"
As part of the agreement, Stratagene has joined the community of
Affymetrix partners developing methods for next-generation gene
expression microarrays.

Premier Research Appoints Anthony Orlando and Bruce C. Stouch to New Senior Management Positions

The
company also has offices in the United Kingdom, Germany and India and is
enhanced by a network of resellers and distributors in more than 30 countries
worldwide.

About Cytel Software Corporation
Cytel Software Corporation has a 18-year track record as the premier
provider of software and services for the design and analysis of clinical
trials.

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In its first release, ArrayAssist Lite will
support RMA, GC-RMA , MAS5, and also PLIER, a new advanced signal
estimator developed by Affymetrix statisticians. Actual results could differ materially from those
projected in or contemplated by the forward-looking statements . in
Biostatistics and Epidemiology from Jefferson Medical College in 1997 through
a program sponsored by Johnson + Johnson, and trained in post-graduate studies
from Temple University, Jefferson Medical College, and Harvard School of
Public Health. StatXact
provides at least one solution for every important nonparametric statistical
problem involving binary, categorical or continuous data.systat .

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"Affymetrix' tiling arrays are revolutionizing
functional analysis," said Dr., and Bedford, Mass . The Company's diagnostic operating unit develops and
manufactures products for urinalysis, and high quality automated
instrument and reagent systems that use blood samples to test for more
than 1,000 different allergies and autoimmune disorders. Stouch Ph. He will be responsible for US data management ,
programming and biostatistics for Premier Research.
Dr.

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In addition,
by combining its expertise in diagnostics and molecular biology, as
well as its experience with FDA regulatory procedures , the Company is
pursuing opportunities to expand its product portfolio to include
molecular diagnostics kits and instrumentation. These forward-looking statements are based on
current expectations, forecasts and assumptions that involve risks and
uncertainties. Stouch has
over 15 years of biostatistics experience in pharmaceuticals.
SYSTAT is a high value, integrated desktop statistics and graphics
software package for Scientists, Researchers and Statisticians, enabling
customers to analyze their data, make meaningful discoveries, and present
their results very efficiently. Cytel Software is a
privately owned company, headquartered in Cambridge, Massachusetts, and with
software development operations in Pune, India.

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In
addition, we're very excited to join Affymetrix' consortium of
developers in an effort to bring to market breakthrough gene
expression microarray technology. Dr. Cytel's
StatXact software was first developed in 1989, it has since evolved to become
the most comprehensive software package for conducting exact statistical tests
with over 10,000 customers worldwide.

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The
Company's life science research supports advances in science by
inventing, manufacturing and distributing products that simplify,
accelerate and improve research. Stratagene generally identifies
forward -looking statements by using words like "believe," "intend,"
"target," "expect," "estimate," "plan ," "anticipate," "predict" or
similar expressions.

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+ LA JOLLA, Calif."

About Affymetrix:

Affymetrix scientists invented the world's first high-density
microarray in 1989 and began selling the first commercial microarray
in 1994.
For 12 years, Dr. He holds
an academic appointment at the Philadelphia College of Medicine as Director,
Biostatistics and Clinical Epidemiology.D. We also believe
that Tony and Bruce place our company at the forefront of trial design,
monitoring and analysis methods worldwide. For more information, visit http://www.

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"We've placed these capabilities in a software tool designed
for life scientists, and the result will be better quality data to
accelerate biological discovery and validation. By partnering with other thought
leaders in our field, we believe we have the opportunity to position
our technology as a standard for expression analysis. The
company maintains important sales and marketing operations in Europe
and Asia and has about 900 employees worldwide.

About Stratagene Corporation:

Stratagene is a developer, marketer and manufacturer of
specialized life science research and diagnostic products. Cytel's East(R) software is used by every division of the FDA and
by hundreds of biostatisticians and clinicians in industry and academia to
design, simulate and monitor group sequential and adaptive flexible clinical
trials.com

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These and other risk factors are discussed in Affymetrix' Form 10-K
for the year ended December 31, 2003 and other SEC reports, including
its Quarterly Reports on Form 10-Q for subsequent quarterly periods. has taken the international position of
Chief Scientific Officer for the company . Dr. We
have enhanced SYSTAT's architecture to integrate best of breed features of
other products to address newer segments. We look forward to working with
Cytel software and developing newer and better products to address the needs
of the scientific and engineering community," added Mueed Khader , Director,
Systat Software, Inc. For more information visit
http://www.cytel.

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Joseph A. Sorge , Chairman and CEO of
Stratagene.

