Effects of Testosterone Dosage on Behavior of Older Males
New research shows that older and younger men experience different
reactions to testosterone dosage regarding sexual function and visuospatial
cognition and that different aspects of male behavior are affected by
testosterone doses. Questionnaires were used to score sexual function
based on libido, sexual activity and erectile dysfunction. Thomas Storer of Charles Drew University,
researchers found older men are just as responsive as younger men to
testosterone doses in building muscle mass.
"Healthy, older men demonstrated significant concentration-dependent
changes in muscle strength, similar to those observed in younger men during
use of graded testosterone doses," said Storer.

This category is for medical clinics that specialize in anti-aging therapies.

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The Endocrine Society is based in Chevy
Chase, Maryland. In the US alone , the
sexual dysfunction medication market generated revenues of
approximately $1. BPH is a common benign disease occurring
in men over the age of 50, and increases in prevalence with age.

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Men's Health Knows No Age

In addition to affecting
sexual function and visuospatial cognition, testosterone doses were all tested
for their effects on mood.
These results indicate that, when taken together with previous data from
studies in young men, testosterone dose-response relationships for sexual
function and visuospatial cognition differ in older and young men."

Founded in 1916, The Endocrine Society is the world's oldest, largest, and
most active organization devoted to research on hormones, and the clinical
practice of endocrinology.botaniex.

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In an effort to gauge the effects of testosterone replacement therapy in a
concentrated, tailored study, healthy 55-year old men with androgen deficiency
symptoms participated in a 52-week study and received either TRT or a placebo. Subjects were randomly assigned different dosages of
testosterone production suppressors as well as varied levels of testosterone
doses for 20 weeks.
This innovative formula combines herbal and certain animal-based
extracts, which should deliver superior results as compared to
currently available herbal remedies. Botaniex expects to complete the development process in
approximately three to five months.

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A group of healthy men, ages 60-75, were prescribed testosterone-
production inhibitors and were randomly assigned five dosage levels of
testosterone to be taken over a 20-week period.

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Mood was measured by using
the Hamilton Depression Inventory and the Young Mania Scale, and no effects of
testosterone were observed in either mood rating.
Sixty healthy men, ages 60 -75 years, and 61 younger men, ages 18-34, were
compared to clarify the relationship of each age group to testosterone and
muscle mass building. All assessments were conducted
at the beginning and end of the study, and results were evaluated based on age
and testosterone dosage. Botaniex has
been approached by several multi-national dietary supplement companies
that have expressed a strong interest in Botaniex's proposed
innovative and all-natural formula for ED. Reducing levels of these hormones can
reduce the size and growth of the prostate.

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Researchers are looking for ways to increase muscle mass,
enhance quality of life and evaluate male behavior all in response to
testosterone administration . "Controlling visceral fat is important because it can cause
cardiovascular disease, insulin resistance and other metabolic problems.

Business Editors/Health Editors

HOUSTON----Botaniex, Inc . (Pink
Sheets: BTXI), announced today that it has initiated the development
of an all-natural formula for Erectile Dysfunction (ED). Botaniex's goal is to develop a formula
that is 100% natural , safe, affordable and as effective as the
synthetic drugs for Erectile Dysfunction. In conjunction with
several reputable Research Institutes and hospitals in China, Botaniex
will perform official clinical trials of this formula once it is
finalized.

Botaniex Inc.
Ardana's lead product , Teverelix LA, is in development for three
initial indications: prostate cancer, BPH and endometriosis .
Teverelix LA has also successfully completed a Phase II study in
Benign Prostatic Hyperplasia .

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Physical performance was evaluated based on stair
climb task, 10-meter walk and timed up-and-go .com

Forward-Looking Statements

Please be advised that statements made herein, other than
historical data, constitute forward-looking statements that involve
risks and uncertainties that could cause actual results to differ
materially from those stated or implied by such forward-looking
statements. Please also be
advised that the company's stock is not currently registered with the
Securities and Exchange Commission. It is widely accepted that
reducing levels of these hormones in advanced disease can help slow
the growth of the cancer and prolong survival. Ardana has marketing and manufacturing rights in Europe
for another product, Invicorp, an injectable combination of drug
treatment for erectile dysfunction.

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(Logo: http://www.

Botaniex Inc. To Develop All-Natural Formula for Erectile Dysfunction; Botaniex is poised to capture a share of the multi-billion dollar sexual dysfunction ma

is an innovative manufacturer of botanical/herbal
extracts, serving the worldwide manufacturers of dietary supplements,
health foods, functional beverage, pharmaceuticals and cosmetics .

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Based on this
questionnaire, libido only increased with testosterone usage in those men that
were sexually active at the beginning of the study. Botaniex not only provides customized ingredients,
but also offers value-added services such as formulation assistance,
clinical trial support and private label manufacturing.

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"Neither young nor healthy,
older men showed a testosterone-dose relationship with fatigability or any
measure of physical function.org. The preliminary results from these
trials have been very favourable and most of the patients have
exhibited a hard and long-lasting erection . These disorders affect more than
175 million men worldwide over the age of 50.
For further information please see www.uk

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The new studies presented below will be presented in a press conference in
San Diego on Monday, June 6 at 2:00pm PT, during ENDO 2005, the 87th Annual
Meeting of The Endocrine Society. Prior
studies measured the effects of testosterone replacement therapy (TRT) in
older men, including obese and non-obese participants, thus skewing the
results of baseline fat accumulation in the body.
This formula will enable Botaniex to capitalize on the large and
high -growth global sexual dysfunction market. Male sexual dysfunction
includes erectile dysfunction (ED ), loss of libido, premature
ejaculation and Peyronie's Disease.
Ardana completed its IPO on the London Stock Exchange in March
2005, raising GBP 21 million and actively pursues product and
technology in-licensing and outlicensing to maintain a robust
pipeline.

