The 100K is the
first in a family of products that will allow researchers at Karolinska
Institutet to perform high-density genome scans and genome -wide association
studies on the genetics of complex diseases.

All statements in this press release that are not historical are
"forward-looking statements" within the meaning of Section 21E of the
Securities Exchange Act as amended, including statements regarding Affymetrix'
"expectations ," "beliefs," "hopes," "intentions," "strategies" or the like.

About Quark Biotech , Inc.

Genpathway(TM) Launches Next-Generation Tools for Analyzing Gene Transcription Regulation and Corresponding Genetic Pathways

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Karolinska Institutet and Affymetrix Announce Translational Medicine Strategic Alliance

Systematic use of the genomic information
obtained will enable development of new and better clinical methods and drugs
hereby reducing mortality and improving quality of life for patients suffering
from these diseases.
"Today we have access to a very broad range of population-based clinical
materials and data, that we want to study in order to understand the
importance of genetic factors for emergence and treatment of various diseases. Agilent had net revenue of $7. Genpathway provides these
tools," said Mary Warren, Chief Scientific Officer of Genpathway.

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Affymetrix expressly disclaims any obligation or undertaking to
release publicly any updates or revisions to any forward-looking statements
contained herein to reflect any change in Affymetrix' expectations with regard
thereto or any change in events, conditions, or circumstances on which any
such statements are based. "Quark is very experienced in the
microarray field and has been performing high volume microarray experiments
based on its patented BiFAR(TM) platform for high-throughput functional
profiling in the last six years.
In contrast to RNA profiling methods, Genpathway's tools measure the
process of transcription rather than the product of the process (RNA).

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Karolinska
Institutet collaborates internationally and nationally with healthcare and
medical institutes, as well as with industry and other universities.
The Certified CGH Service Quark provides includes sample receipt, labeling and
the use of Agilent's CGH platform for hybridization and data analysis. today announced the
availability of its novel tools enabling discovery and characterization of
differential gene transcription, components and processes for gene regulation,
and corresponding genetic pathways.

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"To improve human health , we need to shift the healthcare paradigm from
diagnosing and treating existing diseases, to being able to predicting disease
susceptibility and an individual's response to drugs," said Patrick Kelly ,
European Site Manager and Vice President, Affymetrix.
Awarding the Nobel Prize in Physiology or Medicine has given Karolinska
Institutet an invaluable contact network throughout the medical scientific
community. FREMONT, Calif.com and at
http://www. Genpathway's new tools go beyond RNA profiling
but can also be used to clarify or verify RNA profiling results.

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"This is what
personalized medicine is all about -- enabling clinicians to detect diseases
earlier and manage them more effectively . Affymetrix technology is used by the world's top
pharmaceutical, diagnostic and biotechnology companies as well as leading
academic, government and not-for-profit research institutes. Affymetrix
is headquartered in Santa Clara, Calif., with manufacturing facilities in
Sacramento, Calif.
Genpathway is a systems biology company developing innovative tools that
identify and analyze complex biological pathways to drive discovery and
testing of novel pharmaceuticals, biomarkers and diagnostic tests.

linkage genomic

NOTE: Affymetrix, the Affymetrix logo, and GeneChip are registered
trademarks owned or used by Affymetrix, Inc.info.

-- FactorPath(TM): Discovery and quantitation of binding by transcription
factors and coactivators.

Genpathway offers two informative modes of analysis for each tool:

-- QueryMode(TM): Investigates specific genes or genomic regions for
transcription or protein binding.

genetics annotations

These diseases affect a
large number of patients worldwide."
Karolinska Institutet agreement is part of the Affymetrix Translational
Medicine Initiative.agilent.
Quark Biotech, Inc.
Quark corporate product development teams and research facilities are
based in Fremont, CA with research facilities also in Ness-Ziona , Israel.
"Genpathway's TranscriptionPath(TM) provides insight into changes in gene
expression that could not be obtained by conventional microarray analysis."

Genpathway's proprietary tools include:

-- TranscriptionPath(TM): Identification and quantitation of gene
transcription based on isolation and characterization of
DNA/transcription machinery complexes.

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Since
then, Affymetrix GeneChip(R) technology has become the industry standard in
molecular biology research.com.

-- DiscoveryMode(TM): Scans across the genome for all sequences involved
in transcription or gene regulation.com

microarrays linkage

(Nasdaq: AFFX) and Karolinska Institutet announced today
that they have entered into a strategic alliance designed to improve
healthcare by accelerating the translation of basic genetic research into
tools for better diagnosis, prognosis , and treatment.
The agreement enables us to perform these studies at an acceptable cost and we
will also get access to new technology at an early stage.ki. The company's 28,000 employees serve customers in more
than 110 countries. This technology allows the company to develop conceptually novel
drugs that provide previously unavailable benefits to patients.

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These and other risk factors are discussed
in Affymetrix' Form 10-K for the year ended December 31, 2003 and other SEC
reports, including its Quarterly Reports on Form 10-Q for subsequent quarterly
periods.

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During the next five years the projects include genetic analyses and
measurement of gene expression in patients with atherosclerosis , breast
cancer, rheumatoid arthritis, asthma and dyslexia., and Bedford, Mass.

