, How is a nineteenth-century amateur
mathematician contributing to a twenty-first-century breakthrough in breast
cancer treatment that could result in decreases of 26% in the annual odds of
recurrence and 31% in the annual odds of death?
Dr. Larry Norton, Deputy Physician-in-Chief for Breast Cancer Programs at
Memorial Sloan-Kettering Cancer Center in New York tells the story in the
current issue of The Oncologist. "Conceptual and Practical Implications of
Breast Cancer Tissue Geometry: Toward a More Effective, Less Toxic Therapy "
follows his lecture as recipient of the Susan G.

ComponentOne(R) Announces Studio Enterprise(TM) Beta Program for Microsoft Visual Studio 2005 -- New Components Include the Microsoft .NET Framework 2.0 Versi

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From this
insight, Dr.

Full text of featured article:
http://theoncologist .

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The Gompertzian curve also contributed to Dr.com .

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Norton's observations on
cancer metastasis and cancer stem cell biology. The Studio
Enterprise for the . The ComponentOne product
line includes ActiveX, .

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Dosing at two-week rather
than the conventional three-week intervals interrupts the rapid growth phase,
as it were short-circuiting the Gompertzian growth curve before tumor regrowth
achieves its greatest size gains. He postulates that "self-
metastasis" is responsible for small clumps of cell growth that comprise a
tumor, each clump following the Gompertzian initial rapid growth prior to
distant metastasis.
The Oncologist, an international peer-reviewed journal from AlphaMed
Press, serves more than 21,000 physicians around the world and is read online
globally.

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All product and company names herein may be trademarks of their respective
owners.

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"
Their hypothesis led to the "dose-dense" approach to breast cancer
chemotherapy, shown in multiple studies to achieve those promising drops in
recurrence and death." In fact it may be the
opposite.
"Our Studio subscriptions provide our customers with .com/vs2005 .NET, Borland(R) C#Builder(TM), Delphi(R) for .

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C. The award was
established in 1992 to recognize leading researchers and clinicians involved
in the study and treatment of breast cancer.

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"We have tended to think that
cancers metastasize because they are large; the reality may be that they are
large because they are self-metastatic.

To sign
up for the beta program, visit http://www.NET, Mobile, and Help authoring tools and
solutions used worldwide.

Available Topic Expert(s): For information on the listed expert(s), click
appropriate link.prnewswire.

.

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Rapid growth occurs first, followed by slower growth. Norton developed with colleague Dr.

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Clinical trials have used dosing levels shown in prior research to
be optimal. PITTSBURGH , ComponentOne today announced the
Studio Enterprise beta program for Microsoft Visual Studio 2005 . ComponentOne has received numerous industry and
user accolades for their component tools, including awards from Info World, PC
Magazine, Programmer's Paradise, Software Development Magazine, SD Times ,
Vbxtras, and Visual Studio Magazine.

NET components, controls and assemblies used by developers to create .

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Dose-dense chemotherapy seeks to maximize "cell kill" by maximizing the
rate of drug delivery -- not the level of dosing.

About ComponentOne
ComponentOne LLC is a premier provider of a diverse set of tools and
solutions for software developers who work in Microsoft(R ) Visual Studio(R),
Visual Studio .NET environments,
and Help authors who write and design Help systems.

NET Applications

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org/cgi/content/short/10/6/370

CONTACT: Laurel Ferejohn, Communications Manager of AlphaMed Press,
+1-919-680-0011, ext."
"ComponentOne is one of the first partners to release Visual Studio 2005
versions of their products to the public," said Shawn Nandi, product manager
in the Developer and Platform Evangelism Division at Microsoft Corp."
ComponentOne Studio Enterprise betas will take advantage of the .NET
Framework 2.NET (WebForms): Resource-based Scripts and Images.
Studio Enterprise includes over 110 components targeting all application
layers including Data, Presentation, Reporting, and Transformation.

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Norton's Brinker Award Lecture , from which his peer-accepted article
in The Oncologist is drawn, is a feature of the Susan G.

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In 1825, London insurance actuary Benjamin Gompertz theorized that
biological growth, whether of normal organs or malignancies, follows a common
curve.NET 2005 beta 2 is released.
Gustavo Eydelsteyn
http://profnet.

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0 beta 2 versions of ComponentOne
tools.NET Framework 2.

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Toward a More Effective, Less Toxic Therapy, with Implications for
Understanding Cancer Metastasis and Cancer Stem Cell Biology

DURHAM, N. For more information,
visit http://www.componentone .

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Richard Simon this
hypothesis: "Therapy results in a rate of regression in tumor volume that is
proportional to the rate of growth that would be expected for an unperturbed
tumor of that size .NET Framework 2.0 beta program will begin when Visual
Studio .

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Enabling compressed dosing was the development of granulocyte-colony
stimulating factor (filgrastim, Neupogen(R)), which serves to protect the
patient's ability to make vital white blood cells during strenuous
chemotherapy . This release
will include the Microsoft .

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It is devoted to medical and practice issues for surgical ,
radiation, and medical oncologists entrusted with the care of adult or
pediatric cancer patients .com

At that time, ComponentOne tools will be
made available to a select group of beta program participants.NET, ASP.

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This new approach has not been uncontroversial, largely because "dose-
dense" has been misinterpreted to mean "more toxic. Komen Breast Cancer
Foundation's annual Brinker Award for Scientific Distinction. The lecture was delivered on
December 9, 2004 during the 27th Annual San Antonio Breast Cancer Symposium.alphamedpress. "With access to the beta versions of Studio
Enterprise, customers will be able to develop innovative tools, and cutting
edge applications for rising technologies.

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From The Oncologist - Breast Cancer: A Tale of Two Centuries

Komen Breast Cancer
Foundation's Brinker Award for Scientific Distinction.NET Framework 2.NET (WinForms):
- Smart Tags
- Data-binding
- GDI Text
- Managed Themes
- ASP.com/ud_public.

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"
Dr. 234, or fax, +1-919-680-4411, or
LaurelFerejohn@AlphaMedPress .0-
based beta versions, valuable enhancements, and continuous updates to the
Visual Studio 2005 versions of our components," said Gustavo Eydelsteyn,
Managing Director of ComponentOne.0 features including:

- .

Current Studio Enterprise subscribers will have priority access to the new
Visual Studio 2005 beta 2 versions of Studio Enterprise components.

recurrence webstorm

"The bottom line is this," he writes. "And, we
are very pleased that the Studio Enterprise beta is now available , so our
mutual customers can take advantage of the new features in Visual Studio
2005.componentone . Studio
Enterprise is one of the most complete component toolsets for Windows, Web,
and Mobile application development available anywhere.jsp?userid=336541

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- - kjjkjk

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