"As an organization, we pride ourselves
on our ability to quickly respond to our customers' emerging needs and the
evolution of the marketplace.0 include:

-- Noncompartmental Analysis for Drug Effect Data: WinNonlin's analysis
engine now supports analysis of PD data, including calculation of
selected slopes and areas
-- Noncompartmental Analysis for Sparse Data: WinNonlin now computes the
mean concentration curve, as well as the area under the curve and its
standard error, for sparsely-sampled drug concentration data such as
that which is collected in toxicokinetic studies.
-- Residual Normality Test: WinNonlin now includes a Komogorov-Smirnov
normality test, for use in testing residual normality in Linear Mixed
Effects and Bioequivalnce analyses.NET,
C/C++ and Java to develop classroom applications for a variety of
computationally based disciplines such as engineering, mathematics ,
statistics, financial engineering, and life sciences. The
suggested retail price is $595 (US ). More product details can be
found at: http://www.

sugihara f90

0 Streamlines Data Integration and Enhances Pharmacodynamic
Modeling Capabilities

MOUNTAIN VIEW, Calif.html. All
other trademarks are the property of their respective owners.

Fortran source code mainly for numerical computations , particularly in linear algebra (solution of linear equations, eigenvalues, etc.

g77 vasilchenko

com.NET
and other platforms in the classroom," said Maura McGinnity, vice president
of market strategy and corporate development for Visual Numerics.

About the IMSL Numerical Libraries

The IMSL Numerical Libraries have been the cornerstone of highly predictive
and deep computing applications in science , technical and business
environments for nearly three decades. "We'll
be focused on migrating Mathcad, Maple, and technical Excel users fazed by the
full Mathematica but wanting its trustworthy results and industrial-strength
performance."
Mathematica CalcCenter 3 enjoys other benefits by sharing common
technology with Mathematica. Network licenses and a full-function,
reduced-price student version are also available.

See the main Fortran section for Fortran standards and compilers .

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"I proudly became a member of
Visual Numerics' Knowledge in Motion Program because the company gives the
academic world access to some of the most advanced and reputable
mathematical and statistical routines available.wolfram.

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0(TM) (PKS(TM)), the industry's leading clinical
pharmacology data repository .0 has additional functionality to perform
Noncompartmental Analyses for drug effect or PD data, as well as provide NCA
analysis of sparsely-sampled data, such as toxicokinetic data. It
is also more fully integrated with S-PLUS(R) and SigmaPlot, two leading
analysis and graphing software products as well as PKS 3.
-- PKS Enhancements: WinNonlin offers improved performance and an
enriched feature set in a variety of PKS operations

About Pharsight Corporation
Pharsight Corporation is a leading provider of software products and
consulting services that help pharmaceutical and biopharmaceutical companies
improve and accelerate their decision-making in drug development and
commercialization. Information about Pharsight is available on the World
Wide Web at http://www. The company's
software products help users understand complex data from a variety of
sources and build business-critical applications.vni. "Because Mathematica CalcCenter 3 is an OEM
product of Mathematica, it piggybacks on Mathematica's development rather than
having to be built from scratch in its own right," said Conrad Wolfram,
director of strategic development. Led by Mathematica, its flagship product, the company's software is
relied on today by several million enthusiastic users around the world, and
has been the recipient of many industry awards for technical excellence. Mathematica is
not associated with Mathematica Policy Research, Inc. or MathTech, Inc .

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All forward-looking statements are based on
information available to Pharsight as of the date hereof , and Pharsight
assumes no obligation to update such statements, whether as a result of new
developments or otherwise."

"We are committed to furthering the use of numerical analysis on Java, . Visual Numerics offers
two product lines: the IMSL Numerical Libraries for powerful mathematical
and statistical analysis and the PV-WAVE visual data analysis
development environment. This large and diverse customer base is
supported through a direct sales force, wholly owned international
subsidiaries , and international distributors.
"When you run out of steam with Excel, Maple, or Mathcad, where do you go?
If you ever need more power than Mathematica CalcCenter, you can transition
smoothly to Mathematica," said McLoone.

