pH ADVANTAGE, LLC
is currently selling its products in selected Nordstrom, Sephora, Macy West
and other specialty stores. Cohen stated,
"I am one of the biggest advocates of Kinetin and I am equally excited about
incorporating it into pH ADVANTAGE".
Senetek's patented compounds Kinetin and Zeatin are naturally occurring
cytokinins that have proven effective in improving the appearance of aging
skin with virtually none of the side effects associated with acid-based active
ingredients.

Senetek PLC Investor Relations Contact:
1-707-226-3900 ext. They wanted a product that was affordable,
too.
"After surgery, patients want to begin the healing process as soon as
possible. "Our clinical studies indicate optimum improvements when Zeradan(TM)
is applied early in the healing process, after open wounds have closed.

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Red Rainforest Enterprises Launches First Product

The R+D team
physicians, both from Palo Alto, CA, saw the need for a product like
Zeradan(TM) in their practices.

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The company reports that
Zeradan(TM) flattens scars and takes the color out of them more quickly than
would otherwise occur.


Ask questions of the vendors, especially if there is no listing of product ingredients (required by law on any labeling).

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Senetek's researchers at its dedicated laboratories
adjacent to the University of Aarhus, Denmark, also are collaborating with the
Institute of Experimental Botany, Prague, Beiersdorf AG, Hamburg, the
University of California - Irvine and leading commercial laboratories to
identify and evaluate additional new biologically active compounds for this
high growth field. Forward-looking statements by their nature involve substantial
uncertainty, and actual results may differ materially from those that might be
suggested by such statements.
"Zeradan(TM) is effective on nearly all types of scars.


Whenever treatment claims are made for an ingredient, the
US FDA classifies that ingredient as a drug.

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However, the
Company necessarily can give no assurance that it has identified or will
identify all of the factors that may result in any particular forward-looking
statement materially differing from actual results, and the Company assumes no
obligation to correct or update any forward-looking statements which may prove
to be inaccurate, whether as a result of new information , future events or
otherwise.
The Research + Development team, which was comprised of two Stanford
medical doctors, a distinguished chemist/formulator, and North Carolina
businessman Mark Bloomquist , developed the idea of Zeradan(TM).
For more information about Zeradan(TM), contact RRE at (336 ) 540-1513.

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The licensing arrangement with Senetek calls for
a guaranteed annual minimum sales on future products sold. Zeradan(TM) is
designed to reduce scar size caused by surgery, injury or burns . The product
is also safe to use on children," added Dr.


Listing of products here does not imply endorsement, and web site content often changes.

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senetekplc.C.

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Be sure to research any treatment on your own and discuss it with a qualified skin specialist, especially if it means modifying any current psoriasis treatment.

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Cohen is a renowned Plastic Surgeon in the Washington D. Cohen and I are very excited about the
opportunity to market such a proven and well-tested product as Kinetin and are
equally excited about the development of future products.

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Beware of claims for other 'FDA approved ingredients', as they don't meet FDA approval as safe and effective for the treatment of psoriasis.

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C.


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Additionally, botanical extracts have been used
for centuries for similar purposes. The founding partners decided to design Zeradan(TM) as a
combination of botanical extracts and silicone, without potentially damaging
steroids.

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Senetek Announces New Licensing Agreement With pH ADVANTAGE LLC to Market Kinetin Products in the U.S. Prestige Retail Market

metro area who
has recently published his book "Total Rejuvenation: From Skincare to
Scalpel," which is a comprehensive reference guide for image-conscious women
and men of all ages, that contains advice on controlling photoaging,
forestalling wrinkles and acne, as well as the art of face and body
contouring.

We all have the right to make informed health care decisions.

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Cohen and James Headley in
2004 and rapidly gained entrance into the Prestige Retail Market Place with
their pH ADVANTAGE brand which is a "no-nonsense" cosmeceutical line of
skincare products that fully discloses the contents of it key ingredients.
"We are pleased that a company as prestigious as pH ADVANTAGE, LLC has
become another key partner in endorsing and marketing our proprietary Kinetin
product, a leading antiaging treatment," said Frank J.

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pH ADVANTAGE, LLC is also developing and clinically testing new and unique
products containing Senetek's patented Kinetin ingredient. Important factors identified by the Company
that it believes could result in such material differences are described in
the Company's Annual Report on Form 10 -K for the year 2004. Best
results occur when used up to three times daily for 3-6 months.

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com) to market and sell Kinetin in the United
States in Prestige Retail Stores, Salons and Spas, Direct to Consumer
Channels, and to be distributed under the popular pH ADVANTAGE brand.
pH ADVANTAGE , LLC was founded by Dr.com

Safe Harbor Statement
This news release contains statements that may be considered
"forward- looking statements" within the meaning of the Private Securities
Litigation Reform Act, including those that might imply success in future
clinical trials and the commercial potential of Zeatin and other cytokinins
studied.

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Mr. announces today the release of the company's first
product line, Zeradan(TM), a scar ointment cream formulated with silicone ,
natural ingredients and botanical extracts to soothe, smooth and flatten scars
effectively.
Zeradan(TM) is a topical cream that is designed to flatten and diminish
scars resulting from surgery , minor burns, and accidents.

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Senetek has licensed Kinetin to leading global and regional
dermatological and skin care marketers including Valeant Pharmaceuticals, The
Body Shop and Revlon, and Senetek has granted Valeant Pharmaceuticals an
option to license Zeatin. Applying Zeradan(TM) to the scarred area helps this process along
while protecting the skin in and around the scarred area," states the R+D
medical team's summary of key findings of their evaluation studies.

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com/, a healthcare
technologies company engaged in the development of products for the anti-aging
market worldwide, today announced it has entered into a direct license
agreement with pH ADVANTAGE, LLC of Costa Mesa, California
(http://www. They wanted to get the benefits of both treatments in a single
combination cream. Results have been amazing.

salicylic ingredient

They may be included in products as inactive ingredients, but the labeling (including web sites) can't legally make psoriasis treatment claims about them.

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, Senetek PLC
(OTC Bulletin Board: SNTKY), http://www.

Senetek is a life sciences-driven product development and licensing
company focused on the high growth market for dermatological and skin care
products primarily addressing photo-damage and age-related skin conditions.

These sites have purchasing information specific to psoriasis products, treatments, and services.

The only FDA approved over-the-counter drug treatments for psoriasis currently contain either coal tar or salicylic acid.

All other drug treatments either require a prescription, or are classified as unapproved new drugs.

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Barry J.
"Silicone has been used for years in burn centers and by plastic surgeons
to treat hypertrophic scars.zeradan.

relieving ingredient

phtotalskincare ." Dr. Massino, Senetek
Chairman and CEO., Greensboro, NC-based Red
Rainforest Enterprises Inc . But unlike most
over-the-counter scar creams, Zeradan(TM) uses silicone to accelerate the
healing process, lessen redness surrounding the scar and maintain the skin's
moisture balance.

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NAPA, Calif . Headley stated, "Dr. 102
E-mail: Pknopick@eandecommunications. Art Barnett Jr. So we developed Zeradan(TM) to take
advantage of the benefits of modern science as well as traditional botanical
therapeutics," added Mark Bloomquist, Vice-President and National Sales
Manager.
Zeradan (TM) is an over-the-counter topical cream that will initially be
available only from selected physicians and on line at http://www.


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Dr. Zeradan(TM) designed to soothe, smooth, and flatten scars

GREENSBORO, N., RRE's chief
formulator."
The Research + Development team spent over two years formulating and
testing Zeradan(TM), and selecting the right ingredients to create an
effective scar cream.com .

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