About Crohn's Disease

CD is a chronic inflammatory bowel disorder that commonly affects the lower
part of the small intestine and the large intestine and typically begins in
late childhood or early adulthood.M.

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"This study will evaluate the effect of a targeted, human anti-IL-12
monoclonal antibody on Crohn's disease and its symptoms," said Dennis S.D.ereleases.

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"When it comes to treating blemishes, Zeno is the most scientifically
advanced and effective device available without a prescription," commented
Charles E.
"People are absolutely amazed when they first use Zeno.209.3628

This release was issued through eReleases(TM).

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The disease causes inflammation of the
gastrointestinal tract, typically resulting in symptoms such as diarrhea,
fever, abdominal pain and weight loss.

ZenoZitZapper.com.

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CNTO 1275 is a
human monoclonal antibody that targets interleukin 12 (IL-12) and
interleukin 23 (IL -23), proteins that occur naturally in the immune system
and are believed to play a role in the inflammation associated with CD.

New Zeno 'Zit Zapper': First Home Acne Treatment Device Receives FDA Approval

It is
not a medication or a laser.

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90% of patients involved in an FDA reviewed clinical trial found that
pimples caught early and treated with Zeno faded or disappeared within just 24
hours.

For more information, contact:

Heather K.

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Centocor is a wholly owned subsidiary of Johnson & Johnson, the worldwide
manufacturer of healthcare products.

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EAGAN, Minn.
Zeno does not replace normal skin care programs and is completely
compatible with other acne treatment programs, both prescription and over-the-
counter.

Sites specifically offering information, resources and treatments of acne.

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Centocor's products, developed primarily
through monoclonal antibody technology , help physicians deliver innovative
treatments to improve human health and restore patients' quality of life.

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"We look forward to further analysis and evaluation of this
therapy as a potential treatment for patients with moderate to severe
Crohn's disease.

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For more information about clinical trial sites and specific study
protocol, please call 1-800-624-7994. It is best-
suited to treat newly emerging blemishes - the ones where you can just feel a
new bump forming under the skin. It works by destroying bacteria and shortening the
pimple's life cycle significantly.
For more information, please visit http://www.

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In an FDA-reviewed, controlled clinical trial, 90% of blemishes treated
with Zeno disappeared or faded within 24 hours. He is
also Medical Director of Crutchfield Dermatology in Eagan, MN and a nationally
recognized expert in the treatment of acne.

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Crutchfield III, MD, Board Certified Dermatologist and Associate
Professor of Dermatology at the University of Minnesota Medical School.com.com.

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"

Patients who are eligible to participate in the 28-week study will be
randomized at week 0 to one of four treatment groups to receive active drug
or placebo .

About Centocor

Centocor is a leading biopharmaceutical company that creates, acquires and
markets cost-effective therapies that yield long-term benefits for patients
and the healthcare community.

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Patients will be monitored through 28 weeks with an
additional visit at week 54 for a final blood test. It uses a medical heat dose treatment on
individual acne blemishes in people with mild to moderate acne.

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Crutchfield also believes that it also
increases blood flow in the area of the blemish and promotes quicker healing.

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PRESS RELEASE Centocor Extends Patient Enrollment to Evaluate CNTO 1275 in Treatment of Active Crohn's Disease

Zeno delivers a precisely controlled dose of
heat to the area for 2-1/2 minutes.

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Centocor, Inc.I.
651.

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Riff, MD, Medical Director, Advanced Clinical Research Institute, Anaheim,
California., Zeno is a handheld, portable
electronic medical device that is clinically proven to make pimples disappear
fast.

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The company is dedicated to the research and
development of treatments for a wide range of diseases including cancer,
infectious diseases, cardiovascular and metabolic diseases and
Immune-Mediated Inflammatory Disorders (I. Dr. For the first
time, they can take control of their skin and treat pimples the same day they
appear, without the risk of drug-related side effects.

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announced today the
extension of patient enrollment for a Phase II trial to evaluate the safety
and efficacy of CNTO 1275 for reducing the signs and symptoms of active
Crohn's disease (CD), a serious gastrointestinal disorder. Subjects will be permitted to remain on certain standard CD
medications, including steroids and immunomodulators , while participating
in the study.), such as arthritis and
inflammatory skin diseases.
Zeno is a clinically proven handheld (rechargeable) medical device.
To purchase Zeno, please visit http://www.

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It is estimated that 500,000
Americans and more than 400,000 people in Europe and Canada suffer from
this gastrointestinal disorder. For more information,
visit http://www .

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Crutchfield recommends treating
blemishes 2-4 times, at least one hour apart, over the first 4-12 hours of a
blemish's appearance. It is particularly
effective and convenient for students away at college, image-conscious
high school students, women who tend to have monthly acne flare-ups and for
those aggravating last-minute pimples that seem to pop up while traveling or
on vacation, " said Crutchfield.CrutchfieldDermatology.

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