ingenuity., vice president
of Technology and Business Development for the Fisher Biosciences Group.

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Now for the first
time, scientists will be able to conduct unbiased high-throughput, genome-wide
gene-silencing studies in human cell lines.

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J.com, email:
info@nymox . There
can be no assurance that such statements will prove to be accurate and
the actual results and future events could differ materially from
management's current expectations.
Developed using Dharmacon's proprietary SMARTselection(TM) and
SMARTpool(R) technologies, it is designed to dramatically decrease the time
and cost needed for high-throughput functional genomic studies, while
providing scientists with new capabilities to conduct research that was
formerly not feasible . Marshall continued, "Until now, biological researchers seeking to
elucidate the functions of genes were limited to studies in worms and fruit
flies, or to small-scale studies of human gene function . Dharmacon's SMARTpool siRNA reagents,
innovative mixtures of four highly functional, individual siRNAs, minimize
screening costs and guarantee potent gene silencing while limiting off-target
effects and reducing the likelihood of false-positive and false-negative
results.

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"
NicAlert(TM) is a powerful one-step patented urine test for
detecting smoking and tobacco product exposure that combines the
advantages of semi-quantitative measurement together with an
easy-to-use, cost effective, rapid format. FDA.nymox.

Ingenuity delivers systems biology expertise to biologists and
bioinformaticians through pathways analysis software, genome-scale computable
network databases, and knowledge management services and infrastructure,
resulting in increased productivity and faster drugs to market.

- Library Targets 21,000 Human Genes and Includes Over 100,000 siRNA Reagents
Using Industry -Leading SMARTselection(TM) and SMARTpool(R) Technologies -

- Has the Potential to Revolutionize Functional Genomics and Drug-Discovery
Research -

LAFAYETTE , Colo. Marshall, Ph.D. These qualities are especially important for
high-throughput-screening applications , where both functionality and cost
effectiveness are essential.dharmacon.com or call 303-604-9499 .

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Ingenuity Pathways Analysis is Licensed by the National Cancer Institute (NCI)

About Ingenuity Systems
Ingenuity Systems is helping life science researchers understand
biological systems that are foundational to human health and disease."
Dharmacon's siARRAY whole genome -wide siRNA library includes more than
100,000 siRNA reagents targeting over 21,000 human genes contained in the NCBI
RefSeq database.

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"We are proud to announce Dharmacon's completion of the first complete
human genome-wide library, a milestone event for both the biomedical research
community and for Dharmacon," said William S.

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License Agreement to Serve as Model for Access to Ingenuity Pathways Analysis
for All Leading Research Institutions

MOUNTAIN VIEW, Calif ."
Dr. For more information about
Dharmacon products and services visit http://www.

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It does not require any special instruments or skills and
gives accurate results within minutes.

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Studies have shown that a significant percentage of patients at risk
do not always truthfully report their smoking status.
More information about Nymox is available at www.

Dharmacon's Completion of First Human Genome-Wide siRNA Library Signals New Era in Life-Science Research

Contacts:
Dharmacon:
Julia Kendall
Manager, Marketing Communications
303-604-9499

Media:
Barbara Lindheim
GendeLLindheim BioCom Partners
212-918-4650

geometrical morphological

, the world's
leading supplier of innovative RNA and RNA interference (RNAi) research
products, today announced the completion of the world's first genome-wide,
short-interfering RNA (siRNA) library. The company's advanced siRNA modification technologies
further enhance silencing specificity, stability, and in vivo performance.

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Karl Klingler of the
Hirslanden Lung Center, Zurich , Switzerland."
Ingenuity Pathways Analysis helps researchers gain biological insight and
understanding from their experimental datasets.

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quantitative explained

Dr.

abercrombie biosciences

NicAlert(TM) does not
require any instruments or special training for its use. We believe that it can be a
valuable tool in the campaign to get smokers to quit before it is too
late. Public Health Service and formal
policy positions adopted by the American Medical Association, the
American Heart Association, the American Academy of Family Physicians,
the American Diabetes Association and other medical associations.
"Ensuring broad access to Ingenuity Pathways Analysis for the academic and
government research community is a critical goal for Ingenuity in 2005,"
stated Jake Leschly, President and CEO of Ingenuity.

