"
At the hearing, advocates for the bill, including actress
Fran Drescher
and Sheryl Silver, who conceived of the legislation following her sister
Johanna
's death from ovarian cancer, testified about the critical need for a
public education effort aimed
at informing women about gynecologic cancers.
(Amex: BSM) today noted that this morning's Boston
Globe ran an article
entitled "Getting Warmer in Bid to Kill Tumor Cancers" in which hyperthermia
was named as potentially "among the most powerful anticancer weapons yet. But there must be enough
oxygen
nearby for this damage to occur. Parts of tumors are tough to kill
because they
have a poor blood supply and, thus, low oxygen levels.
telescan meds
Data Presented at 2005 Meeting of American
Society of Clinical Oncology
ORLANDO, Fla.
Of the 82 patients studied, 80 patients (98
percent) achieved a major tumor
response (CR+PR based on reduction in CA-125 levels) during the induction
phase of the therapy, 85 percent complete response (CR) and 12 percent partial
response (PR).
SGO members provide multidisciplinary cancer care including
chemotherapy, radiation therapy, supportive
care and surgery.
4.
Statements contained in this press release that
are not historical facts
are forward-looking statements, as that item is defined in the Private
Securities
Litigation Reform Act of 1995.neoplasms chemo
For additional information, please visit
http://www. WASHINGTON
, The Society of Gynecologic Oncologists
(SGO) commends the Senate Appropriations Subcommittee on
Labor, Health and
Human Services and Education for its hearing today on "Johanna's Law: The
Gynecologic
Cancer Education and Awareness Act of 2005.D.
chemo telescan
com.carcinoid telescan
No grade 4 neuropathy was observed.
"The standard of care for patients with stage III or IV primary ovarian
cancer is tumor debulking
surgery followed by a combination of a platinum and
a taxane, most usually paclitaxel/carboplatin
therapy, which has been shown to
produce an objective response rate of 80 percent or more based on
CA125,"
stated Thomas Herzog, M.
Headquartered in Seattle, CTI is a biopharmaceutical company
committed to
developing an integrated portfolio of oncology products aimed at making cancer
more
treatable. von Eschenbach, MD,
also testified at the hearing.
For further information
about BSD Medical and its technologies visit the
BSD website at http://www.
chemotherapy psychosocial
With the high response
rate observed at the dose of
175 mg/m2, this study suggests that it may be possible to further dose
reduce
to decrease the relatively high incidence of neuropathy without sacrificing
efficacy. XYOTAX
was administered over a 10-minute infusion at
doses of 210mg/m2 in 20 patients and 175mg/m2 in 62
patients followed by
carboplatin (AUC6) on day one of each 21-day cycle for up to six cycles. Treatment
was stopped if the
patient's disease progressed or if intolerable toxicity was observed.com. "Every
effort we can make
to help women understand the signs and symptoms of these diseases is a step
towards
protecting our mothers, sisters, daughters, friends and the other
women in our lives."
"On
behalf of my family, who lost Johanna following a three-and-a-half
year battle with ovarian cancer
, I thank Senator Specter, Senator Harkin and
the Subcommittee for inviting us to speak today about
the need for Johanna's
Law," said Silver.BSDMedical.hca mesothelioma
Grade 3/4 side effects at the 175mg/m2 dose
in combination with
carboplatin (AUC=6) included neuropathy (23 percent), nausea (15 percent),
vomiting
(7 percent), febrile neutropenia (19 percent), anemia (11 percent),
and thrombocytopenia (55 percent
).
Raising the temperature of a tumor brings more blood and, hence, more
oxygen to the
tumor. 'The heat opens these channels so that
chemotherapy drugs can more easily enter in,'
" according to Dr.hyperthermia nccn
Similarly, patients underwent a rigorous examination to determine
and score potential
neurosensory changes. Based on
preclinical studies, it appears that XYOTAX is preferentially trapped
in the
tumor blood vessels allowing significantly more of the dose of chemotherapy to
localize
in the tumor.
