"While there are
several screening tests available, far too many people are not getting
screened for what could be a curable disease."
Schroy's study was designed to compare patient perceptions of
stool-based DNA testing , FOBT and colonoscopy and elicit screening
preferences, following a patient's completion of all three tests. Detailed
information on EXACT Sciences and PreGen-Plus can be found on the
World Wide Web at www."
"Analog Bits is the market leader and world's largest supplier of
sophisticated clocking macro IP," said Alan Rogers, president of
Analog Bits.

Chaos theory, in mathematics and physics, deals with the behavior of certain nonlinear dynamical systems that (under certain conditions) exhibit the phenomenon known as chaos, most famously characterised by sensitivity to initial conditions.

disturbances parlance

com

Certain statements made in this press release that are not based
on historical information are express or implied forward-looking
statements relating to, among other things, EXACT Sciences'
expectations concerning, among other things, the Company's research
and development strategies and programs and their likely future
success, the development of new technologies to enhance the
sensitivity of its products in the detection of cancer, and the
effectiveness and market acceptance of its technologies ., a new analog/RF electronic design
automation company, today announced its initial product, PLL Noise
Analyzer(TM), the industry's first noise analysis tool for
high-performance analog/RF integrated circuits containing phase-locked
loops (PLLs).

deterministic metalink

"Meeting phase noise
and jitter targets is a significant design challenge."
Until now, designers were forced to use manually created models,
linear approximations , and multiple silicon revisions to deliver
working designs. Berkeley Design Automation is a venture -backed, private company
funded by Woodside Fund and Bessemer Venture Partners.

nontechnical mathematic

"Too many people are dying needlessly from this disease. PLL Noise
Analyzer has been adopted by leading semiconductor and analog IP
companies.
The new product is based on the company's proprietary Stochastic
Nonlinear Engine(TM), which allows fast and accurate analysis of the
nonlinear, time-varying behavior of full PLL circuits at the
transistor-level.com

PLL Noise Analyzer and Stochastic Nonlinear Engine are trademarks
of Berkeley Design Automation Inc.

feigenbaum attractors

"It is important that people have options for colorectal cancer
screening," said Dr."

About EXACT Sciences Corporation

EXACT Sciences Corporation is a leader in rapidly applying
genomics knowledge to develop effective, patient-friendly screening
methods to detect cancer early, to assist physicians in saving
patients' lives. EXACT Sciences believes its
genomics-based technologies will enable early detection of colorectal
cancer so that more people can be effectively treated. We have
used PLL Noise Analyzer on our 90nm SERDES and found the tool to be
fast, accurate and easy to use.
PLL Noise Analyzer is available in production immediately for Sun
and Linux operating systems.berkeley-da.

lindenmayer chaos

In addition, more than ninety percent of these people found
PreGen-Plus easy/very easy to use, and the same percentage would be
likely /highly likely to use it again. PLL Noise Analyzer provides complete phase noise and
jitter analysis for noise caused by all sources -- random and
deterministic sources that are inherent or external to the analog
circuits.

chua fractals

----EXACT Sciences
Corporation (NASDAQ: EXAS) announced today that the American Journal
of Preventive Medicine has published the results of a patient
preference study , which found that patients perceived stool-based DNA
testing to have many advantages over both fecal occult blood testing
(FOBT) and colonoscopy, and preferred stool-based DNA testing for
their routine colorectal cancer screening. This study was conducted in
conjunction with EXACT Sciences' multi-center study of its stool-based
DNA test, PreGen-Plus(TM), which showed a four-fold sensitivity
advantage versus Hemoccult II, the most widely prescribed FOBT on the
market today, as published in the December 23, 2004 issue of the New
England Journal of Medicine.

