Thus sample preparation, which can be a
major effort in large-scale DNA sequencing projects, can potentially
be reduced by over 1,000-fold. Present methods generally
provide insufficient information and are costly, which has inhibited
progress, for instance in understanding the genetic components of
common human diseases and the variable response of individuals to
drugs. There are a number of important
factors that could cause the results of Solexa to differ materially
from those indicated by these forward-looking statements including,
among others, risks detailed from time to time in the Company's SEC
reports, including its Annual Report on Form 10-K for the year ended
December 31, 2003, as amended, its Quarterly Report on Form 10-Q for
the period ended September 30, 2004 and its Proxy Statement/Prospectus
filed pursuant to Rule 424(b)(3) on January 24, 2005. Patrinos joins Synthetic Genomics from the Department of Energy
(DOE)'s Office of Science where he was the associate director of the Office of
Biological and Environmental Research.
Synthetic Genomics, Inc.

's initial focus will be on
new approaches to biological energy production.

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Solexa Completes First Full Genome Sequence with Cluster-SBS Technology

----March 10,
2005--

Results Provide End -to-End Experimental Demonstration of Future
DNA Sequencing Technology, Lay Groundwork for Human Re -Sequencing

Solexa, Inc. (Nasdaq:SLXA) today announced the completion of its
first genome sequence , that of the virus Phi-X 174. This accuracy was achieved
despite a number of sub-sequences, which are particularly difficult to
sequence with certain other chemistries. Above this
level, the percentage of the genome covered increases very slowly with
increasing read length, due to the content of highly repetitive
sequences (i.
Dr.

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The company
announced genome coverage of 100%, accuracy of at least 99. Ultimately later this
year fully automated instrumentation is expected to allow hands -off
capture of almost all available data.
Since instrument depreciation is a major contributor to the cost per
data point, this is an important advancement. As part of his duties there, Dr.
Founder and CEO, J.

repeats similarity

In these and other cases, even a
modest error rate can create more false positives than real detected
mutations.

The Pioneering Role of Phi-X 174

In making this announcement , the company noted that the Phi-X 174
virus was again playing a pioneering role.. To participate in the
live call via telephone, please call 877-815-7177 for domestic callers
or (1) 706-679-0753 for international callers.

Dr. Aristides Patrinos Named President of Synthetic Genomics Inc.

Craig Venter, Ph. Patrinos also developed and launched
the DOE's Genomes to Life Program (GTL), a research program dedicated to
developing technologies to understand and use the diverse capabilities of
microbes for innovative solutions to DOE energy and environmental mission
challenges.
"Biotechnology is poised to have a huge impact on the production of clean
and renewable energy and on the development of environmentally benign
industrial processes," said Dr. Patrinos. He is a
Fellow of the American Association for the Advancement of Science (AAAS), a
Fellow of the American Meteorological Society , a Member of the American
Geophysical Union, a Member of the American Society of Mechanical Engineers ,
and a Member of the Greek Technical Society.

rearranged biosoft

He shared the Nobel Prize for Chemistry in
1980 for "., 100, 15440-15445, 2003). Patrinos also led the expanded DOE component of the USGCRP to
attack the principal uncertainties of climate change prediction.

phred similarity

This work
provides end-to-end demonstration of a technology expected to sequence
the DNA of individual humans for the detection of key
disease -predisposing mutations. Bioinformatics
analysis of the human genome reference sequence has shown that read
lengths of 25 base pairs are the point of diminishing returns for
increasing read-lengths in genome-scale re-sequencing work. This focus on accuracy is
expected to be a key competitive advantage for the company. Smith, MD, are developing synthetic organisms with the
hope that they could be engineered into modular "cassette" based systems to
execute specific functions using reprogrammed cells as bio -factories.

cdna mdh

Solexa was formed by the recent combination of Solexa Limited with
Lynx Therapeutics , Inc.
The live conference call will be available via the Internet by
visiting www., the
company founded by J.

