The NFID wants
to reinforce the importance of influenza immunization among
persons age 65 and older, who are at
high risk for complications,
hospitalizations and death from influenza."
DNAPrint's DNAWITNESS
(TM) product for the law enforcement forensics market
is a presumptive (investigative) genetic test
, rather than confirmatory test
such as human ID tests.
strathclyde aneurysms
, The National Foundation for
Infectious
Diseases (NFID) is issuing the following statement in light of two
recent studies which have created
some confusion about the importance of
influenza immunization among the elderly (65+). But using
DNA
analysis for predictive purposes, to create a suspect pool (in contrast to its
current use
to rule in or rule out identity of an individual suspect), extends
the technology into a news sphere
with potentially serious ramifications.morphogenesis anisotropic
dnaprint.blower wiggli
Mark Shriver of Penn State University, Dr. Tony Frudakis
of DNAPrint
genomics and Dr."
Dr.
epidemic wiggli
anisotropic predictive
, in a letter to the editor published in
this week's
edition took exception to an opinion piece previously published in
the magazine.
The two ethicists
, in an addendum to the Company's published response,
stated, "We do not argue against the conduct
of good science. "For example, can anyone imagine an investigator not asking a
human eyewitness what
a suspect looked like because the concept of population
is complex and continuous? It is precisely
because physical appearance and
ancestry are complex and continuous that quantitative, objective
and
confidence-qualified science should be used to infer them.estimation hallam
It is important to note that
authors of both studies maintain that
immunization of high-risk populations, including the elderly
, remains an
important public health strategy.gradients aortic
The first study, conducted by the National Institute
of Allergy and
Infectious Diseases (NIAID) [Archives of Internal Medicine, February 14,
2005]
, looked at overall influenza immunization rates and mortality rates in
the 65+ population and concluded
that despite increases in influenza
immunization among this population, there was little change in
mortality
rates. This approach will also support pandemic planning."
Contact: Jennifer
Corrigan
732-382-8898
"
Dr. The difference between the two is that
while the
former is used to help an investigator prioritize leads and make decisions,
only the
latter can be used to incriminate a suspect in a crime by matching a
person with a crime scene sample
.estimation biomathematics
This ecological study only looked at overall trends and did not look
at whether the individuals
who died were vaccinated or whether they had
underlying conditions. Shriver of Penn State University
's Department of Anthropology,
DNAPrint has developed and implemented novel mathematical methods for
reconstructing these relationships.
212-888-4848
differentiation aortic
Cho of the Stanford University
Center for
Biomedical Ethics and Pamela Sankar of the University of Pennsylvania, Medical
Ethics
, took a position in their commentary that data from human "populations"
cannot and should not be
used in crime solving.biomechanics smoothing
DNAPrint Technology Debated in Nature Genetics Journal
"
A central debate
surrounding the application of genome-based technologies
for forensic science is whether the relationships
between individuals and
populations can be determined objectively, without imposing imperfect prior
assumptions. Shriver and Frudakis are scheduled
to release a textbook early in 2006 with Academic
Press Publishers detailing
the new science of "Molecular Photofitting. uses proprietary human genome
research methods to
develop genomic-based services and products.biomechanics sensitivity
Bruce Budowle, Senior Scientist
for the Federal Bureau of
Investigation (FBI) in Quantico, Va. Ethicists Mildred K. expressly disclaims
any obligation or
undertaking to release publicly any updates or revisions to any forward-
looking
statements contained herein to reflect any change in DNAPrint's
expectations with regard thereto
or any change in events, conditions or
circumstances on which any such statements are based.hallam strathclyde
"The overall body of scientific evidence about the vaccine efficacy and
the public health impact
of the disease supports current CDC recommendations,"
said William Schaffner, MD, NFID board member
and professor and chairman,
department of preventive medicine, Vanderbilt University School of Medicine
.Researchers in Mathematical Biology.
