, Enzo Biochem Executive Vice President . "The results
shown with Alequel tell us that we may now have a well-tolerated,
personalized treatment alternative for patients with active Crohn's
disease.

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(NYSE:ENZ) said today that scientists from Hadassah Hebrew University
Medical Center and Enzo Therapeutics, a wholly-owned subsidiary, will
be making a presentation at the medical profession's Digestive Disease
Week Conference here regarding results of a Phase IIb clinical trial
for Alequel(TM), the Company's protein-containing extract for
treatment of Crohn's Disease. The Neera Super Cleanse is a
fasting diet that stimulates the body 's cleansing process, while
satisfying hunger by replacing solid food with pure, nutritious liquid
food.

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Of the
patients taking Alequel, 43 percent experienced an improvement in
their overall quality of life compared to 12 percent of the placebo
patients."
The studies below analyzed patient response based on the
Inflammatory Bowel Disease Questionnaire (IBDQ), the Crohn's Disease
Activity Index (CDAI), which measures the severity of a patient's
disease and the Mayo score for ulcerative colitis., of the Mayo Clinic and lead
investigator of the study.
Treatment options are limited for people with ulcerative colitis, a
disease that causes inflammation and ulcers in the superficial layers
of the large intestine. While the use of
anti-tumor necrosis factor (TNF) agents like infliximab have recently
shown promise in Crohn's disease and rheumatoid arthritis, its use for
ulcerative colitis has been less defined. This is
very encouraging news for a patient population that has few treatment
options.

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Unfortunately, the available therapies
are not effective in many patients, " said John Johanson, M. Adverse
events were mild to moderate in severity.

Neera Super Cleanse Alleviates Toxicity and Excess Weight Combating the Effects of Toxic Lifestyles

In the West,
mainstream health practitioners are beginning to realize that toxic
lifestyles pose a significant threat to our health. Department of Health and Human Services recently warned that
health issues related to obesity could soon surpass tobacco as the #1,
preventable killer in America. Numerous chemicals and toxins have been
introduced into the natural environment, which can find their way into
our bodies through air, water and processed foods. The body also gets a
chance to remove accumulated toxic substances and break down damaged,
diseased and unneeded cells. During the program the body
moves towards its optimal weight as it detoxifies and eliminates
toxins.

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The meeting showcases
approximately 5,000 abstracts and hundreds of lectures on the latest
advances in GI research, medicine and technology . The Company's
proprietary labeling and detection products for gene sequencing and
genetic analysis are sold to the life sciences market throughout the
world. The
Company also holds a patent covering a method and materials for
correcting point mutations or small insertions or deletions of genetic
material that would allow for editing and correcting certain
abnormalities in genes. For more information visit our website www.

S.
What can be done about it? The Neera Super Cleanse works to
alleviate toxicity and excess weight.

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Trial participants were
monitored for response based on the Crohn's Disease Activity Index
(CDAI) and Inflammatory Bowel Disease Questionnaire (IBDQ).
Adalimumab is a fully human monoclonal antibody that targets tumor
necrosis factor-alpha (TFN-a), a protein produced by the body's immune
system that is thought to contribute to the inflammation in Crohn's
disease and ulcerative colitis.5 percent of patients taking 10mg/kg
of infliximab, respectively, were in clinical remission at week eight
compared to 5. "I am pleased to say
that the ACT I and ACT II results suggest that infliximab is an
effective and well-tolerated treatment for ulcerative colitis. "The
U.

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IBD currently affects more than a million Americans and leads to
many millions of dollars in lost productivity and missed days of work
every year. The most common symptoms of both
ulcerative colitis and Crohn's disease are diarrhea, abdominal pain,
fever , fatigue and weight loss. Based on the promising nature of these results, larger
confirmatory trials are being pursued. "The positive results found in this study
reinforce previous adalimumab findings and are highly encouraging
because they bring one step closer to identifying a new treatment
option for people with Crohn's disease. Recent studies at UC Berkeley
and other universities show that mice , which were made to fast every
other day, lived up to 50 percent longer than other non-fasting mice
and had a greatly decreased risk of cancer.