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----Nymox
Pharmaceutical Corporation 's (NASDAQ: NYMX) NicAlert(TM) has been
shown to increase nicotine replacement therapy (NRT) success according
to a team of Swiss researchers led by Dr. Klinger said, "the benefit of using NRT for smoking cessation
is clearly affected by proper dosing. It is deployed with leading
research labs around the world and at 15 of the largest 20 pharmaceutical
companies where it is being used to make better and faster decisions in all
areas of drug discovery and development, from target identification and
validation to biomarkers, predictive toxicology, and patient stratification.

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inviting quantification

S. (NYSE: FSH).

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The researchers have
found that the success rate was significantly improved when
NicAlert(TM) was used in conjunction with NRT to measure nicotine
consumption. Such factors are detailed from time
to time in Nymox 's filings with the United States Securities and
Exchange Commission and other regulatory authorities . A SMARTpool siRNA reagent and four individual siRNAs are
available for each unique human gene.

The availability of five gene-silencing reagents per gene also
provides researchers the opportunity for independent validation of gene
silencing effects. Dharmacon's
proprietary SMARTselection (TM) and SMARTpool(R) technologies result in potent
and specific gene-silencing agents that can accelerate life-science research
and drug discovery.

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Brian Doyle, Nymox's Global Sales Manager said, "NicAlert (TM)
offers a cost-effective way of determining smoking status right
on-site. The siARRAY(R) genome -wide library is
the first complete library targeting genes across the entire human genome.

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com

This press release contains certain "forward-looking statements"
as defined in the United States Private Securities Litigation Reform
Act of 1995 that involve a number of risks and uncertainties ., Ingenuity announced today
that the National Cancer Institute (NCI) Center for Cancer Research has
licensed access to the Ingenuity Pathways Analysis software. Under the terms
of the agreement all researchers at the NCI will have access to the full
functionality of the Ingenuity Pathways Analysis product. For
more information, visit us at http://www. "We
believe that the release of this genome -wide siRNA collection represents a
fundamental advance in the capabilities available to biological researchers
and will forever change medical research, by making it possible for scientists
to determine the function of every human gene. Dharmacon's whole genome
collection enables researchers to rapidly and efficiently generate accurate
information about gene pathways and to identify new genes and gene functions.

visiopharm histology

Nymox's NicAlert(TM) has received clearance from the U.S. "We are grateful for the
support and guidance that we received from the NCI and other NIH institutes in
developing a licensing arrangement that can serve as the model for providing
access to Ingenuity Pathways Analysis for all leading research institutions.

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Using NicAlert(TM) to accurately
measure nicotine consumption has been shown to increase the efficacy
of NRT therapy by 26%. The company
was founded in 1998 and is headquartered in Mountain View, California., Dharmacon, Inc. Availability of Dharmacon's complete human genome-wide
siRNA library is expected to significantly accelerate drug discovery and
development , and it also has the potential to increase scientists'
understanding of fundamental disease mechanisms . Dharmacon's siGENOME(TM), a comprehensive and flexible
siRNA collection, offers guaranteed silencing reagents for all unique human
mouse and rat genes.

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European Studies Show That Nymox's NicAlert Product Improves Smoking Cessation Success Rates

"
Physicians should routinely assess, review and document the
smoking status of every patient, according to A Clinical Practice
Guideline for Treating Tobacco Use and Dependence (JAMA 2000;
283:3244-54) issued by the U.
The web-delivered application makes use of the Ingenuity Pathways
Knowledge Base, the world's largest curated database consisting of millions of
individually modeled relationships between proteins, genes, complexes, cells,
tissues , drugs, and diseases. Using its core expertise in chemistry,
biology, bioinformatics and production , Dharmacon has developed
industry-leading siRNA design, chemical modification, and delivery
technologies for maximizing the efficiency of gene silencing.

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Business Editors

MAYWOOD, N.com.

About Dharmacon
Dharmacon is the world's leading provider of reliable, high quality RNA
oligonucleotides, small interfering RNA (siRNA) and related RNA-interference
(RNAi) products and technologies.
Dharmacon is a company within the Fisher Biosciences group, a unit of Fisher
Scientific International Inc.

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