"
From 1996-2000 , Dr. He
has served on numerous national policy committees including the National
Academy of Sciences Panel on Scientific Responsibility and the Conduct of
Research (1990-1991), the Public Policy Committee of the ASCB (1992-2001), the
NIH Director's Peer Review Oversight Group, (1996-1999) and the Lasker
Foundation Forum on Ethical Challenges in Biomedical Research and Practice
(2003). Sirna has initiated a Phase 1
clinical trial for its most advanced compound, Sirna-027, a chemically
modified siRNA targeting the clinically validated vascular endothelial growth
factor pathway to treat AMD .com/. Risks and uncertainties include Sirna's early stage
of development and short operating history , whether Sirna can achieve and
maintain profitability, whether Sirna can obtain and protect patents , the risk
of third-party patent infringement claims, whether Sirna can engage
collaborators and obtain regulatory approval for products, Sirna's
concentration of stock ownership, and availability of materials for product
manufacturing. These and additional risk factors are identified in Sirna 's
Securities and Exchange Commission filings, including the Forms 10-K and 10-Q
and in other SEC filings.,
+1-303-449-6500 or Jason Rando, The Ruth Group, +1-646-536-7025

Anderson
Cancer Center has been awarded a National Cancer Institute Specialized
Programs of Research Excellence (SPORE) grant for breast cancer research, the
10th such grant earned by the institution since 1996 . In addition, it was important that we address specific needs and
biology of minority populations . Ultimately, we want to make an impact on
breast cancer science, treatment, detection and prevention worldwide.

permanently lampreys

The school is sponsored by the Department of Conservation and Natural
Resources and the Pennsylvania Fish and Boat Commission (PFBC). Yamamoto was a founder of the journal Molecular Biology of the Cell
and served as Associate Editor, Editor or Editor-in-Chief from 1989-2003. D.

cartilaginous hagfish

"Participants will improve their stewardship skills, leave the school better
equipped to serve as leaders in conservation , and have a heck of a lot of fun
learning. A total of 20 students will be selected.fish.
Dr. More information on Sirna
Therapeutics is available on the Company's web site at http://www . D.

systematics criollos

"This cooperative educational effort gives angling youth a solid
foundation in warm-water aquatic ecosystems, their management, and how they
affect black bass and bass angling," said DCNR Secretary Michael DiBerardinis. Other conservation-related and hands-on
activities also are planned .us. He and his colleagues have
described their research in over 150 published studies. Sirna has strategic partnerships with Eli Lilly
and Company, Targeted Genetics and Archemix Corporation and a leading
intellectual property portfolio in RNAi.
"The five research projects that the SPORE will fund not only are
innovative and exciting, but four are studies that originated in M.

ichthyological hagfishes

S.
A $125 enrollment fee will be charged upon acceptance. Students are
encouraged to seek organizational sponsorships through sporting, community or
civic groups.

hagfish ichthyology

and SAN FRANCISCO, Sirna
Therapeutics (Nasdaq: RNAI) announced today the appointment of Keith Yamamoto,
Ph. Yamamoto is
currently Executive Vice Dean at the UCSF School of Medicine. Yamamoto said, "I am pleased to join the SAB of
Sirna as its Chairperson.
With the three-year, $4.

hagfish neotropical

Youth Bass Anglers Conservation School Invites PA Students to Apply for July Session

Dr. HOUSTON, The University of Texas M ., professor and chair of the Department of Molecular and Cellular
Oncology. Researchers will study
the mesenchymal stem cells in the microenvironment of the tumor and other
models, ultimately taking the delivery system to clinical trials in patients
with advanced breast cancer.

permanently fishes

Instruction will be offered Sunday through Thursday, July 16-20, on Lake
Perez at the Pennsylvania State University 's Stone Valley Recreation Area.pa. Anderson researchers in 2002, this new molecular
tag may be helpful to physicians in predicting which breast cancer patients
need more aggressive treatment and which can forego potentially toxic
chemotherapy.

* Treatment of metastatic breast cancer with gene-modified mesenchymal
stem cells
In 2003 in another discovery made in an M.