Business Editors/High-Tech Writers

SANTA CLARA, Calif.

metalink lyapunov

Patient preference for stool-based DNA testing is also evident in
post -market data for PreGen-Plus, the commercially available version
of the stool-based DNA test, which indicates that more than half of
the people surveyed who have used PreGen-Plus had never been screened
before. was founded in 2003 to address the
verification needs of high-performance analog/RF integrated circuits
(ICs).

theoreticians chua

"PLL Noise Analyzer is the only tool today that provides accurate
noise analysis and has been proven to reduce respins. For more information, see
www.

iterative famously

Stool-based DNA testing
is a novel screening option that offers a convenient, non-invasive and
potentially more acceptable alternative to existing screening tests
for an average-risk patient population. Any test that increases the
number of people who get screened effectively for colorectal cancer is
a test that should be made available to patients as a standard of
care. Overall, the study showed, with a high degree of
statistical significance, that a higher percentage of patients
preferred stool-based DNA testing (45%) to both FOBT (32%) and to
colonoscopy (15%) for routine screening. We are pleased
it has been adopted by leading semiconductor companies and analog IP
providers in their verification flow, enabling them to confidently
make performance, power, area, noise trade-offs."
The Stochastic Nonlinear Engine in PLL Noise Analyzer is the only
technology that provides designers detailed insight into the sources
of noise in a circuit and identifies the circuit's sensitivity to the
noise caused by each device in the design.

lindenmayer theoreticians

"The patient preference data compiled by Dr.

PLL Noise Analyzer eliminates the need for this
time-consuming methodology and enables designers to confidently
optimize performance , area, and power consumption while meeting noise
specifications.

Systems that exhibit mathematical chaos are deterministic and thus orderly in some sense; this technical use of the word chaos is at odds with common parlance, which suggests complete disorder.

metalink lindenmayer

Despite widespread
support for regular screening , however, the majority of Americans over
the age of 50 have never been screened by any method, allowing the
high mortality associated with this disease to persist. Existing and prospective investors are cautioned not to place
undue reliance on these forward-looking statements, which speak only
as of the date hereof. EXACT Sciences undertakes no obligation to
update or revise the information contained in this press release,
whether as a result of new information, future events or circumstances
or otherwise.

randomness lindenmayer

Paul C. Previous
studies have identified a number of practical reasons for this low
adherence rate, including negative attitudes towards FOBT and invasive
tests such as colonoscopy."
PLL Noise Analyzer fits easily into existing analog/RF
verification flows. The company's
technology characterizes the nonlinear, time-varying behavior of
complex analog and RF circuits, providing extremely accurate
predictions that dramatically reduce the need for silicon respins.

chua chaos

American Journal of Preventive Medicine Reports Stool-Based DNA Testing Patient-Preferred over FOBT and Colonoscopy for Colorectal Cancer Screening

The
study included more than 4,000 patients, making it one of the largest
studies ever done comparing patient attitudes about colorectal cancer
screening tests. The
prospective study data have been confirmed by our commercial
experience with PreGen-Plus, which suggests that , when provided with
an option that they prefer, people will in fact get screened for
colorectal cancer - and getting screened saves lives. These
statements are neither promises nor guarantees, but are subject to a
variety of risks and uncertainties, many of which are beyond EXACT
Sciences ' control, and which could cause actual results to differ
materially from those contemplated in these forward-looking
statements.----

Customer-Validated Stochastic Nonlinear Technology Delivers Fast and
Accurate Noise Prediction That Reduces Silicon Respins

Berkeley Design Automation Inc. The tool produces accurate
results and is much faster and more reliable than our previous noise
analysis methodology.

nontechnical attractors

Colorectal cancer is the second leading cause of cancer-related
death among men and women in the United States.
"Today's microprocessor-based silicon solutions require
leading-edge analog circuits for the core and I/O," said Vincent von
Kaenel, director of analog design at P. Spectre is a registered trademark of Cadence Design
Systems Inc.

disturbances proceeding

These data were presented in
abstract form at the most recent annual meeting of the North American
Menopause Society.S.

