GeneGo Is Awarded NIH Grant for Disease Network Algorithms

, GeneGo Inc.

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- 5:00 p.org (click on symposium icon)

MEDIA CONTACT: Gretchen Sorensen
Senior Director, External Affairs + Development
206 -732-1239
gsorensen@systemsbiology.

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In Phase I, GeneGo
will generate and test novel algorithms enabling comparison of disease related
OMICs datasets of different origin, based on networks topology and content.

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JOSEPH, Mich.

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The availability of large numbers of genome sequences also opens
opportunities for decoding the information embedded in DNA: what is
transcribed, under what conditions, and by how much? Such an endeavor
will require comparisons of hundreds, possibly thousands, of genomes
within and across species.m. (PDT)

VENUE: Institute for Systems Biology, 1441 N.systemsbiology.

About GeneGo
GeneGo is a Michigan-based company developing systems biology technology
for life science research.

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The rate at which new types of data and larger data
sets are being generated far exceeds the rate at which we are able to
analyze and exploit these data, and the challenge is growing daily. Because of this, the result
detected by 'genome scale' technologies such as microarray gene expression,
proteomics and genotyping, is complex and multi-level.

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This year's symposium will address the
significant computational challenges in systems biology. The Company's original computational platform
allows an integration and analysis of different kinds of experimental data
(mRNA expression, proteomics, metabolites, phenotypic data etc.

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In North America alone, that translates to nearly
half a billion human genomes which we will want to store and
cross-link to medical records, and to analyze for susceptibility to
diseases and responsiveness to medical interventions. How can we abstract from a system of thousands
of interacting molecular species the underlying operational
principles? Analogous to engineering design principles , we need to
understand the functional and dynamic organizational principles of
biomolecular networks . 34th St.
"Analysis of human biological networks is an exciting new area of systems
biology , and we are glad that our efforts are appreciated by the NIH," said
Dr.

complexity swinburne

"Common diseases have profound effects on both signaling and metabolic
machinery, usually in more than one cell type. GeneGo's first product, MetaCore(TM),
assists scientists in the areas of target selection and validation ,
identification of biomarkers for disease states and toxicology.

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We believe that the integrated approach offered through GeneGo's
advanced computational systems will be critical in deciphering the key
molecular mechanisms of disease progression, and offer new diagnostic and
therapeutic strategies for the future advancement of molecular-based
medicine," said Dr.
For more information , please visit the company's Web site at
http://www.genego.

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These challenges are only the beginning: understanding the dynamic
behavior of evolved systems demands new paradigms in model analysis
and data visualization.org

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Each data type
provides only one level of information, and total reconstruction of the 'big
picture' of molecular pathology is a major challenge. We will study
conditional perturbations of the human interactome assembled from manually
curated physical protein interactions and develop algorithms for assembly of
complete functional networks, from membrane receptors to transcriptional
factors and 'core effector' metabolic pathways.

formulating formalisms

These
changes pose new computational challenges on an unprecedented scale. It will also necessitate the integration of
genomic data with large-scale expression, localization, and
interaction data. ST.

Mathematical biology is closely related.

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But , given the natural variability within cells
over time, between cells within a tissue, and between individuals, how
can we distinguish cause from effect, and essential from
background/context?
These and other challenges will be addressed at the symposium by a
distinguished group of scientists , all experts in the field of
computational biology.

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Systems biology is a new field and is continually changing.m. GeneGo's
second product, MetaDrug(TM), is designed for medicinal chemists and enables
prediction of metabolites and their likely toxicity in human.

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,
Seattle, WA

REGISTRATION: www.

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We will test the approach on
disease datasets in collaboration with the Van Andel Research Institute. Craig Webb, a lab head at Van Andel and an advisor on the
grant .) and relevant
active chemistry (metabolites, drugs, other xenobiotics) within the framework
of biological pathways and networks.com .

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ADVISORY/Institute for Systems Biology to Host Fourth International Symposium; 2005 Event to Address Significant Challenges in Computational Biology

Business Editors/Health/Medical Writers
ADVISORY.

Other featured speakers include (in alphabetical order):

Viktors Berstis Senior Software Engineer, IBM Global Services

Rich Bonneau Senior Research Scientist, Institute for Systems
Biology

David Eisenberg Director, UCLA-DOE Lab of Biological Structure +
Molecular Medicine, University of California Los
Angeles

Terry
Gaasterland Professor of Computational Biology and Director,
Scripps Genome Center, Scripps Institution of
Oceanography, University of California, San Diego

Mark Gerstein Albert L.m.

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MetaCore(TM), MetaDrug(TM) and MetaBase(TM) are trademarks of GeneGo, Inc.

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The Institute is anticipating approximately 250
attendees at the symposium and will begin at 4:00 pm on Sunday, April
24th with a keynote address from Nathan Myhrvold, Founder of
Intellectual Ventures, LLC., a leading provider
of databases, software and services in systems biology, announced today that
they have received a Phase I SBIR grant from the National Institute of General
Medical Science for development of methodologies intended for reconstruction
of functional networks affected in common human diseases.

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Williams Associate Professor of
Biomedical Informatics, Molecular
Biophysics /Biochemistry, and Computer Science,
Yale University

Trey Ideker Assistant Professor, Bioengineering, University of
California San Diego

Richard Karp Senior Research Scientist, International Computer
Science Institute

Joe Nadeau Co-director, Center for Computational Genomics,
Case Western Reserve University

Bernhard Palsson Professor of Bioengineering and Adjunct Professor
of Medicine, University of California San Diego

Mike Tyers Senior Investigator , The Samuel Lunenfeld Research
Institute of Mount Sinai Hospital

TIME: Sunday, April 24, 2005 4:00 - 6:30 p.

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(PDT)
Monday, April 25, 2005 8:00 a."
"We are truly excited at this opportunity to collaborate with the GeneGo
team.

Theoretical biology has the goal of explaining the biological world by formulating theories.

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.for Sunday (April 24)

SEATTLE----The Institute for Systems
Biology (ISB) will hold its fourth annual international symposium on
Sunday, April 24th and Monday, April 25th at the ISB research facility
in Seattle, Washington.
For example, it is predicted that within 10 to 15 years, we will be
able to sequence individual human genomes for less than a $1000 each
in less than a day. Tatiana Nikolskaya , Chief Scientific Officer and President of GeneGo.