* PTEN deficiency and trastuzumab (Herceptin) resistance
Applying their findings published in 2004, researchers will explore new
ways to use the protein, PTEN, to predict response and resistance to
trastuzumab (Herceptin), a powerful drug used in the treatment of breast
cancer patients whose tumors are HER-2 positive.

This news release was issued on behalf of Newswise(TM). For more
information, visit http://www.

losey pamphlet

, The Youth Bass Anglers
Conservation School, Pennsylvania's unique learning experience for young
students with a passion for fishing and a thirst for warm-water fishery
knowledge, will begin accepting registrations March 1.
"Students will learn from experts and professionals in various
conservation fields from across Pennsylvania and the nation," said PFBC
Executive Director Dr.
Dr.
Yamamoto's decision to join Sirna's Scientific Advisory Board and to take on
the position of Chairperson is a major development in Sirna's leadership in
the development of RNAi.

This category is intended for Ichthyology related sites.

chordates pamphlet

"Learning fishing
skills from a dozen volunteers and introduction into aquatic science by
professional staff offer the students insights into opportunities to become
conservation and environmental leaders.state.us; or from Spring
Reilly at (814) 625-9369, or spreilly@state. Leading Expert on Gene Signaling

BOULDER, Colo.
Dr."
About his appointment Dr. In this position, Dr. Sirna undertakes no obligation to revise or update
any forward-looking statements in order to reflect events or circumstances
that may arise after the date of this release. Schmieg, Sr.
M.
Gabriel Hortobagyi, M.D. Anderson
faculty representing 13 disciplines.com .

lampreys hagfishes

(PABF), U.D.6 million grant awarded exclusively for breast
cancer research, M.newswise.

ichthyological ology

Army Corps of Engineers, the Pennsylvania State University and Marsh Creek
Bass Club. Both Sirna
management and the members of the Board of Directors look forward to his
participation in our scientific meetings and decisions. I am impressed with Sirna's capabilities and
believe that Sirna is leading the way in the development of siRNA
therapeutics . Yamamoto currently serves on the Joint Steering Committee for
Public Policy and the National Academy of Sciences, Board on Life Sciences.

parasites lampreys

Contacts:
Martin E.
"The projects reflect a balance between early-stage breast cancer, which
often can be successfully treated, and advanced disease, which can be very
challenging.

lampreys chordates

Sirna Therapeutics Appoints Dr. Keith Yamamoto to Chairperson of SAB

As stated by Howard Robin, President and Chief Executive Officer, "Dr. Yamamoto is one of the most prominent workers in
the field of gene expression regulation. Vice President + CFO of Sirna Therapeutics, Inc.

pathological pamphlet

"
The Youth Bass Anglers Conservation School is a cooperative effort by
DCNR's Bureau of State Parks, the PFBC, PA Bass Federation Inc."
Application and enrollment will begin Wednesday, March 1, for students
ages 14-17. Anderson currently holds SPORE grants in leukemia and melanoma as
well as cancers of the pancreas, ovaries, uterus, head and neck, bladder and
prostate, and shares a lung cancer SPORE grant with UT Southwestern Medical
Center in Dallas .D.

hagfish lapse

"The camp is a combination of non-stop, hands-on fun-filled activities
ranging from boat safety and basic angling skills to fish biology and habitat
management," said PABF Conservation Director Bill Reichert. He served as
the Director of the Biochemistry and Molecular Biology Graduate Program at
UCSF from 1988 to 2001 and as Chairperson of the Department of Cellular and
Molecular Pharmacology from 1994 to 2003. Working with Hortobagyi will be Co-Principal Investigator Mien-Chie
Hung, Ph .

ichthyology neotropical

His research focuses on the mechanisms
of signaling and gene regulation by intracellular receptors that mediate the
actions of several classes of essential hormones. Yamamoto served as Chairperson of the Advisory
Committee to the Center for Scientific Review, the body at the National
Institutes of Health (NIH) that determines how the majority of federal
biomedical research funds are distributed . D.
Anderson labs and now have the opportunity to advance much more rapidly," said
Hortobagyi .

permanently neotropical

pa.

