, AlphaVax announced
today that it has received a significant new vaccine development grant from
the National Institute of Allergy and Infectious Diseases (NIAID) of the
National Institutes of Health (NIH), an agency of the U. This cross-business and
academia effort will be led by Dr. Gabriel (Gabby) Silberman, who recently
joined the Company as senior vice president and head of CA Labs, reporting to
CA Chief Technology Officer Yogesh Gupta."
Silberman is a world-renowned researcher with more than 25 years of
academic and industrial research experience . He joins CA from IBM where he was
program director for the company's Centers for Advanced Studies (CAS),
responsible for developing and adapting the CAS model for IBM research and
development laboratories worldwide.
When combined together with older pSeries systems, the Max Planck Society
supercomputer will double to an aggregated value of 10.

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"We have a unique opportunity here at CA," said Silberman. Prior to that position, Silberman was a
manager and researcher at IBM's T .

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Department of
Health and Human Services. is a biotechnology company dedicated to the development of
vaccines based on its innovative technology, called the ArV(TM) (AlphaVax
replicon Vector) system. The technology was
originally developed by USAMRIID (U. "We are excited
that Gabby has agreed to lead this effort; his experience and credibility in
this area is a tremendous asset to our team as we work together to leverage
the talent and resources in this arena. CA Labs' research
work will complement the existing research and development teams within CA's
Business Units that predominately focus on nearer-term solutions for CA
customers.Y. All trademarks, trade names, service marks, and
logos referenced herein belong to their respective companies.

For future nano -technologies a study of crystal growth
will simulate modern materials.

"The space required for high performance computers continues to shrink,"
says Nurcan Rasig, IBM Director Deep Computing Central Region. The new system
allows up to 128 eight-processor
p5-575 cluster nodes to create a single high-performance system with
supercomputing performance capabilities that can power work in areas such
as genome research, automotive crash-testing, petroleum exploration, and
oceanographic , atmospheric and energy studies.

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RESEARCH TRIANGLE PARK, N. The AlphaVax vaccine
technology holds great promise against influenza as well as many other
important human diseases, and this new grant will accelerate our pursuit of an
effective new influenza vaccine. The company is working with a number of other academic and industry
partners on vaccines for diseases like herpes and human papilloma virus (the
principal cause of cervical cancer), as well as vaccines that can be used to
treat different types of cancer. AlphaVax draws its candidate vaccine vectors from
alphaviruses , a family of viruses that demonstrate promising biological
properties for the development of novel vaccines.
1999;281:901-907.

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"
CA Labs will tap the talents of CA researchers worldwide and fund related
academic research to support and further establish innovation in CA's key
growth areas.com/cgi-bin/prnh/20021111/CALOGO )

About CA
Computer Associates International , Inc.
Founded in 1976, CA is headquartered in Islandia, N.ibm.

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S., Computer Associates
International , Inc.
IBM today announced that The Max Planck Society
will use a
cutting-edge IBM supercomputing system to double its computing power,
allowing research and experiments which before were not possible .com.

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alone. JAMA.Y. "CA Labs will
serve as a conduit for innovation, channeling the outstanding talent already
present in CA's development community, and combining it with cutting edge
research by leading faculty and their students, all to the benefit of our
customers.

(Logo: http: //www.

"We have chosen the eServer p5-575 platform running the AIX operating
system because of its extraordinary performance as far as extremely
demanding storage applications are concerned ," says Hermann Lederer, head
of the applications group at Garching Computing Center. "This is
best demonstrated by Max Planck Society's nanotechnology research being
powered by IBM POWER5 processors , which continue to push the envelope
of Moore's Law by increasing compute power per chip.

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Gabriel Silberman Appointed to Lead Newly Created Program

ISLANDIA, N. In addition, the organization will play an integral role in
developing and promoting industry standards in these areas .

The new supercomputing system will be used in different research areas of
the Max Planck Institutes. At the Fritz Haber
Institute in Berlin, Germany, for example, scientists are simulating
heterogeneous catalysis for developing more efficient and environmentally
friendly catalysts.

About IBM

IBM is the world's largest information technology company, with 80 years of
leadership in helping businesses innovate.

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The new award provides a total of $6. (NYSE: CA) today announced the formation of CA Labs, a new
organization within CA dedicated to promoting and performing advanced research
in systems and security management for the enterprise.
Silberman began his career in academia as a faculty member in computer
science at the Technion -- Israel Institute of Technology. in computer science from the State University of New York at Buffalo. The
system is based on 86 units of IBM's newly announced IBM eServer
p5-575 systems and will bring the Max Planck Society's supercomputing power
to over 10 Teraflops, doubling their existing installed pSeries compute
power. For more information about
IBM, visit http://www.

