from Millennium Pharmaceuticals.

About the Harvard/Partners Center for Genetics and Genomics:
HPCGG (http://www.

expression botany

As a
result, kinases have been implicated in a number of diseases processes such as
cancer, inflammation and diabetes.D. His work exemplifies the high
caliber scientific research at HPCGG, and has enlightened the research
community to many of the fundamental genetic mechanisms of cancer and other
diseases," said Raju Kucherlapati, Ph. The
Center also operates full-service genetic clinics for patients with known or
suspected genetic conditions, and core facilities and services for genetic
study design, DNA sequencing, genotyping, proteomics, bioinformatics and
microarrays.

physiology evolution

SANTA FE, N. The QTL Super-quenching technology accelerates the
process by providing a quick, sensitive, and inexpensive method to develop an
assay. For more information,
visit http: //www. Hundreds of proteins containing the
F-Box motif have been discovered since, leading many to think that this class
of protein is crucial to controlling events in the cell.

cell cytobiology

110
http: //www.A.

chemistry biomolecules

The Company's novel technologies integrate its expertise
in chemistry, molecular and cell biology and instrumentation.qtlbio.
"The GSA is pleased to recognize the contributions of Steve Elledge in
using genetic analysis of the model organism yeast to identify key regulatory
proteins essential for the proper regulation of cell division and then
defining the crucial role these proteins play in human cells to prevent
cancer," said Terry Orr-Weaver, 2005 President of The Genetics Society of
America, Member, Whitehead Institute and Professor of Biology, MIT., Scientific Director of the HPCGG.genetics-gsa.

molecular genomics

Universal Assay Kit for Kinase and Phosphatase Development from QTL Biosystems

M. Together these products provide a platform for developing assays for
the two categories of kinases that make up the human kinome. The Universal
platform for Tyrosine and Serine/Threonine Kinases is based on QTL
Lightspeed(R) Super-quenching technology, which provides advanced tools for
assay development and high throughput screening (HTS) of kinases, one of the
most important target classes in drug discovery today. The Universal Assay Kit is a replacement technology for current
methodologies and eliminates the expensive reagents and hazardous materials
required for radiometric and antibody -based technologies, such as HTRF, SPA,
and FP. "The assay gives excellent performance
at lower volumes and will provide significant savings for enzymes and other
reagents while delivering robust performance.
One of Elledge's discoveries includes a gene known as Cdk2, which was
found to be responsible for controlling the G1 to S cell cycle transition.

analytical transduction

com. CAMBRIDGE, Mass. The Center combines world-class
scientific talent with access to a population of over 2 million patients and
their physicians, providing a continuum of resources and expertise to rapidly
translate scientific discoveries into diagnoses and treatments that benefit
the patient.org and
http://www.

biochemistry ecology

7% of all human genes. I was
able to develop a robust assay using my own substrate and enzyme without
divulging the proprietary nature of our target," stated Chris Sneeringer,
Ph."
"Kinase inhibitors are important drug targets that are screened at all
major pharmaceutical companies. Bioassay products are available for the detection of
viruses, toxins, bacteria, proteins, hormones, nucleic acids and other
biological compounds.ereleases.

bioanalytical evolution

They represent a new generation of drugs that
target the underlying molecular processes of the cell and are in a position to
radically change the future treatments for cancer and other diseases," stated
Paul Gindlesperger, Vice President of Worldwide Sales and Marketing at QTL
Biosystems.

cell apoptosis

com

This release was issued through eReleases(TM).org) is a joint enterprise between Harvard Medical
School and Partners Healthcare System, dedicated to accelerating the
realization of personalized medicine by discovering and integrating genetic
knowledge into the healthcare system.genestory.D.

biochemistry ecology

This transition is a critical step for normal cell division, but often found
to be defective in cancer cells.
Dr.
617-761-6734

ecology botany

D. The Company delivers enzyme
activity and protein binding assays for the pharmaceutical and life sciences
markets , and Biosensor Systems for first responders, medical triage personnel
and military users. Elledge 's work has
elucidated many of the molecular "checkpoints" of cell division that are
essential to maintaining genomic stability, and protecting the cell from
mutations that could lead to the development of tumors. Since Elledge and
co-workers published this discovery, over one thousand articles have examined
F-Box proteins and their role in gene expression, immune response, embryonic
development , circadian rhythms and cancer.
"I am proud that Steve is a member of our faculty. Through its educational programs at Harvard Medical School and
other academic institutions, the Center has created the infrastructure to
educate the medical profession on personalized medicine approaches.

clinical ecology

Elledge also discovered a family of genes known as ribonucleotide
reductases, which play a role in the synthesis of DNA and are switched on in
response to DNA damage in yeast. Clowes Memorial
Award from the American Association for Cancer Research, the Paul Marks Prize
for cancer research from Memorial Sloan-Kettering Cancer Center, the Michael
E.

