In the United States , Takeda
currently markets oral diabetes and cholesterol-lowering treatments.

coffee davids

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Fans of the show can sample the great taste of NESCAFE(R) TASTER'S
CHOICE(R) with a free, two-week supply available at
www.

About NESCAFE TASTER'S CHOICE

NESCAFE TASTER'S CHOICE is one of the largest coffee brands in the
world and is a part of Nestle USA., the company has a
robust pipeline with compounds in development for diabetes, sleep,
cardiovascular disease and other conditions.

withdrawal caffeine

com
The episode challenged contestants to develop a $75,000 public
relations event to create "buzz" for Nestle's premium coffee brand,
NESCAFE TASTER'S CHOICE.

symptomatic 1477

com for their free cup
of "joe" will enjoy the revamped Web site, which includes content from
the show's task, recipes for hot and cold coffee drinks as well as
desserts and a sweepstakes for two tickets to NBC's "The Apprentice"
season finale.

The SCN is known as the body's
"master clock" because it regulates the 24-hour sleep-wake cycle. Together,
it is believed the MT1 and MT2 receptors serve as key facilitators of
sleep-wake regulation.

mellitus symptomatic

We think the
data, which showed no rebound insomnia or withdrawal effects, are
particularly exciting and may add to the potential for ramelteon to provide
another option for older adults living with insomnia," said Steve Sainati,
MD, PhD, vice president of Clinical Research, Takeda Pharmaceuticals North
America, Lincolnshire, Ill.
is a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, the
largest pharmaceutical company in Japan .

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TastersChoice.
"Although it is true that as people age their sleep architecture changes,
sleep by no means becomes less significant.

disseminates drinkers

"NBC's 'The Apprentice' contestants used their book smarts and
street smarts to promote the great taste of NESCAFE TASTER'S CHOICE to
New Yorkers.

Older Adults with Insomnia Report Falling Asleep Faster with Ramelteon

"Improving sleep in older adults is a very important health issue.

Takeda Pharmaceuticals North America, Inc.

consumption parkinson

com or NestleNewsroom . Additionally, no rebound insomnia or withdrawal effects
were observed.
Based in Lincolnshire , Ill.

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TastersChoice.com
NESCAFE TASTER'S CHOICE officially unveiled the free, two-week
supply offer in a commercial that aired immediately following the Feb. For more information on NESCAFE TASTER'S
CHOICE , please visit: www. Participants received bedtime
administration of one of three treatments: ramelteon 4 or 8 mg, or placebo. The
incidence of adverse events for both ramelteon 4 mg and 8 mg dose groups was
comparable with that of placebo.

intake substances

Food Editors

GLENDALE, Calif. The 15-second spot featured Donald Trump's assistant, Robin
Himmler, at her desk at The Trump Organization logging on to
www.TastersChoice.

About Ramelteon
Ramelteon acts via a new mechanism of action , specifically targeting two
receptors in the brain, MT1 and MT2.

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3 episode.
Analysis of data from the questionnaires showed that, in comparison to
those who received placebo, study participants who received ramelteon 4 or 8
mg had statistically significant decreases in estimates of time to fall
asleep.

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com
Coffee lovers who visit www. in Vevey, Switzerland -- the world's largest
food company with sales of $65. For product news and
information, visit Nestleusa.
"We are extremely pleased with the results of this study. The MT1 and MT2 receptors are located
in the brain's suprachiasmatic nuclei (SCN).

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TastersChoice. Worldwide, 440 million cups of NESCAFE
coffee are served daily.5 billion . In addition, after patients discontinued the use of ramelteon, there
was no rebound insomnia, nor did patients exhibit symptoms of withdrawal.
Currently prescribed sleep agents and some investigational drugs work by
targeting gamma-aminobutyric acid (GABA) receptors, which are located
throughout the brain.
To learn more about the company and its products, visit
http://www.

diabetes 1477

Fans of NBC 's "The
Apprentice" and coffee drinkers can enjoy the great taste of NESCAFE
TASTER'S CHOICE coffee by logging on to www. They developed some very creative ideas to showcase the
great taste and the variety of different ways our coffee can be
enjoyed," said Marty Sharkey, marketing manager, NESCAFE TASTER'S
CHOICE. NESCAFE coffee is sold in more than
100 countries around the world.A.

incidence drank

com

As the Feb. Nestle USA,
with 2003 sales of $12 billion, includes Nestle Brands Company, Nestle
Prepared Foods Company and Nestle Purina PetCare Company."

Study Design
A total of 829 older adults (ages 64-93 years) were enrolled in a
randomized, double-blind, 5-week study ., Takeda Pharmaceuticals North America, Inc.com

consumption caffeine

S. In pre-clinical studies, ramelteon has shown no
affinity for GABA or opiate receptors.

symptomatic stimulant

During the task, Magna struggled with its
overall creative vision and fell behind schedule, while Net Worth
created a truly innovative, breakthrough campaign that served up
delicious hot and cold recipes of NESCAFE TASTER'S CHOICE coffee to
New Yorkers. Magna's project manager, Danny, heard the infamous words
"You're Fired!", while Danny's teammate, Verna, quit the show before
the task even began.com. Data on a novel investigational compound for the treatment of insomnia also
showed no rebound insomnia or withdrawal effects

ORLANDO, Fla.tpna.

symptomatic jama

NESCAFE TASTER'S CHOICE Adds a Java Jolt to NBC's ``The Apprentice''

drank stimulant

diabetes mellitus

, Results from a Phase 3 clinical
study presented at the 2005 Annual Scientific Meeting of the American
Geriatrics Society showed that bedtime administration of ramelteon, an
investigational compound currently under review for the treatment of
insomnia, significantly reduced time to fall asleep in older adults with
chronic insomnia.
An estimated 60 million people in the U. Far
too often , older adults and their physicians accept the myth that poor sleep
is a fact of life -- that it comes with aging," said Thomas Roth, PhD,
director of the Sleep Disorders and Research Center, Detroit , Mich. Through
the Takeda Global Research + Development Center, Inc.

stimulant reduced

Other promotional activities in conjunction with NBC's
"The Apprentice"" partnership include a national newspaper coupon on
Sunday , Feb.

1477 mellitus

suffer from insomnia, and
approximately half of all older adults experience one or more symptoms of
insomnia at least a few nights per week.

disseminates symptomatic

6, in-store grocery displays and an online partnership
with Yahoo!. Takeda is committed to striving
toward better health for individuals and progress in medicine by developing
superior pharmaceutical products.

symptons gradually

3 episode of NBC's "The Apprentice" featured a
contestant quitting for the first time, NESCAFE(R) TASTER'S CHOICE(R),
which also was featured in this week's show, officially announced its
own "first" -- a nationwide offer for a free, two-week supply of
NESCAFE TASTER'S CHOICE, the first time the brand has conducted a
product sampling campaign of this magnitude.TastersChoice. "Now we are inviting fans of the show and coffee drinkers to
try a free, two-week supply of NESCAFE TASTER'S CHOICE by visiting
www.TastersChoice.
Study participants completed next-morning sleep questionnaires regarding
their previous night's sleep for each night during the study.

mellitus reduced

com

About NESTLE USA

Named one of "America's Most Admired Food Companies " in Fortune
magazine for the seventh consecutive year, Nestle USA provides quality
brands and products that bring flavor to life every day. Nestle USA
is part of Nestle S.