This category is for sites about stand-alone computer programs which process biological information such as genetic sequences.

cdna biochip

The first complete sequence
of a genome was 0X174 in 1978 by Fred Sanger and co-workers (J. Mol. Solexa does not
undertake any obligation to update forward -looking statements. Patrinos
has represented DOE on the Interagency Program on Global Change Research , and
on other interagency and international bodies dealing with biological and
environmental issues . Patrinos, a native of Greece, received his undergraduate degree from
the National Technical University of Athens and a Ph.

annotation similarity

Cluster Technology, Acquired in 2004, Achieves Record Small
Feature Sizes

The experiments being reported today all were conducted using DNA
cluster technology, which was acquired by the company in early 2004
and has been significantly refined and developed since that time.
The Solexa SBS chemistry reads through these by analysis of each
incremental base in a stepwise fashion. Sci. Eastern Standard Time)
to discuss the subject of this press release. As part of our aggressive
strategy to advance this complex area of research and the commercial
opportunities it presents, we are pleased that Ari Patrinos will become
president."
In his role as president , Dr. By leveraging the vast stores of genomic sequence data, the
Company hopes to integrate its novel processes to design, build, and test
desired outputs from synthetic organisms. Patrinos is well known for his leading role in the development of the
United States government-funded Human Genome Project helping to guide the
historic sequencing of the human genome to completion, a feat which was
announced in a White House ceremony in 2000.

plasmid repeats

Solexa expects future experiments to substantially
increase the fraction of data to be recovered. By lowering instrument
costs per data point while simultaneously achieving extremely low
reagent usage, the company anticipates that cluster technology may
result in substantially lower sequencing costs. These systems are intended
for use by customers in a wide range of applications from basic
research through to the development and implementation of personalized
medicine.lynxgen.

About Synthetic Genomics, Inc.

repeats annotation

K.
The work reported by Solexa today was completed using its
breakthrough/completely novel sequencing biochemistry.
While companies with competing technologies have developed novel
DNA sequencing technologies based on beads spaced by as much as 50
microns apart, Solexa is now working with clusters as small as
one-half a micron in radius., those of least importance to most researchers).

About Solexa

Solexa is developing DNA sequencing systems for the comprehensive
and economical analysis of whole genomes. The bead-based systems
are mainly used for genome-wide, comprehensive gene expression and
small RNA analysis , and the Cluster-SBS technology will enable
sequencing services for the broad genome analysis community . A telephone replay will
be available for 48 hours following the conclusion of the call by
dialing 800-642-1687 (domestic) or (1) 706-645-9291 (international),
and entering reservation code 4620803 .D.

repeats computes

The sequencing technology is not
fundamentally limited to this read length. USA. Patrinos Leaves Department of Energy Office of Science to take a Top Role at
Synthetic Genomics

ROCKVILLE, Md. in mechanical
engineering and astronautical sciences from Northwestern University.

jarnac plasmid

93% and the
detection of at least three mutations subsequently confirmed by
conventional DNA sequencing techniques. Thus
the company estimates that more than 100 million bases of data were
represented in a single flow cell, all from a single sample
preparation.m. A recording of the call will be
available for 14 days following the completion of the call.

oligonucleotide structual

+ CAMBRIDGE, U. Thus reagent costs can
be expected to scale in parallel, likely giving Solexa a substantial
long-term cost advantage. Solexa will continue to provide high volume,
short read DNA sequencing services from its Hayward production
facility via the Lynx bead-based technology platform until the new
fully automated Cluster-SBS instruments begin replacing the older
systems later this year and into early 2006.solexa .com.

This press release contains "forward-looking" statements,
including statements related to the current views of Solexa management
as to future products, product development, the expansion and success
of Solexa's commercial application of its genomics technologies, and
the future financial performance of Solexa. Any statements contained
in this press release that are not statements of historical fact may
be deemed to be forward-looking statements.
Venter and Hamilton O. Dr.

sockeye hybridisation

This approach has successfully
achieved clusters so small that they are beyond the resolving power of
the research microscope used to observe them.
Patrinos directed research activities including the DOE human and microbial
genome programs, structural biology, nuclear medicine and health effects ,
global environmental change, and basic research underpinning DOE's
environmental restoration effort.D.

plasmid biosoft

Whereas conventional DNA sequencing equipment typically delivers no
more than approximately 1,200 bases per sample preparation, this
Solexa experiment delivered more than three million bases from a
single sample preparation. At this
level, up to 82% of the human genome can be uniquely associated with
specific reads, even when those reads record mutations.m.
Dr. Patrinos is the recipient of numerous award and honorary degrees
including three Presidential Rank Awards and two Secretary of Energy Gold
Medals, as well as an honorary doctorate from the National Technical
University of Athens. Synthetic Genomics, Inc.

nucleotide sequence

While impressive, these results significantly underestimate the
amount of data available. Acad.

