-- All equipment - including basins and bowls - must be clean and
disinfected, before a pedicure.
-- In most states, even licensed nail technicians cannot do waxing
services in salons.

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Anacor's Novel Topical Antifungal Agent for Onychomycosis Demonstrates Good Safety Profile and Diverse Activity in Multiple Preclinical Studies

AN2690 is currently
being evaluated in Phase 2 clinical studies to confirm these findings with
top-line data expected this year.0 mg/mL. rubrum in an adapted zone-of-inhibition study.5%, 5% or 7. population.

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The data demonstrated that AN2690 can effectively penetrate the nail plate
and produces activity within and under the nail plate against the fungi most
commonly found in infections of the nail and nail bed."
In the poster presentation entitled Microbiological Activity of AN2690, a
New Antifungal Agent in Development for the Topical Treatment of
Onychomycosis, Anacor scientists and their collaborators showed that AN2690
has broad-spectrum antifungal activity with minimum inhibitory concentration
(MIC) values ranging from 0. Two dermatophyte strains, Trichophyton rubrum and Trichophyton
mentagrophytes, account for over 90% of cases.

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Only licensed cosmetologists and estheticians can
perform waxing services.

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"

INTA recommends the following guidelines for consumers having nail
services:

-- Before beginning any nail service, ask the licensed salon professional
what disinfection processes were used for implements. mentagrophytes, the primary fungi that cause onychomycosis, ranged from
1.0 mg/mL to 8.

AN2690 Phase 2 Program
Anacor is evaluating AN2690 in two Phase 2 studies.5% concentration of AN2690 applied once a day for six months.

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-- Before any nail service, inform the technician if you are diabetic,
have a peripheral vascular disease, or are taking any blood-thinning
medication. INTA and CC members include licensed cosmetologists,
estheticians and nail technicians, salon owners and cosmetology students. rubrum
and T.

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"The International Nail Technicians Association makes every effort to
educate nail technicians and salon owners in proper sanitation and
disinfection procedures," says Paul Dykstra, CEO of INTA.
-- Before a whirlpool footbath, ask if the screen is removed, cleaned and
disinfected every day.
"Because onychomycosis is an infection of both the nail plate and bed, a
topical drug must kill the fungi in the nail and penetrate to the bed
underneath the nail," said Dr. Without treatment, the nails
thicken and cause localized pressure -related pain. Initially,
Anacor is focusing development efforts on dermatological disorders with a
product candidate in Phase 2 clinical trials for atopic dermatitis and another
in Phase 2 trials for onychomycosis, a fungal infection of fingernails and
toenails that affects as much as 14% of the general U.

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IsNow.25 - 8.

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-- Electric files are legal, but cutting the skin is not.com(R).

AN2690 penetrates human nails
over two hundred fold better than current topical treatments.S.

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With the proper education of
both salon and client, it can be a completely safe one as well.

The International Nail Technicians Association(TM) (INTA), comprised of
1100 national and international members, is a wholly owned subsidiary of
Cosmetologists Chicago(R) (CC).

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CHICAGO, The International Nail Technicians
Association(R) (INTA) sets high professional standards for nail technicians. Jacob Plattner, senior vice president of
Anacor.

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INTA offers its members continuing education, free admission to industry trade
shows, discounted product purchases, legislative representation, technology ,
networking opportunities and the extensive website http://www.

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AN2690 also was active in the presence of nail
keratin.

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The second study is a double-blind, placebo-controlled, six-month trial
involving 180 patients who will receive either 2. Dermatophytes, parasitic
fungi that affect skin, hair or nails, are the primary agents that cause
onychomycosis. Current approved topical treatments are rarely
effective (less than 12%), and systemic treatments are effective in only
approximately 50% of cases, yet have known toxicity.S.

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-- You should not have pedicure services if you have any infections
(fungus, mold) or communicable diseases (athlete's foot, eczema) or
other unhealthy conditions of the skin or feet. The first is an
open-label study involving 60 patients with onychomycosis who will receive
either a 5% or 7.

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"We successfully addressed this challenge by applying a new class of
antifungals based on our proprietary boron chemistry and specifically designed
a molecule with potent antifungal properties and the physical properties
necessary to effectively penetrate the nail .5% concentrations
of drug or a placebo applied daily.

About Onychomycosis
Onychomycosis , a fungal infection of fingernails, toenails and the nail
bed, affects up to 14% of the general U . Systemic drugs for
onychomycosis each sell over $1 billion annually.
Anacor, a privately held, clinical-stage pharmaceutical company, is
developing novel product candidates for inflammatory and infectious diseases
based on its proprietary, small-molecule, boron-based chemistry.

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-- The technician's hands must be either washed or sanitized before
touching a client's hands or feet for any service.
-- Your hands or feet must be either washed or sanitized before any nail
service. Disinfectant must to be circulated and flushed
through the whirlpool system for at least 10 minutes.

, Anacor
Pharmaceuticals, a private pharmaceutical company developing novel agents for
inflammatory and infectious diseases, today presented positive preclinical
results for AN2690, the first in a new class of antifungal agents in
development as a topical treatment for onychomycosis, a fungal infection of
the toenail and fingernails.

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AN2690 demonstrated remarkable
ability to penetrate full thickness human fingernails at concentrations that
prevent the growth of T.

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CC, owner and producer of the Chicago Midwest
Beauty Show(R), "America 's Beauty Show"(TM), is an association of 4,900 salon
professionals.0 mg/mL. Primary endpoints for both studies are
greater than 5 mm clear nail growth at six months, or nails judged by
investigators to be "clear" or "almost clear," and a negative culture for
infection at the end of the trial period . The infection causes
nail deformation, discoloration and splitting.

About Anacor Pharmaceuticals .

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To protect their own health, consumers should also be aware of appropriate
safety standards and make informed decisions when seeking nail care and
related cosmetology services. Drill bits
should be clean, without any dust or debris, and stored in a sanitary
manner.

Specifically for Pedicures:

-- Do not shave your legs for at least 24 hours before a pedicure or have
a pedicure service if you have open sores or nicks on your feet or
legs.
In addition, the MIC of AN2690 against 100 clinical isolates each of T.

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International Nail Technicians Association Provides Consumer Guidelines to Safe Nail and Pedicure Services

-- Cutting calluses, ingrown toenails, and living skin is not allowed. population.

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"We truly believe
that education is the key for both salons and consumers. The salon experience
is one of the most enjoyable consumers can have. - Three Posters Presented at American Academy of Dermatology 64th
Annual Meeting

- Phase 2 Clinical Trial Results Expected this Year

SAN FRANCISCO and PALO ALTO, Calif. Yeast-based infections are the
second most common cause.

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Callus razors cannot be legally used in beauty or nail salons.