L. But these treatments do little to control chronic pain," said
Dr . With ownership of, or access to, 40 issued U.
In addition, Avigen has two multi-use rollerbottle -based GMP manufacturing
facilities.

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About WebEx Communications
WebEx Communications , Inc. AV333 is a nonviral-based therapy designed to
deliver the gene that expresses the potent anti -inflammatory, interleukin-10
(IL-10), and thereby eliminates the pain signals emanating from the affected
part of the body. These patents cover the manufacture,
delivery and treatment of numerous diseases.

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"We
are also thrilled that WebEx has sponsored this publication -- it demonstrates
their commitment to the learning and training field and it enabled us to make
it available for free. Please call
+1.

Avigen Discontinues AAV Gene Therapy Funding to Focus Exclusively on Development of Traditional Pharmaceutical Products

Finally, we are considering operating the
clinical programs through academic institutions; terminating internal
operations, sub-leasing our two multi-use manufacturing facilities and
retaining the intellectual property portfolio until the assets further
appreciate in value . "Until recently, pain research
focused exclusively on neurons, which relay pain messages to the brain. For
example, for a broken foot, people take drugs that interrupt the neurons' pain
message .com.

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Watkins received the Frederick W. Pre-clinical animal
studies have confirmed that IL-10 prevents or reverses every enhanced pain
state examined to date.
A growing body of evidence validates the efficacy of Avigen's candidate in
the field, AV333, which demonstrated success in preclinical models by actually
reversing neuropathic pain. These risks and uncertainties include: Avigen has not entered
into any agreements regarding the three options that it is evaluating, and the
parties with which Avigen is in discussions may determine not to pursue a
transaction on the time frame that Avigen currently expects, on terms
favorable to Avigen, or at all; the development of small molecule therapeutics
is a time- and resource-intensive process with no guarantee of success, which
may result in the expenditure of a significant amount of time and resources
with no marketable product resulting from the effort; the risk that if the
three options Avigen is evaluating or the alternative funding are delayed or
do not occur, that Avigen will not be able to reduce its operational expenses
as it currently expects; the risk that unexpected costs will arise in
connection with the pursuit of these transactions that would result in Avigen
not being able to reduce its operational expenses in the amount that it
currently expects; and results obtained in animal models do not guarantee that
similar results will be obtained in humans, which occurred in Avigen's
treatment for hemophilia B."

Registry Mechanic can be downloaded at www.

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In the
same way, the responses illuminated four selection factors that every manager
of e-Learning must consider before assigning an instructor to a virtual
classroom.eLearningGuild. Watkins.
Normally, glia are the "housekeepers" of the central nervous system
regulating the environment and cleaning up debris. Other risks
relating to Avigen are detailed in Avigen's Annual Report on Form 10-K for the
period ended December 31, 2004 , under the caption "Risk Factors" in Item 1 of
Part 1 of that report, which was filed with the SEC on March 16, 2005. The latest
release incorporates a number of enhancements which confirms the product as
one of the world's best registry cleaners and propels it into the next
generation of registry maintenance.
-- The ability to remove temporary (tmp) & fragment (chk) files to clean
up hard disk space.

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This is an amazing accomplishment by our contributors.566.1, the latest version of the world's most popular registry
cleaner that removes unnecessary and inactive programs and files from the
Windows registry that can crash or stall desktop computers.

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S.
In addition, these pain-enhancing substances further activate other glial.

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We intend to build a strong neurologically-focused
pipeline through a combination of internal research, acquisitions and
in-licensing.

Registry Mechanic 5.

The ideal goal is to resolve conflict, but practitioners fill the spectrum from from 'very new-age spiritualistic pacifists' to 'conflict is resolved when my opponent can hear nothing but the pain screaming from every broken part of his body.

Sites exclusively in other languages should be submitted to the appropriate World category.

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"I was amazed by the degree to which comments from hundreds of
contributors converged into a set of coherent professional knowledge," said
Bill Brandon, Senior Editor."
To download a copy of this publication now, click here . The Guild represents a
diverse group of designers, developers, managers, directors, and executives
focused on training and learning services.

,
J.
When this reaches a critical level, it produces a self -perpetuating feedback
loop that potentially can continue even when the original cause of the pain
has been resolved.
As a leader in the field of AAV gene therapy for over a decade, Avigen has
built an extensive asset base.95 per computer install, including free support and live
updates for a year.

