In contrast, men with a shorter
palindromic sequence had a lower frequency of translocations., Ph.
Through its long-standing commitment to providing exceptional patient care,
training new generations of pediatric healthcare professionals and pioneering
major research initiatives, Children's Hospital has fostered many discoveries
that have benefited children worldwide .chop. The Healthy
Babies education kit includes information on depression, stress and
dental care during pregnancy, and materials from the March of Dimes.
CIGNA works with employer -clients to manage their rising health care costs
by helping ensure their employees get the care they need to prevent, manage or
overcome health issues.

kull defect

Chromosome Rearrangements Not As Random As Believed --Genetic Predisposition May Raise Risk of Rare Disabling Syndrome--

Emanuel, Kurahashi and colleagues have detected
other palindromic repetitive DNA sequences at the breakpoints of other
translocations , suggesting that these unstable structures may play a broader
role in chromosome abnormalities beyond the t(11;22) rearrangement.chop.walkamerica.

raulerson quadruplet

Recent research by Drs.
"The greatest opportunity to impact pregnancy outcomes is in the first
trimester and the early part of the second trimester ," said Jeff Kang, MD,
chief medical officer, CIGNA HealthCare.S. In addition to
the critical issues of the health and well-being of the infant, employers
should be aware of the emotional toll prematurity can have on the workforce as
well as the high health and productivity costs. The case manager is a registered nurse
who provides information about their risk factors and helps them coordinate
health care services and benefits.

hypoplastic sids

com/cgi-bin/prnh/20060216/PHTH049A)
A report in the Feb. Members can use these tools to
assess their health, determine their risk for health problems, and
receive customized information to help them take action to improve
their overall health.

CIGNA Works to Help Fight Prematurity

quadruplet sepsis

(Photo: http://www.
Dr.com, gives
members access to a suite of online decision support and health
maintenance tools from WebMD Health. In addition to the larger health care
costs, the extra care a premature baby needs can also impact productivity in
the workplace in terms of more time away from work for the parents as well as
possible presenteeism. For more information, visit the March of Dimes Web site at
http: //www.

stillborn defect

Products and services
are provided by these operating subsidiaries and not by CIGNA Corporation .

memoriam tetralogy

(For technical reasons, egg cells cannot be tested for
translocations. At the request of a parent support
group, the syndrome was recently named after Dr., also of Children's
Hospital. "We already
knew, of course, that every time someone makes gametes, that is, sperm or egg
cells, there is a possibility of introducing DNA changes.

Contact: John Ascenzi
Phone: (267) 426 -6055
Ascenzi@email.edu

Approximately 4 million babies are born in the United States
each year.

* myCIGNA.
Members who are considered to have high-risk pregnancies may take
advantage of case management services.nacersano. For more information on the annual March of Dimes
WalkAmerica, visit the Web site at http://www.

patau loh

newscom.

* Those identified as being at high risk for complications will be
referred to CIGNA HealthCare's High Risk Maternity Program, part of
CIGNA HealthCare's specialty case management program , to work with
nurse case managers and their treating providers on a more intensive
support plan based on identified risk factors.

CIGNA HealthCare, headquartered in Bloomfield , CT, provides medical
benefits plans, dental coverage, behavioral health coverage, pharmacy benefits
and products and services that integrate and analyze information to support
consumerism and health advocacy.

shortly triplet

17 issue of Science by genetics researchers at The
Children's Hospital of Philadelphia and the University of Pennsylvania
analyzes genetic predisposition to the translocation t(11;22) , a swapping of
genetic material between chromosomes 11 and 22. Patients with the condition usually
have mental deficiency, growth retardation, a heart defect, cleft or abnormal
palate, and other symptoms. New Program Offers Members Incentives to Enroll Earlier for More Targeted
Interventions

BLOOMFIELD, Conn. The economic cost of prematurity is
significant for families and for employers who sponsor medical insurance for
their families.marchofdimes.

kull loh

That child, in turn, while otherwise healthy, often has
fertility problems as an adult. For more information , visit
http://www. "About 50% of Cisco's annual
medical claims costs are related to pregnancy .

trisomy shortly

However, when that does occur, the
child has a constitutional t(11;22) translocation - all of their cells carry
the rearrangement.
The disorder, called supernumerary der(22) t(11;22) or Emanuel syndrome,
results from the havoc caused by an extra chromosome composed of parts of
chromosome 11 and chromosome 22. The other 13 percent of the
chromosomes had shorter palindromic adenine- and thymine-rich sequences.
The CIGNA Healthy Pregnancies, Healthy Babies program aims to identify
members with risk factors so they can begin a plan of care early on that could
help minimize potential complications or premature births. CIGNA's expanded
program will provide incentives for members to participate in the program
early in their pregnancy.

