Alan Lambowitz, University of Texas at Austin , and exclusively licensed
from Ingex L.
The TargeTron system provides the most robust and simple method available
for site-specific disruption of DNA sequences within a host cell genome.

"Group II intron-mediated gene disruption offers advantages over the
laborious traditional gene knockout techniques such as randomly integrated
transposons and cumbersome recombination methods ," commented Keith Jolliff,
Global Marketing Manager of Molecular Biology at Sigma-Aldrich. "The cutting -
edge TargeTron technology has potential to be the most widely applicable
functional genomics tool for creating knockouts across a spectrum of host
organisms. The Company's biochemical and organic chemical products
and kits are used in scientific and genomic research, biotechnology,
pharmaceutical development, the diagnosis of disease and as key components in
pharmaceutical and other high technology manufacturing. Over one million scientists and technologists use its products.
"The products and assay that we will provide deCode represent our
comprehensive product menu available from the recent merger of Nanogen and
Epoch Biosciences," said Howard C.

standardisation ncbi

ST. It has customers in
life science companies, university and government institutions, hospitals, and
in industry.

ncbi standardisation

This release contains forward-looking statements relating to future
performance, strategic actions and initiatives and similar intentions and
beliefs and other statements regarding the Company's expectations , beliefs,
intentions and the like, which involve assumptions regarding Company
operations and conditions in the markets the Company serves."

About Nanogen, Inc.

dictylostelium nucleotide

The mutated intron is essentially "re-programmed" to
insert itself into the algorithm predicted site of any user-defined gene.

snp nucleotide

In
fact, permanent gene disruption is performed in a non-random or targeted
manner that does not require host recombination factors to mobilize.
Sigma-Aldrich operates in 34 countries and has over 6,000 employees providing
excellent service worldwide.

arabidopsis unicellular

SAN DIEGO, Nanogen, Inc. Birndorf , Nanogen's chairman of the board
and CEO.

nucleotide standardisation

An extensively validated
TargeTron algorithm designs specific primer sets for use in PCR mutation of
the TargeTron Intron.

zebrafish haldane

The current TargeTron system has been
used to create permanent knockouts across a broad range of bacterial strains
such as Escherichia coli, Staphylococcus aureus, Lactococcus lactis,
Clostridium perfringens, Shigella flexneri and Salmonella typhimurium. For more information about Sigma-Aldrich, please visit
its award-winning web site at http://sigma-aldrich. The assay incorporates a full range of
Nanogen's products, including the Eclipse(R) Dark Quencher, new DNA linker
technology, modified bases and novel fluorescent dyes , and allows rapid SNP
analysis on a large number of patient samples. Nanogen's ten years of pioneering research involving
nanotechnology may also have future applications in medical diagnostics,
biowarfare and other industries.

mutagenesis arabidopsis

standardisation arabidopsis

com .com. Nanogen disclaims any intent or obligation to update these
forward -looking statements.

genbank standardisation

Developed
by Dr. These forward-looking statements speak only as of the
date hereof.

genomics unicellular

The SynX subsidiary offers a line of
point-of-care diagnostic tests and is building expertise in cardiac related
health conditions.

uncovering mutagenesis

snps polymorphisms

"We are pleased deCode has joined our roster of licensing partners
eager to tap our growing portfolio of products that enable rapid,
high-throughput genetic analysis.

silico unicellular

LOUIS, Sigma-Aldrich Corporation
(Nasdaq: SIAL), a $1. Future
systems will be developed for both plant and mammalian targeted gene
disruption.

convene standardisation

L., the TargeTron system promises to revolutionize functional
genomics and systems biology. The
technology exploits the retrohoming ability of group II introns in order to
"target" the exact position of gene disruption.

biolink genbank

Ligation of the PCR product into a TargeTron vector is followed by
transformation of the host cell.

snps standardisation

(Nasdaq: NGEN), developer of advanced diagnostic products, announced today
that it has entered into a supply and license agreement with deCode Genetics
to provide a new genomics assay for single nucleotide polymorphism (SNP)
discovery, validation and screening.
Research and clinical reference labs use the highly accurate and reliable
NanoChip(R) Molecular Biology Workstation, NanoChip(R) Electronic Microarray
and broad suite of analyte specific reagents to develop diagnostic tests for
variety of diseases.

publicizing snps

Thus far, the technology has provided greater than 90% successfully
targeted insertion rate in prokaryotes.

Nanogen Enters Into Supply and License Agreement With deCode Genetics

Nanogen's advanced diagnostics provide physicians and patients worldwide
with sophisticated information to predict, diagnose and treat disease.

snps nucleotide

2 billion Life Science and High Technology company ,
announces commercialization of the TargeTron Gene Knockout System. The Company does
not undertake any obligation to update these forward-looking statements.nanogen.

Forward-Looking Statement
This press release contains forward-looking statements that are subject to
risks and uncertainties that could cause actual results to differ materially
from those set forth in the forward-looking statements, including whether
patents owned or licensed by Nanogen will be developed into products , whether
the patents owned by Nanogen offer any protection against competitors with
competing technologies, whether products under development can be successfully
developed and commercialized , whether results reported by our customers or
partners can be identically replicated, and other risks and uncertainties
discussed under the caption "Factors That May Affect Results" and elsewhere in
Nanogen's Form 10-K or Form 10-Q most recently filed with the Securities and
Exchange Commission .

zebrafish tyndall

"
For more information from Sigma-Aldrich about the TargeTron system, please
visit us online at http://sigma-aldrich.

standardisation uncovering

com/targetron .

mutagenesis dictylostelium

The Company is committed to the success of its
Customers , Employees and Shareholders through leadership in Life Science, High
Technology and Service. Nanogen also offers a broad portfolio of patented
nucleic acids chemistries and molecular tools that accelerate genomic analysis
and are compatible with many systems.

mutagenesis biolink

Expression results in a ribonucleoprotein
complex that targets the intron to the precise insertion site within the host
genome resulting in gene knockout.

About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High
Technology company.

dictylostelium silico

Sigma-Aldrich Introduces the TargeTron(TM) Gene Knockout System

For additional information please visit
Nanogen's website at http://www.