Mathematica and CalculationCenter are registered trademarks and CalcCenter
is a trademark of Wolfram Research, Inc.

rentmeester vectorial

Pharsight's range of software offerings includes the Drug Model Explorer(TM)
Web Server (DMX(TM)), Pharsight Knowledgebase Server(TM) (PKS (TM)), PKS
Reporter(TM), Trial Simulator(TM), and WinNonlin(R) and WinNonMix(R) modeling
tools .

Major corporations, academic institutions, and research laboratories
worldwide use Visual Numerics' software tools, including such high profile
companies as: Bear, Stearns & Company; Barclays Global Investors;
Priceline." Ideal for the engineer,
scientist, educator, or student, Mathematica CalcCenter 3 offers an award-
winning interface -- getting users up and running in as little as 10 minutes
-- while delivering industrial-strength performance and trustworthy results. "That's what allows us to deliver better
price-to-performance than any competitors.

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The application is used by researchers and developers to
perform most of the analyses, and generate all data needed for PK and PK/PD
studies. WinNonlin 5.0 also offers the ability to filter records to
produce a subset of original data, as well as functionality that allows
the user to transform columns using free-form equations.

Pharsight, WinNonlin and WinNonMix, Pharsight Knowledgebase Server, PKS,
Drug Model Explorer, DMX, PKS Reporter and Trial Simulator are registered
trademarks or trademarks of Pharsight Corporation. The expanded program enables university
professors to leverage different programming environments such as .

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All other brand and product names are trademarks or registered trademarks
of their respective holders.

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0, we believe we have achieved this goal and
are providing significant value to our customers. "We've
gone to great lengths to modify education licensing policies to make it
easier for professors to use the highest quality numerical analysis and
visualization software possible, collaborate with their peers to raise the
bar in teaching analytics, and help their students grow to become the best
researchers, scientists, professors and analysts in the world . in the U."
In comparison to CalculationCenter 2, Mathematica CalcCenter 3 adds a host
of new features, including:

-- Data analysis now up to 70 times faster -- matches Mathematica 5's
record-breaking speed
-- New-generation optimized numerical solvers for ordinary and partial
differential equations
-- Fully optimized support for Mac OS X
-- Support for computations with exact fractions
-- Support for vector and array functions in numeric solvers
-- Flexible import and export of DICOM, PNG, SVG, STDS, DXF, FITS, STL,
and sparse matrix formats Matrix Market and Harwell-Boeing
-- Improved export of XHTML, now generating cascading style sheets
-- Extended Copy and Paste on Windows for using typeset formulas in other
applications
-- Streamlined design and user interface improvements
-- Over 50 improvements to quality and robustness

Mathematica CalcCenter 3 is available for Windows and Mac OS X.
Wolfram Research, a privately held company, was founded in 1987 by Stephen
Wolfram and is headquartered in the United States, with offices in Europe and
Japan . Windows is a registered trademark of Microsoft
Corporation in the United States and other countries .

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0 offers a new multi-transformation tool that allows users to
produce new workbooks utilizing both transformed and untransformed data. By integrating scientific, clinical and business decision
criteria into a dynamic, model-based methodology, Pharsight helps its
customers optimize the value of their drug development programs and portfolios
from discovery to post-launch marketing and any point in between. Related software services include pharmacokinetic automation services
and training courses . The IMSL C# Numerical Library is the only program that
allows me to do this," said Richardson.com . and other countries.

Wolfram Research Announces Mathematica CalcCenter(TM) 3 -- An Easy-to-Use 'Lite ' Version of Mathematica(R)

Mac OS is a registered trademark of
Apple Computer, Inc.

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PRESS RELEASE Visual Numerics(R) Expands Knowledge in Motion Education Program(TM) to Include IMSL(TM) C# Numerical Library IMSL C Numerical Library and PV-WA

With the addition of
PV-WAVE, professors can now include the most powerful visualization
techniques available.