The program will draw upon data and resources available through CIGNA
HealthCare and CIGNA business units specializing in disability , behavioral
health, pharmacy management and dental care.

(1) Centers for Disease Control , National Center for Health Statistics,
based on 2003 data.
(2) Danel, Isabella, MS , MD, Berg, Cynthia, MD, MPH, Johnson, Christopher,
MS and Atrash, Hani, MD; "Magnitude of Maternal Morbidity During Labor
and Delivery: United States, 1993-1997," American Public Health
Association, 2003.
The March of Dimes is a national voluntary health agency whose mission is
to improve the health of babies by preventing birth defects and infant
mortality .org.

memoriam sepsis

PHILADELPHIA, As the human genome gradually yields
up its secrets, scientists are finding some genetic events, such as
rearrangements in chromosomes, are less random than they had previously
thought. Approximately one
sperm in 100,000 has the rearrangement, so the chance of an affected sperm
fertilizing an egg is exceedingly low.D.D. To
encourage members to join the program early in their pregnancy, the value of
the incentives would be greater for members the earlier they join the program. Members have access to
the CIGNA HealthCare Healthy Babies(R) program where they receive educational
materials from a recognized source of information on pregnancy and babies -
the March of Dimes. Every year, CIGNA mobilizes
thousands of employees and their families to participate in WalkAmerica events
held throughout the country from late March through early May.

devore stayed

Further, if this adult does become a parent,
his or her offspring may have an abnormal chromosomal composition and suffer a
disabling multisystem disease.
Parents with an affected child who want to have another child can now have
prenatal testing done during a subsequent pregnancy.

CIGNA HealthCare Expands Maternity Program

, March 10, 2006 -- To help
prevent complications during pregnancy and birth, CIGNA HealthCare today
announced the launch of CIGNA Healthy Pregnancies, Healthy Babies, a
comprehensive maternity management program that expands services offered to
expectant members to help improve their chances of having healthy pregnancies
and deliveries. With appropriate outreach by CIGNA, and a financial incentive added
to the program, we will encourage our employees to participate in this
program .

* CIGNA HealthCare 24-Hour Health Information Line(SM) -- Members can
reach a nurse to ask health care questions 24 hours a day, 7 days a
week, from anywhere in the U.

memoriam loh

D . Emanuel, who
played a major role in mapping chromosome 22 for that program.
"Palindromes are unstable sequences of DNA, and are prone to protrude from
the DNA double helix in fragile structures called hairpins and cruciforms,"
said Hiroki Kurahashi, M. The new program will be available for plans that
take effect beginning January 1, 2007. Beyond the direct cost to business, premature birth also
causes lost productivity.

tuberous tetralogy

Originating as structural weaknesses in unstable stretches of DNA,
abnormal chromosomes may, rarely, result in a disabling genetic disease one or
two generations later. A grant from the National Institutes
of Health supported this study. Its pediatric research program is
among the largest in the country, ranking second in National Institutes of
Health funding .(2) Many birth complications, which can
potentially result in significant harm to mother or child and additional
health care costs, can be prevented with proper prenatal care.

* Participants identified as having moderate risk for pregnancy
complications will receive additional interventions and monthly
outreach specifically targeted to their needs.

In addition, CIGNA works to raise awareness of the risks of prematurity by
supporting the March of Dimes Prematurity Campaign and as a leading
fundraising team at WalkAmerica, the March of Dimes' annual fundraising walk-
a -thon.

