Isis Pharmaceuticals, Inc . As an innovator in RNA-based drug discovery and development, Isis is the
owner or exclusive licensee of more than 1,500 issued patents worldwide.

This press release includes forward-looking statements regarding our
business, the financial position of Isis Pharmaceuticals, and the therapeutic
and commercial potential of our technologies and products in development.
Securities and Exchange Commission. JACKSON, Miss. Packages sell for $49.com
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Business Editors

PARIS----With new and more complex
US regulations and an increasing focus on European companies by US
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business code of conduct , European companies have to face growing
legal and financial risks even if not listed on a US stock market.: class action, SEC investigation)

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These and other risks concerning Isis' research and development
programs are described in additional detail in Isis' Annual Report on Form
10 -K for the year ended December 31, 2003, and quarterly report on Form 10-Q
for the quarter ended September 30, 2004, which are on file with the U., U.

therapeutic emphasis

Such
statements are subject to certain risks and uncertainties, particularly those
inherent in the process of developing technology, in discovering and
commercializing drugs that are safe and effective for use as human
therapeutics, and in the endeavor of building a business around such products.sirius-conference.S. See the
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, (Nasdaq: ISIS) announces the following webcast:

What: Isis Pharmaceuticals 2004 Fourth Quarter Financial Results

When: Tuesday, March 1, 2005 at 10:00 am (ET)

Where: http://www.com

How: Live on the Internet.

Contact: Kristina Peterson
Corporate Communications
(760) 603-2331

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The objectives of this 2-day conference are to:

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Examine methods of the Securities and Exchange Commission
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Review strategies to limit risk exposure and to avoid a US
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is exploiting its expertise in RNA to discover
and develop novel human therapeutic drugs for its pipeline and for its
partners . Copies of these and other documents are
available from the company. Edens.com/formspackages/life -documents-military.

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, Isis Pharmaceuticals,
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Ibis Therapeutics(R) is a registered trademark of Isis Pharmaceuticals,
Inc.

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Sirius Consulting Group to Organize Implications of US Regulations on European Companies Conference May 11 and 12 in Paris FR.

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This conference is intended for Chief Executive Officers, Chief
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Reminder - Webcast Alert: Isis Pharmaceuticals Announces 2004 Fourth Quarter Financial Results Webcast

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The Company has successfully commercialized the world's first
antisense drug and has 10 antisense products in development to treat
metabolic, cardiovascular and inflammatory diseases , and cancer. Through its
Ibis Therapeutics(R) program, Isis is developing a biosensor to identify
infectious organisms, and is discovering small molecule drugs that bind to
RNA.
Actual results could differ materially from those discussed in this press
release.

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