In
addition, College Hospital has large and intensive outpatient services
for behavioral health and dual diagnosis treatment/education /awareness
available at its locations in Laguna Woods, Anaheim, Santa Ana and
Costa Mesa, California . Urschel, III, M. Upon final approval to begin the study, each qualified
subject will participate in the trial over a three month period in
Dallas, at the Research Across America clinical research facility. Since the aim of
the study is to initiate abstinence from methamphetamine, patients
will not be required to be drug or stimulant abstinent at the time of
enrollment and treatment.

About HANDS(TM)

Hythiam's HANDS Protocols(TM) are designed for use by healthcare
providers to treat those diagnosed with dependencies to alcohol,
cocaine, methamphetamine and other addictive stimulants , as well as
combinations of these drugs. Headquartered in Dallas, other sites
include Carlsbad , Calif. WASHINGTON, Early alcohol intoxication can lead
to a need for substance abuse treatment later in life. Governor James Aiona, Hawaii, are all scheduled to teach the underage
drinking curriculum . "These
new SAMHSA data confirm that the vast majority of those in treatment for
alcohol misuse had an early initiation into intoxication. In 2002, 57 percent of primary alcohol admissions ages 21 or older
were admitted to treatment for alcohol alone while 43 percent reported abusing
alcohol and drugs.
This is the fourth year of Reach Out Now.S.

reciprocity dependence

Peizer, Hythiam's
Chairman and CEO .

Hythiam is a healthcare services management company, focused on
delivering solutions for those suffering from alcoholism and other
substance dependencies.
"The serious consequences of methamphetamine addiction continue to
spread rapidly across all cultures, races and societies," Peizer
continued.

"Methamphetamine abuse has become a pervasive problem in our
country, as has been recently reported by numerous sources; however,
very few medical options exist for the treatment of methamphetamine
addiction," said Dr.
Consequently, within this scientific situation, an open label trial
which shows positive results would be very valuable for the treatment
community, as it would be a jumping off point on which to focus more
detailed double-blind placebo-controlled trials . The HANDS Protocols also
provide for a maintenance program that includes medications and
incentives for patients to continue with the recovery process through
individualized continuing care programs .,
Community Anti-Drug Coalitions of America, the National Family Partnership,
National Association of State Drug and Alcohol Abuse Directors, National
Council on Alcoholism and Drug Dependence and the Benevolent Protective Order
of Elks.

dependence alcoholism

(NASDAQ:HYTM), a healthcare services management company that delivers
to treatment providers both proprietary administrative services and
physiological protocols designed to treat substance dependence,
announced today that it has signed a licensing and services agreement
to offer its HANDS(TM) Protocols to College Hospital Costa Mesa in
Orange County, California, a College Health Enterprises hospital. The HANDS Protocols include medically
supervised procedures designed to target receptor sites in the brain
that regulate neurotransmitters implicated in brain processes of
substance dependency.

Business Editors/Health/Medical Writers

LOS ANGELES----Hythiam, Inc.
Dr. The study will consist of an initial
three-day outpatient treatment for each patient, followed by an
additional two-day cycle after three weeks, and a 12-week follow up
and assessment period. We believe that alteration in GABA(A)
function, caused or exacerbated by chronic substance abuse, may be
associated with anxiety, sleep and cognition disorders.; Reading , Pa. SAMHSA found that among those persons ages 21 and
older admitted to treatment for alcohol dependence or abuse in 2002, 88
percent were first intoxicated before age 21., on the Reach Out Now initiative to
educate students in fifth and sixth grade classrooms nationwide on the dangers
of underage alcohol use, with a program that includes teach-ins April 18
through 22 in every state.

stigma niaaa

Urschel, a highly-regarded addiction psychiatrist with a
strong background in research, is taking this opportunity to rapidly
provide the industry with data on a much needed physiological option
for treating this disease," said Terren S. Peizer, Hythiam's Chairman
and CEO. Among the neuronal pathways targeted by
the components of the HANDS Protocols(TM) is the GABA system,
including the GABA(A) receptor . To date there have been no clear-cut effective
treatments, either pharmacological or behavioral which are readily
available for this pervasive devastating illness.