About PV-WAVE

PV-WAVE is an array -based programming language used to build and deploy
Visual Data Analysis applications. PV-WAVE solutions allow users to rapidly import, manipulate, analyze
and visualize data. Visual Numerics also offers customized
professional services for applications that involve mathematical,
statistical, or visual data analysis to meet today's business analytical
needs.

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unpack nucleon

Pharsight's
computer-based drug -disease models, dynamic predictive market models, clinical
trial simulation and advanced valuation models create a continuously evolving
view of its customers' development efforts and product portfolios .

Professor Gary Richardson of Central Washington University is the expanded
program's charter member.

Trademark Statement:

Visual Numerics and PV-WAVE are registered trademarks of Visual Numerics,
Inc. Maple is a trademark of
Waterloo Maple, Inc.

kzk nucleon

In addition,
WinNonlin 5.0 release, are clear evidence of our ability to achieve this goal."
Key new features and functionality of WinNonlin 5. The program encourages collaboration among instructors in
comparable disciplines and provides affordable alternatives to software
currently available for classroom use.

For more information about the Knowledge in Motion program, and to apply as
a member, or to learn about special student discount pricing, visit:
http://www.vni.

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In addition, WinNonlin is also fully integrated into
Pharsight's industry-leading PK/PD data management application, Pharsight(R)
Knowledgbase Server 3.
Visual Numerics, Inc., a leading provider of
numerical analysis and visualization software, today announced that is has
expanded its Knowledge in Motion education program to offer comprehensive
mathematics and statistics coverage across multiple programming
environments by including its IMSL C# and IMSL C Numerical Libraries; and
for unprecedented visualization coverage , Visual Numerics also added
PV-WAVE Advantage to the program. Through Knowledge in Motion, Visual
Numerics offers instructors a free copy of the software for their personal
use when they incorporate Visual Numerics' software in their curriculum
development. And, unlike other products, PV-WAVE Advantage includes
a sophisticated set of analysis routines based on the industry-standard
IMSL Libraries .
Mathematica CalcCenter 3 has been derived from CalculationCenter(R), but
is now upgraded to meet the standards of the Mathematica 5 product family.wolfram. Mathcad is a registered trademark of MathSoft, Inc.

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"WinNonlin 5. We believe this release, as well as our recent
PKS 3. With the significant enhancements we
have introduced with WinNonlin 5. WinNonlin 5.
-- Integration with S-PLUS and SigmaPlot: WinNonlin 5. "As a professor of finance, I need the ability to integrate old
Fortran libraries into Visual Basic for Applications (VBA) or Visual
Basic. The IMSL
Libraries are regarded as the most sophisticated, flexible, scalable and
highly accessible technology available for numerical analysis in the most
important mainstream programming environments in use today.S.

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By increasing the functionality of
WinNonlin, Pharsight has created a valuable research and development tool that
allows scientists to reduce the time needed for data management and analysis
of clinical pharmacology studies as well as increase the resources available
for drug development activities .NET quickly and accurately without writing separate wrapper programs
for compatibility.com/calccenter .

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WinNonlin is the industry standard analysis tool for pharmacokinetic (PK)
and pharmacodynamic (PD) modeling and Noncompartmental Analysis, used by over
1,000 pharmaceutical and biotech organizations , as well as academic
institutions.0, increasing the
seamless usage and analysis of study data . Further information on
potential factors that could affect actual results is included in Pharsight 's
Quarterly Report on Form 10-Q, as filed with the Securities and Exchange
Commission on February 14, 2005.

All other
company, product or brand names are the property of their respective
owners.

netcdf unconstrained

He will use the IMSL C# Numerical Library for his
corporate finance course that focuses on topics such as time value of
money, security valuation, financial forecasting, and working capital
management. These embeddable mathematical and
statistical algorithms, written in C, C#, Java and Fortran, are used in a
broad range of applications -- from programs that make airplanes fly and
allow people to predict the weather, to those that enable innovative ways
to study the human genome and predict stock market behavior. The PV-WAVE family of products, which
includes PV-WAVE, TS-WAVE, and JWAVE, delivers engineers with the
development tools to efficiently and accurately meet their data analysis
needs.