New Data Show Costs of Prematurity Can Last a Lifetime and Employers are
Paying the Price

PHILADELPHIA, April 5, 2005 -- CIGNA (NYSE: CI)
today announced it will again be a national sponsor of the 2005 March of Dimes
WalkAmerica (R), the organization's largest annual fund-raising event, for the
eleventh consecutive year.
An estimated one in eight babies in the United States is born prematurely
every year.
As a Business of Caring, CIGNA provides employers with benefits programs,
expertise and services that improve the health, well-being and productivity of
their employees.S.

patau sepsis

"
Chromosome 22 also has palindromic hairpins and cruciform structures,
where breaks occur and DNA swaps places with DNA from chromosome 11.(1) Of these, an estimated one in eight babies will be born
prematurely and an estimated 31 percent of women will suffer some form of
complication during pregnancy. Once enrolled, members undergo a comprehensive health screening
and receive a health management plan tailored to their needs:

* Those identified as being at low risk for pregnancy complications will
receive preventive education and screenings at enrollment, five months
gestation , seven months gestation and postpartum. The service also offers a recorded
audiotape library of over 1,000 different topics. "CIGNA HealthCare" refers to various
operating subsidiaries of CIGNA Corporation (NYSE: CI). By reducing the incidence of prematurity among an
employee population, families will be healthier and employers can avoid
significant direct and indirect costs. Founded in 1938 , the March of Dimes funds programs of research,
community services, education, and advocacy to save babies and in 2003
launched a five-year campaign to address the increasing rate of premature
birth .

graced shortly

"We are learning a lot more about how chromosomes behave, or misbehave,
since the completion of the Human Genome Project," said Dr. In this study, we
asked if some people make those changes at a higher frequency, and found that
this appears to be the case. Unlike
more random, rarer chromosome translocations, the rearrangement between
chromosomes 11 and 22 tends to recur, which led the researchers to investigate
their DNA breakpoints in detail.
"Disorders based on peculiarities of chromosome architecture can be
classified as genomic disorders," said Dr.edu. We will track results over time to better understand what works and
what does not so we can work with CIGNA to improve the program in the years
ahead," said Pamela Hymel, MD, Cisco's Medical Director, Integrated Health.
Eligible members can enroll in the program by contacting CIGNA HealthCare
Member Services to be connected to the CIGNA Healthy Pregnancies, Healthy
Babies team. CIGNA supports the work of the
March of Dimes to reduce prematurity because we know healthy babies mean a
healthier future - for families , workplaces and the bottom line," said David
Cordani, President, Health Segments. CIGNA is also
national sponsor of the March of Dimes Prematurity Campaign, a five-year
public education campaign to raise awareness of prematurity and reduce rates
of preterm birth, which have increased 29 percent since 1981.

tetralogy defect

They found an unexpectedly
high frequency of new translocations in the DNA of sperm samples from healthy
individuals. Like Down syndrome, it is a trisomy, a
disease caused by an extra chromosome . Emanuel, who first described
the disease in 1980 with her colleague Elaine Zackai, M. Emanuel.

About The Children's Hospital of Philadelphia: The Children's Hospital of
Philadelphia was founded in 1855 as the nation's first pediatric hospital. According to the March of Dimes(R), employers pay nearly 15
times more for babies born prematurely in their first year of life than for
full -term babies. The March of Dimes estimates that premature babies
spend nearly 17 days in the hospital in their first year of life, compared to
two to three for full-term babies, and they visit the doctor 's office 50
percent more often, resulting in more time away from work for parents. According to recently released data from the March of Dimes,
employers pay nearly 15 times more in medical expenses for babies born
prematurely in their first year of life than they do for healthy, full-term
babies . and around the globe, CIGNA's operating subsidiaries offer a full
portfolio of medical, dental, behavioral health, pharmacy and vision care
benefits; group life, accident and disability insurance , and health care
coverages for expatriate employees.

trisomy cabral

The disease is rare; hundreds of cases are known worldwide. Emanuel, Ph.
In addition to helping members have a healthy pregnancy and birth, this
program helps employers avoid potentially significant costs associated with
prematurity .
Beyond CIGNA's program offerings to help manage prematurity, CIGNA and its
employees are committed to the March of Dimes.com, or its Spanish Web site at
http://www.