steroid ryans

, intends to conduct
a study of Hythiam's HANDS Protocols(TM) in the treatment of
methamphetamine dependence. For further information please visit www.com

Forward-Looking Statements

Except for statements of historical fact , the matters discussed in
this press release are forward looking and made pursuant to the Safe
Harbor provisions of the Private Securities Litigation Reform Act of
1995.gov.

reciprocity arium

"We are pleased to enhance our programs in Orange County by
offering the HANDS Protocols, an opportunity for patients to take that
first step in breaking the cycle of dependence," said Wayne
Lingenfelter, CEO of College Hospital Costa Mesa."
"California has one of the highest percentages of illicit drug use
among adults in the country," said Terren S.'"

About HANDS(TM)

Hythiam's HANDS Protocols(TM ) are designed for use by healthcare
providers to treat those diagnosed with dependencies to alcohol ,
cocaine, methamphetamine and other addictive stimulants, as well as
combinations of these drugs . For further information please visit www.com

Forward-Looking Statements

Except for statements of historical fact, the matters discussed in
this press release are forward looking and made pursuant to the Safe
Harbor provisions of the Private Securities Litigation Reform Act of
1995. An accomplished
researcher, over the past 15 years he has designed and conducted many
studies targeted at addiction recovery, both for governmental agencies
like the National Institute on Drug Abuse (NIDA) and major
pharmaceutical companies.oas.

SAMHSA, a public health agency within the U.

maac steroid

Veteran Clinical Researcher Dr. Harold Urschel to Investigate Hythiam's HANDS Protocols for the Treatment of Methamphetamine Dependence; First of Several Antic

The CNS
Research Group for Research Across America is headed by Dr. Moreover, as
the major inhibitory neurotransmitter in the central nervous system,
GABA plays a pivotal role in maintaining stable and rational behavior. There were 16 percent
who initiated alcohol use between ages 18 and 20 and 12 percent who were
younger than age 12 when first intoxicated . In 2004, Reach Out Now
materials were distributed to over 300,000 classrooms nationwide. Reach Out Now materials and more information about
the teach-ins are available on the web at http://www .

smmgp arium

Urschel
and specializes in the areas of chemical dependency (addiction);
general psychiatry; and general neurological disorders, including
Alzheimer's disease, Parkinson's disease, chronic pain , headaches and
epilepsy. National
media coverage, as well as studies in Europe, Asia and Africa have
spoken to the gravity and scope of this problem, highlighting the link
between methamphetamine addiction, increased transmission of disease
and escalating criminal behavior. I am looking forward to studying the HANDS
Protocols(TM) as a potential treatment option for the countless number
of people whose lives have been destroyed by this devastating
illness. In the meantime it
would offer a very potent option which could help a great number of
dependent individuals and their families have success in their
recovery.samhsa.

reciprocity precursors

Business Editors/Healthcare Editors

LOS ANGELES ----Hythiam, Inc. Urschel has conducted a number of
notable studies, including the investigation of a new 30-day injection
medication for the treatment of alcoholism and the evaluation of
several new medications for the treatment of cocaine dependency.

About Research Across America

Located across the country, Research Across America is a group of
independent, professional clinical research sites that provide various
medical study capabilities. These risk factors include, among
others , limited operating history and lack of statistically
significant formal research studies; difficulty in developing,
exploiting and protecting proprietary technologies; intense
competition and substantial regulation in the healthcare industry; and
additional risks factors as discussed in the reports filed by the
Company with the Securities and Exchange Commission, which are
available on its website at http://www. The SAMHSA materials, provided to fifth and sixth
grade teachers, contain resources to educate youngsters, before they become
teens, about the dangers to young bodies associated with drinking alcohol., and were based on research supported by the
National Institutes of Health's National Institute on Alcohol Abuse and
Alcoholism and SAMHSA.'s
reputation for excellence in the development of classroom materials.

misuse alac

The HANDS Protocols will be offered at the College Hospital Costa
Mesa site, a 122-bed hospital providing medical, surgical, and
psychiatric services to Orange County.

