Food and
Drug Administration (FDA) today approved
once-monthly oral Boniva (ibandronate sodium) 150 mg Tablets, the first
and only once-a-month medicine for the treatment of postmenopausal
osteoporosis, Roche and GlaxoSmithKline (GSK) (NYSE: GSK) announced.S. pharmacies in April. Patients should take Boniva with plain water on an empty stomach
upon rising in the morning. For more information on this program call
1-800-4BONIVA . "With the approval of your health care provider, consider a
multi-faceted exercise program that includes aerobic, strengthening, and
balance exercises," Dr. Before beginning any new exercise program , consult with your doctor
of chiropractic or other health care provider. However, you should avoid tennis -- or ask your
doctor to closely monitor your progress -- if you have arthritis or
other joint irritation.

ramage severity

Clinical Trial Results(3)

Daily Boniva (2.
Boniva is not recommended in patients with severe renal impairment.1 percent vs.1 percent). "This support program will
be another useful tool for patients.S. (You can measure the
distance with your car.

* Swimming is an especially helpful exercise for older Americans.

* Eat a healthy, balanced diet, including fresh vegetables, fruit, nuts
and seeds.

nutritionist severity

Boniva is the first-ever oral treatment administered as one tablet once a
month for any chronic disease. 3.
Rockville, MD: U."
How can doctors of chiropractic help seniors improve their quality of
life? Advice on age-appropriate exercise and diet are two of the most
important ways. For those who have not
previously been physically active, begin slowly.

nutritionist sexes

, clinical trial investigator and
Medical Director of Radiant Research, Reading, PA.
Adequate intake of calcium and Vitamin D is important in all patients . Hoffmann-La Roche (Roche) and GlaxoSmithKline (GSK)
announced their plans to co-promote Boniva for the treatment and prevention
of postmenopausal osteoporosis in all countries except Japan., The American Chiropractic
Association (ACA) and public health officials across the country are using
National Public Health Week, April 4-8, to encourage Americans to stay strong
and healthy throughout their later years.
"This week the American Chiropractic Association is encouraging older
Americans to make lifestyle changes that will keep themselves strong and
healthy," said ACA President Donald Krippendorf, DC.
Visit the American Chiropractic Association's Web site at
http://www.

densitometry obgyn

5 mg daily are indicated for the treatment and
prevention of postmenopausal osteoporosis.5 mg) was approved for the treatment and prevention of
osteoporosis based on studies showing that, over three years , it
significantly reduced the risk of new vertebral fractures in women with
postmenopausal osteoporosis and increased bone mineral density (BMD) in
postmenopausal women without osteoporosis.3 percent) , dyspepsia (5.6 percent vs. In the U.

(Coffee, tea, soft drinks and alcohol are diuretics/dehydrators. Don't
substitute them for water.

Many older Americans are moving away from the traditional model of
"disease management" medical care to a new model of preventive care, and
chiropractic plays a big role in that shift.com/insurance/wellness/ResPatients. These nutrients have been classified as essential for decades. In a recent evaluation by the Lewin Group , supplementation
with calcium and vitamin D could result in savings of $13 billion in
healthcare costs from reduced fractures.

sexes mcw

"It is never too late to
incorporate simple activities that can protect your health and prolong your
life.) Do that three days a week for a month, then double
the distance, working gradually up to at least one mile a day, three days a
week. Begin at a slow pace and work up to a brisk pace that will improve
cardiovascular function.

* Bicycling is a very good aerobic exercise that can benefit the heart and
the rest of the cardiopulmonary system."
Many notable studies have found benefits from calcium and vitamin D
supplementation.

- The positive public health impact of calcium supplementation is
noteworthy.

oep ageing

"The approval of this
medication is significant because it offers patients a new treatment option
that is effective and easy to take.1 percent), arthralgia (5. Unfortunately, the
prevalence of osteoporosis is growing, especially as the number of
postmenopausal women in the population continues to rise. Although recent federal data report
that Americans are living longer , many older Americans continue to suffer from
preventable health problems that could be diminished if proactively addressed.

* Many seniors enjoy not only the physical benefits of golf, but the
social benefits as well. The
water's natural resistance to movement offers a challenging
cardiovascular workout, while its buoyancy lowers the amount of stress
on muscles and joints that other high-impact exercises create.acatoday.com, where you can find the name of an ACA member in your
area and obtain additional information about chiropractic care."

- The National Osteoporosis Foundation, which recommends calcium and
vitamin D supplementation , has said it has no plans to revise its
guidelines in light of recent studies.

densitometry commoner

(1) Forty-four million Americans over 50 years of age, are
affected by or at risk for osteoporosis, which causes bones to become weak
and more likely to break, and can result in severe pain, deformity,
disability , hospitalization and even death. Boniva 2. Roche has
alliances and research and development agreements with numerous partners,
including majority ownership interests in Genentech and Chugai. ACA is Official Partner in National Public Health Week

ARLINGTON, Va.
Women's Ultra Mega Bone Density contains MBP, a revolutionary ingredient that
helps the body use calcium more efficiently .

osteoporosis bone

002)
-- The once-monthly group also had consistently higher BMD increases at
the other skeletal sites compared to the daily group

Important Safety Information

Boniva is contraindicated in patients unable to stand or sit upright for at
least 60 minutes, with uncorrected hypocalcemia , or with known
hypersensitivity to any component of Boniva.4boniva.

