About 25 percent of hospital patients at any given time have urinary
catheters -- and a substantial proportion of patients have them much longer
than they really need them, experts say.mha.

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aureus (MRSA)
infections.com.
The data were then analyzed and adjusted for the differences in age, sex
and length of hospital stay among the patients on the different wards. When the researchers
excluded the one-third of doctors who ignored the reminders, the numbers got
even better: The percentage of patient days spent on a catheter went down by
25.S.

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Of the six programs in development, two are in
late stage -- telavancin and the Beyond Advair collaboration with
GlaxoSmithKline. These
statements are based on the current estimates and assumptions of the
management of Theravance as of the date of this press release and are
naturally subject to risks, uncertainties, changes in circumstances,
assumptions and other factors that may cause the actual results of Theravance
to be materially different from those reflected in its forward-looking
statements. - Millions of hospital patients could be spared the
humiliation and infection risk that come with a urine-collecting catheter, a
new study finds, if hospitals used a simple reminder system to prompt doctors
to remove the devices after two days.bcbsm. None of the foundation's grant-making resources comes
from BCBSM customer premium payments.

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Theravance is focused on the discovery, development and
commercialization of small molecule medicines across a number of therapeutic
areas including respiratory disease, bacterial infections, overactive bladder
and gastrointestinal motility disorders. The cost of
treating each infection that causes symptoms is estimated to be at least $500., M.
In the meantime, he says, hospitals everywhere may be able to institute
their own reminder system of written reminders and pages, and thereby reduce
the number of days patients are catheterized.

Inclusion to this category requires a site to offer reliable medical information, presented in an easy-to-understand format.

allexperts icu

(Logo: http://www. DETROIT , A University of Michigan study funded by
the Blue Cross Blue Shield of Michigan Foundation demonstrated that a simple
hospital reminder might reduce infections for millions of catheter patients.
Ira Strumwasser, Ph.D. Two of the wards
used the reminder system and two did not, but a nurse checked the records of
every patient each day.

ALR Technologies' Medication Reminders have already demonstrated a 97%
improvement in patients taking prescribed doses, in a study conducted by
Columbia University. When used, the words "estimate," "expect",
"anticipate," "believe" and similar expressions are intended to identify
such forward-looking statements.

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This press release contains certain "forward-looking" statements as that
term is defined in the Private Securities Litigation Reform Act of 1995
regarding, among other things, statements relating to goals, plans, objectives
and future events. But since about 90 percent of American
hospitals still don't have such systems , our study suggests that written
reminders should be used in their place," says Saint, the director of the
UMHS/VA Patient Safety Enhancement Program, which researches ways to prevent
patient injuries and adverse events during hospital care.1 percent in the no-reminder wards.

ALR Technologies , which specializes in health and disease management
products and services, has designed and manufactures medication compliance
products and compliance home-monitoring and intervention systems to meet
the needs for several targeted user groups.

ailments healthtouch

, M.S.umich.umich.
The BCBSM Foundation is the philanthropic affiliate of Blue Cross Blue
Shield of Michigan and is a 501(c)(3) nonprofit, incorporated separately from
BCBSM.
This allows the caregiver to intervene when a patient is non-compliant and
may be at risk.

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For more information, please visit the
company's web site at http://www. Examples of such statements include statements relating to
the expected timing, scope and results of clinical and preclinical studies,
statements regarding the potential benefits and mechanisms of action of drug
candidates and the enabling capabilities of proprietary insights.

