kinexus .

LifeSpan BioSciences, Inc.

relied cytoskeleton

"We believe their association analysis technologies will more rapidly identify
those genetic elements essential for solving a complex biological challenge
and , when combined with DuPont's metabolic engineering capabilities, will
accelerate our commercialization timeline. Steven Pelech, President and Founder of Kinexus and a
Professor at the University of British Columbia.

Kinexus Bioinformatics Corporation is a private, biopharmaceutical
company engaged in the research and development of innovative methods to
understand the relationships of signaling proteins in cellular communication
networks.

Business Editors/Health/Medical Writers
BIOWIRE2K

SEATTLE----LifeSpan BioSciences, NEC
Corporation and NEC Soft of Japan have reached significant milestones
in their collaboration to develop a cancer diagnosis support system to
meet the needs of pathologists, physicians and patients for rapid and
accurate detection and diagnosis of disease .
Through the partnership, LifeSpan, NEC, and NEC Soft plan to provide
clinicians with a system that offers sophisticated image analysis and
advanced diagnostic techniques.

cytokines emerged

the-scientist.

cell recombinant

"
"Microbia has the capability to accelerate the rate of process development
for this important project ," said John Pierce, director of DuPont's
Biochemical Science + Engineering section of Central Research + Development. The unique capabilities of the
Kinetworks(TM) profiling services were also recently featured in an article
entitled "Kinase Screening Services Probe Signalling Pathways" profiled in The
Scientist Magazine (http://www.

biophysical biochemical

ca

constituting biology

0 screens were
developed in collaboration with Biosource International, a life sciences
company that develops and markets biologically active reagents for
pharmaceutical and biomedical research.

NEC Corporation is a global IT company with headquarters in Tokyo.

Cell biology lies at the center of the biological sciences, constituting the bridge between the sub-cellular, molecular levels of organization and the super-cellular, tissue-based and organismal levels.

adhesion biology

The Kinetworks(TM) approach for the detection of phosphoproteins is
designed to assist biomedical researchers in the discovery of new drug
targets, new drugs and the molecular diagnosis of disease.D.

relied organismal

com

0), cell cycle status (KPSS 10. It is intended to assist pathologists by
increasing their accuracy and productivity, and to provide information
crucial for the clinical management of individual cancer patients.
NEC has an ongoing program in Bio-IT that draws on the technologies
discovered and developed by its laboratories around the world. In this
way, NEC aims to provide solutions and applications to enhance
discovery and the delivery of more effective healthcare measures for
everyone.

emerged apoptosis

About Microbia
Microbia (http://www. "Our proteomic
services provide insights into new potential drug targets while at the same
time advancing the signal transduction field in a quantum way over other
approaches," said Dr.kinexus.
The diagnostic assistant, based on jointly developed, proprietary
image capture hardware and computer software, assists in the detection
of cancer cells in pathology specimens and distinguishes them from
non-cancerous cells. For more information, please
visit LifeSpan's web site at www.com, or contact Joseph Brown,
Ph.

recombinant cell

"DuPont is a premier chemical company with a strong track record of
technical achievement and a commitment to developing environmentally
sustainable processes based on renewable resources," said Richard Bailey ,
Ph., President and CEO, at 206-464-1554.

However, with the advent of modern techniques in molecular genetics and recombinant DNA technology, cell biology has become more closely allied to the fields of molecular and developmental biology and genetics.

Much recent progress in cell biology also derives from discovery of new chemical compounds with effects on cellular processes.

organelles adhesion

0 and 9. The milestones resulted in
unspecified payments from NEC to LifeSpan.

immunology emerged

Microbia and DuPont Central Research + Development Collaborate to Develop a Novel Biomanufacturing Process

-- Partnership emphasizes the future of 'green chemistry' --

CAMBRIDGE, Mass. today announced
the formation of a collaborative research and development program between
DuPont Central Research + Development (CR+D) and Microbia 's Precision
Engineering(R) business unit.0) and
substrates of kinases (KPSS 12.

biochemical historically

Corporate Inquiries: Media Inquiries:
Susan Brady Danielle Whitney
Microbia, Inc.0, for
simultaneously tracking the phosphorylation status of over 200 different
regulatory sites in cell signaling proteins. There are over 40
publications referencing the Kinetworks(TM) technology available online at
http://www. In
September 2005, Kinexus is launching KiNET, a bioinformatics service that will
provide clients with access to a proprietary on-line, functional proteomics
database with quantitative information on hundreds of different proteins in
hundreds of different model systems . LifeSpan, through its advanced imaging technologies,
ALIAS(TM) image capture system, and its expertise in pathology,
provides key information used by the pharmaceutical and biotechnology
industries to select and advance promising therapeutic candidates
through the drug development process.

tissue organismal

"
Microbia's Precision Engineering business applies molecular genetics and
proprietary profiling methods to rationally design microbes for the efficient
production of commercially valuable compounds in the pharmaceutical and fine
chemical industries, as well as the developing industrial biotechnology field.0), protein kinases (KPSS 11.

