Isis Pharmaceuticals, Inc . As an innovator in RNA-based drug discovery and development, Isis is the
owner or exclusive licensee of more than 1,500 issued patents worldwide.

This press release includes forward-looking statements regarding our
business, the financial position of Isis Pharmaceuticals, and the therapeutic
and commercial potential of our technologies and products in development.
Securities and Exchange Commission. JACKSON, Miss. Packages sell for $49.com
and LawStore.

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CARLSBAD, Calif. (USLF)
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Business Editors

PARIS----With new and more complex
US regulations and an increasing focus on European companies by US
regulators aiming to protect investors and to establish a stringent
business code of conduct , European companies have to face growing
legal and financial risks even if not listed on a US stock market.: class action, SEC investigation)

All these important issues will be handled by experts in
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leading US law firms, coming straight from Washington, Boston, New
York .newscom. Legal Forms
expands on its Life Documents product line which began with the introduction
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The packages have been designed for Baby Boomers,
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These and other risks concerning Isis' research and development
programs are described in additional detail in Isis' Annual Report on Form
10 -K for the year ended December 31, 2003, and quarterly report on Form 10-Q
for the quarter ended September 30, 2004, which are on file with the U., U.

therapeutic emphasis

Such
statements are subject to certain risks and uncertainties, particularly those
inherent in the process of developing technology, in discovering and
commercializing drugs that are safe and effective for use as human
therapeutics, and in the endeavor of building a business around such products.sirius-conference.S. See the
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, (Nasdaq: ISIS) announces the following webcast:

What: Isis Pharmaceuticals 2004 Fourth Quarter Financial Results

When: Tuesday, March 1, 2005 at 10:00 am (ET)

Where: http://www.com

How: Live on the Internet.

Contact: Kristina Peterson
Corporate Communications
(760) 603-2331

If you are unable to participate during the live event a replay of the
webcast will be available at http://www. Target packages are part
of a growing commitment by USLF to address the specific needs of its
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For further information and for registration, please visit the
website www.95.uslegalforms.uslegalforms.

About U.

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The objectives of this 2-day conference are to:

Evaluate company and Directors + Officers' risks related to US
Securities Law, the Foreign Corrupt Practices Act and US
Antitrust Law

Examine methods of the Securities and Exchange Commission
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Develop a communication strategy in accordance with the new
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Review strategies to limit risk exposure and to avoid a US
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is exploiting its expertise in RNA to discover
and develop novel human therapeutic drugs for its pipeline and for its
partners . Copies of these and other documents are
available from the company. Edens.com/formspackages/life -documents-military.

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, Isis Pharmaceuticals,
Inc. As a result, you are cautioned not to rely on these forward-looking
statements.S..com/formspackages/life-documents-newlyweds.htm. USLegalForms.

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Ibis Therapeutics(R) is a registered trademark of Isis Pharmaceuticals,
Inc.

USLegalForms .com Creates Select Life Documents Packages

Legal Forms, Inc.
Each select Life Documents package includes a Will, Living Will and Power
of Attorney, plus other tailored legal forms. The company sells
legal forms and related products to attorneys, small businesses, and the
public. In 2005 , U.

1976 describe

Sirius Consulting Group to Organize Implications of US Regulations on European Companies Conference May 11 and 12 in Paris FR.

.
This conference is intended for Chief Executive Officers, Chief
Financial Officers, General Counsels, Risk Managers and Audit
Department Officers of European groups and subsidiaries of US
companies.
(Logo: http://www.
Details can be found at the following links:

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http://www.uslegalforms. Legal Forms, Inc.

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htm

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isispharm. 500 list of fastest
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Reminder - Webcast Alert: Isis Pharmaceuticals Announces 2004 Fourth Quarter Financial Results Webcast

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Frank D.htm

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The Company has successfully commercialized the world's first
antisense drug and has 10 antisense products in development to treat
metabolic, cardiovascular and inflammatory diseases , and cancer. Through its
Ibis Therapeutics(R) program, Isis is developing a biosensor to identify
infectious organisms, and is discovering small molecule drugs that bind to
RNA.
Actual results could differ materially from those discussed in this press
release.


com now lists more than 50,000 state-specific legal
forms which are drafted in the required language and style needed to comply
with the laws of each state. U.

particularly step

(http://www.

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com. Any
statement describing our goals , expectations, intentions or beliefs is a
forward-looking statement and should be considered an at -risk statement,
including those statements that are described as Isis' clinical goals.S. The production staff, comprised of attorneys,
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With the addition of select Life Documents Packages, U. This package
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