Wolfram Research is the world's leading developer of computational
software for science and technology, offering organization-wide computing
solutions. Go to http://www.

xyplot tridiagonal

, Pharsight
Corporation (OTC Bulletin Board: PHST), a leading provider of software and
strategic services designed to optimize clinical drug development, today
announced the release of WinNonlin 5. O'Connor , President and
Chief Executive Officer of Pharsight.com/solutions/education/programs. For more information about
Visual Numerics, please visit www. IMSL, JMSL, JWAVE, TS-WAVE and
Knowledge in Motion are trademarks of Visual Numerics, Inc.

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Pharsight Significantly Increases Functionality of Industry -Leading Pk/Pd Modeling Software

0 can pass data to
Sigma Plot or S-PLUS, can return output to WinNonlin, and can quickly
reproduce S-PLUS and SigmaPlot runs and return S-PLUS analyses , scripts
and results into PKS.pharsight. Actual results may differ materially from
Pharsight 's expectations due to a variety of factors including: general
market and business conditions; uncertainties in pharmaceutical drug
development; changes in demand for Pharsight's products and services; changes
in Pharsight research and development focus or operating strategies; the
failure to develop new products and services or to keep pace with
technological changes; delays in the release of new products and services; and
the failure of products and services to obtain anticipated levels of customer
acceptance or to meet customers' expectations.

The PV-WAVE family also includes robust time series analysis software as
well as the ability to share analysis results across the enterprise with a
Java-based solution.com for more information about Wolfram
Research and its products.

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Safe Harbor
This press release includes forward-looking statements, including
statements regarding the expanding market for Pharsight's technology, future
growth and long-term trends in customer demand for Pharsight's software
products, services and technology, Pharsight's anticipated software product
development and performance, and the expected benefits to customers from the
use of Pharsight 's products.

Launched in September of 2003, Visual Numerics' Knowledge in Motion program
was designed to encourage students to better understand the concepts of
numerical analysis and statistical methods with Java, a broadly used,
platform-independent language."

Visual Numerics' Knowledge in Motion program has been highly successful
with professors from prominent academic institutions such as Hong Kong
University, Brigham Young University, York University, the University of
Colorado and the University of Texas, where they currently use the JMSL
Numerical Library to develop new applications and instructional aids for
their course curriculum.

About Visual Numerics

Visual Numerics has provided technical software solutions for numerical
analysis and visualization for more than three decades., Wolfram Research today announced
the release of Mathematica CalcCenter 3 software -- characterized as having
"the power of Mathematica, the ease of a calculator."
Because Mathematica CalcCenter 3 utilizes the base technology of the
latest version of Mathematica, there is a straightforward upgrade path for
those who subsequently need Mathematica Professional's unsurpassed power.

), evaluation of special functions, constrained, unconstrained and global optimization, probability, statistics (particularly least squares), and random number generation.

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WinNonlin(R) 5.0.0 was created to support newly defined needs of our
pharmaceutical development customers," said Shawn M. As
the market leader for PK /PD analysis software, we are committed to remaining
on the forefront of development and introducing novel technology to our
clients aimed at reducing costs and allowing our customers to focus on their
core competencies -- drug development.
-- Enhanced Data Transformations: WinNonlin's new multi-transformation
tool simultaneously transforms data from multiple columns, producing a
new workbook with any combination of transformed and untransformed
data.com; The Dow Chemical Company; Humana, Sandia National
Laboratories; and Boeing Company. "Moreover, workgroups can use
Mathematica and Mathematica CalcCenter interchangeably, swapping notebooks as
required .

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WinNonlin provides major enhancements
to modeling capabilities and data transformations and is now more fully
integrated with leading data analysis and graphing software products including
S -PLUS(R) and SigmaPlot. CHAMPAIGN, Ill.
"Think of Mathematica CalcCenter 3 as Mathematica lite -- with added ease
of use," said Jon McLoone, lead developer of Mathematica CalcCenter 3.