For further information, please, contact Kinexus Bioinformatics
Corporation toll free at 1-866-KINEXUS or visit our website at
http://www. Thanks to
advances in the fields of genetics and molecular biology during the
20th century, we can look forward to continued progress in
understanding the disease in its various forms as well as in
prevention, detection, diagnosis, and clinical management of cancer to
both improve the quality of life and extend the life of cancer
patients.

derives immunology

Kinexus Announces Six New Phospho -Site Profiling Services

biophysical cell

The companies will work together to develop an
economically viable biomanufacturing process for a chemical currently
manufactured from petrochemical-based raw materials. Microbia will also be eligible to
receive performance-based payments through the course of the program.D.com) is an entrepreneurial pharmaceutical
company dedicated to the science and art of great drugmaking.
"We are very pleased with the progress our partnership has made to
date in developing this automated system, which is designed to offer
sophisticated image analysis and advanced diagnostic techniques that
improve the detection and diagnosis of cancers," said Joseph Brown,
Ph .

organismal microscopy

Biosector2
617 621-8304 212 845-5611
dwhitney@biosector2 . The KPSS 7.

apoptosis biochemical

Our
Precision Engineering business unit collaborates with leading pharmaceutical
and chemical manufacturers to improve efficiencies of existing fermentation
processes or to create new bioprocesses. Kinetworks(TM) Phosphoprotein Services Designed for Drug Discovery

VANCOUVER , July 22 - Kinexus Bioinformatics Corporation, a
Canadian proteomics company, is pleased to announce the release of six new
Kinetworks(TM) Phosphoprotein Screening Services, KPSS 7.
"The cancer diagnosis support system will function as a stand-alone
unit serving a single hospital and/or at a centralized core facility
serving pathologists and clinicians regardless of their location. The cancer diagnostic decision
support system will help address those needs.lsbio.

biophysical cell

Microbia has raised $99 million in
private equity financing and is located in Cambridge, Massachusetts.0), stress (KPSS 8.

LifeSpan Biosciences and NEC Reach Milestones in Development of Cancer Diagnosis Support System

Cancer, with its high prevalence and mortality rate, continues to
rank among the world's deadliest and most costly diseases .

adhesion apoptosis

ca. Kinexus currently offers 15 different profiling services for
quantification of over 500 proteins for expression and phosphorylation., president and chief executive officer of LifeSpan Biosciences.

Furthermore, cell biology is at the heart of research on cancer, and as the understanding of the cell grows, cell biology has emerged as an important discipline in the biomedical sciences and medicine.

relied immunology

DuPont CR+D will fund
the joint research and development effort.0 through 12. The phosphoprotein
screens have already uncovered promising research leads in important disease
states, including ALS, Alzheimer's, and Parkinson's disease. The
second is completion of improved software to accurately discriminate
cancer cells from non-cancer cells based on their morphologic
characteristics at high magnification.

Historically, cell biology has relied upon biochemical and biophysical methods , microscopy, cell manipulation and pharmacological intervention for its progress.

constituting microscopy

"Not only does this collaboration provide further validation of our
technology, but also it aligns Microbia with a worldwide leader in the
increasingly important area of green chemistry.0).

apoptosis derives

microbia. These 6 new screens are based on
themes of cell proliferation (KPSS 7.com). The application of this knowledge positions Kinexus and its clients
in drug development, rational drug design, disease diagnosis and personalized
therapies to improve human health. To achieve this, it will be necessary to obtain as much key
information as possible from all sources, including tissue biopsy, and
make efficient use of that information . is a privately held molecular pathology
service and development support company located in Seattle ,
Washington.

derives biophysical

0), neurobiology
(KPSS 9."
Two milestones have been reached in the collaboration .

organismal adhesion

, Microbia, Inc., vice president and general manager of Microbia's Precision Engineering
business .
To date, two Microbia-engineered production strains have been introduced into
commercial use and a third Microbia-engineered strain is currently undergoing
pilot evaluation. Two of the
Company 's drug candidates are in clinical studies-MD-1100 for the treatment of
constipation-predominant irritable bowel syndrome and other gastrointestinal
disorders, and MD-0727 for the treatment of hypercholesterolemia .0, 8. The first
is the development of an enhanced version of LifeSpan's proprietary
automated image capture system (ALIAS(TM)), which can automatically
capture high quality images from up to 300 pathology slides.D.

recombinant apoptosis

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