In pre-clinical cancer models the antibody has demonstrated that it
can efficiently kill chemo -refractory tumors and suppress growth in xenograft
studies."
"This is the first of several antibodies in our product portfolio that the
company plans on advancing into clinical development for cancer, inflammation
and infectious diseases," added Philip M. CHEVY CHASE, Md. A previous trial of GH
treatment in men with abdominal obesity demonstrated reduction in abdominal
fat mass and beneficial effects on insulin sensitivity and lipids. Today, The Endocrine Society's
membership consists of over 12,000 scientists, physicians, educators, nurses
and students, in more than 80 countries .

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, Morphotek, Inc. "In pre-clinical studies MORAb-003 has been shown to be active
against chemo -refractory ovarian tumors. Sass, Executive Vice President and
Chief Operating Officer of Morphotek .

CONTACT:
Dr.

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This
versatile technology has been successfully applied to microbes , plants, and
mammals to yield genetically diverse offspring that are suitable for
pharmaceutical and agricultural product development in the areas of antibody
and protein therapeutics, high-titer protein manufacturing, and drug target
discovery.
"Previous research has shown that obesity is linked to metabolic syndrome,
which has several known risk factors including high cholesterol , high blood
pressure, increased levels of fasting glucose and an increase in waist
circumference ," explains Dr.

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EXTON, Pa. Johansson.

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In 2005, it is estimated that there will be 22,220 new cases of
ovarian cancer in the U.

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MORAb-003 is a monoclonal antibody that has high specificity for a number
of different cancers, including ovarian, breast, colorectal, lung, renal, and
brain.

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today announced that
the United States Food and Drug Administration has accepted its
Investigational New Drug (IND) Application for treatment of advanced ovarian
cancer with MORAb-003, a humanized monoclonal antibody.org.

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The Phase I clinical
study is designed as an open label single dose escalation safety study in
patients with chemo-refractive ovarian cancer. Gudmundur Johannsson and his research team at the Sahlgrenska
University Hospital in Sweden investigated the effect of GH treatment for one
year on insulin sensitivity in postmenopausal women with abdominal adiposity. The Endocrine Society
is based in Chevy Chase, Maryland.

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and approximately 16,000 women will die from the
disease.
For further information visit http://www.
Phone: 610-423-6106

Growth Hormone Treatment Improves Symptoms of Metabolic Disorder in Postmenopausal Women

JCE+M is one of four journals published by The Endocrine Society.endo-society.

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S. Internally,
Morphotek employs its morphogenics technology to develop optimized therapeutic
antibodies for the treatment of cancer, inflammatory and infectious diseases. Philip M. Sass, Executive Vice President and Chief Operating Officer,
Morphotek , Inc. To learn more about the Society, and the
field of endocrinology, visit the Society's web site at
http://www.

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We will file an IND by the end of this year.

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Morphotek Announces Acceptance of Investigational New Drug Application for MORAb-003 a Humanized Monoclonal Antibody for the Treatment of Advanced Ovarian Can

We look forward to updating the progress
of this antibody as it advances through clinical trials ."
Ovarian cancer ranks fourth in cancer deaths among women, accounting for
more deaths than any other cancer of the reproductive system (American Cancer
Society).
They also studied the effects of the hormone on abdominal fat, hepatic fat
content and size of the thigh muscle area. "The results of our study suggest that
growth hormone treatment has a favorable effect on multiple metabolic
disorders associated with abdominal obesity in postmenopausal women. Founded
in 1916, The Endocrine Society is the world's oldest, largest, and most active
organization devoted to research on hormones, and the clinical practice of
endocrinology.

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The antibody targets a receptor
present at high density on cancer cells, and offers a very high degree of
specificity for malignant tissues. Worldwide, more than 182,000 new patients will be diagnosed with
this form of cancer (World Health Organization ).

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Published today in the March issue of The Journal of
Clinical Endocrinology + Metabolism, these findings demonstrate the important
role growth hormone treatment may play in reducing serious metabolic
conditions, such as diabetes and heart disease.

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Many
postmenopausal women experience a natural increase in obesity, particularly an
increase of intra-abdominal fat, which refers to fat that is stored in and
around the internal organs.
The team discovered that the GH treatment in postmenopausal women
significantly reduced their intra-abdominal fat, increased thigh muscle area,
reduced low -density lipoprotein (LDL) cholesterol concentration, and improved
insulin sensitivity.

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"An unmet medical need exists for patients with advanced, chemo-refractory
ovarian cancer," stated Nicholas Nicolaides, President and Chief Executive
Officer.
Typically, GH is known for its importance in the growth of a child, but it
also has powerful metabolic effects in adults. The placebo group did not experience these positive
results.

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is a biotechnology company focused on the generation of
proprietary organisms for product discovery and development. Endocrinologists are specially trained doctors who diagnose,
treat and conduct basic and clinical research on complex hormonal disorders
such as diabetes, thyroid disease, osteoporosis, obesity, hypertension,
cholesterol and reproductive disorders. Together, these members represent all
basic, applied, and clinical interests in endocrinology .

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Morphotek is also marketing an exciting new antibody platform for
developing high-quality, fully human therapeutic antibodies that significantly
reduces the royalty burdens associated with current technologies.morphotek.com."
This information may offer a treatment option for doctors who treat
postmenopausal women and may reduce the metabolic consequences associated with
intra-abdominal fat accumulation.

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Morphotek(R), Inc., Researchers in Sweden have
discovered that growth hormone (GH) treatment may result in the reduction of
multiple metabolic disorders associated with abdominal obesity in
postmenopausal women.

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"We are in the late stages of
development for a second monoclonal antibody, MORAb-009, which is an antibody
that targets a high percentage of pancreatic cancers and other difficult to
treat malignancies. The Company has
a validated and patented platform technology called morphogenics that rapidly
enhances the natural process of genetic evolution within a targeted host to
yield variants with novel, commercially important output traits.
Dr.

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