Cookbook Designed to Give Busy Cooks Good-for-You Recipes That Can Be Prepared
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OWEGO, N.Y.
Cavataio , a gourmet chef with 24 years experience, recently published a
new cookbook titled "Conquering Healthier Recipes and Beyond. The fact
is, you can prepare wonderful, healthy, great-tasting dishes at home in very
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The book includes a complete 6-week menu cycle that keeps cooks from ever
running out of meal ideas. The cookbook has been especially helpful in
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Download the cookbook as an e-book at
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mail.
During the normal drug development process and besides evaluating
Oral-lyn(TM) against its active comparator , it was necessary to test
preparations with different insulin concentrations or different ratios of the
excipients included in the Oral-lyn(TM) formulation. Guevara's study,
the glucodyanmic (GD) profiles induced by single pre-prandial versus pre- and
post-prandial split doses of Oral-lyn (TM) were compared to the GD profile of
Humulin-R in a 3-day (4 hours per day) open-label study performed in patients
with Type-1 diabetes. After evaluation of the GD profiles
of the various preparations , Dr. Kidron and J.

About Generex
Generex (http://www. The Company's
proprietary liquid formulations allow drugs typically administered by
injection to be absorbed into the body by the lining of the inner mouth using
the Company's proprietary RapidMist(TM) device. Unlike
earlier methods, where fasting was required and since alcohol is more likely
to be consumed socially, this study examines how alcohol could work in
reducing heart disease by improving risk factors following a meal.
"We found that artery stiffness, a strong predictor of increased heart
disease risk , was improved when alcohol was consumed with the low carbohydrate
meal but this benefit was not seen following the high carbohydrate meal," says
Dr.org

thanksgiving dinner

Company presents at the American Diabetes Association
65th Scientific Sessions

TORONTO, Generex Biotechnology
Corporation (Nasdaq: GNBT), a leader in the area of buccal drug delivery,
today announced clinical trial results in respect of Oral-lyn(TM), the
Company's proprietary oral insulin buccal spray formulation, presented at the
65th Annual Meeting + Scientific Sessions of the American Diabetes Association
held June 10 - 14, 2005 in San Diego.
In the first experiment , Oral-lyn(TM), in either a single pre-prandial
dose or in a split-dose fashion, was administered to 6 patients with Type-1
diabetes.
Dubinsky, M.
Furthermore, the study found a reduction of fructosamine in the Oral-lyn(TM)
group of 6.generex. CHEVY CHASE, Md.
The researchers also found that alcohol increased the number of calories
burned after both meals, which may account for their previous finding that
moderate drinkers have less body fat than non-drinkers. Together, these members represent all
basic, applied, and clinical interests in endocrinology.

dinner time

" It features
over 300 mouth-watering, delicious, healthy recipes that give you quick and
easy preparation time, with step by step easy to follow directions. Saavedra). Guevara was able to identify the preparation
that exhibited the best GD profile for use in longer term trials. The primary hypothesis was that
Oral -lyn(TM) can be used safely at mealtimes and will improve 7 point glucose
profiles, fructosamine and the baseline HbA1c levels 12 weeks after treatment.
This was a randomized, double-blind, long -term (12 weeks) study in 26
patients with Type-2 diabetes (male or female) with poorly controlled blood
glucose maintained on once a day s. In cases where self-glucose values were above
12mmol /L before any meal or before bedtime, an additional 7 puffs were added.

Safe Harbor Statement: This release and oral statements made from time to
time by Generex representatives concerning the same subject matter may contain
"forward- looking statements" within the meaning of the Private Securities
Litigation Reform Act of 1995. Generex cannot be sure
when or if it will be permitted by regulatory agencies to undertake additional
clinical trials or to commence any particular phase of clinical trials., Researchers have discovered that
a small amount of alcohol after dinner reduces the health risk of insulin and
glucose related diseases in postmenopausal women.
Previous studies have shown that healthy people who drink small amounts of
alcohol regularly have a smaller risk of developing heart disease and diabetes
compared to people who either don't drink or drink in excess. This benefit was not seen when alcohol was consumed with a meal high
in carbohydrate and fat. Today, The Endocrine Society's
membership consists of over 12,000 scientists, physicians, educators, nurses
and students , in more than 80 countries.endo-
society.

time frame

"Over the years I've had just about everything
you imagine go right and wrong.
Parents everywhere are remembering how many of their childhood memories
have to do with the kitchen.
In addition, Generex clinician Professor Itamar Raz published a paper in
the Abstract Book for the 65th Annual Scientific Sessions titled "Addition of
Oral -lyn(TM) at Mealtimes in Subjects with Type-2 Diabetes Maintained on
Glargine + Meformin -- A Comparison with Placebo" (co-authored with A. After the
initial screening visit, subjects maintained their regular treatment for two
weeks as a run-in period.
Each subject had routine blood chemistry and HbA1c as well as fructosamine
levels at the beginning of the study and at the end of every month during the
study period. Forward-
looking statements frequently are used in discussing potential product
applications, potential collaborations, product development activities,
clinical studies , regulatory submissions and approvals, and similar operating
matters.

suggested for

These are stories a lot of people can really
relate to," he said. These parents are determined to create cooking
memories with their own children. Guevara tested the relative
efficacy of various Oral-lyn(TM) preparations in a series of similar 4-hour
open label studies performed in the same individuals with a view to
determining the most appropriate Oral-lyn(TM) preparation for longer term
trials. The corresponding GD profiles were compared to the GD profiles
induced by the administration of the active comparator (subcutaneous injection
of Humlin-R) 30 minutes prior to the same test meal. Wainstein).4% versus 3. No forward-
looking statement is a guarantee of future results or events, and one should
avoid placing undue reliance on such statements. Generex claims the
protection of the safe harbor for forward-looking statements that is contained
in the Private Securities Litigation Reform Act. Founded
in 1916, The Endocrine Society is the world's oldest, largest, and most active
organization devoted to research on hormones, and the clinical practice of
endocrinology.