College Hospital Costa Mesa is
known in the community for providing specialty services, and treats
approximately 900 patients for chemical dependency each year. Our approach is to help restore each patient to full health
for a productive life. These risk factors include, among
others, limited operating history and lack of statistically
significant formal research studies, difficulty in developing ,
exploiting and protecting proprietary technologies, intense
competition and substantial regulation in the healthcare industry; and
additional risks factors as discussed in the reports filed by the
company with the Securities and Exchange Commission, which are
available on its website at http: //www.D.
An imbalance between the inhibitory and excitatory activity in the
brain, such as occurs during substance withdrawal, can change activity
in the dopamine system, as well as in other neuronal circuits,
triggering undesirable symptoms and behaviors.
The hypothesis is that restoring the balance within this pathway is
analogous to resetting the circuit breakers, so that the pathway
functions normally and a patient who is in recovery stays sober, and
is able to have a relatively quick return to normal of their sleep and
anxiety levels, as well as their thinking patterns.

About Hythiam , Inc. Hythiam researches, develops, licenses and
commercializes innovative physiological treatment protocols for
substance dependence. Department of Health and
Human Services, is the lead federal agency for improving the quality and
availability of substance abuse prevention, addiction treatment and mental
health services in the United States.

Sites by or about community or national organizations that deal with various aspects of substance abuse.

coalitions aftab

(NASDAQ:HYTM), a healthcare services management company that delivers
to treatment providers proprietary administrative services and
physiological protocols designed to treat substance dependence,
announced today that renowned addiction expert and Board Certified
Psychiatrist Harold C. "Acknowledged by experts as highly resistant to treatment ,
its cascading effects cause significant and long-standing problems --
not only to the patient but to families and communities. Urschel continued, "Methamphetamine addiction is an extremely
destructive and devastating addiction for an ever-increasing number of
people in the US.

Hythiam is a healthcare services management company focused on
delivering solutions for those suffering from alcoholism and other
substance dependencies.
All are members of the Leadership to Keep Children Alcohol Free , an
organization of governors' spouses, federal agencies and public and private
organizations .

normalize eata

sec.
To combat continuation of this pattern of abuse of alcohol by young teens,
SAMHSA has teamed up with Scholastic, Inc.
The new SAMHSA report is available on the web at
http://www .

misuse normalize

It founded College
Hospital Costa Mesa in 1987, which is a JCAHO accredited, 122-bed
facility that provides high quality medical, surgical and psychiatric
care. Urschel. Its vast network of
board-certified physician investigators and professional research
coordinators are experienced in all therapeutic areas. The CNS Group
at Research Across America specializes in clinical trials of
investigational and conventional medications for treating general
psychiatric, addiction and neurological disorders.

Most in Treatment for Alcohol Abuse Started Drinking Early; Classroom Programs April 18-22 Will Teach Pre-Teens Not to Start; Hawaii's Lt. Governor James Aiona

A Family Resource Guide is part of the school program.

niaaa intoxicants

"College Health's Orange County location joins our
existing licensees in San Pedro, Alhambra, and Santa Maria as we
strive towards making HANDS accessible to a broader base of residents
of this state.

About College Health Enterprises

College Health Enterprises is a privately held healthcare system
headquartered in Santa Fe Springs, California . Hythiam researches, develops, licenses and
commercializes innovative physiological treatment protocols for
substance dependence. These forward-looking statements reflect numerous assumptions
and involve a variety of risks and uncertainties, many of which are
beyond the company's control that may cause actual results to differ
materially from stated expectations."
Dr. Urschel's study of the HANDS Protocol will include 30 men and
women, 18-65 years of age, who are dependant on methamphetamine ,
according to the criteria as defined by the Diagnostic and Statistical
Manual of Mental Disorders - Fourth Edition (DSM-IV). Of the many brain
reward pathways which methamphetamine affects, the Mesocortical
pathway within the Limbic system is a focus of the destructive forces
of methamphetamine molecules .; and New York.