All statements in this press release that are not historical are
"forward-looking statements" within the meaning of Section 21E of the
Securities Exchange Act of 1934, as amended, including statements
regarding Affymetrix' "expectations," "beliefs," "hopes ,"
"intentions," "strategies" or the like. Among
the important factors that could cause actual results to differ
materially from those contained in or implied by the forward-looking
statements are risks associated with the absence of a public market
for the Stratagene common stock prior to the Hycor merger transaction,
the failure of the company to manage the cost of integrating
Stratagene and Hycor, the company's inability to sufficiently
anticipate market needs and develop products and product enhancements
that achieve market acceptance, the company's ability to compete
effectively in the diagnostics and life sciences research markets,
variability of the company's quarterly revenues and operating results,
the failure of the company to retain key employees, the company's
ability to obtain additional debt or equity financing, the possibility
of declining sales due in part to a reduction in research and
development budgets or government funding, and the company's ongoing
ability to protect its own intellectual property rights and to avoid
violating the intellectual property rights of third parties.

NOTE: Stratagene, the Stratagene logo, and ArrayAssist are
trademarks owned or used by Stratagene.
"This joint development effort to create interoperability between SYSTAT
and the licensed StatXact components adds yet another milestone for Systat. It covers every mainstream non-parametric
procedure, using a user-friendly GUI interface under Windows.com .

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Affymetrix customers
will also be given the option of upgrading to Stratagene's ArrayAssist
software , which provides advanced downstream analysis capabilities
such as gene clustering, pattern detection , and interactive
visualizations.
"ArrayAssist Lite software will provide highly accurate, precise
and sensitive methods needed to support expression research," said
Jason Goncalves, General Manager of Stratagene's software solutions
business. Such statements are subject to
risks and uncertainties that could cause actual results to differ
materially for Affymetrix from those projected, including , but not
limited to risks of the Company's ability to achieve and sustain
higher levels of revenue , higher gross margins, reduced operating
expenses, uncertainties relating to technological approaches ,
manufacturing, product development personnel retention, uncertainties
related to cost and pricing of Affymetrix products, dependence on
collaborative partners, uncertainties relating to sole source
suppliers, uncertainties relating to FDA and other regulatory
approvals, competition, risks relating to intellectual property of
others and the uncertainties of patent protection and litigation.D.

Systat Software and Cytel Software Form Strategic Alliance

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As part of this
agreement, Stratagene will develop a new software package for
Affymetrix, ArrayAssist(R) Lite, which will be offered as a standard
statistical analysis solution of Affymetrix gene expression
microarrays.

This communication contains "forward-looking statements" within
the meaning of Section 27A of the Securities Act of 1933 and Section
21E of the Securities Exchange Act of 1934.
Dr.
Orlando holds a Ph.

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"We believe that our technology will provide key
functionality needed to support important genomic studies . Such forward-looking
statements are therefore entitled to the protection of the safe harbor
provisions of these laws. 333-109420) relating to the Hycor merger transaction
and in other reports filed by Stratagene from time to time with the
Securities and Exchange Commission, including quarterly reports on
Form 10-Q and annual reports on Form 10-K.

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Since then, Affymetrix GeneChip(R) technology has become the
industry standard in molecular biology research. Affymetrix is headquartered in Santa Clara, Calif."

About Premier Research
Premier Research Group plc is a contract research organization focused on
the design, management and reporting of all phases of clinical trials on
behalf of pharmaceutical and biotechnology companies.

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"The combination of our
GeneChip platform and the ArrayAssist software makes the
industry-leading methods for measuring gene expression on a
genomic-scale available to an ever broadening community of life
scientists. For more
information about these and other factors that could cause actual
results to differ materially from those contained in or implied by the
forward-looking statements please refer to the "risk factors"
contained in Stratagene's Form S-4 Registration Statement
(Registration No. to senior management positions in
Premier Research . Orlando's position, Premier Research also is pleased to
announce that Bruce C. This partnership will broaden our
customer base and bring the benefit of this computing power to the greater
scientific community," said Xiao-Wei Zhu, Vice President of Cytel Software
Corporation. With over 65,000 users globally, SYSTAT has
become a global success.com.

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Affymetrix and Stratagene Announce Strategic Software Alliance

In April 2005, Affymetrix will make ArrayAssist Lite available to
its existing GeneChip customers via the Internet and will also begin
pre-installing the software on new GeneChip workstation desktops.D. Orlando brings an exceptional background in Biostatistics and Data
Management over the past thirty years including key roles in pharmaceutical
companies, the National Center for Toxicological Research/FDA and at major
contract research organizations.

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, with
manufacturing facilities in Sacramento, Calif.