Hey Doc Do I Still Need This Catheter? Michigan Blues Foundation-Funded Study at U-M Shows Simple Way to Reduce Infections for Millions of Patients

edu/opm/newspage/2004/patientsafety.com.

surgerydoor digestion

newscom. aureus. This greatly raises their risk of
getting a painful urinary tract infection or even a blood infection.
But a new University of Michigan Health System study, funded by a patient
safety grant from the Blue Cross Blue Shield of Michigan Foundation, shows
that simply having nurses flag patients' records with a written reminder can
jog the memory of busy doctors, prompt them to consider removing the catheter ,
and lead to a much shorter time with a catheter for many patients.H.
"Catheter reminders may become automatic as hospitals implement
computerized doctors-orders systems. Then, for the next eight months on the two wards where reminders were
used, the nurse attached a pre-written order and a sign-here sticker to each
patient's chart every day after the catheter had been in place for 48 hours., began e-
mailing doctors as they started their one-month rotations on the wards. The company is expected to generate approximately
$900,000 in twelve month revenue from the volume of this first production
run alone. In addition, reduced cost of care was demonstrated by
a study conducted by Missouri Medicaid.

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The multifunctional mechanism of action
provides a rational basis for the improved pharmacodynamic activity and low
potential for resistance observed for telavancin.
Theravance is a biopharmaceutical company with a pipeline of internally
discovered product candidates. In addition to Saint,
Chenoweth and Thompson, the new paper's authors are research associate Samuel
Kaufman , M.med.

The emphasis is placed on 'Education'--sites which offer timely information to enhance the relationship between a patient and their healthcare professional.

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SOUTH SAN FRANCISCO, Calif .

severity medinfo

com/cgi-bin/prnh/20030512/THERAVANCELOGO )
Telavancin, a rapidly bactericidal injectable antibiotic with a
multifunctional mechanism of action, is a novel lipoglycopeptide discovered by
Theravance through the application of multivalent drug design in a research
program dedicated to finding new antibiotics for serious infections due to
Staphylococcus aureus (including multi-drug resistant strains ) and other
Gram-positive pathogens.
aureus is mediated by multiple mechanisms.

For more information on the ALRT500, please visit:
http://www.

This release contains certain "forward -looking statements" relating to ALR
Tech's business, and these statements reflect the current views of ALR Tech
with respect to future events and are subject to certain risks,
uncertainties and assumptions.

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Also, at higher, clinically-achievable concentrations, direct effects on
bacterial membrane function, such as dissipation of membrane potential and
increased permeability, are observed . He is also a member
of the Patient Safety Committee that oversees clinical patient safety
improvement efforts at UMHS., M.

For more information on patient safety research at UMHS, visit
http: //www.edu/psep
For more on patient safety at U-M, visit
http://www.com/foundation

The Blue Cross Blue Shield of Michigan Foundation is dedicated to
improving the health of Michigan residents through the support of research and
innovative health programs.

ALR Technologies (OTC BB: ALRT) is
pleased to announce that it has completed the development of its next-
generation medication and treatment compliance reminder system, the ALRT500
and has scheduled a
small-scale first production run to be delivered in the third quarter of
2006.

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Telavancin is currently being evaluated in Phase 3 multinational,
multicenter, double-blind, active control studies designed to assess the
efficacy and safety of telavancin compared to vancomycin in the treatment of
hospital -acquired pneumonia and complicated skin and skin structure infections
caused by Gram-positive organisms such as S.
After about four months, she began paging doctors who didn't fill out the
order to either continue the catheter or remove it.
About two-thirds of the doctors on the reminder wards routinely filled out
the daily order after the paging reminders began.htm
For more on the Keystone ICU project, visit
http://www.

The ALRT500, in conjunction with the Home Health Monitoring System allows
caregivers and healthcare providers to monitor the patient and determine if
the patient is taking medications or treatments at the appropriate times. Products are now in use by
patients taking medications or treatments for conditions such as
hypertension, high cholesterol, Parkinsons , diabetes, organ transplant,
depression, anxiety, asthma, glaucoma and more.