CONTACT: Terry Brady, DCNR
(717) 772-9101

Dan Tredinnick, PFBC
717-705-7805

He will provide insightful guidance
to both internal research as well as assisting with relationship building that
can potentially support our external collaboration efforts. According to the National Cancer
Institute, 58 such grants have been awarded nationally focusing on 14 disease
sites."
The SPORE grant for breast cancer will fund these five primary projects,
all of which advance personalized risk assessment, detection and treatment:

* Molecular and epidemiologic classification of early-stage breast cancer
tumors
With a special emphasis on minorities, researchers will study molecular
and genetic characteristics of early breast cancer tumors to determine new
indicators or markers to more accurately predict risk , detect cancer or
measure response to treatment. D.

pamphlet lapse

to its Scientific Advisory Board as Chairperson . Yamamoto has been a member of the UCSF faculty for more than 25 years
starting as an Assistant Professor in the Department of Biochemistry and
Biophysics in 1976. Dr.

About Sirna Therapeutics
Sirna Therapeutics is a clinical-stage biotechnology company developing
RNAi-based therapies for serious diseases and conditions, including
age-related macular degeneration (AMD), Huntington 's disease, diabetes,
asthma, oncology, hepatitis C and hair removal. With the breast cancer SPORE and the recent renewal of the
ovarian cancer SPORE, the 10 grants total more than $107 million. D .

pathological pamphlet

HARRISBURG, Pa."
The five-day/four-night program will address topics like fishery biology ,
fisheries management, habitat improvement, boating safety, fishing skills and
techniques, fish and boating law enforcement, fisheries and conservation
careers and tournament angling.sirna., professor and chair of the Department of Breast
Medical Oncology, is the principal investigator of the newest SPORE overseeing
the administration of the grant as well as one of the five major research
projects . Anderson lab, genetically
engineered stem cells were found to home in on tumors and then produce
biological killing agents at the site of the cancer. D.

(Ichthos is Greek for fish and the suffix -ology means the study of).

pamphlet lampreys

"Instruction will be geared toward
youth who already possess some basic outdoor skills and fishing experience but
want to further develop those skills and learn more about bass angling. Enrollment applications and more details can be obtained at the
Fish and Boat Commission website: http://www.
Yamamoto was elected as a member of the American Academy of Arts and Sciences
in 1988, the National Academy of Sciences in 1989, as a fellow of the American
Association for the Advancement of Sciences in 2002 and to the Institute of
Medicine in 2003.

Statements in this press release which are not strictly historical are
"forward-looking " statements which should be considered as subject to many
risks and uncertainties. Anderson continues to hold more SPORE grants than any
other institution in the United States. D.

ichthyological hagfish

Applicants must submit a written one-page essay addressing "What
fishing means to me"; the importance of conservation; and why they want to
attend the school, as well as a letter of recommendation from a teacher or
close associate. The SPORE grant will allow this discovery to be taken to the
next steps in the lab and clinic, validating cyclin E as a valuable tool. Research in this area
ultimately could yield new therapies that inhibit a tumor's resistance to a
drug proven to be effective.

confocal ichthyologists

Yamamoto
played a key role in reforming the grant peer review process at the NIH. He
serves on numerous other editorial boards and scientific advisory boards.

* Targeting breast cancer-specific gene therapy
Building on earlier discoveries, researchers will take into the clinic a
Phase I gene therapy trial that transports Bik, a gene that has been found in
early studies to suppress breast tumor development and induce cell death, to
the tumor.

The SPORE grant for breast cancer brings together 28 M.

ichthyologists permanently

Dr. Dr.

Newest M. D. Anderson SPORE to Fund Breast Cancer Research

Ichthyology is the study of fish.

ichthyological confocal

Douglas Austen. Yamamoto's research has had a major impact on the fields of molecular
biology, endocrinology and physiology.

* Cyclin E as a novel and powerful prognosticator for breast cancer
First discovered by M.