About Cell Therapeutics, Inc. "Hyperthermia also seems to 'jump-start the
immune response' at least
in mice, said Elizabeth Repasky, an immunology professor at the Rosewell
Park Cancer Institute in Buffalo, who is now looking at the effects in
humans.
According
to an article in the Journal of Clinical Oncology, in a study
following 109 patients, most of whom
were experiencing recurrent breast
cancer, 68% of patients receiving hyperthermia plus radiation
experienced
tumor disappearance compared to 24% tumor disappearance for those who received
radiation
alone. Cancer medical specialists are termed oncologist.
mesothelioma hca
"
The study was designed to evaluate
the toxicity and efficacy of XYOTAX in
combination with carboplatin as an induction therapy followed
by single-agent
XYOTAX as monthly maintenance therapy in patients with newly diagnosed stage
III
or IV ovarian cancer.cticseattle. Blood vessels in tumor tissue, unlike blood
vessels in normal tissue
, are porous to molecules like polyglutamate. Jay Harris, Chairman of
Radiation Oncology at both
Dana-Farber Cancer Institute and Brigham and
Women's Hospital.nausea uncontrolled
D. BSD Medical Corporation
produces
systems that deliver precision-focused microwave/RF energy to
increase the temperature of cancerous
tumors, producing hyperthermia in the
tumors. Just as a fever with the flu may boost immune response
, so might
hyperthermia, a kind of artificial fever.nausea cinvestav
Data
presented at ASCO include only the
induction phase of the trial.
CTI and the Gynecologic Oncology Group (GOG) are presently evaluating
XYOTAX (135mg/m2) as monthly maintenance in a phase III clinical trial in
ovarian cancer patients
who have achieved a complete response following
standard first-line chemotherapy.
Karlan
, M. Its purpose is to improve the care of women with
gynecologic cancer by encouraging research,
disseminating knowledge which will
raise the standards of practice in the prevention and treatment
of gynecologic
malignancies and cooperating with other organizations interested in women's
health
care, oncology and related fields.sgo. Mark Dewhirst of Duke University.
The Boston Globe article
names four mechanisms by which hyperthermia
fights cancer:
1.oncologist gynecologic
"Tragically, Johanna's
story of delayed diagnosis due to a
lack of knowledge about ovarian cancer symptoms is all too common
-even among
health-conscious women like Johanna."
The Boston Globe has a circulation of 414,225
.com.mesothelioma hyperthermia
More information
on the SGO can be found at http://www. David Wazer, Chief Radiation Oncologist
at Turts-New England Medical
Center, also quoted in the article.chemotherapy cinvestav
This polymer technology results
in a new chemical entity, designed to
selectively deliver higher and potentially more effective levels
of active
chemotherapeutics to tumors.nausea oncologists
The
maintenance portion of the trial is ongoing. We need
to change that-and Johanna's Law
provides a way to do so.org. According to an article in Cancer
following 68 patients,
hyperthermia combined with radiation and chemotherapy produced a 90% complete
remission for patients with advanced cervical cancer.chemotherapy hca
"After the induction phase of the XYOTAX trial
, 98
percent of the patients achieved an objective response based on CA125 levels,
which is quite
remarkable.
About XYOTAX
XYOTAX (paclitaxel poliglumex) is a pharmaceutical that links
paclitaxel,
the active ingredient in Taxol(R), to a biodegradable polyglutamate polymer.
The SGO is a national medical specialty organization of physicians who are
trained in the comprehensive
management of women with malignancies of the
reproductive tract. All forward-looking statements
and
projections or expectations of future events, including the prospects for
future sales of
the Company's cancer therapy systems based on media following
of its cancer therapies, are subject
to risks and uncertainties detailed in
the Company's filings with the Securities and Exchange Commission
. The branch of medicine concerned with diagnosis, treatment, and research into the causes of cancer
is oncology.
chemo mesothelioma
CTI is under no obligation to (and expressly disclaims any such
obligation to) update
or alter its forward-looking statements whether as a
result of new information, future events, or
otherwise. SALT LAKE CITY, BSD Medical Corp.