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Coupled with
shortages in the nation 's influenza vaccine supply during the annual seasonal
outbreaks of the disease in the last two years , these factors have placed
improved influenza vaccine technologies and infrastructure development among
the top priorities for U. Army Medical Research Institute of
Infectious Diseases) and the University of North Carolina at Chapel Hill. (NYSE: CA), one of the world's
largest management software companies, delivers software and services across
operations, security, storage, life cycle and service management to optimize
the performance, reliability and efficiency of enterprise IT environments .

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C. public health agencies., Chief Medical Officer of AlphaVax, commented, "We
are extremely pleased that the NIH will support our efforts to develop a new
vaccine against such a significant public health threat."
Data from a collaboration between AlphaVax and the U. Pharmaco-
Economics ., and serves customers
in more than 140 countries.

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The appearance of new strains of avian influenza in Asia in
the last few years that have caused as much as 70% mortality in the several
dozen humans who have become infected has raised the specter of a new,
potentially devastating human influenza pandemic in the future. 1999;16(suppl 1):27-32.Y. For more information, please visit http://ca.

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AlphaVax Announces a New NIH Vaccine Grant for Influenza

"The creation of CA Labs formalizes and accelerates our efforts in working
with academic research organizations and industry standards bodies to ensure
that we are developing the most innovative systems and security management
solutions for our customers' long term needs," said Gupta.

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Influenza-associated
morbidity and mortality in young and middle-aged women.newscom.
The new systems use ultra-dense packaging technology innovations to provide
high-speed connections between eight POWER5 processors.

rti oldenberg

5 million over
a three-year period to support the first pre-clinical development and
preparations for clinical stages of development of an influenza vaccine using
the company's promising new vaccine technology, the ArV(TM) (AlphaVax replicon
Vector) system.S.
The new grant is the seventh vaccine development grant that AlphaVax has
now received from the NIH supporting vaccine programs in HIV, biodefense, and
SARS. He was a visiting
professor at Carnegie Mellon University, and serves in academic advisory
boards at several universities and research institutes around the world. One Computer Associates
Plaza, Islandia , N.

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D. The collaboration with SEPRL will continue under the new grant,
Dr.

CA Establishes CA Labs for Advanced Research in Systems and Security Management

The new supercomputer will help researchers in the Garching
Computing Center advance research in the fields of nanotechnology and
environmental protection as well as other innovative research projects
envisioned by the Society. At the Max Planck Institute for Metals
Research in Stuttgart, Germany, simulations of
biomolecules-nanotube-systems will be run, to model and design bio and
biomedical sensors for future applications. "With this
platform , we are able to significantly decrease the time it takes to
complete a project, allowing us compete against some of the largest
organizations in the research community."

The installation of 86 p5-575 servers running a UNIX operating system
extends the Society's existing supercomputing platform of 32 IBM eServer
pSeries systems. Drawing on resources from across
IBM and key IBM Business Partners , IBM offers a wide range of services,
solutions and technologies that enable customers, large and small, to take
full advantage of the new era of e-business.

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S.

(2) Szucs TD. Influenza: the role of burden-of-illness research.

PRESS RELEASE Max Planck Society Deploys IBM Supercomputer for Advanced Nanotech and Environmental Research

In smaller configurations,
the 8-way p5-575 can be deployed as a highly modular and cost-effective
platform for memory-intensive Business Intelligence (BI) and Data
Warehousing (DW) applications.

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The additional p5-575 compute resources, consisting of
single core 1.

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AlphaVax is located in Research Triangle Park and currently employs 60 people .

2005 Computer Associates International, Inc.

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About AlphaVax
AlphaVax, Inc.S. 11749.

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Influenza remains a leading cause of illness and death around the world,
causing over an estimated $1 billion in direct economic costs(1), as much as
$15 billion in lost earnings due to illness(2), and 36,000 deaths annually in
the U. Chulay noted.com.

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S. It is particularly exciting that this
program will give us our earliest opportunity to evaluate the efficacy of our
vaccine system in a Phase II clinical trial.2 Teraflops.

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J.
Silberman earned a Bachelor of Science and Master of Science degree in
computer science from the Technion -- Israel Institute of Technology , and a
Ph.D.

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(1) Neuzil K, Reed GW, Mitchel EF, Griffin MR."


The new p5-575 is an ultra-thin cluster building block that delivers "off
the shelf" supercomputing technology to customers in a small form factor.

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Jeffrey Chulay, M. Department of
Agriculture's Southeast Poultry Research Lab in Athens, Georgia, has already
shown that an ArV(TM) vaccine can protect birds from being infected by avian
influenza. Watson Research Center where he led
exploratory and development efforts. The major part of the installation is dedicated
to extremely demanding simulations in materials science .9 GHz 8-way nodes, have a peak performance of five Teraflops. The
solution is one of the first p5 -575 installations worldwide. With this solution the
Compute Center Garching will become pioneer for future HPC installations.

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