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Notably, the studies are
designed with co-primary clinical cure endpoints versus the vancomycin arm:
the standard endpoint of non-inferiority overall and a superiority endpoint of
clinical cure among those patients with methicillin-resistant S. By leveraging its proprietary insight
of multivalency to drug discovery focused on validated targets, Theravance is
pursuing a next generation drug discovery strategy designed to discover
superior medicines in large markets. These and other risks are described in greater detail
under the headings "Special Note Regarding Forward-Looking Statements," "Risk
Factors" and "Management's Discussion and Analysis of Financial Condition and
Results of Operations" in Theravance 's prospectus dated October 5, 2004 filed
with the Securities and Exchange Commission pursuant to Rule 424(b)(4) and
"Management's Discussion and Analysis of Financial Condition and Results of
Operations " and "Other Factors Affecting Operating Results" in the Company's
Quarterly Report on Form 10-Q for the quarter ended September 30, 2004.
The written-reminder system isn't expensive, and in fact the study finds
that its cost equals or is less than the savings that a hospital could achieve
by reducing infections among patients.
"Doctors are responsible for ordering the removal of catheters , but
research has shown that many of them forget which patients have catheters and
how long they have them," says lead author Sanjay Saint, M.6 percent on the reminder wards compared with
baseline , and went up by 15.7 percent in the reminder group.N., notes that catheter reminders are now a routine part
of patient care in UMHS intensive care units.med. In early 2007, the
ALRT Home Monitoring system will also have enhanced capabilities that will
enable the monitoring of use and data from medical diagnostic equipment
such as blood pressure and blood glucose monitors.

icu glucose

"
The controlled trial, carried out for 16 months in four wards of the U-M's
University Hospital, involved patients who had been admitted for surgery or
with general ailments including kidney and lung problems.
The nurse who checked the records for the entire study period, Maureen
Thompson, R.N. The foundation is an independent licensee of the Blue Cross and Blue
Shield Association. There are many factors that could cause
the actual results, performance or achievements of ALR Tech and its
products to be materially different from any future results, performances
or achievements that may be expressed or implied by such forward-looking
statements.

glossaries listservs

Saint says that his team has applied for funding to extend the program
into more non-ICU wards until the U-M Health System begins using a
computerized physician order-entry system in 2006. "A major way for health care
facilities to reduce hospital -acquired infections is to get rid of unnecessary
devices, including catheters," he says.A.
Rogers , Ph. BCBSM Foundation grant programs are conducted in
Michigan by Michigan-based researchers and nonprofit organizations to address
issues of quality and costs of care, access to care, and community health. ALR Technologies generates its revenue from the
sale of the hardware as well as monthly monitoring service fees, in
addition to other product sales. An average annual cost savings of
$3,400 per diabetes was achieved for patients using a compliance reminder
system compared to the control population. More information on ALR
Technologies and its products can be found at http://www.

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Theravance Announces Publication of Telavancin's Multifunctional Mechanism of Action

(Nasdaq: THRX) announced today that a scientific paper describing the
multifunctional mechanism of action of its lead medicine , telavancin, is
published in the March 2005 issue of Antimicrobial Agents and Chemotherapy.P., president and CEO of BCBSM Foundation, says, "This
is a terrific example of how a simple change in a process can make a real
difference in lessening the risk of infection for thousands of patients, as
well as reduce costs associated with treating infections. The medical director of
the Infection Control + Epidemiology division, Carol Chenoweth, M.D. It has been designed to
continuously prompt a patient until notification is received that the
appropriate action has been taken.

overactive listservs

, Theravance,
Inc.

In all, the proportion of each patient's hospital stay that involved a
catheter went down by 7.
The cost of the reminder system, including the nurse's time and the
printing of reminders , would be about $53,200 per year, the researchers
estimated. The savings, based on conservative estimates of the number of
catheterized days, the proportion of doctors who would comply, the risk of
urinary tract infection (5 percent for each day on a catheter) and the cost of
treating symptomatic infection, would be about $53,449. It's a
systems-based solution, and could even be used for other applications.M.

Plans are already being formalized for larger production runs with expected
delivery before year end.

