, there can be no assurance that the necessary
regulatory approvals will be obtained or that HepaLife will be able to
develop commercially viable products on the basis of its technologies. That marked its second straight
quarter of record production. The goal is to
unlock these pros' profitable insights for individual investors
hard-pressed to find this valuable information in one source.

adopted solemn

At present , the Company does not have commercial products intended
to diagnose, treat, cure or prevent any disease .

07 per
share, which easily exceeded the year-ago result while also edging
past the consensus.zacks.com/?id=97

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neoclassicism revived

html

Echoing similar sentiment, USA Today quotes Paul Seligman,
director of the FDA's Office of Pharmacoepidemiology and Statistical
Sciences: "There are more drugs on the market and more use of
pharmaceuticals in general.
Currently, HepaLife is concentrating its efforts on creating the
first-of-its-kind artificial liver device and developing proprietary
in vitro toxicology and pre-clinical drug testing platforms.51 per share on total revenues of $40. Overall,
ConocoPhillips produced 1. Nothing herein should be construed as an offer
or solicitation to buy or sell any security.

propagandistic 1750

com

To receive future press releases via email, please visit
http://www.com/Investor/PressReleases/20050323-1.1 billion. ConocoPhillips said its upstream
operations enabled the company to benefit from the strong commodity
price environment, while its downstream domestic operations benefited
from improved heavy-light crude oil differentials. Furthermore , the company replaced 280%
of its production of 114.com/?id=99

About Zacks

Zacks.

With the rise of the romantic movement, a preference for personal expression replaced an art based upon fixed , ideal values.

neoclassicism triviality

Earlier CDC report finds
almost half of all Americans now using prescription drugs . Rayat, Chairman of
HepaLife. However,
physicians, nurses and patients are not required to file -- instead,
their participation is entirely voluntary."
The NIH report further states that, " .

In Vitro Toxicology Testing

Hepatotoxicity, or liver damage caused by medications and other
chemical compounds, is the single most common reason leading to drug
withdrawal or refusal of drug approval by the Food and Drug
Administration (FDA).hepalife.zacks.

msn.

moralizing neoclassicism

com/Investor/PressReleases /20041215-1. The
reader is cautioned not to put undue reliance on these forward-looking
statements , as these statements are subject to numerous factors and
uncertainties, including but not limited to adverse economic
conditions, intense competition, lack of meaningful research results,
entry of new competitors and products, adverse federal, state and
local government regulation, inadequate capital, unexpected costs and
operating deficits, increases in general and administrative costs,
termination of contracts or agreements, technological obsolescence of
the Company's products, technical problems with the Company's research
and products, price increases for supplies and components , litigation
and administrative proceedings involving the Company, the possible
acquisition of new businesses or technologies that result in operating
losses or that do not perform as anticipated , unanticipated losses,
the possible fluctuation and volatility of the Company's operating
results , financial condition and stock price, losses incurred in
litigating and settling cases, dilution in the Company's ownership of
its business, adverse publicity and news coverage, inability to carry
out research, development and commercialization plans, loss or
retirement of key executives and research scientists, changes in
interest rates, inflationary factors, and other specific risks. We
currently have no products intended to diagnose, treat, prevent or
cure any disease.43 and beat the consensus by almost +14%, while total revenues
increased from $26 billion.3 million BOE.com is a property of Zacks Investment Research, Inc.

1750 moralizing

With 25 million Americans suffering from liver disease , the need
for an artificial liver device able to remove toxins and improve
immediate and long -term survival results is more critical today than
ever before. The statements contained in this press release
regarding our on going research and development and the results
attained by us to-date have not been evaluated by the Food and Drug
Administration. Discover the full story at Zacks. Kerr -McGee reported that fourth quarter daily
production jumped +41% from the same period in 2003 to average 372,100
barrels of oil equivalent (BOE).

neoclassicism rococo

Business Editors/Health/Medical Writers

VANCOUVER , British Columbia----

'USA Today' reveals over 422,500 adverse-events filed with the FDA --
an increase of nearly 14% from previous year..hepalife. A free
subscription to "Profit from the Pros" weekly e-mail newsletter
provides the best way to use these expert's insights for more
profitable investing.zacks.

neo neoclassicism

---

- - kjjkjk

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