David Perlmutter and Bruce Trapnell.

The AASLD is a leading organization of scientists and healthcare
professionals committed to preventing and curing liver disease.

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About Narcolepsy

Narcolepsy is a chronic , debilitating neurological disease whose
primary symptoms are excessive daytime sleepiness (EDS) , fragmented
nighttime sleep and cataplexy.

Balistreri, M.alphaone. 211

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Orphan Medical Issues Xyrem Prescriptions Update

, Director, Pediatric Liver Care Center, Cincinnati Children's
Hospital Medical Center. ( http://www.org )

The American Liver Foundation is the nation's leading nonprofit
organization promoting liver health and disease prevention.

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, the 2004 Nobel Prize
Winner in Chemistry, will be a featured presenter," says John Walsh, President
and CEO of the Alpha-1 Foundation.

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(These
documents can be accessed through the Orphan Medical Web site at
http://www.

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About Fibromyalgia

Fibromyalgia is a chronic condition that is estimated to affect as
many as four million individuals in the United States and represents a
market opportunity in excess of $1 billion dollars per year.D.org )

Contact: Marlene Erven
+1-305-567-9888, ext.

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The Company is also
conducting a trial to evaluate Xyrem as a treatment for symptoms of
fibromyalgia syndrome. A number of factors
could cause actual results to differ materially from the Company's
assumptions and expectations. All forward-looking statements are qualified
by , and should be considered in conjunction with, such cautionary
statements.
"This is a novel gathering of scientists and clinicians in related areas
to focus on the important emerging topic of the molecular pathogenesis and
therapeutic approaches to the hepatotoxicity associated with the inherited
metabolic disorder Alpha-1 Antitrypsin Deficiency," says William F.

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About Orphan Medical, Inc.D. "This Workshop will build upon the work of
the Foundation's previous scientific conferences and the significant recent
advances in the understanding of AAT Deficiency.liverfoundation.

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Business Editors/Health/Medical Writers

MINNEAPOLIS----Orphan Medical, Inc.

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Cataplexy, a sudden loss of muscle
tone, is usually triggered by strong emotions such as laughter, anger
or surprise. Participants will discuss the current concepts of the molecular
mechanisms responsible for liver injury in patients with Alpha-1 Antitrypsin
Deficiency.Sc.

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These are set forth in the cautionary
statements included in Orphan Medical's most recent Form 10-Q or Form
10-K filed with the Securities and Exchange Commission ., D.

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Other symptoms include
persistent fatigue, headaches, cognitive or memory impairment, morning
stiffness and non-restorative sleep.
Such forward-looking statements are based upon current expectations
and beliefs and involve numerous risks and uncertainties, both known
and unknown, that could cause actual events or results to differ
materially from these forward-looking statements.aasld.

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This represents an 8 percent
sequential increase from the six-week period ended December 31, 2004,
and a 104 percent increase over the 2,349 prescriptions filled during
the six-week prior-year period ended February 15, 2004. The
sNDA is expected to expand the Xyrem label to encompass the other
primary symptoms of narcolepsy, specifically the reduction of EDS and
the improvement in fragmented nighttime sleep , in addition to the
established efficacy of Xyrem in treating cataplexy. In some cases, you can identify forward-looking
statements by terminology such as "expects," "anticipates," "intends,"
"may," "should," "plans," "believes," "seeks," "estimates," "could,"
"would" or the negative of such terms or other comparable terminology.org .

The Alpha-1 Foundation is dedicated to providing the leadership and
resources that will result in increased research, improved health, worldwide
detection and a cure for Alpha-1 Antitrypsin Deficiency (Alpha-1).

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Experts From Around the World to Convene in Atlanta

MIAMI, The Alpha-1 Foundation, in conjunction with
the American Association for the Study of Liver Diseases (AASLD) has organized
a Basic Research Single Topic Conference on Alpha-1 Antitrypsin Deficiency and
Other Liver Diseases Caused by Aggregated Proteins on January 26-28, in
Atlanta, GA.

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Orphan
Medical submitted a Supplemental New Drug Application (sNDA) for Xyrem
to the Food and Drug Administration (FDA) on January 18, 2005.orphan.
The objectives of the conference are to understand the molecular biology
of protein folding, the role of the protein degradation system, and the
consequences of misfolding of specific proteins seen in several clinical
disorders." For a full agenda and
information, visit: http://www.

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(Nasdaq:ORPH) announced that the total number of Xyrem(R) (sodium
oxybate) oral solution prescriptions filled in the six -week period
ended February 15, 2005, was 4,790.

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Patients often
selectively isolate themselves from social interaction with others
resulting in a worsening effect on a patient's quality of life .

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Scientific Meeting on Alpha-1 Antitrypsin Deficiency and Other Liver Diseases Caused by Aggregated Proteins

Dr Balistreri is conference co-director with
Drs.
"We are pleased that Aaron Ciechanover , M. Alpha-1 is
a genetic disorder that can cause liver and lung disease in children and
adults .

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Narcolepsy afflicts 100,000 to 140,000 Americans of which an estimated
50,000 receive some form of treatment for their symptoms. The
disease is characterized by widespread muscle pain and stiffness and
affects women three times more often than men.

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The Company's trial evaluating
Xyrem as a treatment for symptoms of fibromyalgia syndrome is fully
enrolled with data expected to be available in mid -2005.

Orphan Medical acquires, develops and markets pharmaceuticals of
high medical value for inadequately treated and uncommon central
nervous system (CNS) diseases treated by specialist physicians. Orphan Medical's Internet Web site address is
www.orphan.

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Other sponsors include the National Institutes of Health --
National Institute of Diabetes and Digestive and Kidney Diseases , and Office
of Rare Diseases -- and American Liver Foundation.
( http://www.

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All patients with narcolepsy suffer from EDS and an
estimated 60 to 90 percent suffer from cataplexy. Xyrem
has now been assessed as a treatment for the full range of narcolepsy
symptoms including excessive daytime sleepiness.com

The information in this press release contains forward-looking
statements within the meaning of the Private Securities Litigation
Reform Act of 1995.com).

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This conference will highlight studies and future research
opportunities which may help to define molecular approaches underway to
develop effective therapies to treat the liver manifestations of disorders
involving protein misfolding.