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Symptoms for both conditions
are very similar and it is often difficult for physicians to
differentiate between the two. These
biomarkers, an antigen -specific T cell immune response, C reactive
protein (CRP) levels and peripheral blood T cell subpopulations , may
also be applicable as surrogate markers for the clinical effect of the
drug.
Study findings show that the rate of clinical remission increased
from 5.
Results from these two phase three , randomized, placebo-controlled
studies show that infliximab appears effective in reducing signs and
symptoms of the disease, inducing remission, attaining mucosal healing
and allowing for reduced corticosteroid therapy, while maintaining
remission. The Company's therapeutic division is in various stages of
clinical evaluation of its proprietary gene medicine for HIV-1
infection and its proprietary immune regulation medicines for
hepatitis B and hepatitis C infection and for Crohn's disease. Investors are
cautioned that any such forward-looking statements are not guarantees
of future performance and involve a number of risks and uncertainties
that could materially affect actual results.

About Neera Super Cleanse

The Neera Super Cleanse is a fasting diet where solid foods are
replaced with the pure and nutritious Neera Drink.

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A clinical response was seen in 67 percent of the
participants receiving the drug compared to 29 percent of those that
took placebo.2 percent after six months of therapy. A total of 220 patients participated
in the study, receiving 40mg of adalimumab every other week for one
year."
What is toxicity? Basically, anything we take into our bodies that
is not eliminated or assimilated becomes toxic.

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"

Induction Maintenance of Clinical Remission and Response in
Subjects with Crohn's Disease Treated During a Six-Month, Open -Label
Period with Fully Human Anti-TFN-Alpha Monoclonal Antibody Adalimumab
(Humira(R)) -- (Abstract 723)

In a study presented today, researchers from the Mayo Clinic
assessed the long-term efficacy and safety of adalimumab in an
open-label study of patients with active Crohn's disease. This study only includes data from the first six months of the
study. Infliximab was
generally well tolerated with a safety profile similar to that
previously reported. The special
ingredients invigorate the body's cleansing process, eliminating
excess fats, wastes and accumulated toxins, while satisfying hunger,
giving the body a break from the work of digesting solid food and
allowing it to focus on cleansing.

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The Enzo-Haddasah paper presented is entitled "A Double Blind
Clinical Trial for Treatment of Crohn's Disease by Oral Administration
of Alequel(TM) a mixture of Autologous Colon Extracted Proteins: A
Patient-Tailored Approach. A
clinical response was seen in 67 percent of the participants receiving
the drug compared to 29 percent of those that took placebo.
Clinical trial results show that Alequel(TM), adalimumab (Humira(R))
and infliximab (Remicade(R)) are effective in decreasing the severity
of IBD symptoms and increasing rates of clinical remission and
response in patients.D., of the
University of Illinois.7 percent of those receiving placebo.
"Given that anti-TNF agents like infliximab appear to be effective
in treating Crohn's disease, it made sense to explore its use in
ulcerative colitis as well," said Dr.
Jointly sponsored by the American Association for the Study of Liver
Diseases (AASLD), the American Gastroenterological Association (AGA),
the American Society for Gastrointestinal Endoscopy (ASGE) and the
Society for Surgery of the Alimentary Tract (SSAT), DDW takes place
May 14-19, 2005 in Chicago, Illinois. Such
statements include declarations regarding the intent, belief or
current expectations of the Company and its management. Some
symptoms of toxicity include fatigue, irritability, nervousness, poor
digestion , headaches, edginess, sore throat, congestion, frequent
colds, coughs, immune weakness, insomnia , feeling lethargic and skin
rashes. A diet high in saturated fats, excess proteins, refined and
processed foods, drugs and artificial additives usually leads to
toxicity and obesity.

