"Now, I hope to create games that
will give gamers the most emotional and thrilling gaming experience possible
-- joy, thrills, sympathy and speed.

About Microsoft
Founded in 1975, Microsoft is the worldwide leader in software, services
and solutions that help people and businesses realize their full potential.

About PopCap
PopCap Games (http://www.

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(Logo: http://www."
The addition of Mizuguchi and Okamoto further reveals Microsoft's strategy
for attracting Japanese gamers.popcap.

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Assays from Tm operate on the Luminex
xMAP(R) system, a well-established bead based instrument.com. Game Republic's Yoshiki Okamoto and Q Entertainment's Tetsuya Mizuguchi to
Create Exclusive Content for Microsoft Game Studios

REDMOND, Wash. Bejeweled(R) 2, Bookworm(R) and Zuma(R) Now Available for the Mac(R)

MACWORLD EXPO, SAN FRANCISCO, PopCap Games(TM),
the leading developer and publisher of casual games for digital entertainment
platforms, today announced the immediate availability of three of its
top-selling word, puzzle, arcade and action games for Mac OS X version 10.

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TSX: TMC

TORONTO, May 18 - Tm Bioscience Corporation
(Toronto, Ontario; TSX: TMC), a leader in the commercial genetic testing
market, today announced it has signed an agreement to supply Akron Children's
Hospital (Akron, Ohio) with the Tag-It(TM) ASR(x) reagents for use in its
Cystic Fibrosis gene assay. "The Tag-It(TM) reagents from Tm
Bioscience are a technology upgrade improving our ability to handle higher
test volumes with less operator time. (Nasdaq: MSFT) today
announced that esteemed video game developers Yoshiki Okamoto, president and
CEO of Game Republic Inc. in the United States and/or other countries.

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More Japanese Game Luminaries Pick Next-Generation Xbox Platform

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The Company 's Tag-It(TM) Cystic
Fibrosis (CF) Kit is the first multiplexed human disease genotyping test to be
cleared by the U. In July 2003, he founded Game Republic, where he
and his team have next-generation Xbox exclusive titles currently in
development.

Pricing and Availability
The games will debut in the Game Pavilion Arcade at Macworld Expo this
week and are also available at http: //www.

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About Tag-It(TM) reagents and genetic tests
Tm Bioscience's product menu is focused in the fields of human genetic
disorders, pharmacogenetics and infectious disease. The announcement comes on the
heels of last week's news that video game legend Hironobu Sakaguchi, president
of Mistwalker game studio, has joined with Microsoft Game Studios to develop
role-playing games exclusively for the next-generation Xbox platform.newscom. PopCap's games have been downloaded more than 150 million times,
and its flagship title Bejeweled has sold more than 5 million units across
all major platforms .

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Tm Bioscience is located
in Toronto, Ontario.com/cgi-bin/prnh/20000822/MSFTLOGO )
For more than 20 years, Okamoto has been thrilling gamers with franchises
such as "Street Fighter" and "Resident Evil. More than 100 million consumers now
play such games on a regular basis and according to industry research firms
approximately 53 percent of those players are female and two thirds are over
age 35.95 each.com) is the leading provider of casual games in
the world.

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" The available games are Bejeweled 2, Bookworm and Zuma. Apple, Mac and Macintosh
are copyrights of Apple Computer, Inc.

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"The Molecular Diagnostics Lab at Akron Children's Hospital has been
performing asymptomatic carrier screening as well as some CF diagnostic
testing for over two years," said Dr. Akron
Children's operates as a full-service, 253-bed pediatric hospital and houses a
regional burn trauma center for both adults and children, as well as a
pediatric trauma center." Gamers worldwide have long been
attracted to Mizuguchi's distinctive style that blends music and action. "Gamers will be riveted by the experiences enabled by such creators
when given the proper canvas and tools.

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"
"Regional laboratories like the one at Akron Children's Hospital
increasingly are playing a lead role in providing genetic testing services." Widely considered an industry
pioneer, Okamoto is best known for his ability to conceive and drive
completely new game genres. Last week, the company announced that
Mistwalker, a studio run by the legendary Hironobu Sakaguchi, will develop two
exclusive titles for Microsoft.com ) is the video game system from Microsoft that
brings people together for the most exhilarating game and entertainment
experiences.
"We rely on Apple innovation in various stages of the game design and
development processes and are extremely impressed with what the power and
tools allow us to create," said Jason Kapalka, founder and Chief Creative
Officer of PopCap.

NOTE: PopCap and PopCap Games are trademarks, and Bejeweled, Bookworm and
Zuma are registered trademarks, of PopCap Games, Inc.

x laser

It also offers more than 100 advocacy, education,
outreach and research programs .

