and European regulations. He earned a bachelor of science in biology from
Ursinus College in 1977. We deliver innovative and robust
clinical development solutions - from first-in-human studies through market
launch and surveillance - to help the world's biopharmaceutical companies
maximize product life cycles and grow market share.

newscom.

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(Logo: http://www.

About Kendle
Kendle International Inc. Investor kits are available upon request from Kendle, 1200 Carew
Tower , 441 Vine Street, Cincinnati, OH 45202, or from the company's Web site
at http://www.

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Angelucci Brings Global Experience in Validation, cGMP
to Leadership Role in Regulatory Affairs Division

CINCINNATI, Kendle (Nasdaq: KNDL), a
leading, global full-service clinical research organization, today announced
the appointment of Louis A. The Company's biochemical and organic chemical products
and kits are used in scientific and genomic research, biotechnology,
pharmaceutical development, the diagnosis of disease and as key components in
pharmaceutical and other high technology manufacturing.
Sigma-Aldrich operates in 34 countries and has over 6,000 employees providing
excellent service worldwide.

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He also is a member of the industry
advisory board for the Stevens Institute.

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His prior experience includes serving as Vice
President of Validation Operations for a major pharmaceutical firm, and
responsibility for the global validation activities for two international
companies .com .

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Regulatory Consulting and Submissions. With the expertise of our
more than 1,700 associates worldwide, Kendle has conducted clinical trials or
provided regulatory, pharmacovigilance and validation services in 70
countries. LOUIS, Sigma-Aldrich Corporation
(Nasdaq: SIAL) has launched the Assay Library on its web-based Enzyme
Explorer.

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(Logo: http://www.

About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High
Technology company.

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Angelucci
will oversee the day-to-day operations of the validation unit and maintain the
quality and consistency of its service to clients. It has customers in
life science companies, university and government institutions, hospitals , and
in industry.

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newscom.
Angelucci is a member of the International Society of Professional
Engineers (IPSE) and the board of directors of the Institute of Validation
Technology (IVT).

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Steele , Vice President of U.S.kendle. Researchers should find this tool useful in many
areas of biomedical research, including drug discovery, metabolic processes,
and disease studies.

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For more information please visit
http://sigma-aldrich.

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"
Angelucci earned Master of Science degrees in Engineering Management from
Drexel University in 1990, and in Biomedical Engineering from the University
of Pennsylvania in 1980. The Assay Library features over 600 detailed procedures for
measuring enzyme activity and related metabolites.

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He serves as adjunct professor at both Temple University and
the Stevens Institute of Technology.

Sigma-Aldrich Launches New Online Assay Library

"
The Enzyme Explorer features in-depth resources on protein research
including new metabolic pathway animations .

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The Company is committed to the success of its
Customers, Employees and Shareholders through leadership in Life Science, High
Technology and Service.

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com .

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com/cgi-bin/prnh/20050215/CGSIGMAALLOGO )
Robert Gates, Product Manager at Sigma-Aldrich stated, "The Assay Library
provides the largest commercial compendium of enzymatic assay procedures
available on-line to date.

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Kendle Names Louis A. Angelucci III Vice President Validation

"He also
has experience working on commissioning , validation and cGMP issues with
clients around the globe, and is familiar with U.

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, subsidiary based in Rockville, Md. ST.

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(Nasdaq: KNDL) is among the world's leading
global clinical research organizations .

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S.

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com/cgi-bin/prnh/20030429/KNDLLOGO )
Angelucci most recently served as Senior Director of Validation and
Compliance in the life sciences division of global engineering and
construction firm Technip . The Library is the result
of over ten years of in-house process development by Sigma-Aldrich scientists .

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"Lou brings more than 20 years experience in all aspects of cGMP,
validation and validation project management to Kendle," says Edward A. The addition of the Assay Library
to the Enzyme Explorer enhances the comprehensive technical content that is
available free of charge to all researchers .com/enzymeexplorer .

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Angelucci III as Vice President, Validation, for
its AAC Consulting Group, Inc . For more information about Sigma-Aldrich, please visit
its award-winning web site at http://sigma -aldrich.

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Over one million scientists and technologists use its products.

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