Advocates Physicians and Entertainers to Gather for Low Dose Naltrexone Conference

As a
result, Nicholas has waived his performance fee for the conference in an
effort to promote recognition of LDN as a viable treatment for MS.

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Still , LDN remains largely unknown in the U. Phil Boyle, a family
physician in Ireland, who will discuss some "stunning clinical results"; and
Dr. Pat Crowley, also from Ireland, who will show his documentary on LDN
treatment. MN-166 is an orally administered drug with a novel mechanism
of action that includes the inhibition of phosphodiesterase IV. of Tokyo,
Japan, MediciNova obtained exclusive worldwide rights, except for Japan,
China, Taiwan and South Korea, to develop and commercialize MN-166 for
multiple sclerosis. Ibudilast was also launched in Korea in September 2002. is a publicly traded specialty pharmaceutical company
focused on accelerating the global development and commercialization of
innovative pharmaceutical products.

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BETHESDA, Md.

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For additional information about the company, please visit
http://www.
Naltrexone was originally approved by the FDA in 1984 at the 50mg level
for narcotics addiction. LDN has no known harmful side
effects, and at an average price of under $50 per month's supply, the compound
is extremely affordable.

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The objective of this
trial is to assess the safety, tolerability and pharmacokinetics of escalating
single doses of REN-850 in healthy volunteers.renovis. All other product names and marks are or may be trademarks or
registered trademarks used to identify products or services of their
respective owners. This Phase II study is being conducted in nine countries in Eastern
Europe and will compare two oral doses of MN-166 to placebo in 300 patients
with relapsing-remitting MS. These statements are
based on certain assumptions made by the Company's management that are
believed to be reasonable at the time .

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SOUTH SAN FRANCISCO, Calif. We are
independently developing REN-1654, an oral drug for neuropathic pain in Phase
II clinical trials and REN-850, an oral drug for multiple sclerosis in Phase I
clinical trials.

Safe Harbor Statement
This press release contains forward-looking statements within the meaning
of the Private Securities Litigation Reform Act of 1995 that involve
substantial risks and uncertainties.

Contacts:

INVESTORS: MEDIA:
Renovis, Inc.poe@eurorscg. David
Gluck, host of last year's conference, with a brief review of the year in LDN;
keynote speaker Dr.
Under a licensing agreement with Kyorin Pharmaceutical Co. Such statements are subject to a number
of assumptions, risks and uncertainties, many of which are beyond the control
of the Company, including results of clinical studies and other risks and
uncertainties, including those described in the Company's filings with the
Securities and Exchange Commission.

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, in which she studied the compound's effects on Crohn's
disease; Dr.lowdosenaltrexone . For more information,
visit http://www. These
statements include statements regarding the expected progress of the
development of one of the Company's product candidates.

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About Renovis
Renovis is a biopharmaceutical company developing drugs to treat
neurological diseases and disorders. Noonan/Russo
John C.com

org

This release was issued through eReleases(TM).D.medicinova.

This press release may contain "forward looking statements" within the
meaning of the Private Securities Litigation Reform Act of 1995.

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"The Phase Ia trial with REN-850 represents the first step towards
establishing safety and tolerability in humans," said Randall Moreadith, MD,
PhD, Chief Medical Officer of Renovis. These studies have also shown that oral administration
of REN-850 significantly reduces severity of outcomes in multiple in vivo
models of MS and rheumatoid arthritis (RA).

CEROVIVE (NXY-059) is a registered trademark of the AstraZeneca group of
companies. Doyle Emily Poe
(650 ) 266-1407 (212) 845-4266
emily.
Singer/songwriter Paul Nicholas, who debuted his hit song "Please Remember
Me," now the anthem in the fight against MS, on the Montel Williams Show in
June, will perform at the Second Annual LDN Conference. Novel Oral Compound Demonstrated Benefits in Earlier Clinical Studies in
Patients with Relapsing-Remitting MS

SAN DIEGO, MediciNova, Inc.

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Ltd. These assumptions, risks and uncertainties
could cause the Company's actual results to differ materially from those
implied or expressed by the forward -looking statements.

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Renovis Announces Initiation of Phase Ia Clinical Study with Investigational Medicine for Multiple Sclerosis

S.

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Nicholas, who has MS,
recently began taking LDN and has experienced dramatic improvements.com.

MediciNova Initiates a Phase II Clinical Trial With MN-166 in Multiple Sclerosis

, Chief Development
Officer at MediciNova.

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(Nasdaq: RNVS) announced today the initiation of a Phase Ia clinical
trial for REN-850, an investigational oral small molecule that is being
targeted for the treatment of multiple sclerosis (MS). The Phase Ib study is currently planned to
start enrolling subjects in the fourth quarter of 2005. Our most advanced product candidate is
CEROVIVE (NXY-059 ), an intravenous drug for acute ischemic stroke that is in
Phase III clinical trials with our exclusive licensee, AstraZeneca AB. These and other risks are described in greater detail in
the "Risk Factors " section of our Quarterly Report on Form 10-Q, which was
filed with the Securities and Exchange Commission on November 15, 2004.5mg range --
the compounded medication, taken nightly, stimulates the immune system and
helps the body fight off devastating diseases. On the schedule are: Dr., please visit
http://www.

merle herts

, On April 7, 2006, physicians,
patient advocates and entertainers will gather at the Second Annual Low Dose
Naltrexone (LDN) Conference (http://www.lowdosenaltrexone.