niaaa reciprocity

We are especially pleased with their
commitment towards utilizing the HANDS Protocols (TM) as a critical
medical treatment within their greater paradigm of addressing `the
whole patient .hythiam. Specific imaging data have
shown that normal brain function may take as long as up to a year and
a half with complete sobriety after the use of methamphetamine. The HANDS Protocols include medically
supervised procedures designed to target receptor sites in the brain
that regulate neurotransmitters implicated in brain processes of
substance dependency. The public/private partnership allows SAMHSA to merge
its knowledge about underage drinking prevention with Scholastic, Inc.

normalize dependence

"Addiction is a
disease that touches people from all walks of life and in every social
stratum.M. An analogy would be that the circuit
breakers within this important brain pathway have flipped off, and
consequently there is significantly impaired control in the normal
functioning of this pathway in methamphetamine and other addictions. Changes in the neurochemistry of the brain
underlie the hallmarks of substance dependency, including craving,
tolerance, withdrawal symptoms and relapse.
With the help of the governors' spouses and our partners we are reaching out
to classrooms nationwide to prevent the early use of alcohol and delay the age
of initiation.

cadca stigma

The HANDS Protocols also
provide for a maintenance program that includes medications and
incentives for patients to continue with the recovery process through
individualized continuing care programs. The Clinical Outcomes
Registry will be comprised of 15 sites nationwide where the HANDS
Protocols(TM) are currently offered or will be offered commercially in
the near future. Standard, validated outcome measure will be included
for the duration of the registry period, which is expected to last
approximately 24 months. Research Across
America has conducted over 1,000 clinical trials for more than 50
pharmaceutical companies, as well as most contract research
organizations and numerous biotech companies. These forward-looking statements reflect numerous assumptions
and involve a variety of risks and uncertainties, many of which are
beyond the company 's control, that may cause actual results to differ
materially from stated expectations.gov

Of those in treatment for alcohol abuse or dependence, 35 percent were
first intoxicated at ages 15-17. SAMHSA's Treatment Episode Data Set defines
age of first use for alcohol as the age of first intoxication. Three first ladies, Mary Perdue of Georgia, Anita Perry
of Texas and Barbara Richardson of New Mexico are writing newspaper op-eds.
Partnering with SAMHSA in the effort are MADD, Pride Youth Program, Inc.

referrers ncadd

Research Across America has conducted over 1,000 clinical trials for
more than 50 pharmaceutical companies, as well as most contract
research organizations and numerous biotech companies. The methamphetamine
molecule itself is extremely destructive to the cells in and around
many important pathways within the brain.

precursors alac

Hythiam Expands HANDS Availability in California Through Licensing Agreement with College Hospital Costa Mesa; Hospital to Be First to Offer HANDS in Orange Co

Changes in the neurochemistry of the brain
underlie the hallmarks of substance dependency , including craving,
tolerance, withdrawal symptoms and relapse.A.
The 30-patient open label study will be conducted on
treatment-seeking subjects who are currently methamphetamine
dependent. Urschel has worked for years designing addiction treatment
protocols and treating patients with various substance dependencies,
including alcohol, cocaine and methamphetamine. The guide urges
parents to establish and maintain good communications with their children; get
involved in your child's life; make clear rules and enforce them with
consistence and appropriate consequences; be a positive role model; teach
children to choose friends wisely; and monitor the activities of your
children.gov.

csam alcoholism

Additionally , he has published numerous articles on addiction
treatments (many as lead author) in a variety of journals and
textbooks, including Psychopharmacology Bulletin, Archives of General
Psychiatry and the DSM-IV Sourcebook. "This study has been designed in order
to rapidly accrue patients and provide clinical outcomes data into the
market as soon as possible."
In November 2004, Hythiam announced it had established a Clinical
Outcomes Registry for the monitoring and evaluation of patients
undergoing Hythiam's HANDS Protocols(TM) for alcohol and/or stimulant
dependence at commercial licensee locations. The organization
is physician owned and operated, maintaining the highest medical
standards for patient care and data integrity."
He pointed out that "those who used alcohol prior to age 12 were more
likely than all others to have had five or more prior treatment episodes ."
The SAMHSA data on who is in treatment for alcohol abuse and dependence is
extracted from the Treatment Episode Data Set 2002.