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A majority of herbal
supplements currently on the market for ED fail to effectively deliver
satisfactory results to the consumers .
CEO Melson Liao stated: "With Botaniex's expertise and alliance
with highly-respected Traditional Chinese Medicine scientists, we are
confident that we can develop a formula for ED that helps men who
suffer from this disorder to regain their confidence and improve the
quality of their family life. Therefore, Teverelix LA can also
reduce testosterone levels to the low end of the normal range ,
avoiding a chemical castration and its related symptoms.

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New Findings Show Effects of Testosterone on Quality of Life

SAN DIEGO, Today, leading researchers are gathering
at the annual meeting of The Endocrine Society in San Diego to present the
latest research on men's health issues , treatments and lifestyle practices.
Doctors monitored their baseline body mass index (BMI), waist circumference
and mean serum.
"Testosterone replacement therapy in healthy aging men decreases visceral
fat, the fat that surrounds the organs and increases the risk of developing a
variety of diseases," said Carolyn Allan of Prince Henry's Institute of
Medical Research. The Company is
in the process of expanding its operations, including its client and
asset-base, in Asia and overseas .
Ardana plc, the emerging pharmaceutical company focused on the
discovery, development and marketing of innovative products to improve
human reproductive health, is developing a broad portfolio for the
treatment of a range of reproductive indications. This makes it
suitable for clinical development in benign as well as malignant
indications.

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Muscle function was evaluated based on leg press strength, leg press power
and leg press fatigability. This formula incorporates a two
centuries -old Chinese folk prescription with highly purified herbal
extracts based on Traditional Chinese Medicine theory.

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Further studies are needed to determine whether
testosterone improves physical function in frail, older men. Botaniex has
completed Phase I of the formulation and has conducted informal
clinical trials of the formula.com or visit the Corporate website at
www.00 am at the Windhover
Euro-Biotech Forum 2005 on 2 June 2005, taking place at the Le
Meridien Montparnasse Hotel, Paris.

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The medically -proven drugs for
the treatment of ED include Viagra and Cialis, which are effective but
raise health and safety concerns for consumers. In addition, the cost
of these drugs is high compared to natural substitutes and can only be
purchased with a prescription.91 billion in 2002 and is expected to grow at a
Cumulative Annual Growth Rate (2002-2009) of approximately 25. The
Company's product line is broad, ranging from tea and herbal extracts
to essential oils.

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Testosterone Replacement Therapy Decreases Fat and Increases Muscle
New studies show testosterone replacement therapy (TRT) in older men
decreases fat surrounding the organs and increases skeletal muscle.16
percent .
The progression of prostate cancer is usually driven by male sex
hormones (androgens) such as testosterone. The production of
testosterone can be reduced either surgically, with the removal of the
testicles, or through drugs that affect production of testosterone.
The Phase II studies have confirmed that Teverelix LA can attain and
maintain suppression of testosterone to castration levels in patients
with advanced prostate cancer.
The company already has one product on the market, Striant(TM) SR,
a testosterone-replacement therapy that has been launched by Ardana
through its own sales force in the UK as a treatment for men with
hypogonadism.

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For more information please contact CEO Melson Liao at
melsonliao@botaniex.

Ardana to Present at the Windhover Euro-Biotech Forum 2005

The growth of prostatic tissue is driven by male sex hormones,
primarily testosterone and its more potent metabolite
dihydrotestosterone (DHT).

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To learn more about the Society, and the field of
endocrinology, visit our web site at http://www."

About Botaniex Inc. BPH
is characterised by an enlargement of the prostate gland, which
results in urinary flow problems such as hesitancy , weak or
interrupted stream, urgency and more frequent urination, especially at
night. In clinical studies,
Teverelix LA has been shown to decrease testosterone and subsequently
DHT in a dose-dependent manner.ardana.

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newscom.com/cgi-bin/prnh/20050405/ENDOLOGO )
Men's health is becoming increasingly important in the medical industry,
especially following the introduction of erectile dysfunction drugs to the
mass markets."

Men of All Ages Respond to Building Muscle Mass with Testosterone Doses
In a new study by Dr. Together, these members represent all basic, applied, and
clinical interests in endocrinology.

Botaniex's goal is to become a major
player in the multi -billion dollar global herbal products industry. The potential risks and uncertainties include, among
others, potential volatility in the company's stock price, increased
competition, customer acceptance of new products and services offered
by the company, and uncertainty of future revenue and profitability
and fluctuations in its quarterly operating results. Teverelix
LA has successfully completed two Phase II trials in prostate cancer.

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New findings could help doctors identify risks and treat men 's conditions more
effectively.

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Today, The Endocrine Society's membership consists
of over 12 ,000 scientists, physicians, educators, nurses and students in more
than 80 countries.

Business Editors/Health/Medical Writers
Euro-Biotech Forum 2005

PARIS----Ardana plc (LSE:ARA) today
announced that it will be presenting at 10.co.

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endo-society.