com/reports/c16054 ) has announced the addition
of The Journal of Computational Finance to their offering.

The Journal of Computational Finance features:

- Numerical solutions of pricing equations - finite differences, finite
elements and spectral techniques in one and multiple dimensions.mscsoftware.

hypergraph variational

Pharsight's
computer -based drug-disease models, dynamic predictive market models, clinical
trial simulation and advanced valuation models create a continuously evolving
view of its customers' development efforts and product portfolios.

Pharsight, WinNonlin and WinNonMix, Pharsight Knowledgebase Server, PKS,
Drug Model Explorer, DMX, PKS Reporter and Trial Simulator are registered
trademarks or trademarks of Pharsight Corporation.
All other brand and product names are trademarks or registered trademarks
of their respective holders. Further information on
potential factors that could affect actual results is included in Pharsight's
Quarterly Report on Form 10-Q, as filed with the Securities and Exchange
Commission on February 14, 2005.

MSC.Software (OTC: MNSC) is the leading global provider of virtual product
development solutions, including simulation software and services, that helps
companies make money, save time and reduce costs associated with designing and
testing manufactured products.

fourier constrained

- Simulation approaches and optimisation techniques in hedging, pricing
and risk management.pharsight. We look forward to continuing to deliver significant
enhancements that will improve our customers' product development processes. MSC.

* Enhancements to speed up contact analyses involving a large number of
multi-point constraint equations (deformable contact) and/or kinematic
constraint equations (rigid contact) with a reduction of up to 70% in
CPU time.Software employs
more than 1400 people in 23 countries.

hypergraph netlib

(Lpgo: http://www.0 offers a new multi-transformation tool that allows users to
produce new workbooks utilizing both transformed and untransformed data. "As an organization, we pride ourselves
on our ability to quickly respond to our customers' emerging needs and the
evolution of the marketplace.0 also offers the ability to filter records to
produce a subset of original data, as well as functionality that allows
the user to transform columns using free-form equations.Marc 2005 r2 has a number of significant
enhancements and improvements in capacity and performance aimed at better
enabling customers to perform real-world analyses.com.

eigenvalue numerical

We believe this release, as well as our recent
PKS 3.
Pharsight's range of software offerings includes the Drug Model Explorer(TM)
Web Server (DMX (TM)), Pharsight Knowledgebase Server(TM) (PKS(TM)), PKS
Reporter(TM), Trial Simulator(TM), and WinNonlin (R) and WinNonMix(R) modeling
tools.Marc has, since 1971, continually delivered innovative and easy -to-use
solutions that address the need for simulating static and dynamic structural,
thermal, and other coupled physics problems.

solvers variational

researchandmarkets.

Pharsight Significantly Increases Functionality of Industry-Leading Pk/Pd Modeling Software

The application is used by researchers and developers to
perform most of the analyses, and generate all data needed for PK and PK/PD
studies. With the significant enhancements we
have introduced with WinNonlin 5. New Release Highlighted by Improved Robustness and Boost in Performance
for Nonlinear Modeling and Analysis of Real-Life Models

SANTA ANA, Calif. MSC.
"This release demonstrates our sustained commitment to being a customer
and market driven solutions provider devoted to open standards," said Reza
Sadeghi , vice president, solvers development, MSC.Software.

Numerical analysis techniques include finite difference analysis, finite element analysis, fast Fourier transforms, and related.

newmat addix

researchandmarkets.Marc's ability to efficiently simulate
real-life scenarios by accommodating up to a 300% increase in the
degrees of freedom (DOF) specified for FEA models running on all
supported platforms .

daes solvers

com/cgi-bin/prnh/20040820/RESEARCH )
The main focus of this quarterly refereed journal is on the advances in
numerical and computational techniques in pricing, hedging and risk management
of financial instruments. WinNonlin provides major enhancements
to modeling capabilities and data transformations and is now more fully
integrated with leading data analysis and graphing software products including
S-PLUS(R) and SigmaPlot.0 can pass data to
Sigma Plot or S-PLUS, can return output to WinNonlin , and can quickly
reproduce S-PLUS and SigmaPlot runs and return S-PLUS analyses, scripts
and results into PKS.

