This is the first commercially available, comprehensive genetic test for a
heart rhythm disorder. At 12 months
out from radiation therapy, he still suffers from dry mouth, but finds relief
from both Numoisyn products.

worn clinicians

and other countries relating to the five cardiac ion channel genes
examined by the FAMILION (TM) Test.

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claim syndrome

If not
corrected, ventricular fibrillation can cause death.

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Syncope (fainting) is the most common symptom.

Align Pharmaceuticals Makes Its Debut With Three New Products for Radiation Dermatitis and Xerostomia

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Symptoms of LQTS may include fainting, seizures, abnormal, very fast
heartbeats and even death.
Align has two products for xerostomia under the brand Numoisyn (TM).

clinicians facial

Genaissance Pharmaceuticals' New DNA Test - FAMILION(TM) - Becoming Key Tool for Detecting Long QT Syndrome a Potentially Fatal Cardiac Disorder

A patient's family members also benefit from the test because it can
identify if they inherited the same mutation as the initially symptomatic
patient and may be at risk of a potentially fatal arrhythmia.
"The FAMILION(TM) Test has had a successful launch as evidenced by its
steady growth, particularly in the second half of 2004 when Genaissance booked
over $200,000 of test revenue.

Sudden Cardiac Death
Long QT and Brugada Syndromes, two types of cardiac channelopathies, are
disorders that are typically discovered in the first four decades of life and
can be fatal if not diagnosed and treated appropriately.

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For example,
these people may have an unusual response when they are startled, experience
emotional stress or engage in vigorous physical activities.
Numoisyn(TM) Lozenges are saliva stimulants for people with some salivary
function.

emitting treat

Instead of waiting six to twelve months or more for
results of tests conducted in a research setting, doctors now obtain results
in as little as four to six weeks. These products
will provide relief to people undergoing radiation therapy, as well as the
four million people who suffer from Sjogren's syndrome, an autoimmune disorder
that causes dry mouth symptoms.

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NEW HAVEN, Conn.com.
LQTS is a condition that impairs the electrical system of the heart. The Company's product development strategy is focused
on drug candidates with promising clinical profiles and finding genetic
markers to identify a responsive patient population. "Our CFO is an oral cancer survivor
who has experienced both radiation dermatitis and xerostomia.com

grinds claim

Medicare and a significant number of major insurance companies now provide
coverage for the Genaissance test., Director of
the Long QT Syndrome Clinic and Sudden Death Genomics Laboratory at Mayo
Clinic.

More information regarding the FAMILION(TM) Test can be found at
http: //www.
Xclair(TM) Cream is a water-based cream with ingredients that hydrate
skin, as well as provide protective barriers to maintain skin integrity during
the course of radiation therapy .

Find links to sites offering products that assist in treating Temporomandibular Joint Syndrome (TMJ ).

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, Genaissance
Pharmaceuticals, Inc. (Nasdaq: GNSC), a leading developer and user of genetic
information to help guide medical therapy, said its DNA test, FAMILION(TM), is
on its way to becoming a key tool to help physicians save the lives of people
who are genetically predisposed to potentially fatal cardiac arrhythmias
caused by Long QT Syndrome (LQTS), Brugada Syndrome and related cardiac ion
channel diseases or channelopathies.
The diagnosis of LQTS and other channelopathies by an electrocardiogram
(ECG) is often difficult and may be missed, which leaves a patient at risk for
sudden cardiac death.

About Genaissance
Genaissance Pharmaceuticals, Inc."
Align has hired a 40-person sales force for its three products and will
target radiation oncology and rheumatology physician practices initially.

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Genaissance disclaims any obligation to update any
forward-looking statement.
"Our products serve an unmet need in these two communities. Numoisyn(TM) Liquid is a saliva replacement for people with little
or no salivary function.

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These specialists utilize
the test as a vital component in their evaluation and management of patients
with symptoms of inherited Long QT Syndrome and other ion channel
abnormalities that, if left undetected, can cause sudden cardiac death.

This press release contains forward-looking statements, including
statements about the expected growth and development of Genaissance's
business, such as Genaissance's ability to detect associations between
clinical outcomes and genetic variation, the ability to assess how genetic
variation can affect drug response, efforts to build a drug candidate
pipeline, the timing and outcome of its genetic testing programs, the timing
of its ability to enter into drug development collaborations with
pharmaceutical companies, the ability of Genaissance to apply its
technologies to the development , marketing and prescribing of drugs and
Genaissance's ability to detect associations between clinical outcomes and
genetic variation. CARY, N. Both products will benefit people with xerostomia as
a result of radiation treatment for head and neck cancers, or Sjogren's
syndrome.