NOTE: Affymetrix, the Affymetrix logo, and GeneChip are registered
trademarks owned or used by Affymetrix, Inc. These products are used throughout
the academic, industrial and government research sectors in fields
spanning molecular biology, genomics, proteomics, drug discovery and
toxicology.D. Stouch has
been involved in over two dozen publications and acknowledgements . Stouch received his Ph.

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Through an easy-to-use interface and tightly integrated workflow,
ArrayAssist Lite will enable the application of industry-leading
statistical algorithms and generation of standard Affymetrix-format
data files and reports.
Dr. He will also establish and expand the company's
new initiative into Bayesian monitoring and analysis methods., Systat
Software, Inc.

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Stouch's new role, he will
lead the company's efforts supporting expert FDA/statistical clinical design
and analysis capabilities.
Systat Software, Inc. Cytel Software's Pharma Division provides software , training and
consulting to clinical trial sponsors seeking to run their trials more
efficiently .

Contact:
Sean McIntosh
Director of Marketing
Cytel Software Corporation
1-617-661-2011
sean@cytel.

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Affymetrix technology
is used by the world's top pharmaceutical , diagnostic and
biotechnology companies as well as leading academic, government and
not-for-profit research institutes. Stouch, Ph., and RICHMOND, Calif. ("Systat"), a leading provider of specialized scientific
software products and services, today announced a strategic partnership with
Cytel Software Corporation ("Cytel"), a leading provider of statistical
software and services for optimized clinical trial design and analysis.
"We are very excited about this alliance with Systat Software .

About Systat Software, Inc.

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----Affymetrix (Nasdaq:AFFX) and Stratagene (Nasdaq:STGN) announced
today that they have entered into a non-exclusive strategic alliance
under which Stratagene will provide Affymetrix customers with new
software solutions for GeneChip(R) data analysis.
Affymetrix expressly disclaims any obligation or undertaking to
release publicly any updates or revisions to any forward-looking
statements contained herein to reflect any change in Affymetrix'
expectations with regard thereto or any change in events, conditions,
or circumstances on which any such statements are based.D. Stouch held the position of Director of Biostatistics
and Scientific Data Management at Johnson + Johnson in Exton, PA, where he was
responsible for strategic development and implementation of pharmacoeconomic
models of emerging technologies in several therapeutic areas. Dr. More than 10,000 customers also use Cytel's award-winning StatXact and
LogXact(R) software for exact statistical inference.

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Affymetrix' patented
photolithographic manufacturing process provides the most information
capacity available today on an array, enabling researchers to use a
whole-genome approach to analyzing the relationship between genetics
and health.

in Biometry from Yale University, has co -authored many
papers in his area of expertise and has supported several drug NDAs for a
variety of indications.
In addition to Dr., headquartered in Point Richmond, California, is a
leading developer and supplier of award-winning scientific software and
services to the world's top companies , research centers and universities.
The family of Systat products include SYSTAT, a comprehensive statistical
analysis package, SigmaPlot(R), technical graphing and presentation software,
SigmaStat (R), step-by-step guided statistical analysis, PeakFit, automated
peak separation + analysis software , SigmaScan(R), powerful image analysis
software, TableCurve 2D(R) and TableCurve 3D(R), automated curve and surface
fitting software.

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Business Editors/High-Tech Writers/Health/Medical Writers

SANTA CLARA, Calif. and Bruce C. has joined the US Operations of Premier
Research Group plc in the new position of Executive Director, Data Operations. Simon Yaxley, CEO of Premier Research Group plc, commented: "We are
proud and pleased to announce the significant strengthening of our data
management and statistics capabilities in the US Operations.
Systat will license components of Cytel's award -winning StatXact software
to create a new module for SYSTAT specializing in exact statistical tests . The
integrated module will be marketed under the SYSTAT brand and distributed by
Systat in 2006 .
StatXact is a package for exact non-parametric statistical inference on
continuous or categorical data.

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"
"We are very pleased to announce this expansion of our
longstanding relationship with Stratagene ," said Steve Lincoln,
Vice-President of Informatics at Affymetrix. He most recently joined the company from his
position as Vice President, Biostatistics at SFBC New Drug Services. In Dr. The Company specializes
in oncology, central nervous system, paediatrics and anti-infectives. To Undertake Joint Development Efforts to Create
Interoperability Between Systat(R) and StatXact(R)

CAMBRIDGE, Mass.

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More than 1,200 systems have been
shipped around the world and nearly 3,000 peer-reviewed papers have
been published using the technology. PHILADELPHIA, Premier Research Group plc
(AIM: PRG) ("Premier Research," "Company" or "Group"), the international
pharmaceutical services group today announces the appointment of -- Anthony
Orlando, Ph.D. Anthony Orlando, Ph. Dr.

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---

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