predictive aneurysms
SARASOTA, Fla.cinquino gradients
"In addition, we hope that in the coming months
, the immunization community
engages in vigorous discussion about how to implement immunization of
schoolchildren, based on sufficient availability of vaccine. In particular, they criticize
the
forensic use of data derived from human populations, the outdated method
of "racial classification
" or "binning," and the notion of inferring elements
of physical appearance from ancestry -- claiming
that the latter is tantamount
to "stereotyping. Both in house and through collaboration with experts
such as Dr. The Company's ANCESTRYbyDNA(TM)
is a consumer product for individuals interested in
learning their family
heritage.sensitivity differentiation
* Among elderly nursing home residents, influenza immunization
can be
50%-60% effective in preventing hospitalization or pneumonia and up to
80
% effective in preventing death from influenza. "We think it speaks
volumes that our technology is
so impactful and thought-provoking that people
feel compelled to write commentary about it in 'Nature
Genetics,'" he said.aneurysms estimation
They note that many previously published
observational studies suggest a higher
level of influenza vaccine
effectiveness against death in the elderly than indicated in the NIAID
paper. DNAWitness(TM) is a forensics market tool for analyzing DNA
evidence recovered at a crime
scene.com .sensitivity watton
The article proposes that future influenza prevention strategies add
schoolchildren
as a key target, which will reduce the spread of influenza to
those at high risk for complications
of the disease. The article concludes
that the best strategy for minimizing the number of influenza
-related deaths
and morbidity for interpandemic influenza is to concentrate vaccine in both
high
-risk and high-transmitting population groups (schoolchildren)
simultaneously.strathclyde inference
NFID Statement Regarding
Findings of Two Influenza Vaccination Studies on the Elderly and Schoolchildren
Current Centers
for Disease and Prevention (CDC)
recommendations are based on observational studies, which compare
vaccinated
people with those who choose not to be vaccinated, and are considered by many
experts
, including the Centers for Disease Control and Prevention, to be more
appropriate than ecological
studies for evaluating vaccine effectiveness.
The second study [American Journal of Epidemiology
, February 14, 2005]
notes that while influenza vaccination of the elderly has been shown to have
a
moderate, but important effect on mortality in that age group, as a nation, we
have largely
ignored one of the key vectors of influenza -- schoolchildren. Shriver, Frudakis and Budowle, in their
response, published under the
heading "Getting the Science and the Ethics Right in Forensic Genetics
,"
pointed out that population is and has always been a central concept in
biology, that advanced
statistical methods enable the characteristics of
populations to be clearly defined, that the current
state-of-the-art method in
measuring ancestry is admixture estimation, not binning or categorization
, and
that the inference of phenotype indirectly from a knowledge of ancestry
admixture can be
made through the use of systematic and rational approaches,
such as DNAPrint's objective and empirical
database-driven processes.
"It is quite common and healthy to have meaningful debates in such forums
regarding new technology such as ours. Drs.gurney strathclyde
"
Drs.
"DNA is considered authoritative
, and, therefore, with good reason, many
apply a double standard to DNA that is not applied to less
objective and
scientific sources," said Richard Gabriel, DNAPrint's Chief Executive Officer
and
President.
DNAPrint genomics, Inc.differentiation strathclyde
Dr."
About DNAPrint genomics, Inc. Such
statements are subject to risks and uncertainties
that could cause actual results to differ materially
from those projected,
including, but not limited to, uncertainties relating to technologies, product
development, manufacturing, market acceptance, cost and pricing of DNAPrint's
products, dependence
on collaborations and partners, regulatory approvals,
competition, intellectual property of others
, and patent protection and
litigation.biomathematics aneurysms
To date, observational studies on influenza immunization
have found the
following:
* When the match between the vaccine and circulating influenza
strains is
close, the vaccine is 30%-70% effective in preventing hospitalization
for pneumonia and influenza among elderly persons living outside
chronic care facilities
and those persons with chronic medical
conditions.morphogenesis estimation
National Foundation for Infectious Diseases
Reinforces the Importance of
Influenza Vaccination of Persons 65 and Older
BETHESDA, Md., DNAPrint genomics
(OTC Bulletin Board: DNAP) announced today that its technology
is reviewed and
debated in a series of letters to the editor in "Nature Genetics," one of the
world
's premier scientific journals. Frudakis, DNAPrint's Chief Scientific Officer, said after publication
of their letter that debate on the issue is welcome.
Forward-Looking Statements
All statements in this press release that are not historical are forward-
looking statements. DNAPrint
genomics, Inc.cinquino gurney
Shriver said, "To date, many forensics investigators can testify that
when empirical
database-driven methods are used to interpret genome-based
conclusions, and when interpretation is
made in a quantitative and confidence-
qualified manner, precise and reliable estimates for certain
phenotypes or
elements of physical appearance can be made from a knowledge of genome-
determined
ancestry admixture. DNAPrint is also developing products in
the pharmacogenomic market, including
OVANOME(TM), a genomic-based diagnostic
tool that matches ovarian cancer patients with the most suitable
form and dose
of chemotherapy, and STATINOME(TM), a test for the cardiac drug market to
determine
whether patients will be good or poor responders to statins, which
are effective in cholesterol reduction
. For more information about the
company, please visit http://www.biomathematics gurney
Many consider this to be an esoteric
debate, of interest mainly
to academic scholars.
Company Contact:
Richard Gabriel
President and CEO
941-366-3400
-or-
Ron Stabiner
The Wall
Street Group, Inc.watton aortic
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