loh stillborn

Members must complete the program through the postpartum assessment to receive
the incentive payment. The
CIGNA Healthy Pregnancies, Healthy Babies program helps reduce the financial
and emotional toll of pregnancy complications for families and helps employers
track and reduce potentially high health and productivity costs .5 million to
the March of Dimes. Members also have round-the-clock access to the toll-free
CIGNA HealthCare 24-Hour Health Information Line(SM) and may talk to a
registered nurse about questions or concerns. The High-Risk Maternity program proactively
identifies pregnant women who are at high risk for pregnancy-related
complications and prenatal hospitalizations because of co-morbid conditions ,
such as hypertension or diabetes. Serving millions of customers, clients and members in the
U .

tetralogy quadruplet

"The
hairpins and cruciforms are weak points where the DNA can break and rearrange
with DNA from other chromosomes. "Our goal is to identify expectant
mothers at a greater risk for complications and lower their risk of
complications with patient education, wellness programs and targeted support
from nurse case managers.
To encourage greater participation in the program, CIGNA is offering
eligible members incentives to join the program. Since 1995, CIGNA and its employees have contributed $17. Since 1994, CIGNA and its employees have
contributed $16 million to the March of Dimes.
CIGNA offers several resources to help educate expectant members on having
healthy pregnancies and preventing premature births. If a baby is born prematurely, CIGNA members
may take advantage of the Neonatal Intensive Care Unit (NICU) Case Management.

Memorial sites for babies lost after birth .

meakin raulerson

,
chief of Human Genetics and Molecular Biology at The Children's Hospital of
Philadelphia, and a co-author of the study.
Surprising was the finding that newly arising t(11:22) translocations occurred
with a frequency of approximately one in 100,000 sperm cells from healthy men
with the longer palindromic sequences. Kurahashi is now at the Institute for Comprehensive Medical Science of
Fujita Health University, Fujita, Japan. With the integration of
information from all of these health-related areas, CIGNA Healthy Pregnancies,
Healthy Babies clinicians will be able to better understand the full scope of
an expectant member's condition and care to help coordinate the appropriate
resources from many health disciplines for the member. It takes a tremendous emotional and financial toll on families as
premature babies fight to survive and may continue to face ongoing health
challenges throughout their lives.

stillborn tetralogy

CIGNA HealthCare also offers the following programs that promote the
health and wellness of members.com -- CIGNA's personalized web portal, myCIGNA.
"While the consequences of premature birth are most obvious on a baby and
its family, they also have a significant impact on employers.
Through this program, CIGNA seeks to appropriately reduce the length of stay
for infants in the NICU by resolving barriers to discharge, and facilitating
parental education and use of community resources.

memoriam hypoplastic

In addition, its unique family-centered care and public
service programs have brought the 430-bed hospital recognition as a leading
advocate for children and adolescents . If we can help our members
ensure they are receiving appropriate medical care and follow up, we are
hopeful we can help our mothers have healthy pregnancies and fewer premature
infants. These incentives may come in
the form of reimbursement of medical expenses, additional contributions to a
member's Health Reimbursement Arrangement or other incentive arrangement. Members with specific
medical conditions that impact pregnancy outcomes, such as diabetes or
pregnancy -induced hypertension, will receive support and care
coordination to ensure they understand their conditions and are able to
adhere to treatment recommended by their providers.org.

defect quadruplet

)
By and large, these translocations are not cause for alarm, because those
men and their offspring are highly unlikely to be affected.
Although the heart defects were often lethal in the past , advances in
heart surgery are allowing children with Emanuel syndrome to survive longer. Many of those
children and their families have been studied by Beverly S."
The researchers found that at the site where the translocation would
occur, 87 percent of 394 normal chromosome 11 samples examined had repetitive
stretches enriched in the DNA bases adenine and thymine, 450 bases long, in an
unstable configuration called a palindrome.D., corresponding author of the paper. Unlike single-gene
diseases such as cystic fibrosis or hemophilia that result from mutations in
one gene, genomic diseases originate in the broader structure of the genome -
the full complement of DNA sequences in sets of chromosomes ."
Employers are excited about the program. These programs continue to be available to
expectant members:

* CIGNA HealthCare Healthy Babies(R) -- This program provides members
with education on healthy behaviors during pregnancy.