"Meeting stringent PLL noise and jitter specifications is critical to
the success of these designs .

fractals orbits

In particular, the risks and uncertainties include, among
other things, the ability of EXACT Sciences to become profitable; the
ability to convince medical practitioners to order tests using EXACT
Sciences ' technologies; the ability to increase the performance of the
PreGen-Plus test; the inclusion of PreGen-Plus in cancer screening
guidelines; the number of people who decide to be screened for
colorectal cancer using EXACT Sciences' technologies; the ability to
comply with federal and state statutes and regulations relating to
EXACT Sciences' products and services, including FDA requirements, the
U.25 micron to below 90nm from
the world's leading integrated device manufacturers and foundries ,
including Taiwan Semiconductor Manufacturing Corporation (TSMC), the
world's largest dedicated semiconductor foundry.
"We were an early adopter of Berkeley Design's technology," said
Bill Walker , vice president of Advanced LSI Technology Research at
Fujitsu Laboratories. With this tool, we can
confidently make performance, noise, area, and power trade-offs during
design.

exponents feigenbaum

Schroy III, MD , MPH, Boston University
School of Medicine, lead investigator of the study.
Colorectal cancer , which is the most deadly cancer among non-smokers,
is curable if detected early. "We use PLL Noise Analyzer to analyze jitter in
clock and data recovery (CDR) circuits. "We are pleased to use BDA 's PLL Noise Analyzer,
providing high speed and accuracy for PLL noise analysis, and enabling
a high-quality design methodology.A.

disturbances appliations

Founded in
1995, EXACT Sciences is based in Marlborough, Mass .

Berkeley Design Automation Announces the Industry's First PLL Noise Analysis Tool for High-Performance Analog/RF ICs

chaotic metalink

Business Editors/Health/Medical Writers

MARLBOROUGH, Mass. Our engineers , who are fluent in HSPICE, were
able to master PLL Noise Analyzer in a matter of minutes.

chua exponents

Despite the availability of colorectal
cancer screening and diagnostic tests for more than 20 years, the rate
of early detection of colorectal cancer remains low, and deaths from
colorectal cancer remain high. PLL Noise
Analyzer is an innovative tool that enables us to accurately analyze
the noise of a full, transistor-level PLL before tape-out. PLL Noise Analyzer reads HSPICE and Spectre format
netlists and standard device models.

chaos mathematic

chaos iterative

Department of Transportation and the Clinical Laboratory
Improvement Amendments; and the possibility that other companies will
develop and market novel or improved methods for detecting colorectal
cancer. PLL Noise Analyzer is proven to dramatically reduce the
need for silicon respins due to noise, enabling circuit designers to
reliably meet cost, performance, and schedule goals.
"Lack of accurate noise prediction is one of the leading causes of
respins and product delays for analog/RF integrated circuits," said
Ravi Subramanian, president and CEO of Berkeley Design Automation.

nonlinear orbits

Schroy provide more
evidence for the important role that stool -based DNA testing can have
in the armamentarium of tools available to detect, and fight,
colorectal cancer," stated Don Hardison, EXACT Sciences' President and
CEO.pregenplus.
"We design a wide variety of high-performance I/Os at speeds up to
and beyond 10Gbits per second," said Kunio Mori , general manager of
the Server System Division at NEC Corporation. PLL Noise Analyzer is the only tool that
can accurately analyze the noise of a full PLL.

About Berkeley Design Automation

Berkeley Design Automation Inc. The
company's first product, PLL Noise Analyzer(TM), the industry 's first
noise analysis tool for phase-locked loops (PLLs), has already been
adopted by semiconductor industry leaders.

nontechnical chaotic

Its first commercial test, PreGen-Plus(TM), is used
for screening colorectal cancer in the average-risk population. For additional disclosure regarding these and other
risks faced by EXACT Sciences, see the disclosure contained in EXACT
Sciences' public filings with the Securities and Exchange Commission
including, without limitation, its most recent Annual Report on Form
10 -K and subsequent SEC filings."
PLL Noise Analyzer is a complete solution for noise and jitter
analysis in analog integrated circuits and provides:

Fast and accurate phase noise and jitter analysis of full PLLs

Quick identification of top circuit noise contributors

Thorough analysis of circuit noise sensitivity

Easy integration with existing analog verification flows

These benefits have been demonstrated on more than 35 customer
designs in silicon technologies from 0. Semi , a fabless
microprocessor startup developing world-class, high performance,
low-power, SOC solutions for the embedded and computing markets. HSPICE is a registered trademark of
Synopsys Inc.