(x) Analyte Specific Reagent."
Mizuguchi, who founded Q Entertainment in 2003, is the creative force
behind a litany of innovative blockbusters including "SEGA Rally
Championship ," "Rez" and "Space Channel 5."
The casual games sector, comprising family-friendly puzzle, word , trivia
and arcade-style games, has experienced tremendous growth in recent years via
the web , PC, console and mobile phones.

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The Company has
commercialized Analyte Specific Reagents(x) and a series of Tag-It(TM)
tests(xx) for a variety of genetic disorders., and Tetsuya Mizuguchi, chief creative officer and
producer of Q Entertainment Inc.

PopCap Games(TM) Makes Biggest Hits Available for Mac OS X

tag intersphere

S.tmbioscience.

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Donna Galehouse, Director of Molecular
Diagnostics at Akron Children 's Hospital. The performance characteristics of
these products have not been established

About Tm Bioscience - Putting the Human Genome to Work(TM)
Tm Bioscience is a DNA -based diagnostics company developing a suite of
genetic tests. Additional information about Tm Bioscience can be found
at http://www., In another creative coup
for its next-generation Xbox(R) platform , Microsoft Corp., have aligned with Microsoft Game Studios to
develop exclusive next-generation Xbox games.xbox."
"Apple's use of powerful technologies like OpenGL and our breakthrough
Xcode development tools make Tiger a great platform for developing eye-popping
entertainment," said Ron Okamoto, Apple's vice president of Worldwide
Developer Relations. All other trademarks and registered
trademarks are the property of their respective owners, without intent to
infringe.

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"With the next-
generation Xbox platform, I can turn this vision into a reality. Xbox delivers an expansive collection of breakthrough games,
powerful hardware and the unified Xbox Live(TM) online service . Based in Seattle, Washington, PopCap was founded in 2000 by three
friends from the online games industry, and has grown tremendously in the past
five years.

x tag

Tm Bioscience to supply Akron Children 's Hospital with Tag-It(TM) reagents

Tm Bioscience's product pipeline includes tests for genetic
disorders, drug metabolism, and infectious diseases.
"By combining various factors, including exciting storylines, action,
graphics and music, I've created video games that have brought gamers the
ultimate fun in gaming," Mizuguchi said.
"We are excited for Mizuguchi-san and Okamoto -san to develop next-
generation Xbox games unlike anything the world has ever seen," said Peter
Moore , corporate vice president of Worldwide Marketing and Publishing for
Microsoft. "The Mac is a popular gaming platform and Mac owners are
among the most ardent consumers and creators of entertainment content so we're
excited to have our top games fully optimized for Tiger. PopCap games are available for Web, PC and Mac, videogame
consoles, cell-phones, PDAs and other mobile devices, on-demand TV , in-flight
on leading airlines, and more.

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S. Food and Drug Administration (FDA) as an in vitro device
(IVD) for diagnostic use in the United States. Analytical and performance characteristics
are not established.
(xx) For Investigational Use Only. The power and advanced technologies of
the next-generation Xbox platform will enable winning games with powerful
emotions, high-quality graphics and sound. Perhaps more important, it underscores a
growing preference among the world's most talented game developers for the
next-generation Xbox platform.com and other leading
entertainment -oriented websites.

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We plan to evaluate additional products
from Tm to provide an extended CF panel and also add additional genetic assays
to our testing menu.
The names of actual companies and products mentioned herein may be the
trademarks of their respective owners. The full, deluxe versions of these games can
be downloaded from those same websites and played for free for 60 minutes
using the "try-before-you-buy" sales model pioneered by PopCap.

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This agreement reflects the continuing success of our U. Combined, the
Universal Array and Luminex instrument enable the rapid production of
flexible, high-throughput, low-cost DNA-based tests. Xbox is now available in North
America , Asia, Europe and Australia.

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It cares for more than 350,000 patients each year and performs
more pediatric surgeries than any other hospital in Northeast Ohio. All genetic tests from Tm
Bioscience are based on the Tag-It(TM) Universal Array platform, which
utilizes a proprietary universal tag system that allows for easy optimization,
product development and expansion.

The tag line,
"It's good to play together," captures the spirit of Xbox as the social hub of
the new digital entertainment lifestyle.

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4
"Tiger. "PopCap's commitment to the platform with its suite of
extremely popular games is an exciting addition to the great gaming experience
the Mac offers.

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"My goal in creating these games is to make completely fresh and riveting
experiences that gamers have never had before," Okamoto said.

NOTE: Microsoft, Xbox and Xbox Live are either registered trademarks or
trademarks of Microsoft Corp. The games are
priced at US $19.

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based sales force
in cementing relationships with these customers to create a long-term
commercial base for our growing menu of products," said Greg Hines, President
and CEO of Tm Bioscience.apple.

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About Akron Children 's Hospital
Akron Children's Hospital is the largest pediatric care provider in
Northeast Ohio ."

About Xbox
Xbox ( http://www.

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- - kjjkjk

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