today announced
the formation of a collaborative research and development program between
DuPont Central Research + Development (CR+D) and Microbia's Precision
Engineering(R) business unit. DuPont CR+D will fund
the joint research and development effort. As a scientist, I am
excited about the wealth of knowledge about the biochemistry,
physiology, and genetics of C1 that the sequence will afford us.

Cautionary Statement for Forward-Looking Statements

Statements contained in this press release may contain information
that includes or is based upon certain "forward-looking statements"
relating to Dyadic 's business.

bioscience faseb

Business Editors/Health/Medical Writers

JUPITER, Fla.

43rd dioxygen

, vice president and general manager of Microbia's Precision Engineering
business."
"This is a tremendous resource ," said Dr."
According to Dr., filings from time
to time with the Securities and Exchange Commission , all of which are
available free of charge on the SEC's web site at http://www.sec.

invertebrate chobe

zoology genomes

Two of the
Company 's drug candidates are in clinical studies-MD-1100 for the treatment of
constipation-predominant irritable bowel syndrome and other gastrointestinal
disorders, and MD-0727 for the treatment of hypercholesterolemia . "The genome sequence should help us to use our C1 Host
Technology to accelerate product development and market launches of
our own enzymes, as well as to assist a variety of agricultural,
chemical , pharmaceutical, personal care, diagnostic and other
companies to develop novel products to meet their needs.

biologists microbes

The parties completed the high quality
sequencing of the 38,000,000 bases in the C1 genome ahead of its
scheduled time period. We can now do in hours, or even
minutes, what used to take us months."
"We now have at our disposal a comprehensive blueprint of the C1
fungus," commented Dr.

Dyadic International, Inc. Dyadic
expressly disclaims any intent or obligation to update any
forward-looking statements.

dioxygen plasmid

-- Partnership emphasizes the future of 'green chemistry' --

CAMBRIDGE, Mass.
"We believe their association analysis technologies will more rapidly identify
those genetic elements essential for solving a complex biological challenge
and, when combined with DuPont's metabolic engineering capabilities, will
accelerate our commercialization timeline.gov,
including our Annual Report on Form 10-KSB for the year ended December
31, 2004 , which was filed with the SEC on April 15, 2005.

microbes transpiration

"Not only does this collaboration provide further validation of our
technology, but also it aligns Microbia with a worldwide leader in the
increasingly important area of green chemistry. Dyadic has spawned a
successful business based on the ability of the C1 organism to produce
large volumes of low cost industrial enzymes for industrial, textile ,
and agricultural applications. "I am sure that Dyadic, as a
business, is excited about the possibility of readily finding novel
enzyme products to add to their portfolio., is engaged in the development ,
manufacture and sale of biological products (proteins, enzymes,
peptides and other bio-molecules ), as well as the licensing of its
enabling proprietary technology to business collaborators for the
discovery, development and manufacture of biological products from
genes.

genomes dioxygen

, Microbia, Inc.com ) is an entrepreneurial pharmaceutical
company dedicated to the science and art of great drugmaking . Microbia has raised $99 million in
private equity financing and is located in Cambridge, Massachusetts . (OTCBB: DYAD), a biotechnology company, today announced the early
completion of the genome sequence of Dyadic's C1 fungus by Agencourt
Bioscience Corporation, Beverly, Massachusetts.

microbe biologists

faseb zoology

Microbia will also be eligible to
receive performance-based payments through the course of the program."
"Microbia has the capability to accelerate the rate of process development
for this important project ," said John Pierce, director of DuPont's
Biochemical Science + Engineering section of Central Research + Development.----Dyadic International,
Inc. Other genomes deposited into
Genbank of this size and character, tend to assemble into many more
supercontigs at this level of sequence coverage, primarily due to
fewer long range mate pairs from large insert clones being generated
in the shotgun phase .

microbes 43rd

dioxygen thymallus

"In our first
examination of the sequence, we looked for six genes and found all six
of them. For a discussion of the factors that
could cause actual results to vary from these forward -looking
statements, please see Dyadic International, Inc.

zoology systematics

About Microbia
Microbia (http://www. Our
Precision Engineering business unit collaborates with leading pharmaceutical
and chemical manufacturers to improve efficiencies of existing fermentation
processes or to create new bioprocesses.

