ISB has built
advanced computer systems to process data and formed a multidisciplinary
faculty and staff.gov/

Lighthammer CMS provides the core services required to enable
customers to rapidly build composite applications that span the full
breath of manufacturing excellence initiatives including: Performance
Management, Continuous Improvement and Operational Synchronization.

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Hood and his center are likely
to continue to help define the discipline and, at the same time, advance our
understanding of complex biological processes that impact human health. They are devoted to developing new technology and
biological research to advance our understanding of disease.systemsbiology. For more information
about NIGMS visit: http://www.

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This version extends
Lighthammer's leadership position in the Manufacturing Intelligence
and Collaborative Manufacturing software space by delivering
significant enhancements in the areas of enterprise scalability ,
security and compliance. This service provides the ability
to implement a security strategy that fits any existing enterprise
architecture and extends "single sign-on" into the domain of plant
applications improving compliance.
Additional compliance and traceability features have been added
with the addition of an e-signature service to the product.com

Lighthammer, Lighthammer CMS, Collaborative Manufacturing Suite,
and all other Lighthammer products and services mentioned herein are
trademarks or registered trademarks of Lighthammer Software
Development Corp.

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"With his track record in technological innovation and his interest in
training the next generation of scientists, Dr.

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The Center will be only the sixth of its kind in the U.

Lighthammer Releases Collaborative Manufacturing Suite 11 .0; Featured Enhancements to Enterprise Scalability Security and Compliance Extend Leadership Positio

Lighthammer CMS provide the
complete set of services required to quickly assemble operational
excellence applications in the areas of Performance Management,
Continuous Improvement and Operational Synchronization .

seb interdisciplinarity

Resources and results
from the work conducted at the Center will be shared with the larger
scientific community.

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$16 Million Grant Awarded to Institute for Systems Biology

"The future of systems biology depends on effective collaborations among
researchers from different disciplines," said John Aitchison, the new
associate director of the Center for Systems Biology.

"This grant will help
the institute grow in its capacity to conduct collaborative research, develop
new technologies and reach out to the larger community. The ISB team of leading-edge researchers are
committed to pursuing the innovations that will transform science and medicine
in the 21st century and eventually lead to the prediction and prevention of
disease.
Lighthammer is an SAP Powered by NetWeaver and SAP xApps Partner,
and is currently in use at hundreds of companies worldwide .lighthammer.

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Lighthammer CMS 11 is easily the most significant release in the
company's history . Built on a
modern, service-oriented architecture, Lighthammer CMS enables
composite applications to be created in a fraction of the time of
traditional approaches, increasing responsiveness and delivering
exceptional business returns.

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As the prefix 'trans' indicates, transdisciplinarity concerns that which is at once between the disciplines, across the different disciplines, and beyond all discipline .

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ISB's goal is to unravel the mysteries of human biology and
identify strategies for predicting and preventing diseases such as cancer,
diabetes and AIDS."
Lighthammer CMS 11 now includes a powerful Security Manager
service, which allows unified user management, single-sign-on, and
integration with a wide range of third party authentication systems
including: SAP, LDAP/Active Directory, SAML , Windows Domains,
Kerberos, and others.

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A
multi-level confirmation/challenge capability has been added to
securely control and document user actions for regulatory compliance
such as 21 CFR 11 , Sarbanes-Oxley, and others.

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3 million grant from the National
Institutes of Health (NIH) to fund the operation of a Center for Systems
Biology in Seattle. Other systems biology centers have been established at
Harvard University, Princeton University, University of Washington Friday
Harbor Laboratories, Massachusetts Institute of Technology and Case Western
Reserve University.
"The emergence of systems biology as a defined discipline can partly be
attributed to the vision of Dr. Berg, Ph.

Pluridisciplinarity concerns studying a research topic not in only one discipline but in several at the same time.

transdisciplinary transdisciplinarity

Hood," said Jeremy M.

Business Editors/Technology Writers

EXTON , Pa.----Lighthammer(R),
supplier of the world's first composite application platform for
manufacturing operational excellence, announces the release of
Collaborative Manufacturing Suite(TM) 11.

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Enterprise integration capabilities have also been enhanced, with
the addition of new business logic capabilities that take advantage of
web services in SAP NetWeaver(TM) to simplify data integration between
plant systems and enterprise systems.

