Tm Bioscience to supply Emory Genetics Laboratory with Tag-It(TM) reagents

Analytical and performance characteristics
are not established.
(xx)For Investigational Use Only.

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, Associate Professor and
Director of Hematology , Johns Hopkins University., Department of Hematology, Leeds
Teaching Hospitals NHS Trust Leeds, England and coauthor of the review. The pexelizumab trials are conducted in
collaboration with Procter and Gamble Pharmaceuticals.

(x) Analyte Specific Reagent.

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The
syndrome includes symptoms such as abdominal and swallowing pain, erectile
dysfunction, blood clotting and systemic and pulmonary hypertension. Tm Bioscience is located
in Toronto, Ontario.tmbioscience.

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, Professor, Center for Free Radical Biology, University of Alabama at
Birmingham. "This important report focuses attention on the critical medical
implications of this phenomenon and underscores that even small amounts of
hemolysis can deplete nitric oxide and disrupt many aspects of normal
physiology.

Contacts:
Alexion Pharmaceuticals, Inc. Food and Drug Administration (FDA) as an in vitro device
(IVD) for diagnostic use in the United States.

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The symptoms caused by hemolysis had not been
previously tied together into a single syndrome.S.

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"
There are currently no therapies targeted to specifically reduce
hemolysis, however, research with an experimental monoclonal antibody,
eculizumab, designed to prevent red blood cell destruction in PNH patients,
has shown promise.D. Also under the Special Protocol Assessment process, the FDA has
agreed to the design of protocols for the two trials of eculizumab in PNH
patients that could, if successful, serve as the primary basis of review for
approval of a licensing application for eculizumab in the PNH indication. The
Molecular Genetics Laboratory offers testing for over thirty genetic diseases.
These include common genetic conditions such as Cystic Fibrosis, Fragile-X
syndrome and Galactosemia.

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The report was authored by researchers from the National Heart, Lung and
Blood Institute of the National Institutes of Health, the Leeds Teaching
Hospital NHS Trust, Leeds, UK and Alexion Pharmaceuticals, Inc.
Leonard Bell, M .

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"The understanding that a
common thread likely connects seemingly unrelated conditions further
highlights the medical importance of effectively treating hemolysis and its
downstream effects . Lancaster, Jr.
Eculizumab is also being studied in rheumatoid arthritis and membranous
nephritis .com.

This press release contains forward-looking statements within the meaning
of the Private Securities Litigation Reform Act of 1995.

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The researchers reviewed clinical data from volunteers
that received hemoglobin preparations as well as from patients with sickle
cell disease or PNH , two hemolytic diseases characterized by many of the
symptoms of the clinical syndrome."
"Emory Genetics Laboratory is one of the largest academic diagnostic
laboratories in the southeastern United States and its Molecular Genetics
Laboratory offers a comprehensive suite of genetic assays ," said Greg Hines,
President and CEO of Tm Bioscience."

About Emory Genetics Laboratory

Emory Genetics Laboratory has been providing superior genetic laboratory
testing and clinical genetic services to physicians within Atlanta, throughout
the state of Georgia and around the globe for more than 30 years. The performance characteristics of
these products have not been established

About Tm Bioscience - Putting the Human Genome to Work(TM)

Tm Bioscience is a DNA-based diagnostics company developing a suite of
genetic tests.

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, Researchers have
identified a new clinical syndrome that produces serious and sometimes fatal
symptoms in a variety of seemingly unrelated diseases. The syndrome,
described in the April 6 issue of the Journal of the American Medical
Association, is caused by hemolysis, the destruction of red blood cells. The researchers reported on data published in the New
England Journal of Medicine (2004;350:552-559) showing a dramatic reduction in
hemolysis in PNH patients. Alexion's two lead product candidates, pexelizumab and
eculizumab , are currently undergoing evaluation in several clinical
development programs, including two Phase III trials of eculizumab for the
treatment of paroxysmal nocturnal hemoglobinuria (PNH), a Phase III trial of
pexelizumab in coronary artery bypass graft (CABG) surgery patients undergoing
cardiopulmonary bypass (CPB), and a Phase III trial of pexelizumab in acute
myocardial infarction (AMI) patients . Kasinathan Muralidharan, Director of the Molecular Genetics
Laboratory.

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These statements are
subject to certain factors which may cause our plans and results to differ
significantly from plans and results discussed in such forward-looking
statements, including but not limited to the risks discussed in Alexion's
Annual Report on Form 10-K for the year ended July 31, 2004 and in our other
filings with the Securities and Exchange Commission.genetics.

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"

About Alexion Pharmaceuticals
Alexion (Nasdaq: ALXN) is engaged in the discovery and development of
therapeutic products aimed at treating patients with a wide array of severe
disease states, including hematologic and cardiovascular disorders, autoimmune
diseases and cancer. This press
release and further information about Alexion Pharmaceuticals, Inc.