This reminder system was designed for patients with chronic conditions such
as diabetes, heart disease, pulmonary disease, HIV, mental disorders, organ
transplant, post surgery and severe asthma, or even those with less severe
problems but must be compliant with medications .

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An estimated 40 percent of infections
developed by patients during their hospital stay are urinary tract infections,
and most of these infections are due to urinary catheters., a
hospitalist at the VA Ann Arbor Healthcare System and an associate professor
of internal medicine at the U-M Medical School. "Our reminder system helps
doctors do the right thing," he adds., and research assistant professor of internal medicine Mary A.alrt.

electrolytes musc

Its antibacterial activity results
from interaction with D-Ala-D-Ala-containing peptidoglycan intermediates that
leads, at submicromolar concentrations , to inhibition of the
transglycosylation step of peptidoglycan synthesis during cell wall synthesis . Important factors that could cause actual results to differ
materially from those indicated by its forward-looking statements include,
among others, risks related to delays or difficulties in commencing or
completing clinical and preclinical studies, the potential that results of
clinical or preclinical studies indicate product candidates are unsafe,
ineffective, inferior or not superior , and delays or failure to achieve
regulatory approvals. Given
these uncertainties, you should not place undue reliance on these
forward-looking statements. The company has already received an overwhelming response from
healthcare providers, disease management companies and private insurers and
expects to sell out entirely of the first production run before its third
quarter shipment .html

About ALR Technologies, Inc.

convincing healthful

theravance.

NOTE: THERAVANCE(R), the Theravance logo, and MEDICINES THAT MAKE A
DIFFERENCE(R) are registered trademarks of Theravance, Inc.
The University of Michigan released the following news about that study:

Study shows simple hospital reminder system can reduce urinary catheter use,
cutting risk of infection - and cost

ANN ARBOR, Mich.
The first eight months of the study gathered baseline data on catheter
use.org/mha/keystone/icu
For more on the BCBSM Foundation, visit http://www. The foundation was funded through an
endowment from Michigan physicians in 1983 and from proceeds of an earlier
prescription drug lawsuit settlement.

PRESS RELEASE ALRT500 a Medication and Treatment Compliance Reminder System to Be Delivered to Wholesale and Retail Customers by Third Quarter 2006

ALRT500


About the ALRT500

The ALRT500 is a medication and treatment reminder system that prompts a
person to take the necessary treatments, medications or other health
related actions in addition to the appropriate dosage with caregiver
instructions at the appropriate time(s) of day. The ALRT monitoring
system is the only system that provides monitoring of nebulizer
compressors, used by COPD patients to maintain health.com/PC500/index.

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The bactericidal activity of telavancin against S. Theravance assumes no obligation to update its
forward-looking statements. The study
is published in the August issue of the Joint Commission Journal on Quality
and Patient Safety. That means the system
would pay for itself with $249 left over.
If all doctors in a hospital complied fully, the savings could be in the
tens of thousands, Saint says."
Saint emphasizes that a successful reminder system, like the one
implemented in the study, needs to be interdisciplinary, involving infection
control professionals , nurses, and physicians. The directions are
displayed on a screen on the handheld sized device.

alrt.

icu ailments

The Company's goal is for telavancin to become first line therapy
in treating these very serious infections.D. "Through our involvement with
the Keystone statewide initiative to improve patient safety within ICUs, we
have made the daily consideration of invasive line discontinuation a key
element of our daily patient safety review," she says. "Rather than just relying on the
memories of over -worked doctors who are focusing on a patient's medical
condition and not their catheter status, we may be able to reduce both the
morbidity and mortality associated with urinary tract infections.

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D. The
researchers measured this proportion as a percentage of each patient's total
days in the hospital -- if a catheter was used for three of six days, that was
a 50 percent proportion. Further management discussions of risks and uncertainties can
be found in the company's quarterly filings with the Securities Exchange
Commission.

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- - kjjkjk

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