* Numerous quality enhancements for existing features that better enable
customers to perform real-world analyses.mscsoftware.

nystrom statically

0 release, are clear evidence of our ability to achieve this goal.Software's customer and market driven strategy to deliver product
enhancements in-line with industry demands that improve customers' product
development processes .

* New capability to handle beam and shell offsets, which eases geometric
modeling by allowing beams and shells to be conveniently specified at
a geometric location other than the actual physical location.Software's products and services, please visit http://www.

solvers statically

0 Streamlines Data Integration and Enhances Pharmacodynamic
Modeling Capabilities

MOUNTAIN VIEW, Calif. It
is also more fully integrated with S-PLUS(R) and SigmaPlot, two leading
analysis and graphing software products as well as PKS 3.
"WinNonlin 5."
Key new features and functionality of WinNonlin 5.com.

Safe Harbor
This press release includes forward-looking statements, including
statements regarding the expanding market for Pharsight 's technology, future
growth and long-term trends in customer demand for Pharsight's software
products , services and technology, Pharsight's anticipated software product
development and performance, and the expected benefits to customers from the
use of Pharsight's products.

fourier transforms

-- Enhanced Data Transformations: WinNonlin's new multi-transformation
tool simultaneously transforms data from multiple columns, producing a
new workbook with any combination of transformed and untransformed
data. Information about Pharsight is available on the World
Wide Web at http://www. The development of automated and high-performance
features built upon the open architecture of MSC. MSC.

hypergraph sleign2

newscom.

MSC.Software Releases MSC.Marc 2005 r2

octave solvers

Examples of articles appearing in past issues of The Journal of
Computational Finance:

- Valuing Moving Barrier Options
- A technique for calibrating derivative security pricing models:
numerical solution of an inverse problem
- Valuation of mortgage backed securities using Brownian bridges to reduce
effective dimension
- The equity option volatility smile: an implicit finite-difference
approach
- Robust numerical methods for PDE models of Asian options
- Accelerating Monte Carlo quasirandom sequences and variance reduction
- Using progam sythesis to price derivatives
- A parity result for American options
- The Passport option
- Pricing of interest rate contingent claims: implementing a simulation
approach
- Double barrier options: valuation by path counting
- A series expansion for the bivariate normal integral
- Accurate approximations for European -style Asian options
- The pricing of floating rate instruments
- The pricing of multi -asset options using a Fourier grid method
- The pricing of discretely sampled Asian and lookback options: A change
of numeraire approach
- Option pricing and linear complimentarity
- LP Valuation of exotic American options exploiting structure
- Approximating American options and other financial contracts using
barrier derivatives
- Computation of deterministic volatility surfaces
- A non-Gaussian stochastic volatility model
- Pricing continuous Asian options: a comparison of Monte Carlo and
Laplace transform inversion methods
- The Brownian bridge E-M algorithm for covariance estimation with missing
data

For more information visit
http: //www.com/reports/c16054

Laura Wood
Senior Manager
Research and Markets
press@researchandmarkets.0, we believe we have achieved this goal and
are providing significant value to our customers.
-- Residual Normality Test: WinNonlin now includes a Komogorov-Smirnov
normality test, for use in testing residual normality in Linear Mixed
Effects and Bioequivalnce analyses. All forward-looking statements are based on
information available to Pharsight as of the date hereof, and Pharsight
assumes no obligation to update such statements, whether as a result of new
developments or otherwise."

Recognized as the world's first commercial nonlinear FEA software,
MSC.

solvers constrained

0 was created to support newly defined needs of our
pharmaceutical development customers," said Shawn M. As
the market leader for PK/PD analysis software, we are committed to remaining
on the forefront of development and introducing novel technology to our
clients aimed at reducing costs and allowing our customers to focus on their
core competencies -- drug development . Related software services include pharmacokinetic automation services
and training courses.Software SimOffice
product line and is an advanced, general-purpose nonlinear finite element
analysis (FEA) product for simulating a wide range of engineering applications
and manufacturing processes . This new release continues
MSC.

