"These data indicate substantial, and largely unmet, mental health and
social service needs among vulnerable individuals presenting with facial
injury to inner-city trauma centers," says Dr . Lento
says. CNTO 1275 is a
human monoclonal antibody that targets interleukin 12 (IL-12) and interleukin
23 (IL-23), proteins that occur naturally in the immune system and are
believed to play a role in the inflammation associated with CD. It is estimated that 500,000 Americans
and more than 400,000 people in Europe and Canada suffer from this
gastrointestinal disorder.D.

misner phenomenon

Facial Trauma Patients Have Unmet Needs for Mental Health and Social Services Study Shows

com/cgi-bin/prnh/20050125 /CGTU021LOGO )
Facial trauma patients, most of whom had been involved in interpersonal
violence , showed significantly higher rates of depression, anxiety, hostility
and phobic and obsessive-compulsive tendencies than a control group of
patients undergoing elective wisdom tooth surgery, according to the study of
adults treated for mandible (lower jaw) fractures between 1996 and 2001 at
King/Crew Medical Center, a hospital serving the socioeconomically
disadvantaged, predominantly minority populations of South-Central Los
Angeles. The company is dedicated to the research and
development of treatments for a wide range of diseases including cancer,
infectious diseases, cardiovascular and metabolic diseases and Immune-Mediated
Inflammatory Disorders (I. Centocor's products, developed primarily through monoclonal antibody
technology, help physicians deliver innovative treatments to improve human
health and restore patients' quality of life. Centocor is a wholly owned
subsidiary of Johnson + Johnson, the worldwide manufacturer of healthcare
products.

undiagnosed obsessive

Lento, who is currently an
assistant professor of psychology at the University of San Diego. The trauma and non-trauma groups
consisted predominantly of African-American and Latino males. They also urge
oral and maxillofacial surgeons to probe for signs of psychosocial distress
and be prepared to refer patients to appropriate resources .

undiagnosed phenomenon

Centocor Extends Patient Enrollment to Evaluate CNTO 1275 in Treatment of Active Crohn's Disease

"
Patients who are eligible to participate in the 28-week study will be
randomized at week 0 to one of four treatment groups to receive active drug or
placebo.

phenomenon ts

explain lesser

The study points to the need for a more comprehensive, "case management"
approach to facial injury care that links patients with mental health and
social services while providing surgical treatment and follow -up, Dr.I.

adhd tics

The Journal of Oral and Maxillofacial Surgery is the peer-reviewed journal
of the American Association of Oral and Maxillofacial Surgeons (AAOMS), the
professional organization representing more than 7,000 oral and maxillofacial
surgeons in the United States, supports its members' ability to practice their
specialty through education, research, and advocacy. AAOMS members comply
with rigorous continuing education requirements and submit to periodic office
examinations, ensuring the public that all office procedures and personnel
meet stringent national standards.

compulsive ts

Despite the group 's relatively high service needs,
however, their service use was less than half that of the control .

phenomenon layman

(Logo: http://www.
The authors recommend training for trauma care providers in administering
brief psychological assessments to facial trauma patients. Investigational, Human Anti-IL-12, Anti -IL-23 Monoclonal Antibody Focus of
Phase II Clinical Research Trial

CHESTERBROOK, Pa.

adhd darin

undiagnosed ts

"This study will evaluate the effect of a targeted, human anti-IL-12
monoclonal antibody on Crohn's disease and its symptoms," said Dennis S. Patients will be monitored through 28 weeks with an additional
visit at week 54 for a final blood test.

phenomenon defiant

, a
research associate with the VA Greater Los Angeles Health Care System at the
time of the study., Centocor, Inc. "We look forward to further analysis and evaluation of this
therapy as a potential treatment for patients with moderate to severe Crohn's
disease.

syndrome fellow

announced today
the extension of patient enrollment for a Phase II trial to evaluate the
safety and efficacy of CNTO 1275 for reducing the signs and symptoms of active
Crohn's disease (CD), a serious gastrointestinal disorder.

obsessive devin

For more information about clinical trial sites and specific study
protocol, please call 1-800-624-7994.

lesser probability

D.), such as arthritis and inflammatory skin
diseases.

fellow layman

According to the
study, published in the January 2005 issue of the Journal of Oral and
Maxillofacial Surgery, these problems often go untreated and may interfere
with recovery .
The trauma group also reported a significantly higher incidence of current
or previous mental health and social problems, such as alcohol and drug use,
problems with the law, unemployment, school suspensions, suicide attempts and
homelessness.
Previous research has shown that the psychological symptoms following a
facial injury due to violence may be intrusive enough to meet the diagnostic
criteria for post-traumatic stress disorder (PTSD) and can impair social and
occupational functioning for extended periods, Dr. The disease causes inflammation of the
gastrointestinal tract, typically resulting in symptoms such as diarrhea,
fever, abdominal pain and weight loss.

About Centocor
Centocor is a leading biopharmaceutical company that creates, acquires and
markets cost-effective therapies that yield long-term benefits for patients
and the healthcare community.

struggles ts

devin adhd

, Facial injuries caused by physical
assault can intensify existing mental health and social problems, a study of
indigent patients at an inner-city trauma center shows. One study
found PTSD symptoms in patients up to seven weeks following facial injury.
The vast majority of facial injuries resulted from physical violence
(82 percent), with the rest resulting from a fall or accident (14 percent) or
a motor vehicle accident (4 percent).

defiant tourette

ts devin

Although the intensity of some psychological symptoms, such as depression ,
declined over time within the trauma group, patients continued to report
higher levels of mental health and social service needs than the control group
at all assessment intervals, notes principal author Jennifer Lento, Ph.

phenomenon compulsive

The current study administered brief psychological and mental
health /social service needs assessments to 336 facial trauma patients and
119 non-trauma patients 10 days , 6 months and 12 months after treatment. Riff,
MD, Medical Director, Advanced Clinical Research Institute , Anaheim,
California.

devin struggles

oppositional fellow

Lento notes. The two groups
did not differ significantly in rates of high school graduation, employment,
marital status or ethnicity. Subjects will be permitted to remain on certain standard CD
medications, including steroids and immunomodulators, while participating in
the study.

ts probability

ROSEMONT, Ill.

tics misner

newscom.

About Crohn's Disease
CD is a chronic inflammatory bowel disorder that commonly affects the
lower part of the small intestine and the large intestine and typically begins
in late childhood or early adulthood.