(NASDAQ: SLXP) today reported results of an
investigator-initiated trial of rifaximin that are being presented at
Digestive Disease Week(R) 2005 (DDW) today.0% in patients treated
with rifaximin 1200 mg daily (p<0. No significant differences in
patient compliance and incidence of adverse events were reported among
the groups.2% (vs.

sanofi pasteur Seeks to Broaden Age Group for New Vaccine to Protect Against Meningococcal Disease

"At
the same time, it has the potential benefit of increasing meningococcal
immunization rates because the 2-10 age group generally are seen by a
pediatrician on a regular basis for the recommended schedule of childhood
vaccinations.com .

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Glucose breath test normalization rate was 60.3% (vs.2% (vs.
Two were randomized, multi-center, active-controlled , modified double-blind
clinical studies of children aged 2 through 10 years comparing the safety and
immunogenicity of Menactra vaccine to Menomune(R)-A/C/Y/W-135 (Meningococcal
Polysaccharide Vaccine, Groups A, C, Y and W-135 Combined), sanofi pasteur's
currently-licensed polysaccharide meningococcal vaccine.

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8%).
Sanofi pasteur, the vaccines business of the sanofi-aventis Group, sold
950 million doses of vaccine in 2004, making it possible to protect more than
500 million people across the globe , which is about 1.

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until 5:00 p.6% in
patients treated with 600 mg daily.2%), abdominal pain 7.com
Salix trades on the Nasdaq National Market under the ticker symbol
"SLXP".com. In addition,
compared to Menomune vaccine, Menactra vaccine resulted in longer-term
persistence of bactericidal antibody , improved production of high avidity
antibody, and the establishment of immune memory.
In general, the benefits of a successful conjugate vaccine include
longer-lasting immune responses and boostable memory responses.

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Leonard Baidoo May 18

(a) Posters are available for viewing from 8:00 a.salix.

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10.
Menactra vaccine is the world's first quadrivalent conjugate vaccine
licensed for the prevention of meningococcal disease and is designed to offer
protection against four serogroups of Neisseria meningitidis (A, C, Y, and
W-135), the bacterium that causes meningococcal infection . Centers for Disease Control and
Prevention's (CDC) Advisory Committee on Immunization Practices (ACIP)
recommended immunization with Menactra vaccine for young adolescents at the
pre-adolescent visit (11-12 year old), adolescents at high school entry (15
year old) and college freshmen living in dormitories. Backed by a world-class R+D
organization, sanofi-aventis is developing leading positions in seven major
therapeutic areas: cardiovascular disease, thrombosis, oncology, metabolic
diseases , central nervous system, internal medicine, and vaccines. Although sanofi-aventis' management believes that the
expectations reflected in such forward-looking statements are reasonable,
investors are cautioned that forward-looking information and statements are
subject to various risks and uncertainties , many of which are difficult to
predict and generally beyond the control of sanofi-aventis, that could cause
actual results and developments to differ materially from those expressed in,
or implied or projected by, the forward-looking information and statements.

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Salix's strategy is to
in-license late-stage or marketed proprietary therapeutic drugs,
complete any required development and regulatory submission of these
products, and market them through the Company's 100-member
gastroenterology specialty sales and marketing team. XIFAXAN(TM)
(rifaximin) tablets 200 mg are indicated for the treatment of patients
(=>12 years of age) with travelers' diarrhea caused by noninvasive
strains of Escherichia coli. XIFAXAN should be
discontinued if diarrhea symptoms get worse or persist more than 24-48
hours and alternative antibiotic therapy should be considered.
For full prescribing information on Xifaxan, please visit
www. These risks
and uncertainties include market acceptance for approved products,
management of rapid growth, intellectual property risks, and the need
to acquire additional products. The reader is referred to the
documents that the Company files from time to time with the Securities
and Exchange Commission.

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, headquartered in Raleigh, North
Carolina , develops and markets prescription pharmaceutical products
for the treatment of gastrointestinal diseases.
government approval to broaden the age indication for its new meningococcal
vaccine Menactra(TM) (Meningococcal [Groups A, C, Y and W-135] Polysaccharide
Diphtheria Toxoid Conjugate Vaccine).

About Meningococcal Disease
Meningococcal disease is a rare but serious bacterial infection that
strikes between 1,500 and 3,400 Americans every year, causing meningitis or
sepsis in the majority of cases. For more information, please visit:
http://www.

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salix. These statements are just
predictions and are subject to risks and uncertainties that could
cause the actual events or results to differ materially. The third was a Phase
2, controlled, multi-center , open-label study of children aged 3 through 5
years who had been vaccinated previously with Menactra vaccine approximately
two years earlier. They were reported for the most part as mild
reactions and were reversible.
These risks and uncertainties include those discussed or identified in the
public filings with the SEC and the AMF made by sanofi-aventis and Aventis,
including those listed under "Forward-Looking Statements" and "Risk Factors"
in sanofi-aventis's annual report on Form 20-F for the year ended December 31,
2003 and those listed under "Cautionary Statement Regarding Forward-Looking
Statements" and "Risk Factors" in Aventis's annual report on Form 20-F for the
year ended December 31, 2003.

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m. The meeting showcases approximately 5,000
abstracts and hundreds of lectures on the latest advances in GI
research, medicine and technology. The most common
side effects (vs.1 %) and rectal tenesmus
7. Submits supplemental license application

SWIFTWATER, Pa .
There are risks associated with all vaccines. Of those who survive, up to one in
five suffer permanent disabilities such as hearing loss, neurological damage
and limb amputations. Forward-looking statements
are statements that are not historical facts.

dysphagia retraction

C. The poster is available
for viewing from 8:00 a. today.S. The most common complaints were irritability and
drowsiness.