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"This grant provides crucial support to ISB as we continue to push the
limits of science in order to make new discoveries about biology and the human
body, and ultimately find new ways to fight diseases," said Leroy Hood,
Institute for Systems Biology's president and co-founder.
Designed to leverage, not replace, existing system investments,
Lighthammer CMS offers time-to-value in days and weeks and
return-on-investment typically in the 5X-20X range .

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In addition, it will be a place for students in grades
K-12 to experience inquiry-based science , a method encouraging young
scientists to explore, ask questions, engage, and analyze data as they study
the field of science.D.

About the Institute for Systems Biology
The Institute for Systems Biology (ISB) is an internationally renowned
non-profit research institute dedicated to the study and application of
systems biology.
ISB carries out its research with a specific mission: to not only cure
complex diseases but also predict an individual's future health prognosis , in
order to get early treatment.nigms.
"Version 11 takes CMS to the next level" said Greg Gorbach , Vice
President of Collaborative Manufacturing for ARC Advisory Group."

About Lighthammer

Lighthammer, a privately held corporation headquartered in Exton,
PA., develops and markets Lighthammer Collaborative Manufacturing
Suite (CMS), the world's first and only composite application platform
for manufacturing Operational Excellence. More than 100 Fortune 500 manufacturing
companies have deployed Lighthammer solutions.

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ISB to Create a Center for Research, Collaboration and Technology

SEATTLE, The Institute for Systems Biology (ISB),
an internationally renowned non-profit research institute with a mission of
exploring the complexities of human genes in order to prevent and treat
diseases, received a five-year, $16."
Systems biology uses advanced computer methods to model complex biological
systems, like the human body, based on large quantities of data.

Interdisciplinarity concerns the transfer of methods from one discipline to another.

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The driving force behind the innovative "systems" approach
is the integration of biology, computation and technology. Located in Seattle , Washington, the Institute's
team includes 11 faculty members and more than 170 staff members, and an
extensive network of academic and industrial partners.org.

About the National Institute of General Medical Sciences
The National Institute of General Medical Sciences (NIGMS), a component of
the National Institutes of Health, supports basic biomedical research that is
the foundation for advances in disease diagnosis, treatment, and prevention. These features allow customers to manage user
roles, memberships, attributes and define authentication/authorization
services from existing enterprise user management directories, and/or
through the Lighthammer application.

Its goal is the understanding of the present world, of which one of the imperatives is the unity of knowledge.

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With a faculty and staff composed of
biologists, chemists, computer scientists, engineers, mathematicians and
physicists, ISB designed the Center to bring its researchers together in order
to further the systems approach to biology and medicine they have pioneered
since its formation in 2000. The National
Institute of General Medical Sciences (NIGMS), part of NIH, is funding the
centers in an effort to support the systems biology work already being done at
institutes like ISB. This approach
allows scientists to analyze all of the elements in a system rather than one
gene or protein at a time.

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The center will provide professional development, including workshops,
courses, internships , and sabbatical opportunities, in order to help
researchers learn about the systems biology approach , combine their expertise
and further ISB's research on human biology and disease. For more information about the ISB visit:
http://www.nih.

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, director of
NIGMS.
"Lighthammer has extended the capability of its Collaborative
Manufacturing Suite in precisely the areas global manufacturers need:
security , compliance, and scalability.
"We continue to extend our lead in deployment of service-oriented
architectures for manufacturing by delivering new services in the
areas of electronic signature, multi-site metrics , advanced analytics
and security," said Rick Bullotta, CTO and co-founder of Lighthammer.
"In doing so, we have substantially increased the value of Lighthammer
CMS to manufacturers looking to multiply the benefits by deploying on
global basis while simplifying compliance and security concerns .

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"By gathering
together researchers from multiples fields, using the new technologies that we
have developed and the computer modeling programs we've pioneered, we will
advance our research in ways not possible before.

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The new Center will be housed at ISB's research and office building,
located on Lake Union, and will foster collaborative research among the
diverse set of researchers at ISB .S. The organization has an
annual budget of more than $25 million. The initiative provides grants to
research centers like ISB to conduct systems research.
Further information on Lighthammer and its products can be found
at www.

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The Institute launched an initiative in 2002 to create Centers of Excellence
in Complex Biomedical Systems Research.

cybernetic interdisciplinarity