S.

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html) works with government
agencies and commercial pharmaceutical /biotech companies to provide a
broad range of preclinical drug discovery and development services ,
including medicinal chemistry, custom synthesis, regulatory support,
efficacy and safety evaluations , pharmacokinetics and metabolism
studies, analytical chemistry and formulation design in production in
GLP and cGMP environments.

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About SRI International's Biosciences Division

SRI's Biosciences Division
(http://www.

About SRI International Computer Science Laboratory

The Computer Science Laboratory http://www.

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"We are proud of the success of the regional championship teams
and wish them well at the National Science Bowl. The
school won two national titles in 1996 and 1997.----

SRI's Systems-Based Pathway Logic Software
Helps Predict Response to Cancer Therapies

SRI International, an independent nonprofit research and
development organization, today announced a grant from the National
Cancer Institute (a unit of the National Institutes of Health) and the
Lawrence Berkeley National Laboratory (LBNL) for the study of
signaling systems in biological networks associated with cancer cell
lines.
"Pathway Logic software, the core of the 'system' that will be
used for this important project, is a computational approach designed
to automatically generate and display complex networks of components
such as biological molecules and their interactions," said Keith
Laderoute, Ph., director of SRI's Cancer Biology Program.com/biosciences/indexN.

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Venice High School and Santa Monica School Teams Leave This Week for National Science Bowl; LADWP Championship Teams Have Won Four National Titles and Placed i

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In Science Bowl all the questions
cover college level subjects such as physics, chemistry, earth and
space , science, calculus, trigonometry and computer programming.
Such model structures provide a way to organize diverse
information concerning biological and biochemical states and
processes, creating models that show how the systems evolve from a
starting state.

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City Desks/Energy Editors/Education Editors

LOS ANGELES----The five-member
Venice High School and Santa Monica High School Science Bowl teams
leave this week to participate at the U. Virgin Islands. The division specializes in cancer ,
infectious disease and neurobiological research.

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C. April 28 to May 2. Santa
Monica, the champion of the regional competition at the Jet Propulsion
Laboratory (JPL), covers Los Angeles areas outside of the city and
LAUSD.

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Potential
biological mechanisms, such as susceptibility or resistance to
therapeutic intervention, can be experimentally tested using
hypotheses created by a model or by querying the model itself. In addition to conducting contract R+D, SRI
licenses its technologies , forms strategic partnerships and creates
spin-off companies.

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"The regional
championship teams represent the best high school science scholars
from the Los Angeles area.
Science Bowl is a competition that follows the game-show format of
the old GE College Bowl television series.ladwp.sri.sri.

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S."
SRI's Biosciences Division and Computer Science Laboratory will
co-develop the Pathway Logic model of cellular networks.sri.

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com) is one
of the world's leading independent research and technology development
organizations.


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This year 12,000 students in 1800 schools participated in the 63
regional qualifying competitions throughout the nation.com
The Los Angeles Department of Water and Power has provided utility
services to residents and businesses of the city for more than a
century.

SRI International's Pathway Logic Tools Model Cellular Networks for Breast Cancer Research

com in SRI 's
Information and Computing Sciences Division studies the logical
foundation of scalable systems that are beyond the scope of
traditional testing or simulation, and builds and applies efficient
high-level tools for rigorous mechanical analysis. Founded as Stanford Research Institute in 1946 , SRI has
been meeting the strategic needs of clients for almost 60 years.

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The U.
Department of Energy created the National Science Bowl in 1991 to
encourage high school students of all backgrounds to excel in math and
science and to pursue careers in these fields.

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Our volunteers and
staff are consistently amazed at how much complex science and math
content the students have mastered," said LADWP General Manager Ronald
Deaton. It is the nation's largest municipally owned utility. SRI will be a subcontractor to LBNL and will develop a model of
cellular signaling networks related to human breast cancer. The broad expertise of SRI's
interdisciplinary research team -- coupled with SRI's powerful Pathway
Logic tools for studying biological and biochemical change -- can
greatly aid in understanding human disease processes such as cancer
development.

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Department of Energy
National Science Bowl program in Washington, D. Other teams from the
LADWP Science Bowl that have won national titles are Van Nuys High
School in 1995 and North Hollywood High School in 2001. A system modeled by
Pathway Logic(TM) software offers compelling advantages for
understanding biological processes such as signal transduction and
metabolism at a global level.D. "Pathway
Logic software permits researchers to pose logical questions about
large biological networks -- which are actually formal models derived
entirely from experimental findings.

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csl. Current systems of
interest include not only traditional computer hardware and software,
but also biological systems and nanoelectronics .

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Venice is the champion of the LADWP Science Bowl, covering the
city of Los Angeles and the Los Angeles Unified School District.

Business Editors/High-Tech Writers/Health/Medical Writers
BIOWIRE2K

MENLO PARK, Calif.

About SRI International

Silicon Valley-based SRI International (http://www.

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I commend these kids for their dedication,
and wish them the best of luck in the National Science Bowl."
LADWP regional championship teams have the best record at the
National Science Bowl compared to any other area or region in the
nation.
LADWP Science Bowl is one in a series of educational partnerships
sponsored by the Los Angeles Department of Water and Power that also
includes the Youth Service Academy, for "at-risk" students,
Adopt-A-Schools and the Teacher Workshops Series. Further information
about LADWP Education Programs can be received by logging into
www .com). The structure of a model can be altered on demand
according to user-specified conditions, and is easily modified to
accommodate new information and respond to queries.

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This year marks the fifth time that Venice High School is
competing in the National Science Bowl as the regional champion of the
Los Angeles Department of Water and Power (LADWP) Science Bowl. Two teams of four students
(each with an alternate team member) answer toss-up and bonus
questions asked by a moderator.

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The teams have won four national titles and placed in the top
five teams eight of the past 10 years . Pathway Logic(TM)
software, founded on the computational science of formal methods,
allows a rich set of logical operators to define relationships among
the components of complex biological systems.sri.

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The teams will compete in the prestigious event, in a field of 63
regional championship teams from 40 states, the District of Columbia
and the U.S.
"As a father of two children in Los Angeles public schools, I
believe that supporting our schools and educational opportunities for
our kids is crucial," said Los Angeles Mayor Jim Hahn.
For this project, SRI will apply Pathway Logic (TM) software, SRI's
approach to modeling biological entities and processes based on the
Maude computer language (http://maude.csl. The
nonprofit research institute performs contract research and
development for government agencies, commercial businesses and
nonprofit foundations.

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