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New Data from Women's Health Initiative Study Show No Increased Risk of Coronary Heart Disease with Conjugated Estrogens Alone In Any Age Group Studied

It is important to note that
estrogen therapy, with or without a progestin, should not be used for the
prevention of coronary heart disease," concludes Dr. The
estrogen-alone sub-study enrolled more than 10,700 hysterectomized women.

About Wyeth
Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), has leading
products in the areas of women's health care, cardiovascular disease , central
nervous system, inflammation, transplantation, hemophilia, oncology, vaccines
and nutritional products.

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In the search for safe ways to reduce menopausal symptoms and discomfort
without HRT , many have embraced black cohosh -- used traditionally as a remedy
by Native Americans, and by Europeans since the 19th century.
Not all black cohosh is the same. Furthermore, study investigators did not observe increased CHD
risk in any of the subpopulations analyzed.
The estrogen-plus-progestin study arm of the WHI concluded in July 2002;
the estrogen-alone arm concluded in March 2004.

* PREMARIN and PREMPRO should be used at the lowest effective dose and
for the shortest duration consistent with your treatment goals and
risks. If using PREMARIN or PREMPRO only to treat your symptoms of
vaginal dryness, consider topical therapies first.

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"Comprising a proprietary, standardized extract (uniform dosage) of
pure black cohosh root called RemiSure(TM ), it is the #1 OB/GYN-recommended
non-prescription menopause therapy.
Mary Jane Minkin, MD
http: //profnet."
"Wyeth continues to support the appropriate use of hormone therapy for its
approved indications -- the relief of moderate to severe menopausal symptoms,
such as hot flashes, night sweats and vaginal dryness, and the prevention of
postmenopausal osteoporosis -- and recommends that therapy be taken at the
lowest effective dose for the shortest duration consistent with treatment
goals and risks for the individual woman.

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Twenty percent of patients sail through
menopause without problems , but eighty percent have varying degrees of
symptoms, some severe," she explains. The secondary
endpoints included hip fracture, colorectal cancer, stroke, pulmonary embolism
and death from other causes. Sub-study participants were
then asked to enter into a follow-up phase.3 mg
and 0.

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79-1. It was designed to evaluate HT, dietary modification, calcium and
vitamin D as preventive therapies for postmenopausal women.
Estrogen-plus-progestin therapy is used by women who have not had a
hysterectomy. It is a leader in the
discovery, development, manufacturing, and marketing of pharmaceuticals,
vaccines, biotechnology products and nonprescription medicines that improve
the quality of life for people worldwide.

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supplement
industry. In one of the planned sub-analyses
by age, however, the investigators reported a statistically significant (34%)
lower risk for the combined endpoint of myocardial infarction (heart attack),
coronary death, coronary revascularization and confirmed angina among women
who were between the ages of 50 and 59 at the start of the study (RR 0.

About the Women's Health Initiative
The WHI was a large-scale study sponsored by the National Institutes of
Health.

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"Almost all of the scientific literature on black
cohosh was conducted on Remifemin including recent clinical trials showing no
estrogenic activity of the product . I respect the
personal preferences of my patients, many of whom do not want drug
intervention .66; 95%
CI 0.45-0. The HT
sub-studies were designed to assess selected long-term risks and benefits of
PREMARIN(R) (conjugated estrogens tablets, USP) and PREMPROTM (conjugated
estrogens/medroxyprogesterone acetate tablets).5 mg.
Hormone therapy -- either estrogen-alone or
estrogen-plus-progestin --should not be used to prevent CHD. Vaginal bleeding after menopause may be a warning sign
of cancer of the uterus (womb).

* Do not use estrogens with or without progestins to prevent heart
disease, heart attacks, strokes, or dementia. You and
your health care provider should talk regularly about whether you still
need treatment with estrogens .5 mg than with placebo were breast
pain/enlargement, vaginitis due to yeast or other causes , leg cramps,
vaginal spotting/bleeding, and painful menstruation.

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com/ud_public."
This most recent analysis of WHI data follows a January 2006 report
published in the Journal of Women 's Health, in which researchers from the
Nurses Health Study (NHS), a large observational trial, reported a significant
reduction in CHD among women who initiated hormone therapy (HT) early in
menopause .
The primary efficacy endpoint of WHI was the prevention of CHD, and the
primary safety endpoint was the risk of breast cancer.
The WHI was not designed to assess the relief of menopausal symptoms , such
as hot flashes, night sweats and dryness from vaginal atrophy -- the primary
reasons women initiate therapy. The role of the progestin is to protect the lining of the
uterus from overstimulation by estrogen, which can lead to endometrial cancer. Its low dose hormone therapies are part of a family of
well-studied products, which includes multiple strengths of PREMARIN and
PREMPRO. Your health care provider should check
any unusual vaginal bleeding to find out the cause.5 mg and PREMPRO 0.625 mg/2.