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In addition, members of the Enzo-Haddassah research team today
participated in a press meeting for members of the scientific , trade
and general media to discuss, what the conference sponsors described
as, "three promising biologic therapies" that may provide new
treatment options for sufferers worldwide of Inflammatory Bowel
Disease. Results show
that adalimumab's efficacy increased over time, while maintaining a
strong safety profile.9 percent of those on placebo.
In both studies, 364 patients suffering from active ulcerative
colitis were randomized to receive infliximab at 5mg/kg and 10 mg/kg
or placebo at weeks zero, two and six, then every eight weeks for 46
weeks (ACT I) or 22 weeks (ACT II). Also, most people really like the
added benefit of losing excess weight.

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Enzo Biochem Alequel Clinical Trial Results Highlighted at Digestive Disease Week Conference Press Meeting Today; Research Team to Report on Phase IIb Study of

Digestive Disease Week(R) is the largest
international gathering of physicians, researchers and academics in
the fields of gastroenterology, hepatology, endoscopy and
gastrointestinal surgery.

A Double Blind Clinical Trial for Treatment of Crohn's Disease by
Oral Administration of Alequel(TM), A Mixture of Autologous Colon
Extracted Proteins: A Patient -Tailored Approach (Abstract W1042)

The concept of personalized treatment options, such as gene
therapy for cancer, has increasingly become a reality.5 percent
at baseline to 78. William Sandborn of the Mayo
Clinic and lead investigator of the ACT II trial.
"Toxicity and obesity are fast becoming leading health problems in
America," said Chitvan Rebich, president of Neera Super Cleanse.

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D.8 percent of the patients taking
5mg/kg and 32. In the ACT II trial, 33. Occasional fasting, a
thousands -year-old practice, with its dual benefits of safe weight
loss and detoxification is becoming more and more accepted as an
effective medical and diet treatment.
During a fast the digestive and eliminative organs of the body are
able to rest and focus on internal cleansing.

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Overall , a progressive
increase in clinical response and clinical remission was seen in
patients receiving adalimumab, as one-third of study participants were
in clinical remission at the end of six months . Patients in both studies were
assessed for clinical response (defined as a decrease in Mayo score of
greater than or equal to 30 and greater than or equal to 3 points,
accompanied by a rectal bleeding score of 0 or 1 at week eight),
clinical remission (defined as a Mayo score of less than or equal to
2, with no individual sub-scores greater than 1) and mucosal healing
(defined as an Endoscopy sub-score of 0 or 1). The Company owns or licenses over 230 patents
worldwide. The Company disclaims any
obligations to update any forward-looking statement as a result of
developments occurring after the date of this press release. In fact any excessive diet will create too much of a
burden on the body, which creates toxins.

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" The Phase IIb study notes that clinical
remission rates observed during the trial were 58 percent for patients
receiving Alequel, compared to 29 percent for patients on placebo. Of the patients taking Alequel, 43 percent experienced
an improvement in their overall quality of life compared to 12 percent
of the placebo patients. Trial participants were assessed for clinical remission
(defined as a CDAI less than 150) and clinical response (defined as a
decrease in CDAI score, as compared to baseline, of greater than or
equal to 70 or greater than or equal to 100) and received an increased
dosage if they experienced flare ups or were not responsive to the
treatment.

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DDW is the largest international gathering of
physicians, researchers and academics in the fields of
gastroenterology, hepatology, endoscopy and gastrointestinal surgery .
"Crohn's and ulcerative colitis are serious and complex diseases
with varied treatment options . The standard first- and second-line therapies,
5-ASA agents and corticosteroids, are not effective in all patients
and are often associated with severe side effects. In the ACT I trial, 38.
The Neera Super Cleanse is not a traditional fast.

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"The notion of personalized therapy is an exciting new model for
treating patients and is especially applicable in Crohn's disease,
where a misfiring of the body's immune system is believed to be
related to the inflammation observed with this condition ," said Dean
Engelhardt, Ph.2 percent after six months of
treatment and the rate of clinical response improved from 40.