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on the day listed above. 19. 8.com or calling 1-800-VACCINE (1-800-822-2463). Sanofi
pasteur is the sole supplier of Menactra(TM) vaccine.

About sanofi-aventis
The sanofi-aventis Group is the world 's third-largest pharmaceutical
company, ranking number one in Europe.

Forward Looking Statement
This press release contains forward-looking statements as defined in the
Private Securities Litigation Reform Act of 1995.

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Small Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome

Dr.m. The company has filed a supplemental
application with the U. The FDA
licensed Menactra vaccine on January 14 this year for use among 11 through 55
year olds.vaccineshoppe .

insipidus motility

m.
The diagnosis of irritable bowel syndrome was based on the Rome II
criteria and the presence of small intestinal bacterial overgrowth was
based on a glucose breath test. Brian Bosworth May 18

Mild-Moderate Crohn's Disease Dr.m.org
Salix Pharmaceuticals, Ltd.

The supplemental license application is based upon three clinical studies. Approximately 10 percent of individuals who
contract meningococcal disease will die. These statements include
financial projections and estimates and their underlying assumptions,
statements regarding plans , objectives and expectations with respect to future
operations, products and services, and statements regarding future
performance.

retinopathy dercum

Patients were treated for 7 days with
rifaximin dosed at either 600 mg daily, 800 mg daily or 1200 mg daily.m."
Studies have demonstrated that serogroups C, Y and W-135 account for about
48% of meningococcal disease in 2 through 5 year-olds and 65% in 5 through 11
year-olds. Meningococcal disease often begins with symptoms that
can be mistaken for common viral illnesses, such as the flu.

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6% in patients treated with 800 mg daily and 16.ddw. Information on our web site is
not incorporated in our SEC filings.

Please Note: This press release contains forward-looking
statements regarding future events.S.
"The additional age indication would help protect a younger segment of the
population against a serious and devastating disease," said Michael Decker,
MD, MPH, vice president, scientific and medical affairs at sanofi pasteur. No clinically significant
adverse events were identified after a 6-month controlled follow-up. The
company offers the broadest range of vaccines, providing protection against 20
bacterial and viral diseases. Forward -looking statements are generally identified by the words
"expect," "anticipates," "believes," "intends ," "estimates" and similar
expressions.

dercum deformans

The investigator has
been requested to be present at the poster from 12:00 noon until 2:00
p. until 5:00 p.


Digestive Disease Week (DDW) is the largest international
gathering of physicians, researchers and academics in the fields of
gastroenterology , hepatology, endoscopy and gastrointestinal surgery.
Overall, data presented in the studies demonstrated that for children aged
2 through 10 years Menactra vaccine is safe and immunogenic. Other than as required by applicable law,
sanofi-aventis does not undertake any obligation to update or revise any
forward-looking information or statements.

deafblindness herpetiformis

Cristiano Lauritano, Gemelli Hospital, Catholic University of
Rome, et al.05, compared to other treatment
groups), 26. placebo) were flatulence 11.

XIFAXAN (TM) is licensed from Alfa Wassermann SpA. Food and Drug Administration (FDA) to amend the
vaccine 's license to include children aged 2 through 10 years.
Immunization providers can order Menactra vaccine by visiting
http://www.sanofipasteur.

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On February 10 this year, the U . Solicited systemic reactions were similar among
the study groups and were described for the most part as mild, reversible, and
of short duration.

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conducted a study to investigate the efficacy and
tolerability of three doses of rifaximin in 90 irritable bowel
syndrome patients affected by small intestinal bacterial overgrowth.
Glucose breath test was reassessed one month after the end of therapy . 9.
For more information please contact the Company at 919-862-1000 or
visit our web site at www . However, unlike
more common infections, meningococcal disease can progress very rapidly and
kill an otherwise healthy young person in 48 hours or less.4 million per day.

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In
clinical trials, XIFAXAN was generally well tolerated., Sanofi pasteur, the
vaccines business of the sanofi-aventis Group (NYSE: SNY), is seeking U. The committee recognized
the need to reduce the threat of this potentially fatal bacterial infection
among segments of the population found to be at increased risk of infection
relative to the general population. The objective of this study was to evaluate the antibody
memory response to the vaccine.

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Investigators are requested to be present at
their respective poster from 12:00 noon until 2:00 p. The
sanofi-aventis Group is listed in Paris (EURONEXT: SAN) and in New York (NYSE:
SNY).

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Business Editors/Biotech Writers
BIOWIRE2K

RALEIGH, N.

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----Salix
Pharmaceuticals , Ltd. Asher Kornbluth May 18

Small Bowel Bacterial Overgrowth Dr. For more information , please visit
www.S.

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Salix Pharmaceuticals Reports Digestive Disease Week Update; Rifaximin Investigated in Small Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome

m.
Schedule information on upcoming poster presentations is provided
below:

TOPIC LEAD AUTHOR DATE/TIME(a)

Moderate to Severe Crohn's Disease Dr.
Jointly sponsored by the American Association for the Study of Liver
Diseases (AASLD), the American Gastroenterological Association (AGA),
the American Society for Gastrointestinal Endoscopy (ASGE) and the
Society for Surgery of the Alimentary Tract (SSAT), DDW takes place
May 14-19, 2005 in Chicago. XIFAXAN should not be used in patients
with diarrhea complicated by fever or blood in the stool or diarrhea
due to pathogens other than Escherichia coli.7%), headache
9.7% (vs. In the studies, the
immediate reactions were uncommon and consisted primarily of local redness at
or near the injection site.

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- - kjjkjk

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