The Company has two other
businesses, Words+, Inc.

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Stottler Henke Announces Integration between SimBionic Visual Authoring Tool and PathEngine

Business Editors/High-Tech Writers
Game Developers Conference 2005

SAN FRANCISCO----

Two Advanced Tools Now Work Together to Give Game AI Developers
More Power to Create Intelligent Behaviors and Interesting
Interactions for Game Agents

Stottler Henke Associates, Inc."
SimBionic and PathEngine are available immediately .

SimBionic's components

SimBionic consists of two major components: a visual authoring
tool and a runtime engine. The SimBionic runtime
engine takes the behavior description, and makes it operational within
a game or training simulation. Powerful 'collision context' mechanisms seamlessly integrate
dynamic obstacles into this movement mode and the inclusion of ground
management functionality makes PathEngine a truly complete agent
movement solution and an ideal partner for SimBionic's visual behavior
authoring system. The
company delivers intelligent software solutions for education and
training, planning and scheduling, knowledge management and discovery,
decision support, and computer security and reliability.

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Simulations Plus Announces Release of DDDPlus 1.0; New Core Product is First in Industry

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(AMEX:SLP), the leading provider of simulation software for
oral drug absorption and neural net structure-to-property prediction
of ADMET properties for pharmaceutical discovery and development,
announced today that it has released version 1.0 of DDDPlus(TM), a
simulation of in vitro dissolution experiments for formulation
scientists in the pharmaceutical industry. Web: http://www.

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Dissolution rate is a critical parameter in
the development of new dosage forms, in making generic versions of
existing drugs, and in quality control for production. "The simplicity of the
SimBionic AI Middleware architecture made integration with PathEngine
a no-brainer. Visual representations can be understood by experts and
software programmers alike, so they can speak the same language
resulting in superior collaborative development. Email: generalcontact@pathengine.pathengine.

This category is for artificial life information, simulations, discussions and related sub topics like art and games.

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"
"In the past," Woltosz continued, "formulation scientists worked
by the 'cut and try ' method. The SimBionic authoring tool is a standard
Windows application. In addition to pathfinding , PathEngine also provides
collision and ground management functionality and helper methods for
robust movement along paths.com.

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The company is
exhibiting there in booth #119.

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"Providing a combined solution of SimBionic AI middleware and
PathEngine's superior pathfinding middleware gives our customers the
power and flexibility they have been demanding," said Dan Fu, head of
the SimBionic group at Stottler Henke. The SimBionic authoring tool runs on
Microsoft Windows 98, Windows NT, Windows 2000, and Windows XP
operating systems.

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(www.

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Business Editors/Health/Medical Writers

LANCASTER, Calif. Stottler
Henke's clients include manufacturers, retailers, educational media
companies and government agencies.com

About PathEngine

Founded in 2000, PathEngine is built on experience providing
pathfinding and AI to the games industry over a period of more than 10
years.

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If it did not meet requirements,
another was made and tested, making for a time-consuming and expensive
process.

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stottlerhenke.

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We believe this new core product
will have a very positive impact on revenues and earnings in fiscal
year 2005.com

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----Simulations
Plus, Inc.

com), a leading
provider of AI middleware for games and simulations, today announced
integration between SimBionic(TM) -- Stottler Henke's award-winning
visual authoring tool for rapidly creating intelligent behaviors that
enhance characters in computer games without programming -- and the
PathEngine (TM) toolkit for pathfinding and intelligent agent movement. Contact
Stottler Henke for details. SimBionic presents its logic graphically,
communicating more information to more people compared to textual
methods. The PathEngine toolkit uses a 'points of visibility' approach
to pathfinding, which enables extremely fast pathfinding, even over
long distances, and pathfinding against a sophisticated integrated
movement model.

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An initial formulation was developed
based on instinct and experience. We believe this simulation is the first to
detail all of the interactions that affect dissolution rate in an in
vitro experiment."

About Simulations Plus, Inc. is a premier developer of groundbreaking
drug discovery and development simulation software, which is licensed
to and used in the conduct of drug research by major pharmaceutical
and biotechnology companies worldwide.

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These interactions include particle size
distribution, type of experimental apparatus, pH in the fluid, volume
of fluid, speed of agitation, buffer composition, and effects of
excipients such as surfactants and solubilizers.

Simulations Plus, Inc.

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DDDPlus is the result
of a two-year development effort and the result is truly exciting. and With the exception of historical information,
the matters discussed in this press release are forward-looking
statements that involve a number of risks and uncertainties.

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Walt Woltosz, chairman and chief executive officer of Simulations
Plus, said: "DDDPlus stands for Dose Disintegration and Dissolution,
and Plus is our branding for Simulations Plus. Further information on the Company's risk
factors is contained in the Company's quarterly and annual reports as
filed with the Securities and Exchange Commission. "The functionality offered by
the two products is perfectly complimentary and a combined solution is
extremely compelling for companies wishing to save development costs
and reduce risk without giving up power or flexibility .

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"
Ron Creeley, vice president of marketing and sales of Simulations
Plus, said: "We've been demonstrating beta versions of DDDPlus for
several months, and the level of enthusiasm has exceeded even our
expectations . Numerous companies have requested evaluation copies, and
one company ordered prior to release.
The products can now be used together by game AI developers to more
easily and efficiently specify complex behaviors and interactions with
game characters. PathEngine's movement model supports arbitrary connections
between overlapping ground layers and accounts (exactly) for agent
size.

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The
actual future results of the Company could differ significantly from
those statements. Factors that could cause or contribute to such
differences include, but are not limited to: the ability of the
Company to book revenues and earnings as it expects for the current
quarter, the ability of the Company to maintain its competitive
advantage, the general economics of the pharmaceutical industry, the
ability of the Company to attract and maintain sufficient scientific
and technical staff to sustain its R +D and customer support functions,
and a sustainable market.

An 'integrated movement model ' architecture for robust agent
movement

By providing both collision and pathfinding operations against a
single advanced movement model, PathEngine is unique in providing a
fundamentally robust basis for the implementation of intelligent agent
movement.

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alastair cranswick

DDDPlus is a new tool
for formulation scientists that will enable them to predict how
changes in formulation or changes in experimental setup are likely to
affect dissolution rate.

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"
"We're excited to be working closely with Stottler Henke," said
Thomas Young, president of PathEngine. The engine is efficient, highly
scalable, and provides a Java technology or C++ application
programming interface so software developers can easily interface it
with simulations and games.
Web: http://www.

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stottlerhenke.
Stottler Henke, a San Mateo, California-based software development
and consulting firm, made its announcement today at the 2005 Game
Developers Conference in San Francisco, California.

About Stottler Henke

Founded in 1988, Stottler Henke Associates, Inc. applies
artificial intelligence and other advanced software technologies to
solve problems that defy solution using traditional approaches .

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Time to market is money in the pharmaceutical industry, and
we perceived that simulation could be a useful tool in this area as it
has been for gastrointestinal absorption with our flagship
GastroPlus (TM) software. The SimBionic runtime engine runs on these
operating systems and also on Linux.