intoxicants smmgp

About Hythiam, Inc. Disruption of this pathway in addiction
leads to impaired control over the important body functions of sleep,
nervousness and thinking .
"While we know that the majority of youth do not drink, research tells us
that people who start drinking at early ages are more likely to have problems
with alcohol as adults," said Charles Curie, Administrator of SAMHSA.

intoxicants dependence

, M. "Hythiam seeks to build upon a solid foundation of clinical
evidence for HANDS(TM) and this will be the first of several research
studies that we anticipate will be initiated in ensuing months,
including both comparative as well as double-blind placebo-controlled
studies ."
Dr.hythiam. First ladies Patsy Riley,
Alabama; Nancy Murkowski, Alaska; Janet Huckabee, Arkansas; Columba Bush,
Florida; Karen Baldacci, Maine; Mary Easley, North Carolina; Hope Taft, Ohio;
Mary Oberst; Oregon; Mary Kaye Huntsman, Utah; and Nancy Freudenthal, Wyoming;
and Lt. The
materials were developed by SAMHSA's Center for Substance Abuse Prevention
(CSAP) and Scholastic, Inc.

casat intoxicants

College Hospital Costa Mesa provides a continuum of superior
medical, surgical, ICU and psychiatric healthcare services in a
cost-effective manner to meet the needs of patients, community,
professional staff and payors. Additionally, Hythiam provides proprietary
administrative services to assist physicians and facilities with staff
education, marketing and sales support, and outcomes tracking for data
analysis.gov

Additionally, Hythiam provides proprietary
administrative services to assist physicians and facilities with staff
education, marketing and sales support, and outcomes tracking for data
analysis. The new SAMHSA
report, "Characteristics of Primary Alcohol Admissions by Age of First Use of
Alcohol: 2002" shows that a quarter of the 683,000 admissions to treatment
ages 21 and older began drinking between ages 12-14.
Public figures, including the first ladies of states, will go into
classrooms in their states to teach the anti-underage drinking message. These data indicate that
those admitted to treatment with an age of first use of alcohol younger than
15 years old were more likely to report both alcohol and drug use upon
admission than those who reported their age of first use of alcohol as 15 or
older.teachin.samhsa.

casat eata

"
Peizer continued , "College Hospital Costa Mesa has an excellent
reputation in the areas of addiction medicine and psychiatric
treatment, as well as solid relationships with health plans, county
services and area drug courts. As a result, the HANDS
Protocols represent a comprehensive approach to managing substance
dependence that is designed to address both the physiological and
psychological aspects of the disease, thereby offering patients an
opportunity to transition into a healthier lifestyle.
"Hythiam is proud of its leadership role in developing an acute
medical intervention for methamphetamine dependency and is gratified
that Dr. Primary outcomes will measure:

Number of days abstinent from methamphetamine use following
discharge from the outpatient HANDS Protocols(TM) treatment

Change in scores for methamphetamine cravings

Results of urine drug screens performed at weekly intervals
during the 12-week evaluation period

In the event of patient relapse, number of days until first
methamphetamine use and/or other drug use following HANDS
treatment . Urschel explained, "The HANDS Protocol(TM) for Stimulant
Dependence is a promising new treatment option for those with
methamphetamine dependence. That is the conclusion
of a new analysis by the Substance Abuse and Mental Health Services
Administration (SAMHSA).

casat alcoholism

Dr."
Dr. As a result, the HANDS
Protocols represent a comprehensive approach to managing substance
dependence that is designed to address both the physiological and
psychological aspects of the disease, thereby offering patients an
opportunity to transition into a healthier lifestyle.sec. There
will be at least one teach-in in every state.