2.uncontrolled chemo
, of Columbia University and principal
investigator
for the XYOTAX trial.usnews hematologists
XYOTAX in Combination with Carboplatin Produces Major Tumor Response
in 98 Percent of First-line Ovarian Cancer Patients
(CTI) (NASDAQ and Nuovo Mercato: CTIC) reported
preliminary data from a phase
II study of XYOTAX in combination with carboplatin for first-line induction
and single-agent maintenance therapy of advanced stage III/IV ovarian cancer., SGO
President,
and Director, Women's Cancer Research Institute and Division of
Gynecologic Oncology, Cedars-Sinai
Medical Center. Wazer also
quoted above.hca uncontrolled
After
six cycles, patients with stable disease or
better continued on to receive
single-agent XYOTAX at a dose of 175mg/m2 for up to 12, four-week
cycles. To
determine the true incidence of hematologic suppression, weekly blood counts
were drawn
following each dose of the XYOTAX/carboplatin combination (day
8,15, 21).
For more information
about this presentation or our clinical trials,
please visit our website at http://www. The Society
's membership is
primarily comprised of gynecologic oncologists, as well as other related
medical
specialists such as, medical oncologists, radiation oncologists and
pathologists.
"At least
eight studies in recent years have shown that adding
hyperthermia to chemotherapy or radiation increases
the effectiveness of those
treatments against melanoma, tumors in the esophagus, cervix, head, neck
and
brain, and breast cancers that have spread to the chest wall," the article
stated, quoting
Dr."
The Globe article referenced articles in major medical journals.usnews hyperthermia
SGO looks forward
to working with Congress to pass
Johanna's Law and to making a difference.nccn neoplasms
This press
release includes forward-looking statements that involve a
number of risks and uncertainties, the
outcome of which could materially
and/or adversely affect actual future results."
According
to the American Cancer Society, gynecologic cancers will affect
approximately 79,480 women and take
28,910 lives this year.gynecologic nccn
, At the 2005 Annual Meeting
of the American Society of Clinical Oncology
(ASCO) Cell Therapeutics, Inc. Only three patients (5 percent) required
dose delay due to neutropenia
. Because more of the chemotherapy is targeted to the
tumor and the levels of chemotherapy delivered
to normal tissue are reduced,
XYOTAX may be potentially more effective and have less severe side
effects
than currently available chemotherapeutics.Subcommittee Hearing on Gynecologic Cancer Bill
is Commended by Society of Gynecologic Oncologists
'Hyperthermia Could Turn Out to be Among the Most
Powerful Anticancer Weapons Yet' - Boston Globe
"When you combine heat and radiation, the cell
-killing of cancer cells
is better," according to a quotation by Dr.Cancer is the common term
for tumors (neoplasms) characterized by uncontrolled growth at the cell level.
uncontrolled mesothelioma
cticseattle. Specifically
, the risks and
uncertainties that could affect the development of CTI's products under
development
include risks associated with preclinical and clinical
developments in the biopharmaceutical industry
in general and with XYOTAX in
particular including, without limitation, the potential failure of
XYOTAX to
prove safe and effective for treatment of ovarian cancer, determinations by
regulatory
, patent and administrative governmental authorities, competitive
factors, technological developments
, costs of developing, producing and
selling XYOTAX, and the risk factors listed or described from
time to time in
the Company's filings with the Securities and Exchange Commission including,
without
limitation, the Company's most recent filings on Forms 10-K, 8-K, and
10-Q. "Radiation works by
damaging DNA."
3. "With chemotherapy, drugs get inside tumor cells through small
channels on the cell surface.psychosocial oncologist
The Director of the National Cancer Institute, Andrew C.
"This
bill has the power to save women's lives by improving awareness and
therefore, early detection of
these cancers," said Beth Y. "I'm amazed at some of
the tumors that melt away with the combination
of radiation and heat," said
Dr.hyperthermia telescan
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