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, Ph. Ackerman is a paid consultant and member of Genaissance Pharmaceuticals'
scientific advisory board. Such statements are subject to certain factors, risks and
uncertainties that may cause actual results , events and performance to differ
materially from those referred to in such statements, including , but not
limited to, the extent to which genetic markers (haplotypes) are predictive of
clinical outcomes and drug efficacy and safety, the attraction of new business
and strategic partners, the adoption of our technologies by the pharmaceutical
industry, the acceptance of our cardiac tests by health care providers, the
timing and success of clinical trials, competition from pharmaceutical ,
biotechnology and diagnostics companies, the strength of our intellectual
property rights and those risks identified in our Quarterly Report on Form 10-
Q for the quarter ended September 30, 2004, filed with the Securities and
Exchange Commission on November 15, 2004, and in other filings we make with
the Securities and Exchange Commission from time to time.
"We started this company to find therapies that would improve the quality
of life in patients with no other therapeutic solutions ," said Greg Preston,
vice president of sales and marketing.
http://www.

screening alarm

D. If a genetic mutation is
detected, its type and location can assist the physician in making treatment
selections that could include life-style modification, prescription or
avoidance of specific classes of drugs or the implantation of a defibrillator. These relatives
often have ambiguous findings on an ECG, while the results of the FAMILION(TM)
Test can answer whether or not they carry the familial mutation.

Significant intellectual property
facilitating the FAMILION(TM) Test has been provided by the Mayo Clinic, and
Dr. During
ventricular fibrillation, blood flow to the body is reduced.genaissance . Xclair Cream
is steroid, alcohol and fragrance free.

Align Pharmaceuticals is a privately owned company that was founded to
market and develop recently approved pharmaceuticals, Phase III compounds or
currently marketed drugs that are undervalued drugs in the marketplace.

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"This genetic test for cardiac ion channel mutations may remove
uncertainty for the patients, their families , and their physicians with
respect to establishing a diagnosis and can guide the physician in determining
the best treatment options," says Michael Ackerman, M.S. Some people with LQTS have a normal ECG at rest
but experience abnormal responses under certain conditions.
Brugada Syndrome is very similar to LQTS, however, the characteristic ECG
finding is different.com., Align Pharmaceuticals , based in Cary,
NC, made its debut last week with the launch of three new products for the
treatment of radiation dermatitis and xerostomia (dry mouth).

headaches treating

familion.

grindalert grinds

The Genaissance test helps clarify the diagnosis in
these patients by examining five cardiac ion channel genes for a mutation that
is likely to cause LQTS or Brugada Syndrome.
Ventricular fibrillation, a rapid, irregular heartbeat affecting the lower
chambers of the heart, called the ventricles, can also occur. Genaissance also
markets its proprietary FAMILION(TM) Test, designed to detect mutations
responsible for causing Familial Long QT and Brugada Syndromes, two causes of
sudden cardiac death.

grinding joint

At the current rate of receipt of four or more
test samples each week, along with the reimbursement obtained from a large
number of insurance providers, we believe that FAMILION(TM) revenues will
continue to grow significantly and contribute to our revenue goals for 2005,"
stated Kevin Rakin, President and CEO of Genaissance . Most of the deaths can be
prevented with early diagnosis and treatment of LQTS. The Company's lead
therapeutic product, vilazodone for depression, is in Phase II of development. Use of the cream begins on "day one" of
radio-therapy and is applied three times a day for the duration.

facial clinicians

No other
products available provide the significant relief to patients that these do,"
said Align Pharmaceuticals ' Chief Executive Officer, William Collins.

purchased neck

Genaissance has a patent estate of more than 50 issued and pending patents
in the U. People with LQTS have
hearts that look and sound normal but may have abnormal electrical activity
when examined with an ECG. is developing innovative products based
on its proprietary pharmacogenomic technology and has a revenue-generating
business in DNA and pharmacogenomic products and services.

claim alarm

The FAMILION(TM) test is conducted at
Genaissance's CLIA -approved laboratory located in New Haven, CT. This strategy enables
Genaissance to leverage existing clinical data and, thus, reduce the costs and
risks associated with traditional drug development and increase the
probability of clinical success and commercialization.C.

syndrome bruxism

Since its launch in late spring 2004, the FAMILION(TM) Test has quickly
gained acceptance with over 130 patient referrals made by nearly 50 pediatric
and adult cardiologists and electrophysiologists. The forward-looking
statements contained herein represent the judgment of Genaissance as of the
date of this release . All
three products require a prescription.alignpharma.

pillow facial

D. For some people, these symptoms only occur when
they are stressed or taking certain medications. LQTS can be an
inherited or an acquired disorder.
For more information on Genaissance, visit our website at:
http://www.