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625 mg therapy
did not increase the risk of coronary heart disease (CHD) in women aged 50 to
79 after an average of 7.

About Estrogen-Alone Therapy
Both estrogen-alone and estrogen-plus-progestin therapy are indicated for
the relief of moderate to severe menopausal symptoms, and the prevention of
postmenopausal osteoporosis. The abrupt changes in
hormone levels following this surgery can cause a woman to experience the
transition into menopause suddenly, rather than over the course of a few
years.

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J.45 mg and PREMPRO 0.

* PREMARIN is used after menopause to reduce moderate to severe hot
flashes; to treat moderate to severe dryness, itching, and burning, in
and around the vagina; and to help reduce your chances of getting
osteoporosis (thin, weak bones). In general, the addition of a
progestin is recommended for women with a uterus to reduce the chance
of getting cancer of the uterus.

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Data Suggest Lower Coronary Heart Disease Risk Among Women Aged 50-59

MADISON, N., Wyeth Pharmaceuticals, a
division of Wyeth (NYSE: WYE), reports that data published today in the
Archives of Internal Medicine showed that in the estrogen-alone arm of the
Women's Health Initiative (WHI) study, conjugated estrogens 0.625 mg therapy did not increase CHD risk (RR 0.

* PREMPRO is used after menopause in women with a uterus to reduce
moderate to severe hot flashes; to treat moderate to severe dryness ,
itching, and burning, in and around the vagina; and to help reduce your
chances of getting osteoporosis (thin, weak bones).

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A recent study found that Remifemin black cohosh extract reduced
menopausal symptoms by 70 percent in 12 weeks, including hot flashes, night
sweats , mood swings, irritability, and related occasional sleeplessness.com . Study investigators also concluded that
there was a suggestion of lower coronary heart disease risk with conjugated
estrogens among women 50 to 59 years of age.
The HT portion of the WHI study enrolled approximately 27,000 women
between 1993 and 1998.

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Major Study Finds Remifemin(R) a Safe HRT Alternative

Most products in the market lack the
standardization and research that can ensure efficacy and safety, and multi-
ingredient compounds can potentially create problems from drug interactions.1 years.

* Report any unusual vaginal bleeding right away while you are taking
these products.

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"While its
mechanism of action is unclear, black cohosh is one of the few products that
seems to relieve hot flashes.
The WHI estrogen-alone study evaluated 10,738 women age 50 to 79 years
(mean age 63 years) who had previously had a hysterectomy.3 mg/1.

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" Remifemin is completely hormone-free,
without plant-based estrogens that can affect breast and uterine cell growth., exclusive distributors of Remifemin in North America
and one of the first to introduce standardization to the U. The NHS data support the premise that timing of therapy may
influence CHD risk.16). Wyeth provided the
medications used in the HT portion of the WHI study, but did not have a role
in the analysis or reporting of study findings.
It is important to note that the estrogen-alone sub-study of WHI evaluated
the 0.3 mg/1.

* PREMARIN and PREMPRO should not be used if you have unusual vaginal
bleeding, have or had cancer of the breast or uterus, had a stroke or
heart attack in the past year, have or had blood clots, have liver
problems, are allergic to any of the ingredients in PREMARIN or
PREMPRO, or think you may be pregnant.

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S. "These findings, coupled with other recent data, support the
emerging belief that the age of the woman and time since menopause should be
considered when assessing the overall benefit and risk of hormone therapy. Currently taken by about 4 million women in the United States, these
products are prescribed more often than any other brand of postmenopausal HT. Wyeth is one of the world's largest research-driven
pharmaceutical and health care products companies.

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WASHINGTON, The controversy over Hormone
Replacement Therapy (HRT) rages on. The results were similar to recent hormone replacement
therapy study results showing Remifemin is a safe and effective alternative to
HRT." Dr.
"This new information is important for many women taking or considering
postmenopausal estrogen therapy to relieve the symptoms of menopause and/or to
prevent osteoporosis," says Lila Nachtigall, MD, New York University School of
Medicine . The estrogen-plus-progestin sub-study began with more
than 16,000 women randomized to estrogen -plus-progestin or placebo.

* Using estrogens with or without progestins may increase your chances of
getting heart attacks, strokes, breast cancer, and blood clots.

