Advanced Cell Technology Expands Somatic Cell Nuclear Transfer (Cloning) and Cellular Reprogramming Intellectual Property Portfolio

ACT's IP portfolio collectively represents one of the strongest in the field

WORCESTER , Mass.T.

revealed contributed

This patent family includes granted claims related
to somatic cell nuclear transfer and the use of oocytes and oocyte extracts to
reprogram somatic cells.com

Forward-Looking Statements
This press release contains forward-looking statements that involve risks
and uncertainties .com

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"Cell fusion along with nuclear transfer may open the door to the
cost-effective reprogramming of human somatic cells, and as a result, may
allow the generation of cells of any kind , not expected to be rejected by the
patient as foreign tissue. Advances in stem cell biology will improve our understanding
of degenerative diseases and assist in developing therapies for replacing
damaged or diseased parts/tissues. This research is supported by the
National Institute of Dental and Craniofacial Research, one of the National
Institutes of Health (Bethesda, MD).

Most research in developmental biology focuses on model biological systems for which powerful tools of manipulation exist, each offering its own advantages.

advantages contributed

The patents
include published US patent applications numbers 20030224345, 20040199935, and
20040219563 which describe the fusion of the cytoplasm of egg cells , or
embryonic stem cells with somatic cells to reprogram the somatic cells back to
a pluripotent stem cell state and the use of gene trap technology to identify
and induce differentiation of stem cells.

hereditary botany

"This new technology we
call 'cell fusion' has the potential to dramatically reduce the costs
associated with cloning human cells for clinical use.
During the 83rd General Session of the International Association for
Dental Research, convening today at the Baltimore Convention Center, several
research groups are reporting on dramatic progress in the use of various
techniques -- including genetic mutations, post-natal dental stem cells, and
tooth tissue engineering -- to facilitate replacement tooth therapy
development in humans.

promise botany

, a Delaware corporation, is a
biotechnology company applying stem cell technology in the emerging field of
regenerative medicine.

Research in developmental biology has contributed immensely to our understanding of hereditary diseases affecting human development, and the promise of better treatments or cures for human diseases based on basic research in other species is very exciting.

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"
"There are few phenomenon in cell biology as remarkable as the ability of
the egg cell to reprogram a cell from the human body back to its original
embryonic state," said Dr.
Researchers from the Forsyth Institute (Boston, MA) and the University of
Texas Health Science Center at San Antonio will describe successful
experiments in bioengineering mineralized tissues, including periodontal
tissues and replacement tooth phenotypes.

remarkable revealed

Holdings, Inc. (collectively , "ACT") announced today that ACT has entered
into two separate agreements to expand its portfolio of intellectual property
in regard to somatic cell nuclear transfer (SCNT) and cellular reprogramming . Michael West, ACT's President and Chief Scientific
Officer.

This refers to abstracts #32, 36, 386, 3634, and 3636, to be presented on
Wednesday, March 9 (2:30 and 3:30 p.

promise encompasses

(OTC Bulletin Board: ACTH) and its wholly-owned subsidiary, Advanced Cell
Technology, Inc.
In the first agreement, ACT acquired an option to exclusively license
cloning patents from TranXenoGen, Inc."

About Advanced Cell Technology
A.
For more information about Advanced Cell Technology visit
http://www.), Thursday, March 10 (2 p.m.

developmental contributing

Actual results, events and performance could vary
materially from those contemplated by these forward-looking statements.

contributing remarkable

CONTACT
Chad Griffin
Noelle Gambill
(310) 888-3523
http://www.

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advancedcell.

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Saturday, March 12 (2 p.

embryology relatedness

"These patents and patent applications represent some of the earliest
filings on advanced cellular reprogramming technologies that do not utilize
egg cells in the traditional sense of somatic cell nuclear transfer," remarked
William Caldwell, Chief Executive Officer of ACT.

Modern molecular studies on model systems have revealed a remarkable degree of conservation of genes and proteins involved in development between even distantly related organisms, contributing to a new awareness of the relatedness of all species.

organism embryology

, A.m.), in Room 336 and Exhibit Hall E-F of the Baltimore
Convention Center, during the 83rd General Session of the International
Association for Dental Research.

developmental progenitor

You should not
place undue reliance on forward-looking statements because they involve these
risks and uncertainties.

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T., a Nevada corporation, and its wholly-owned
subsidiary, Advanced Cell Technology, Inc.

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Separately, ACT announced today that it has acquired
the patents to a second generation cloning technology known as "cell fusion"
and additional patents related to their gene trap technology. The company is currently headquartered in Worcester,
Massachusetts .

Growing Your Own Replacement Teeth? Not Science Fiction!

Developmental biology encompasses the field of embryology - the study of the embryo - and touches upon a number of other disciplines, including cell and molecular biology, genetics and biochemistry.

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You should independently investigate and fully
understand all risks before making investment decisions.

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The
patents include US patents 5,480 ,772; 5,651,992; 5,773,217; 6,245,567;
6,753,457; and 6,878,546. These newly licensed patents are in
addition to the 31 patents and over 280 patent applications pending worldwide
that ACT owns or has licensed in the field of regenerative medicine, cloning,
cell fusion, and related stem cell technologies. Together with our other
technologies in somatic cell nuclear transfer and cellular reprogramming, we
believe we are well poised to lead in the development of important new
products within the field of regenerative medicine. BALTIMORE, Dental medicine is on the brink of
profound change due, in large measure, to unprecedented advances in science
and technology.

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of Shrewsbury , Massachusetts.

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C. Holdings, Inc. These
statements involve known and unknown risks and uncertainties that may cause
the company's actual results in future periods to differ materially from
results expressed or implied by forward-looking statements.m.