"The patients in my clinical trials found easy ways to remember their
once-monthly Boniva, such as writing a note on their calendar or taking it
the first Sunday of each month," Dr. For further
information, visit www.rocheusa .

(2) America's Bone Health: The State of Osteoporosis and Low Bone Mass in
Our Nation: The National Osteoporosis Foundation; February 2002.

Joseph C.

mcw densitometry

PRESS RELEASE FDA Approves Once-Monthly Boniva(R) for Osteoporosis

"Boniva is the first and only
once-monthly osteoporosis medication that maintains and actually builds
bone density," said Ronald Emkey, M. Once-monthly oral Boniva (150
mg) was approved based on results from the MOBILE study (Monthly Oral
iBandronate In LadiEs), a randomized, double-blind, multinational,
non-inferiority trial in 1,602 women with postmenopausal osteoporosis. Having clubs that are comfortable will increase the
chances of playing for a long time without significant physical
limitations.

Osteoporosis is a disease of ageing and, although commoner in women, can occur in both sexes.

bone fracture

, although it is undergoing regulatory review in markets
across the world, including Europe, where it will be marketed under the
trademark Bonviva.
MOBILE showed the following:

-- The monthly dose was at least equivalent to the daily dose in
increasing BMD after one year at the lumbar spine and other skeletal sites
-- The mean increase from baseline in lumbar spine BMD was 4.8 percent vs. each
year.S.
Some important facts to consider regarding calcium and vitamin D:

- Calcium and vitamin D are both recognized by the Institute of Medicine
as essential nutrients that must be consumed by all people to maintain
health.

GNC offers several products that contain these vital nutrients, including
Women's Ultra Mega Bone Density (R).

paget ageing

(2) To improve persistence, the
Surgeon General's Report has recommended, among various measures,
simplifying and organizing treatment regimens .

Rarely, patients have reported severe bone, joint and/or muscle pain after
taking bisphosphonate therapy for osteoporosis.3 percent), hypertension (6.

Patients who take Boniva are eligible to sign up for MyBONIVA, a patient
support program designed to help enhance compliance (taking therapy as
directed) and persistence (staying on therapy) with this unique
once-monthly regimen.gsk.shtml .

osteopenia fracture

"

Why Monthly Boniva?

This new treatment option comes in the wake of the Surgeon General 's Report
elevating osteoporosis to a major public health threat on par with smoking
and obesity .S."

About Osteoporosis

Osteoporosis (porous bones) is a disease in which bones become brittle and
more likely to break., Nutley, NJ; 2005. Krippendorf recommends.

mcw fractures

(1)

"Osteoporosis is a serious, widespread and growing public health threat.

Boniva 150 mg
once-monthly and Boniva 2.

About Once-Monthly Oral Boniva(3)

Once-monthly Boniva is a small, film-coated , easy-to-swallow tablet dosed
at 150 mg.(2) Direct
medical costs of osteoporosis total nearly $18 billion in the U. Maroon, a
world-renowned neurosurgeon and GNC Corporation's national medical consultant. An
important three year study, published in the New England Journal of Medicine,
of elderly men and women supplemented with calcium and vitamin D showed
reduced bone loss of the hip and spine as well as a reduced incidence of
vertebral fractures.

- Dietary intake surveys repeatedly demonstrate that most Americans are
not consuming recommended intakes of calcium and vitamin D. This new formula can help women meet
their bodies' needs for calcium, vitamin D and many other important nutrients.

osteopenia sexes

D. Doctors of chiropractic believe
that prevention is the key to health and wellness.
This fact is not disputable, and a large number of studies over many decades
have shown vitamin D and calcium supplementation to be effective in building
and maintaining healthy bones.

mcw drdonnica

With
once-monthly Boniva, an effective bisphosphonate, patients would take 12
tablets a year versus 52 required with current weekly bisphosphonate
treatments.3 percent
vs.com. PITTSBURGH , Recent studies have created confusion
regarding the importance of vitamins, minerals and other nutritional
supplements, but consumers need to understand a simple fact: Vitamins and
other nutrients , including calcium and vitamin D, are necessary to our health
and wellbeing. A recent meta-analysis of double blind, randomized controlled
trials, published in the Journal of the American Medical Association , showed a
26% risk reduction in hip fractures in elderly consuming vitamin D at doses
above 700 IU.S. Food and Drug Administration says, "an inadequate calcium
intake contributes to low peak bone mass and has been identified
as one of many risk factors in the development of osteoporosis . MBP has been shown in clinical
trials to increase bone mass.
GNC, based in Pittsburgh, PA , is the largest global specialty retailer of
nutritional supplements, which includes vitamin, mineral and herbal
supplements, sports nutrition products, diet and energy products and specialty
supplements .