Quark Biotech Inc . Is the First Certified Service Provider for Agilent Technologies' Array CGH (Comparative Genomic Hybridization ) Products

"

About Agilent Technologies
Agilent Technologies Inc. Quark has focused development efforts on treatment of fibrotic and
ischemic diseases of the eye, kidney and lungs, in indications with clear
unmet medical needs.

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Information about Agilent is available on the Web at
http://www. Through innovative
combination of gene silencing and DNA microarray technology , Quark has
pioneered and patented its BiFAR(TM) platform for high-throughput functional
profiling , allowing significant advances in the identification of target genes
and proteins.

morphogenesis genomic

Such statements are subject to risks and uncertainties that could cause actual
results to differ materially for Affymetrix from those projected, including,
but not limited to risks of the Company's ability to achieve and sustain
higher levels of revenue, higher gross margins, reduced operating expenses,
uncertainties relating to technological approaches, manufacturing, product
development, market acceptance, personnel retention, uncertainties related to
cost and pricing of Affymetrix products, dependence on collaborative partners
(including uncertainties related to the outcome of the collaboration discussed
in this press release), uncertainties relating to sole source suppliers,
uncertainties relating to FDA and other regulatory approvals, competition,
risks relating to intellectual property of others and the uncertainties of
patent protection and litigation. Quark is
currently harvesting novel targets identified using this enabling foundation
technology. These
innovative tools -- TranscriptionPath (TM), FactorPath(TM) and PromoterPath(TM)
-- provide knowledge about changes in gene expression and regulation with
greater accuracy and reproducibility, and generate information that is
unattainable using other available technologies."
"When studying changes in gene expression, I would rather measure
transcription directly than accumulated levels of RNA," said James Kadonaga,
Chairman of Molecular Biology at the University of California, San Diego.COM

CONTACT:
Mary Moynihan
M2Friend Communications
802 951 9600
mary@m2friend.

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The company maintains important sales
and marketing operations in Europe and Asia and has about 900 employees
worldwide.

About Karolinska Institutet:
KAROLINSKA INSTITUTET is Sweden's only exclusively medical university. Our
mission is to improve the health of mankind through research , education and
information. announced
today that the Company is the first Certified Service Provider for Agilent
Technologies' (NYSE: A) microarrays to be certified for Array CGH (Comparative
Genomic Hybridization) services. Quark was already a Certified Service
Provider for Agilent gene expression microarrays.

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The Karolinska Institutet/Affymetrix Translational medicine research
projects will use sufficiently large sample sizes to establish true clinical
relevance of both gene expression and DNA sequence variation in key areas of
unmet medical needs.
Karolinska Institutet will have access to a number of new microarray
technologies from Affymetrix, including the Mapping 100K . It
is also one of the largest centres of medical education and research in
Europe.
"This Agilent certification will allow Quark to continue to provide
dependable and high-quality microarray services," said Dr. Daniel Zurr, Chief
Executive Officer of Quark Biotech, Inc. SAN DIEGO, Genpathway , Inc.

-- PromoterPath(TM): Identification of promoters and enhancers, and
quantitation of their use.GENPATHWAY.

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, Quark Biotech, Inc.
This additional Agilent certification confirms Quark's continued ability
to provide complete premium DNA microarray services.
"Scientists use RNA profiling to measure accumulated levels of RNA.

ABOUT GENPATHWAY, INC.

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More than 1,200
systems have been shipped around the world and nearly 3,000 peer-reviewed
papers have been published using the technology.quarklabs. They
also see substantial added value in tools that measure the actual
transcription of genes -- including the relative levels at which genes are
being expressed -- and tools that generate a more accurate picture of
differential gene activation and repression .

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(NYSE: A) is the world's premier measurement
company and a technology leader in communications, electronics, life sciences
and chemical analysis.2 billion in fiscal year
2004.
HTTP://WWW .

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Researchers at Karolinska Institutet Will Undertake Large-Scale Clinical
Studies With the Goal of Translating Basic Research Into Tools for
Better Treatment

SANTA CLARA, Calif. Our expectation is
that this cooperation will help us to improve peoples health", said Professor
Jan Carlstedt-Duke, dean of research at Karolinska Institutet. The goal of the initiative is to bridge the gap between
clinical research and application of genomics in patient care by bringing
together leading clinical research institutes with advanced Affymetrix
microarray technology.

About Affymetrix:
Affymetrix scientists invented the world's first high -density microarray
in 1989 and began selling the first commercial microarray in 1994. Research at Karolinska Institutet spans a huge area, from sub-cellular
structures to societal ones; from endorphins to the environment. "RNA
profiling faces challenges because RNA is relatively unstable, the data
analysis is difficult, and determining which genes are coordinately regulated
can only be done by inference.

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se.quarkbiotech.

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Affymetrix' patented
photolithographic manufacturing process provides the most information capacity
available today on an array, enabling researchers to use a whole-genome
approach to analyze the relationship between genetics and health.
These tools are particularly useful to anyone who wants to identify or
characterize genes that are activated or repressed upon treatment with a
stimulus, such as a drug.

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For more information about Karolinska Institutet please visit the website:
http://www.
Additional information is available at http://www.

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and STOCKHOLM , Sweden, Affymetrix Inc. We are excited about the potential
of this agreement to move the translational medicine field forward. Certification for the
Agilent program was granted once Quark's personnel completed a training
program and the laboratory, as a whole, passed a rigorous set of assessments . is a privately held development-stage,
biopharmaceutical company headquartered in Fremont, CA.

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com .