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Patent 6,881,586, directed to
methods of rapidly purifying proteins. Examples of such forward-looking statements include statements
regarding the use of ProteinChip arrays to rapidly purify proteins for protein
identification, interaction studies , crystallography or activity assays as
well as statements regarding the diagnostic tests that Ciphergen Diagnostics
is developing. Actual results may differ materially from those projected in
such forward-looking statements due to various factors, including ProteinChip
technology's ability to consistently and rapidly purify proteins, ProteinChip
technology's ability to successfully discover , validate and assay biomarkers
and patterns of biomarkers that are highly predictive and therefore meet with
customer acceptance as diagnostics, and our ability to protect and promote our
proprietary technologies.

NOTE: Ciphergen, ProteinChip and Biomarker Discovery Center are
registered trademarks of Ciphergen Biosystems, Inc.

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"
Using a range of ProteinChip array chromatographic surfaces and wash
conditions, scientists can quickly identify those combinations that optimize
target protein purification conditions.

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The methods involve using
ProteinChip(R ) chromatographic arrays integrated with SELDI-TOF-MS detection
to rapidly identify "on-chip" conditions for purifying a protein for
applications including protein identification. Ciphergen's
Diagnostics Division is dedicated to the discovery of protein biomarkers and
panels of biomarkers and their development into protein molecular diagnostic
tests that improve patient care; and to providing collaborative R+D services
through its Biomarker Discovery Center(R) laboratories for biomarker discovery
for new diagnostic tests as well as pharmacoproteomic services for improved
drug toxicology, efficacy and theranostic assays. Investors should consult Ciphergen's filings with
the Securities and Exchange Commission, including its Form 10-Q dated May 10,
2005, for further information regarding these and other risks of the Company's
business.

FEI Introduces Nova(TM) NanoSEM

"
The Nova NanoSEM also features in-lens as well as low-vacuum secondary and
back scatter electron (BSE) imaging modes , and FEI's proprietary beam gas
chemistries for e-beam writing of nanostructures, making it the ideal SEM for
research and advanced study of nano-structures and nano-materials.

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The combined effect
delivers ultra-high resolution, low-vacuum characterization capabilities in an
environment that suppresses charge build-up on non-conductive materials. "FEI led the market with its
ESEM technology for charging and non-coated samples.

Sites for companies or individual analytical laboratories that have established procedures in place to perform tests on submitted samples, to identify, assay, analyze, or aid research .

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com. This newest system joins FEI's growing line of market-leading tools
that are enabling nanoscale research, development and manufacturing in a
diverse range of markets and applications. Now it extends its
leadership by combining the most advanced low-vacuum and ultra-high resolution
design features for these challenging yet critical sample types. With R+D centers
in North America and Europe and sales and service operations in more than
40 countries around the world, FEI is bringing the nanoscale within the grasp
of leading researchers and manufacturers and helping to turn some of the
biggest ideas of this century into reality. More information can be found on
the FEI website at: http://www .

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"Protein purification is a major bottleneck today in protein
identification," said William E.

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feicompany.

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FEI's Helix
detector technology, introduced with the Nova NanoSEM, combines magnetic
immersion lens and low-vacuum SEM technologies for the first time in the
history of field emission scanning electron microscopy.

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Scientists can then translate these
on-chip conditions into a column chromatography protocol for purifying the
protein at lab scale. It is the world's first
low-vacuum , field emission scanning electron microscope (FEG-SEM) solution for
ultra-high resolution characterization of charging and/or contaminating
samples such as organic materials, substrates, porous materials , plastics and
polymers.

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com.

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S.

Safe Harbor Statement
Note Regarding Forward-Looking Statements: For purposes of the Private
Securities Litigation Reform Act of 1995 (the "Act"), Ciphergen disclaims any
intent or obligation to update these forward-looking statements, and claims
the protection of the Safe Harbor for forward-looking statements contained in
the Act., FEI Company
(Nasdaq: FEIC) today released the newest member of its Nova(TM) family of SEM
and DualBeam(TM ) systems, the Nova NanoSEM.

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, Ciphergen Biosystems,
Inc.

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In 2004, FEI was the
first electron optics manufacturer to deliver sub-Angstrom or atomic scale
resolution on a commercially available transmission electron microscope.

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(Nasdaq: CIPH) announced today that the United States Patent and
Trademark Office has issued Ciphergen U. ProteinChip Systems enable protein
discovery, characterization , identification and assay development to provide
researchers with predictive, multi-marker assay capabilities and a better
understanding of biological function at the protein level.
The Nova NanoSEM brings new capabilities to researchers and developers
working with non-conductive and contaminating nanoscale materials.

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Rich, President and CEO of Ciphergen.

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About Ciphergen
Ciphergen 's Biosystems Division develops, manufactures and markets a
family of ProteinChip(R) Systems and services for clinical, research, and
process proteomics applications.

About FEI
FEI's Tools for Nanotech(TM), featuring focused ion- and electron-beam
technologies, deliver 3D characterization , analysis and modification
capabilities with resolution down to the sub-Angstrom level.

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Ciphergen Announces Issuance of Patent for SELDI-TOF-MS Assisted Protein Purification

New System is the World 's First SEM for Ultra-High Resolution Characterization
of Non-Conductive or Contaminating Samples

HILLSBORO, Ore. The
unique technology incorporated in the Nova NanoSEM also suppresses
electron-beam induced contamination resulting from previous sample processing
steps.

For sites offering services primarily to analyse chemicals in materials or products, try Science: Chemistry: Analytical: Products and Services: Testing Services.

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"Our
Biomarker Discovery Center(R) scientists as well as leading researchers in our
customer base have successfully used this process to purify and identify
protein biomarkers discovered and validated through our Pattern Track
process.
"The Nova NanoSEM, with its proprietary optics and detection systems, was
developed to meet the growing needs of customers who are faced with evolving
applications and expanding challenges," commented Tony Edwards , FEI's business
line manager for SEM and small DualBeam products.
The growing complexity and shrinking dimensions of materials, devices and
biological samples, have resulted in increased demand for nanoscale
characterization tools across all markets served by FEI. With
the Nova NanoSEM and its other tools for enabling nanotechnology, FEI
continues to lead advances in ultra-high resolution characterization and
analysis of a wide variety of samples at nanoscale dimensions.

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Complements Existing Patents Covering Ciphergen's Pattern Track(TM) Biomarker
Discovery to Assay Process including Protein Identification

FREMONT, Calif. This method greatly aids in providing rapid protein
sequencing as well as purification for protein-protein interaction studies,
crystallography or activity assays. Additional information
about Ciphergen can be found at http://www.