osteoporosis densitometry

We
welcome any new treatment options such as Boniva that will help patients
address this all too prevalent disease," said Judith Cranford, Executive
Director, National Osteoporosis Foundation .6
percent vs. For complete prescribing information for
Boniva, see contact information at the end of the news release or go to
www.com. today, ten million individuals, eight
million of whom are women, are estimated to already have osteoporosis, and
almost 34 million more are estimated to have low bone mass (osteopenia),(2)
placing them at increased risk for osteoporosis. The Roche and
GSK collaboration provides expertise and commitment to bringing new
osteoporosis therapies to market as quickly as possible.)

* If you take vitamins, take them with a meal to allow for proper
absorption.
"Human beings require these essential nutrients to grow and thrive and to
reduce the risk of chronic health problems," said Dr.

Osteoporosis is a condition where the bones become thin and fragile, increasing the chance of breaking following even minor injury.

webmd sexes

7.
Its core businesses are pharmaceuticals and diagnostics.com.

About GSK

GSK, one of the world 's leading research-based pharmaceutical and
healthcare companies, is committed to improving the quality of human life
by enabling people to do more, feel better and live longer. If you show some signs of arthritis in the
hands, consider a larger, more specialized grip for added safety and
performance.

* Tennis is a good exercise for those who want to strengthen their joints
and joint muscles.

Eating Right
* Drink 10 eight-ounce glasses of water a day to help keep the kidneys
active, dilute and remove toxins from the body, and replace lost fluids. For the extra calcium needed to maintain strong bones and
help prevent osteoporosis , try broccoli, kale, collard greens, cabbage,
and turnip greens.

osteoporosis mcw

Developed in response to patient need,
once-monthly Boniva was approved based on a supplemental new drug
application .9 percent in
the once-monthly group and 3. Together,
osteoporosis and osteopenia are expected to affect an estimated 52 million
women and men age 50 and older by 2010, and 61 million by 2020 .

(3) BONIVA (ibandronate sodium) TABLETS [prescribing information]
Roche Laboratories Inc.

oep severity

Once-monthly Boniva is expected
to be available by prescription in U.

The most commonly reported adverse events with
once-monthly Boniva regardless of causality were abdominal pain (Boniva 150
mg 7. Emkey said.

References

(1) Bone Health and Osteoporosis: A Report of the Surgeon General. Department of Health and Human Services, Office
of the Surgeon General; 2004.
The ACA suggests the following tips to help older individuals maintain a
healthy lifestyle:

Walking
Walking improves elasticity in blood vessels, which makes them less
susceptible to formation of aneurysms or rupture. Experiment with tofu, salmon, sardines, and grains.acatoday. I will continue to recommend these critical
supplements to my patients because I continue to believe in their
effectiveness.

densitometry sexes

1

Roche and GSK Collaboration

In December 2001, F.

American Chiropractic Association Encourages Older Americans to Kick the Sedentary Lifestyle

- Decades of research in animals and humans confirm the contribution of
calcium and vitamin D in building and preserving bone mass across all
age groups.

nutritionist drdonnica

The U.S. Start with one -third of a
mile per day -- one-sixth out and one-sixth back.

- The U.

imaginis bone

Boniva, like other
bisphosphonates administered orally, may cause upper gastrointestinal
disorders such as dysphagia , esophagitis, and esophageal or gastric ulcer. Additionally, osteonecrosis
of the jaw has rarely been reported in patients treated with
bisphosphonates; most cases have been in cancer patients undergoing dental
procedures.5 mg 5.5 percent), nausea (5. 4. For more information on ACA's wellness initiative , visit:
http://www. An earlier meta-analysis in the same publication found that
vitamin D reduced the risk of falls in older individuals by more than 20%.

ramage healthcentral

9 percent in the daily group (p=0 . 7. 4.8 percent) and diarrhea
(5.1 percent vs.S.

About Roche

Roche is one of the world 's leading innovation-driven healthcare groups.

Other Types of Exercise
Because today 's older Americans are remaining active well into their
golden years, many seniors may be able to participate in more strenuous
exercise. However, those people who have
not previously been physically active should ease into bicycling slowly.
One drawback to bicycling is that your weight is not distributed
normally while riding, and this can exacerbate or cause back pain .

You Need to Know: Calcium and Vitamin D Are Essential Nutrients

"Vitamin D and calcium are essential in maintaining healthy bones and teeth.

severity prevalence

Once-monthly oral Boniva is not currently approved for use
outside of the U. They should remain upright and avoid food,
drink and other medications for at least 60 minutes. For company
information, visit GSK on the World Wide Web at www.
In fact, the ACA recently launched a new Web page devoted to Wellness
Resources.