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Jack R. Alexion is providing this
information as of the date of this press release and does not undertake any
obligation to update any forward-looking statement , whether as a result of new
information, future events, or otherwise. TSX: TMC

TORONTO , June 2 - Tm Bioscience Corporation
(Toronto, Ontario; TSX: TMC), a leader in the commercial genetic testing
market, today announced it has signed an agreement to supply the Emory
Genetics Laboratory at Emory University (Atlanta, Georgia) with the Tag-It(TM)
ASR(x) reagents for use in its Ashkenazi Jewish Panel (AJP) gene assay, which
detects gene mutations associated with Tay-Sachs disease, Canavan Disease,
Familial Dysautonomia, Gaucher Disease, Bloom Syndrome, Fanconi Anemia,
Neimann-Pick Disease, and Mucolipidosis Type IV.

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D.
"There are many reasons why nature has chosen to keep hemoglobin hidden
inside the red blood cell, but one of the most important is to prevent the
removal of nitric oxide from the blood," said Dr. All genetic tests from Tm
Bioscience are based on the Tag-It(TM) Universal Array platform, which
utilizes a proprietary universal tag system that allows for easy optimization,
product development and expansion.

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"This report should raise awareness of physicians from various disciplines
of the potential clinical consequences of hemolysis, hemoglobin release and
nitric oxide depletion," said Robert Brodsky, M. Long-term evaluation of these patients has shown a
decrease in symptoms attributed to hemoglobin release and the subsequent
depletion of nitric oxide, including abdominal and swallowing pain and
erectile dysfunction. "The
improvement in patients with PNH following resolution of hemolysis highlights
the potential importance of hemoglobin release in the disease process.alexionpharm.D.

About Tag-It(TM) reagents and genetic tests

Tm Bioscience's product menu is focused in the fields of human genetic
disorders, pharmacogenetics and infectious disease. The Company has
commercialized Analyte Specific Reagents(x) and a series of Tag-It(TM)
tests(xx) for a variety of genetic disorders.

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D.
"We are encouraged by the data on eculizumab in the treatment of
hemolysis," said Peter Hillmen, MB, Ph.

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Researchers Uncover New Clinical Syndrome: Destruction of Red Blood Cells Tied to Severe Symptoms in Diverse Diseases and Conditions

CHESHIRE, Conn. "We are delighted to add this renowned
laboratory to our growing base of customers .

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For additional information, please visit
http://www. Combined, the
Universal Array and Luminex instrument enable the rapid production of
flexible, high-throughput, low-cost DNA-based tests. Tm Bioscience's product pipeline includes tests for genetic
disorders, drug metabolism, and infectious diseases.

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Nitric oxide depletion has a
profound impact on smooth muscle cells, causing blood vessel constriction,
gastrointestinal contractions and cramping, and erectile dysfunction. Alexion is engaged in discovering and developing a pipeline of
additional antibody therapeutics targeting severe unmet medical needs, through
its wholly owned subsidiary, Alexion Antibody Technologies, Inc.
"We are seeing growing demand for genetic screening across the state of
Georgia," said Dr. The Company 's Tag-It(TM) Cystic
Fibrosis (CF) Kit is the first multiplexed human disease genotyping test to be
cleared by the U.

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Nitric
oxide is also an important inhibitor of platelet activation and aggregation ,
and its depletion may play a pivotal role in blood clotting in patients with
hemolytic conditions . can be
found on the World Wide Web at: http://www. "Incorporating the Tag-It(TM) reagents from Tm Bioscience, will
help us serve our patient population by providing a multi-disease panel that
will produce fast results, with high throughput and a minimum of operator
time.com.

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Hemolysis is a critical factor in such conditions as sickle cell disease,
paroxysmal nocturnal hemoglobinuria (PNH), malaria, and certain anemias,
including those caused by infection, mechanical heart valves and
cardiopulmonary bypass.
According to the researchers, the syndrome is caused by a novel disease
mechanism that begins with the destruction of red blood cells and leads to
elevated levels of free hemoglobin in the blood and the subsequent depletion
of a key chemical mediator, nitric oxide ."
The researchers also emphasize the need for intensive ongoing
investigation into the link between hemoglobin release, nitric oxide
consumption and symptoms of hemolytic disease.,
Ph.

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Assays from Tm operate on the Luminex
xMAP(R) system, a well-established bead based instrument.

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Under the Special
Protocol Assessment process, the FDA has agreed to the design of protocols for
the Phase III pexelizumab trials that could, if successful, serve as the
primary basis of review for approval of licensing applications for the two
indications.edu.

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Chief Executive Officer
(203 ) 272-2596

Rx Communications
Patricia Garrison (Scientific Media)
(917) 322 -2567

Rhonda Chiger (Investors)
(917) 322-2569

Noonan/Russo
Emily Poe (Business and Financial Media)
(212) 845-4266

emory. Additional information about Tm Bioscience can be found
at http://www.

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