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A synopsis of the paper is included in the aforementioned
Digestive Disease Week press release:

BIOLOGIC THERAPIES FOR BOWEL DISEASE SHOW PROMISE IN CLINICAL
TRIALS

CHICAGO, IL - (May 16, 2005) - Research presented today at
Digestive Disease Week(R) 2005 (DDW ) highlights three promising
biologic therapies that may provide new treatment options for millions
of people suffering with inflammatory bowel diseases (IBD) worldwide. IBD is an umbrella term referring to several chronic
diseases that cause inflammation of the intestines, including
ulcerative colitis and Crohn's disease. Anti-TNF agents work by
blocking the action of the reaction that causes abnormal joint
inflammation.
Toxicity is not solely caused by the things we ingest; the
environment also plays a role.

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A public file of the press
conference is not available. "These findings deliver promising news for
patients who do not respond to currently available therapies and is a
much needed step in improving the lives of people suffering from IBD. This study from
Hadassah Hebrew University Medical Center and Enzo Therapeutics
applies that principle to gastroenterology and explores the safety and
efficacy of a personalized treatment for Crohn's disease by oral
administration of Alequel(TM), a protein-containing extract
manufactured from tissue removed from a patient's own colon.5 percent at baseline to 33.0 percent of patients taking 10mg/kg of infliximab,
respectively , were in clinical remission at week eight compared to
14.

About Enzo

Enzo Biochem is engaged in the research, development and
manufacture of innovative health care products based on molecular
biology and genetic engineering techniques, and in providing
diagnostic services to the medical community.enzo.com

Except for historical information, the matters discussed in this
news release may be considered "forward-looking" statements within the
meaning of Section 27A of the Securities Act of 1933, as amended and
Section 21E of the Securities Exchange Act of 1934 , as amended.

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Thirty-one patients with moderate to severe Crohn's disease were
enrolled in the 27-week randomized, placebo-controlled, double blind
trial and received either placebo or the study drug, which was
prepared from extracted colon proteins.

Business Editors/Health/Fitness Writers

SAN FRANCISCO----Toxicity is thought
to be the major source of all illness, according to homeopathic ,
naturopathic, ayurvedic and traditional Chinese medicine.

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9 percent of
the patients taking 5mg /kg and 27. It was invented
to stimulate the body's natural cleansing ability while offering
liquid nourishment to keep us from feeling hungry and to give us
energy during the cleansing process.

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Clinical remission rates observed during the trial were 58 percent
for patients receiving Alequel, compared to 29 percent for patients on
placebo.
"The results from this trial illustrate the importance of
follow-on studies to clarify long-term effects of potential new
therapies," said William Sandborn , M.D."

A Randomized Placebo-Controlled Trial of Infliximab Therapy for
Active Ulcerative Colitis: ACT 1 Trial (Abstract 689) and Infliximab
Induction and Maintenance Therapy for Ulcerative Colitis: the ACT 2
Trial (Abstract 688)

Results presented today from the ACT I and ACT II Trials show
infliximab may be a promising treatment for active ulcerative colitis."

Digestive Disease Week(R) (DDW) is the largest international
gathering of physicians, researchers and academics in the fields of
gastroenterology, hepatology, endoscopy and gastrointestinal surgery. Toxicity has been
linked to being overweight because the foods consumed that lead to
obesity generally are comprised of foods that cause toxins to build up
in the body.

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Business Editors/Health/Medical Writers
Digestive Disease Week Conference

CHICAGO----Enzo Biochem, Inc. A copy of the press release discussing the event hosted by
the conference sponsors is below.
Three biomarkers were identified that may be used to generate an
immune profile to predict clinical response to the treatment . Adalimumab, which is currently approved to
treat rheumatoid arthritis, has also shown positive results for
Crohn's disease in previous clinical trials. In addition, excess toxins
can lead to minor ailments and even more serious illness. Studies have shown that during a fast the
primary cleansing organs of the body, the liver and kidneys, become
more active.