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About Vertex
Vertex Pharmaceuticals Incorporated is a global biotechnology company
committed to the discovery and development of breakthrough small molecule
drugs for serious diseases.

ATTENTION CALENDAR EDITORS! For more information on attending Chips to
Hits(R) in Boston, Massachusetts visit http://www.chipstohits.com

CONTACT:
Kerry Patterson
EMAIL: kpatterson@ibcusa .

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Vertex's press releases are available at http://www.

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Chips to Hits(R) attendees will gain
free access to two days of the Molecular Diagnostics and Personalized Medicine
conference sessions.

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com . The Company's strategy is to commercialize its
products both independently and in collaboration with major pharmaceutical
companies.

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, M. Vertex's presentation and discussion at
the Morgan Stanley conference will be audio webcast only on Wednesday, May 4
at 10:30 a.vrtx.' To ensure a timely
connection , it is recommended that users register at least 15 minutes prior to
the scheduled webcast.

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The keynote presentations will cover Pfizer's outlook and recent deals in
the macromolecule markets, and about Amylin's success story with Byetta.

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390.

Review the full brochure online.
Lexiva (R) is a registered trademark of the GlaxoSmithKline group of
companies.

The World's Largest Microarray and Microtechnology Conference Set to Take Place in Boston

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PRESS RELEASE Recent Deals New Technologies and Regulatory Updates to Be Discussed at IBC Life Sciences' Annual TIDES(R) Conference +amp; Exhibition

The keynote presenters are Christina Wan, J.D.

Vertex Pharmaceuticals Announces Webcast of its Presentations at Two Investor Conferences

The presentations will be webcast live and may be accessed by visiting the
Vertex website at http://www. Albine Martin, Vice President of Compugen .

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4078 or visit the website
at www. A replay of the webcasts will also be
available on the Company 's website for two weeks following the presentations.

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Vertex's presentation at the Deutsche Bank conference will be webcast on
Monday, May 2, 2005 at 4:30 p.
It continues to be the industry's most comprehensive and crucial event in the
microarray and microtechnology field. New product launches
and scientific breakthroughs will be presented across the exhibition hall
featuring over 100 exhibit booths and more than 75 scientific posters.

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Top sponsors include
Avecia Biotechnology, Executive Sponsor; Chemgenes Corporation, Corporate
Sponsor; Girindus Solvay Organics, Corporate Sponsor and SAFC Biosciences
is a Biopharmaceutical Production Series Sponsor for IBC Life Sciences.

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A, Director ,
Strategic Alliances, Pfizer Inc and Alain D.

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The conference will cover 20+ updates on regulatory strategies and products
in clinical and preclinical development, in addition to the following
sessions:

-- Progress in delivery of siRNA, Oligos and Peptides
-- Optimizing API manufacturing
-- Analytical methods: critical evaluations of emerging technologies and
regulatory strategies
-- Financial forecasts for oligos, peptides and diagnostics
-- Updates on products in development from Novo Nordisk, Acuity
Pharmaceuticals, KAI Pharmaceuticals, Anges

In addition, a new expanded session has been added -- Nucleic Acid
Diagnostics. In collaboration with
GlaxoSmithKline , Vertex co-promotes the HIV protease inhibitor, Lexiva(R).

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WESTBOROUGH, Mass., IBC's 12th annual
international conference and exhibition, Chips to Hits(R) will be held
September 12-15, 2005 at the Boston Convention and Expo Center in Boston, MA.

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This
year's event includes 2 keynote presentations , 75 conference sessions and
an exhibit hall with more than 75 companies.D.com/TIDESemassa@ibcusa .

, Vertex
Pharmaceuticals Incorporated (Nasdaq: VRTX) will webcast its presentations at
Deutsche Bank's 30th Annual Health Care Conference on May 2, 2005 and at
Morgan Stanley's Third Annual Global Healthcare Unplugged Conference on May 4,
2005.m.

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CAMBRIDGE, Mass.com.

Vertex Contact:
Lora Pike, Manager, Investor Relations, (617) 444-6755

It's categorized into four topics; FDA + Government
Perspectives, Emerging Technologies, Scientific + Commercial Strategies , and
Validated Applications.
Held in conjunction with Chips to Hits(R) will be IBC's 4th Annual
Molecular Diagnostics and Personalized Medicine conference covering
scientific, business and regulatory strategies for companion diagnostic
products and individualized therapeutics.

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" noted Dr.

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Baron, M . This day and a half conference session will be held May 2 and
May 3.

The TIDES exhibit hall includes more than 70 booths offering attendees
the chance to learn about new products and services .com.vrtx.

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IBCLifeSciences. Ian Smith, Vertex's Senior Vice President and Chief Financial Officer,
will present at both conferences. Vertex's product pipeline is principally focused on viral
diseases , inflammation, autoimmune diseases and cancer. Chips to Hits(R) is the largest of its
kind, bringing in over 70 of the world's leading experts to present new
information.

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S.m.
Combining high quality scientific data, validated case studies, and
networking opportunities both in the conference sessions and on the exhibition
floor, Chips to Hits(R) will cover the entire spectrum from emerging
technologies to soon-to-be-commercialized products and validated case studies
of current applications.com

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, M. This session is designed for diagnostics manufacturers and offers
detailed sessions focusing on manufacturing and technical considerations
with additional information on business and regulatory considerations. EDT.

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B.

For questions contact IBC Life Sciences, 800.
To access the webcasts, go to Vertex's website and select the 'Deutsche Bank
30th Annual Health Care Conference ' or the 'Morgan Stanley Third Annual Global
Healthcare Conference' from the 'Events Calendar.

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These four topics include over 20 sessions providing
unbiased, practical and novel information on developments , challenges and
opportunities in:

* Utilizing new and existing technology to improve discovery and
development
* Learning how to succeed from validated applications and case studies
* Gaining a competitive edge from proven commercial and scientific
strategies

"One of the most comprehensive meetings that incorporate both cutting edge
science and commercialization strategies for maturing segments within this
arena.

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The TIDES Conference and
Exhibition brings together more than 450 professionals working in
oligonucleotide and peptide technology and product development.
Molecular diagnostics generate $2 billion in revenue annually and offer a
huge market opportunity to oligonucleotide manufacturers.

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, Senior Vice
President, Research, Amylin Pharmacueticals.
This event offers unparalleled formal networking opportunities with over
1400 attendees from industry, academia and government.

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