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"People are so busy these days they feel they just
don't have time to prepare a healthy home-made dinner," says Nick Cavataio.
A favorite for many readers are Cavataio's personal stories about
experiences in the kitchen.

In a second experiment, Dr.c. Glargine and Metformin. The Company's flagship
product, oral insulin (Oral-lyn(TM)), is in late stage clinical trials around
the world.

After Dinner Drink Proves Beneficial to Some

Published in the February
issue of The Journal of Clinical Endocrinology + Metabolism , these findings
may explain the decreased risk of heart disease, diabetes and obesity, in
people who drink alcohol in moderation. Endocrinologists are specially trained doctors who diagnose,
treat and conduct basic and clinical research on complex hormonal disorders
such as diabetes, thyroid disease , osteoporosis, obesity, hypertension,
cholesterol and reproductive disorders. The Endocrine Society
is based in Chevy Chase, Maryland. To learn more about the Society, and the
field of endocrinology , visit the Society's web site at http://www.

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"I would just shake my head when I saw McDonalds and Burger King crammed
with people who would be eating better if they just had the time. Also included are tips for fast, effective
cooking, how to let kids get involved, and tips for getting the best buys at
grocery stores.

Generex Biotechnology Presents Oral-lyn(TM) Clinical Trial Results

6%
reduction in the Oral-lyn(TM) group versus 3.4% in the placebo group. Generex undertakes no
obligation to update publicly any forward-looking statements, whether as a
result of new information, future events or otherwise.

meal suggested

Veteran Gourmet Chef Presents 300 Healthy Recipes That Taste Great From ConqueringHealthierRecipes .com

The purpose of the Professor Raz study was to determine the metabolic
effect of Oral -lyn(TM) at mealtime on a long-term basis (12 weeks) in patients
with Type-2 diabetes maintained on once-a-day subcutaneous Glargine insulin
injection therapy at bedtime and Metformin. Following the training of the Oral-lyn(TM) device
operation and dosing schedules, they were divided into two groups .6% in the placebo group and for HbA1c there was a 6.
Because of this, statements regarding the expected timing of clinical trials
cannot be regarded as actual predictions of when Generex will obtain
regulatory approval for any "phase" of clinical trials.
JCE+M is one of four journals published by The Endocrine Society.

preparation suggested

, With Americans of all ages setting
new records for obesity, the causes are largely being accredited to frequent
consumption of fast food. Guevara and J. The study determined
that a pre - and post-prandial split-dose of Oral-lyn(TM) was better than
a pre-prandial single dose and comparable to the GD profile induced by
Humulin-R.
The second experiment included a series of open-label studies at which the
same 6 patients with Type-1 diabetes received, in different days, single does
of each preparation of Oral-lyn(TM) in a split-dose regimen with 5 puffs
before and 5 puffs after the test meal. The
effective post-prandial trend can be seen clearly, although the results are
not statistically significant.com) is engaged in the research and
development of drug delivery systems and technologies. Generex has developed
a proprietary platform technology for the delivery of drugs into the human
body through the oral cavity (with no deposit in the lungs). These statements can be identified by
introductory words such as "expects," "plans," "intends," "believes," "will,"
"estimates," "forecasts," "projects" or words of similar meaning, and by the
fact that they do not relate strictly to historical or current facts.
The researchers from the Garvan Institute in Sydney, Australia studied 20
postmenopausal women who were given a small amount of alcohol (15 grams ) after
their meals. Lesley Campbell, lead author of the study.

thanksgiving holidays

Both groups took the puffs 10 minutes before mealtime in addition to
their regular treatment. Beginning with the initial screening visit , each subject had to
monitor his/her blood glucose at least three times a day and once a week for a
7-point profile. Many factors may cause actual results to differ from forward-looking
statements , including inaccurate assumptions and a broad variety of risks and
uncertainties, some of which are known and others of which are not. Although
significant research has been conducted to discover why alcohol in moderation
may have these benefits, most previous studies have measured fat levels in the
blood when people are fasting, many hours after their last drink.

preparation meal

conqueringhealthierrecipes. Additional recipes are also available. In Dr.
The interim results, after 8 weeks of treatment , showed no change in
fasting glucose while in post-prandial glucose there was a 15.4% reduction in
the Oral-lyn(TM) group versus 3.
The study concluded that in patients with Type-2 diabetes maintained on
Glargine and Metformin, Oral-lyn(TM) was especially effective in controlling
post -prandial glucose excursions. Known
risks and uncertainties include those identified from time to time in the
reports filed by Generex with the Securities and Exchange Commission, which
should be considered together with any forward-looking statement. They found that when alcohol was consumed with a meal low in
carbohydrate but high in fat, the increase in glucose levels after the meal
was lessened, particularly in those with lower body fat and lower insulin
levels.

time suggested

Generex clinician Dr. Jaime Guevara-Aguirre presented a poster in the
Clinical Therapeutics/New Technology -- Insulin Delivery Systems category
titled "A Series of Open-Label Studies Comparing Various Formulations of
Oral-lyn(TM) Propellant Spray in Patients with Type-1 Diabetes Mellitus"
(co-authored with M.

One group
had 7 puffs of Oral-lyn(TM) TID, and the other group had 7 puffs of placebo
TID.9% elevation in the placebo group. This may be partially due to the short time
period and small sample size of the study.