Conference Call Information

An investor conference call has been scheduled for Thursday, March
10, 2:00 p., Synthetic Genomics, Inc.
Dr. The
initial focus of the research at the Company is on ethanol and hydrogen
production . He was one of the original architects of the U.

similarity hmm

The genome sequence has already been
repeated a number of times.

Sequencing by Synthesis (SBS) Provides Read Lengths Needed for
Future Human Re-Sequencing

Since Solexa was founded, it has labored to increase the read
length of the sequences it is able to determine.
Biol."
Dr.

sequence rearranged

The new approach provides high fluorescence signals while
achieving submicron feature sizes, thereby enabling rapid and
inexpensive detection of large numbers of DNA sequencing data points. contributions concerning the determination of base
sequences in nucleic acids." More recently, the first complete
synthesis of a genome was described with 0X174 by Craig Venter et al
in 2003 (Proc.

Patrinos helped create the DOE's Joint Genome
Institute (JGI) in 1997 to unite the expertise and resources in genome
mapping, DNA sequencing, technology development, and information sciences
pioneered at four DOE genome centers.

mdh taqman

Re-sequencing is often used to look for very rare mutations,
particularly in cancer samples. Ari's rare combination of breadth and depth of knowledge in areas
affecting environment and energy, along with his solid, steadfast leadership
style make him an ideal person to help drive the business and science goals of
Synthetic Genomics. Global
Change Research Program (USGCRP), a $2B per year research effort involving
thirteen agencies that addresses the causes and effects of global climate
change.

biochip similarity

Business Editors /Health/Medical Writers

HAYWARD, Calif.

Over 1,000-Times Improvement in Data Generated Per Sample
Preparation

While the Phi-X 174 genome sequenced was small at just over 5,000
bases , the amount of sequence data generated was considerably larger. In these experiments, because of the
prototype nature of the hardware used, the instrument system was
directed to image only 3% of the available area in its flow-cell. This density of sequence reads is up to
500 times higher than the bead-based approach.e. As part of his leadership in the
Human Genome Project, Dr. was founded in 2005 to develop and commercialize
synthetic biology.

mauve sockeye

Notably, the results were implemented with proprietary surface
chemistry developed by the company. Solexa
expects to begin placing Cluster -SBS instruments in its production
facility and development partner laboratories by the end of this year
and to begin broad commercial sale of instruments in early 2006. Words such as "believes,"
"anticipates," "plans," "predicts," "expects," "envisions," "hopes,"
"estimates," "intends," "will ," "continue," "may," "potential,"
"should," "confident," "could" and similar expressions are intended to
identify forward-looking statements.D. Patrinos will help shape the research and
business direction at the Company.

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Solexa has now achieved this read length in the Phi-X experiment and
has obtained greater than a hundred thousand reads of this length on a
wide range of sequence contexts. The amount of information required about individual genomes
depends upon the scientific application. Craig Venter commented "While still only less than a
year old, Synthetic Genomics, like the field of science in which it is
situated, is a young, dynamic, and growing company.S. These breakthroughs present unprecedented opportunities that
could restructure and revolutionize industries including energy, industrial
organic compounds, pharmaceuticals, CO2 sequestration, fine chemicals, and
environmental remediation.

distributable ncbi

This achievement
confirms Solexa's decision to move from earlier bead based work to
clusters .
The sequence covered by Solexa in this demonstration of the
"Cluster-SBS" technology includes a numbers of cases in which the same
nucleotide occurs for many consecutive positions, a type of
subsequence that can be problematic for other sequencing chemistries., 125, 225-246, 1978).. Natl . The systems Solexa is developing are designed to provide very
large amounts of information about individual genomes including the
entire individual human genomic sequence, and to do so economically .com, or on the investor resources section of the
company's Web site at www. Scientists at the Company , co- led by Dr.
In addition to his expertise in human and microbial genomics, Dr. "I am thrilled to be joining Craig
Venter and his talented and multi-disciplinary SGI team as I believe the
company will play an important role in this new scientific revolution. The Company is applying recent scientific advances,
including newly discovered genetic sequences of novel photosynthetic and
metabolic pathways , to execute various life functions within a synthetically
devised organism.

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Pacific Standard Time (5:00 p., and dedicated to developing and
commercializing synthetic biology advances in energy fields , announced today
that Aristides Patrinos, Ph., will become president of the company effective
February 9, 2006. Dr.