solvers helmholtz

0(TM) (PKS(TM)), the industry's leading clinical
pharmacology data repository. Actual results may differ materially from
Pharsight's expectations due to a variety of factors including: general
market and business conditions; uncertainties in pharmaceutical drug
development; changes in demand for Pharsight's products and services; changes
in Pharsight research and development focus or operating strategies; the
failure to develop new products and services or to keep pace with
technological changes; delays in the release of new products and services; and
the failure of products and services to obtain anticipated levels of customer
acceptance or to meet customers' expectations.
(OTC: MNSC), the leading global provider of virtual product development (VPD)
solutions including simulation software and services today announced the
release of MSC .Marc is part of the MSC.Marc enables us to offer
versatile solutions that help users minimize design risk and maximize their
productivity.

statically numerical

As an individual subscriber you will additionally, during the period of
your subscription, have online access to the full text of every article ever
published in the history of the journal.Marc 2005 r2 is currently being distributed worldwide.

constrained variational

Research and Markets: Get the Latest Information on Advances in Numerical and Computational Techniques in Pricing Hedging and Risk Management of Financial Ins

com
Fax: +353 1 4100 980

WinNonlin(R) 5. In addition,
WinNonlin 5. Some of these enhancements
include:

* Substantial improvements in MSC.Marc, please visit http://marc.

fourier conjugate

0 include:

-- Noncompartmental Analysis for Drug Effect Data: WinNonlin's analysis
engine now supports analysis of PD data, including calculation of
selected slopes and areas
-- Noncompartmental Analysis for Sparse Data: WinNonlin now computes the
mean concentration curve, as well as the area under the curve and its
standard error, for sparsely-sampled drug concentration data such as
that which is collected in toxicokinetic studies.Marc's effectiveness in performing advanced modeling to simulate
real-world behavior.

eigenvalue sleign2

In addition, WinNonlin is also fully integrated into
Pharsight's industry-leading PK/PD data management application, Pharsight(R)
Knowledgbase Server 3.
WinNonlin is the industry standard analysis tool for pharmacokinetic (PK)
and pharmacodynamic (PD) modeling and Noncompartmental Analysis, used by over
1,000 pharmaceutical and biotech organizations, as well as academic
institutions . By increasing the functionality of
WinNonlin, Pharsight has created a valuable research and development tool that
allows scientists to reduce the time needed for data management and analysis
of clinical pharmacology studies as well as increase the resources available
for drug development activities .
-- Integration with S-PLUS and SigmaPlot: WinNonlin 5., MSC.Software Corp.Marc 2005 r2. For more
information on MSC.com.

ocde octave

, Pharsight
Corporation (OTC Bulletin Board: PHST), a leading provider of software and
strategic services designed to optimize clinical drug development, today
announced the release of WinNonlin 5.0 has additional functionality to perform
Noncompartmental Analyses for drug effect or PD data, as well as provide NCA
analysis of sparsely-sampled data, such as toxicokinetic data.

About MSC. MSC. For additional information about
MSC.

transforms spline

- Fundamental numerical analysis and developments in free-boundary
problems in finance

As the only publication devoted exclusively to applied computational
research, The Journal of Computational Finance provides unique access to the
latest thinking from the best minds in this rapidly evolving field, making it
essential reading for anyone with an interest in this area. WinNonlin 5. By integrating scientific , clinical and business decision
criteria into a dynamic, model-based methodology, Pharsight helps its
customers optimize the value of their drug development programs and portfolios
from discovery to post-launch marketing and any point in between.

fourier sleign2

DUBLIN, Ireland, Research and Markets
(http: //www. "We continue
improving MSC.

pde numerical

0, increasing the
seamless usage and analysis of study data . O'Connor, President and
Chief Executive Officer of Pharsight. WinNonlin 5.
-- PKS Enhancements: WinNonlin offers improved performance and an
enriched feature set in a variety of PKS operations

About Pharsight Corporation
Pharsight Corporation is a leading provider of software products and
consulting services that help pharmaceutical and biopharmaceutical companies
improve and accelerate their decision-making in drug development and
commercialization.

The optimization in memory utilization will
enable customers to solve larger, more complex problems with greater
precision.Software works with thousands of companies
in hundreds of industries to develop better products faster by utilizing
information technology, software, services and systems .

solvers octave

Software Corporation
MSC.