* In a clinical trial, the most commonly reported (greater than or equal
to 5%) side effects that occurred more frequently with PREMARIN than
with placebo were vaginitis due to yeast or other causes, vaginal
bleeding, painful menstruation, and leg cramps.

The statements in this press release that are not historical facts are
forward-looking statements based on current expectations of future events that
involve risks and uncertainties including, without limitation , risks
associated with the inherent uncertainty of the timing and success of
pharmaceutical research , product development, manufacturing,
commercialization, economic conditions including interest and currency
exchange rate fluctuations, changes in generally accepted accounting
principles, the impact of competitive or generic products, trade buying
patterns, wars or terrorist acts, product liability and other types of
lawsuits, the impact of legislation and regulatory compliance and obtaining
reimbursement, favorable drug pricing, access and other approvals,
environmental liabilities, and patent, and other risks and uncertainties,
including those detailed from time to time in the Company's periodic reports,
including current reports on Form 8-K, quarterly reports on Form 10-Q and the
annual report on Form 10-K, filed with the Securities and Exchange Commission.

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A
randomized , placebo-controlled, double-blind, study published in Obstetrics
and Gynecology (2005;105:1074-83 ) found that Remifemin significantly reduced
menopausal symptoms.
"Remifemin, with over 90 scientific papers, is the most researched black
cohosh product in the world," explains Matt Schueller, Senior VP Marketing for
Enzymatic Therapy, Inc.jsp?userid=10014989

About the PREMARIN Family of Products
Wyeth Pharmaceuticals is the leader in women's health, with a long history
of product innovation.

What is the most important information you should know about PREMARIN
(estrogens) or PREMPRO (a combination of estrogens and a progestin)?

* Estrogens increase the chances of getting cancer of the uterus.45
mg/1.
Actual results may vary materially from the forward-looking statements. The
Company assumes no obligation to publicly update any forward -looking
statements, whether as a result of new information, future events or
otherwise.

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"This new information may be
reassuring to millions of women who currently take, or are appropriate
candidates for, estrogen-alone therapy. Constantine.5 mg and 0. Post hysterectomy, many women experience sudden -- and often
severe -- menopausal symptoms such as hot flashes, night sweats and vaginal
dryness , and are at increased risk for bone loss.

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" For more information visit:
http://www.96).45 mg/1. In a clinical
trial, there was no difference in the commonly reported (greater than
or equal to 5%) side effects for women taking PREMPRO 0.

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Over 40 million American women are within
menopause age, and in five years the numbers will increase to over 60 million.
"Remifemin is clearly the world's most clinically tested black cohosh
product, with over 15 clinical trials that demonstrate the safety and efficacy
of the product," says Mark Blumenthal, Founder and Executive Director of the
American Botanical Council.
"Smart German chemists have been working on Remifemin for over 50 years,"
says Yale University School of Medicine Clinical Professor Mary Jane Minkin,
MD, who recommends Remifemin as a standard alternative to HRT. "I talk to everyone about Remifemin ,
along with lifestyle issues like healthy diet and exercise. Minkin is author of A Woman's Guide to Menopause +
Perimenopause (Yale University Press 2005).

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"Both studies clearly show no increased risk of coronary heart disease
with estrogen-alone therapy, and help clarify the individual assessment of
risk and benefit," says Ginger Constantine, MD, Vice President, Women's Health
Care and Bone Repair, Wyeth Pharmaceuticals. In the latest
report, reflecting analyses of the final, adjudicated data, the WHI
investigators concluded that in the overall study population conjugated
estrogens 0.

* In a clinical trial, the most commonly reported (greater than or equal
to 5%) side effects that occurred more frequently with PREMPRO 0.5 mg
compared to those taking placebo. The Company's major divisions
include Wyeth Pharmaceuticals, Wyeth Consumer Healthcare and Fort Dodge Animal
Health.

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prnewswire. These data are particularly
interesting because this younger age group most closely resembles the typical
patient treated with hormone therapy.
Estrogen-alone therapy is most commonly prescribed to treat menopausal
symptoms and prevent osteoporosis in women who have had a total hysterectomy
(surgery to remove a woman's uterus and ovaries).

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95; 95 % CI
0. If you do not have
symptoms, non-estrogen treatments should be carefully considered before
taking PREMARIN and PREMPRO solely for the prevention of postmenopausal
osteoporosis .

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It is safe for women with a history of breast cancer who cannot take estrogen.remifemin .625 mg strength of PREMARIN; today, a number of lower doses of the
PREMARIN Family of Products are widely available, including PREMARIN 0. Using
estrogens, with or without progestins, may increase your risk of
dementia, based on a study of women age 65 years or older.