gene analytical

Kinase pathways play an essential role in signal transduction and the
control of metabolism, transcription, apoptosis and differentiation .com

QTL Biosystems, LLC
2778 Agua Fria Street
Santa Fe, NM 87507
(505) 424-1000, ext.

analytical cytobiology

Media contact:
Mike Silver, Ph.

cytobiology biomolecules

With the QTL Lightspeed(R ) platform, the pace of assay development
and screening for unique or proprietary kinases is accelerated with the same
ease of miniaturization and low cost-per-well that QTL Lightspeed(R) users
have come to expect., The Harvard Medical School-
Partners Healthcare Center for Genetics and Genomics (HPCGG) and the Genetics
Society of America (GSA) announced today that faculty member Stephen Elledge ,
Ph.org ).

apoptosis physiology

hpcgg.

genetics signal

, QTL Biosystems today announced
the introduction of its Universal Development Kit for Kinase and Phosphatase
Assays following the release of additional Serine/Threonine and Tyrosine
Kinases.

, has received the 2005 Genetics Society of America Medal for outstanding
contributions in the field of genetics over the past 15 years. An award
ceremony will take place today at 2pm (EST) at Harvard Medical School's New
Research Building in Boston, Massachusetts. Using these genes as a springboard, and new
tools invented in his laboratory to examine the human counterparts of yeast
genes, Elledge was able to identify the genes and molecular networks
responsible for sensing and responding to DNA damage. Elledge's previous honors include receiving the G.

expression physiology

One of the major challenges
facing pharmaceutical and biotechnology companies searching for potential drug
targets is finding a technology that enables them to develop a proprietary
kinase target with a platform that is easy to use, cost-effective, and meets
sensitivity requirements. This platform will enable the end user to utilize as much as fifty
percent less reagents and enzyme to develop a superior assay.
"The QTL Lightspeed(R) Universal Assay Development kit is very easy to use
and is more cost effective when compared to SPA, FlashPlate, or HTRF."

About QTL Biosystems
QTL Biosystems, LLC of Santa Fe, New Mexico, develops and markets
bioassays that deliver superior sensitivity, specificity , and speed in simple
to use formats with low total cost of detection.H. He was recently elected a fellow of the
American Academy of Arts and Sciences and the National Academy of Sciences.

signal proteins

It is rapidly becoming the preferred assay to screen for kinase
activity. Elledge, one
of the founding research investigators of the HPCGG and the Gregor Mendel
Professor of Genetics at the Harvard Medical School, received the GSA award
for his seminal research in understanding cell cycle regulation - - the set of
molecular events that control cell proliferation and growth. This
regulatory function is necessary to maintain the viability of cells and to
properly control their ability to divide.

Elledge has pioneered the development of new tools to systematically
uncover the function of genes expressed in mammalian cells.D. The Society promotes the
communication of advances in genetics through publication of the journal
GENETICS and by sponsoring scientific meetings focused on key organisms widely
used in genetic research.

signal transduction

Over 500 different kinases have been
identified, representing ~1.

Contact:
Tom Buscher
Product Manager
info@qtlbio.
Another significant discovery to emerge from Elledge's research was the
identification of proteins with a conserved region called F-box, which are
responsible for identifying and tagging other proteins for destruction. Steve was among the
first group of scientists I recruited when we established the Harvard /Partners
Center for Genetics and Genomics, and is an important part of our efforts,
which are focused on discovery and translation genetic knowledge into
diagnoses and treatments that benefit patients.

clinical proteins

D. DeBakey Award for research excellence, the Department of Defense Breast
Cancer Research Program Innovator Award, and the 2002 National Academy of
Sciences Award in Molecular Biology.

Biochemistry , Molecular Biology, Molecular Genetics and Proteomics.

biochemistry bioanalytical

"QTL's Super-quenching technology continues to meet the growing
demands of high throughput screening, with its stable signal, precision,
inherent flexibility and the ease in which it is incorporated into all kinase
screening.

Stephen Elledge Ph .D. of Harvard/Partners Center for Genetics and Genomics Receives Premier Award from Genetics Society of America

(See http://www.

bioanalytical proteins

The development of
successful drugs that target kinases, such as Gleevac and Iressa - which
selectively target cancer cells but leave healthy cells unharmed - is being
aggressively pursued by pharmaceutical and biotechnology companies, who are
looking for quicker, easier solutions for targeting kinase inhibitors. of Cold Spring Harbor Laboratory in New York , Elledge is
creating a library of small interfering RNAs (siRNAs) that are capable of
shutting down the expression of specific genes in the human genome.

About the Genetics Society of America:
The GSA was founded in 1931 and includes over 4,000 scientists and
educators interested in the field of genetics.

transduction apoptosis

Together with
Gregory Hannon, Ph. He will
be applying these libraries to understanding the function of genes involved in
cell cycle control, checkpoint signaling, tumor development, and cell growth.

botany proteomics

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