Dyadic Announces Successful Completion of Sequencing of C1 Fungal Genome - Dyadic's Proprietary Source of Proteins and Enzymes; Sequence Data To Accelerate Dya

We
expect that this will allow us all to rapidly characterize and improve
the C1 Host Technology platform.

eger 43rd

Microbia and DuPont Central Research + Development Collaborate to Develop a Novel Biomanufacturing Process

The high quality assembled sequence we have
completed will make it easier for Dyadic and its collaborators to more
rapidly identify novel genes of commercial interest and to make
improvements in the C1 Host Technology . Richard Burlingame,
Dyadic's Executive Director, Research + Development.

plasmid faseb

"
Microbia's Precision Engineering business applies molecular genetics and
proprietary profiling methods to rationally design microbes for the efficient
production of commercially valuable compounds in the pharmaceutical and fine
chemical industries, as well as the developing industrial biotechnology field.com

"Dyadic's C1 fungal genome assembled into 8
supercontigs with only 6X sequence coverage in the shotgun sequence
phase of this project.

transpiration 43rd

Some of the genes were ones we have been
struggling to find using traditional gene cloning methods; others were
genes we had not looked for before. Peter Punt, a respected fungal molecular
biologist for TNO Quality of Life (Zeist, the Netherlands) and a key
developer of Dyadic's C1 Host Technology.

eger biovision

"DuPont is a premier chemical company with a strong track record of
technical achievement and a commitment to developing environmentally
sustainable processes based on renewable resources," said Richard Bailey,
Ph.

Corporate Inquiries: Media Inquiries:
Susan Brady Danielle Whitney
Microbia, Inc. Biosector2
617 621-8304 212 845-5611
dwhitney@biosector2 . Dyadic is working to both expand the
commercial capabilities of this technology, and further extend its
market reach to develop new and better therapeutic proteins more
affordably.

radiations thymallus

The companies will work together to develop an
economically viable biomanufacturing process for a chemical currently
manufactured from petrochemical-based raw materials."

About Dyadic International, Inc.

faseb microbes

To date, two Microbia-engineered production strains have been introduced into
commercial use and a third Microbia-engineered strain is currently undergoing
pilot evaluation. The C1 genome sequencing completion will permit Dyadic to
mine the information from this uniquely enabling fungal host for novel
and improved protein products for a broad spectrum of industries,
including Energy, Feed and Food, Pulp + Paper, and Pharmaceuticals. This high quality assembled genome was made
possible using Agencourt 's SPRINTPrep technology in which Fosmids,
large insert clones, can be prepared just as readily and
cost-effectively as high copy plasmids.

biologists systematics

In
addition, the sequence information is expected to enable Dyadic and
its collaborators to expand the variety of proteins and enzymes that
can be brought to market. Dyadic markets its products and services for applications in
the textile, chemical, agricultural , pulp + paper, pharmaceutical,
biotechnology and other industries, using its proprietary C1 Host
Technology and C1 Expression and Screening Systems for the discovery,
development and production of biological products.

rearing thymallus

We expect
this wealth of information to result in faster development of more
environmentally-friendly and functionally-superior industrial products
and processes as well as potential new treatments for human diseases". Gerald Fink, American Cancer Society Professor of
Biology at Massachusetts Institute of Technology (MIT), a renowned
expert in fungal research and a member of Dyadic's Scientific Advisory
Board, "This development provides a gold mine of information that will
help us to unlock the secrets hidden in the genome of this remarkable
organism.

biologists dioxygen

"The C1 genome sequence produced for Dyadic is a true success
story," said Kevin McKernan, Chief Scientific Officer of Agencourt
Bioscience Corporation. In fact, we found nine genes of interest, all in about two
hours of searching.

eger grayling

microbia.
"Dyadic will use this information to enhance the utility of its
patented C1 Host Technology, which forms a cornerstone of its Enzyme
and Biosciences businesses ," said Mark Emalfarb, President and CEO of
Dyadic.