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"
REN -850 acts by inhibiting leukocyte trafficking and preclinical studies
have shown that REN-850 modulates the cell migration driven by multiple
chemokine receptors. We do not assume any obligation to update any forward-looking
statements. Jacqueline McCandless, who will present her achievements using
LDN in treating childhood autism and report findings from parents whose
children with bipolar disorder are responding to LDN; Dr. For additional information, visit
http://www., a specialty
pharmaceutical company that is publicly traded on the Hercules Market of the
Osaka Securities Exchange (Code number: 4875), today announced the enrollment
of patients in a Phase II clinical study with MN-166 for the treatment of
multiple sclerosis (MS), an inflammatory demyelinating disease of the central
nervous system.

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, Renovis,
Inc. "It has a proven record of safety and tolerability,
and has the major advantage of oral dosing.

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- and according to Susan
Sedlock, coordinator of the Second Annual LDN Conference, big pharma remains
uninterested in LDN, perhaps because of naltrexone's status as a generic drug
and LDN's extremely low cost to the patient.com
http://www.

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Approximately 45 subjects are
planned to participate in the study. Various important factors could cause actual results or
events to differ materially from the forward-looking statements that we make,
including risks related to: our heavy dependence on the success of CEROVIVE
(NXY-059), which is still under development; our dependence on our strategic
collaboration with AstraZeneca; AstraZeneca's success in obtaining regulatory
approval to market CEROVIVE (NXY-059); our ability to successfully develop
other product candidates, such as REN-1654 and REN-850; obtaining, maintaining
and protecting the intellectual property incorporated into our product
candidates; and our ability to obtain additional funding to support our
business activities.ereleases. For the past 16 years, MN-166 has been marketed in Japan
as Ketas(R) (ibudilast), for the treatment of asthma and cerebrovascular
disorders.

ms sclerosis

"Successful completion of this trial
will provide valuable data to support a Phase Ib study of escalating multiple
doses of REN-850 in MS patients. In small, open label studies in
patients with relapsing-remitting MS, MN-166 produced some rather encouraging
activity.

Sites in this category serve the support needs of people with Multiple Sclerosis or similar conditions.

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"MN-166 may represent a significant advance in the treatment of
relapsing-remitting MS," stated Richard Gammans, Ph.

About MediciNova
MediciNova, Inc.

The sites provide information and resources.

Many sites listed are interactive - you will find message boards

sclerosis stevenage

All statements, other than statements of
historical facts, included in this press release regarding our strategy,
future operations, future financial position, future revenues, projected
costs, prospects, plans and objectives of management are forward -looking
statements. We may not actually achieve these plans, intentions or
expectations and Renovis cautions investors not to place undue reliance on our
forward-looking statements.lowdosenaltrexone .org) to bring
awareness to a promising treatment for HIV/AIDS, cancer, multiple sclerosis
(MS ), autism and a host of other life-altering autoimmune conditions.S. Jill Smith, professor of gastroenterology at Pennsylvania
State University, who will discuss her impressions of the first LDN clinical
trial in the U."
The study will measure reduction in MS lesions in the brain as detected by
MRI (magnetic resonance imaging), reductions in annualized relapse rates and
functional status as determined by the EDSS (Expanded Disability Status
Scale).

sclerosis attacked

Actual results or events could differ materially
from the plans, intentions and expectations disclosed in the forward-looking
statements we make .

literate attacked

"Preclinical data suggest that targeting the actions of multiple chemokine
receptors may represent a more effective approach to the treatment of MS and
other autoimmune diseases than drugs that are more narrowly targeted," said
Tito Serafini, PhD, Vice President of Discovery Research of Renovis. Our research and development programs focus on major medical
needs in the areas of neuroprotection , pain and neuroinflammatory diseases. Our
forward-looking statements do not reflect the potential impact of any future
acquisitions, mergers, dispositions, joint ventures or investments we may
make .
The event's theme, "The Future Is Now," reflects the strides made in LDN
research and clinical trials in the past year.

Contact:

Susan Sedlock
Second Annual Low Dose Naltrexone Conference
703-998-0272
2002eldo@msn. For more information on MediciNova Inc .

Many sites provide up to the minute news on issues related to health.

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com.
But if Sedlock and the speakers at the Second Annual LDN Conference have
anything to say about it, many more patients will soon know about LDN.
The Second Annual LDN Conference will be held on the campus of the
National Institutes of Health in the Lister Hill Center Auditorium of the
National Library of Medicine.org. MediciNova's pipeline, which includes
several compounds in clinical testing, targets a variety of prevalent medical
conditions, including premature labor, cancer, asthma, multiple sclerosis and
anxiety disorders.

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But around the world, physicians and researchers are
discovering that at much lower doses -- most commonly in the 4.com.

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- - kjjkjk

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