'
Websites in this category must be in English.

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"
"The best thing about this collection of tips and advice is that every
item comes from actual experience," said David Holcombe , the Guild's CEO.
http://www. Above all, I
would like to express my deep appreciation to the participants in our clinical
studies who have given so selflessly of their time and energy in the hopes of
someday making better products for serious diseases a therapeutic reality.com and is available for
purchase at $29.

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"Loaded with practical advice from experienced e-Learning
practitioners, this e-book will be an indispensable addition to any training
professional's toolkit. The eLearning Guild is a subsidiary
of Focuszone Media, Inc, based in Santa Rosa, California.
"For more than a year, we have been assembling a strong management team
with outstanding experience in small molecules and biologics and are now
positioned to redirect our resources from viral-based gene therapy to fully
commit to more traditional drug development," said Kenneth Chahine, Ph. EDT.com/webcasts/cibcwm/biotech05/06204336 .
-- Support for both basic and dynamic drives in the compacting tool.

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D. During the past decade, Watkins and others discovered that
treating pain is not just about neurons but also involves glial cells, which
are active in creating and maintaining pain.m.
PC Tools, creator of award winning
security and utility software, today announced the release of Registry
Mechanic 5. With the new "Smart Live Update" tool, users will
receive the latest technology in registry cleaning. PC Tools publishes
software and provides technical resources for securing, protecting and
maintaining the Windows operating system.

Aikido is a modern, Japanese martial art that incorporates techniques and motions from Jujutsu as well as sword and spear forms.

Bilingual sites may be listed in both categories.

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707 . Alternatively,
we could combine our assets with another company with an existing gene therapy
effort or complementary technology. We are in advanced discussions with several parties and
expect to make a decision very soon. However, when glia are
activated in response to nerve damage, tumors, or particular viruses and
bacteria, they produce increased levels of pro-inflammatory substances, which
greatly enhance the neuron's response to pain signals.

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'834 Tips for Successful Online
Instruction' offers an extensive set of best practices that will prove
invaluable for e-instructors," said Jack Chawla , Director, WebEx Training
Center.eLearningGuild.8990 or visit http://www. WebEx applications are used across the
enterprise in sales, support, training, marketing, engineering and product
design ., Avigen, Inc. Avigen has already secured one funding source for its Parkinson's
disease program and is actively exploring additional options to fund its other
AAV development activities through mechanisms that will allow Avigen to
participate in the technology's commercial upside potential . "One option is a spin-out of
the AAV technology into an independent venture-backed company."
Dr."

Neuropathic Pain
Neuropathic pain is widely viewed as an underserved condition with limited
and problematic treatment options. These assets also include clinical and
preclinical gene therapy programs in the neurological and coagulation fields;
including Avigen's current Phase I clinical program, AV201 for Parkinson's
disease, and an open IND for the treatment of hemophilia B.

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"
"As organizations offer an increasing number of classes online, many
traditional classroom instructors face the challenge of adapting their skills
and techniques for the virtual classroom .. The Company has exclusively licensed rights to the
treatment of chronic pain using anti-inflammatory cytokines, including
interleukin 10 (IL-10), from the University of Colorado at Boulder.S.
-- New GUI that is more intuitive and consistent with other PC Tools
products.

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509., Avigen's President and CEO.cfm

Investors Please Note:
The statements in this news release regarding anticipated cost savings
resulting from Avigen's decision to discontinue funding its proprietary AAV
technology , Avigen's belief that its decision to focus its existing resources
on traditional pharmaceuticals offers a greater potential to increase
shareholder value, Avigen's expectation on making a decision soon on pursuing
a transaction, Avigen's intention to build a strong neurologically-focused
pipeline through a combination of internal research, acquisitions and
in-licensing, and the benefits that Avigen believes it will obtain from its
change in focus, are forward-looking statements that are subject to risks and
uncertainties. Volume pricing is available for multi-user and business
installations .

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com for more
information. This lower annual rate of
spending approximates more than a 40% reduction from the 2004 net cash burn of
$23M.

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, The eLearning Guild announced
the publication of a free e-Book titled "834 Tips for Successful Online
Instruction. WebEx delivers its suite of applications over the WebEx MediaTone
Network, a global network specifically designed for secure delivery of on-
demand applications. The decision to
fund AAV development through external sources will significantly reduce
Avigen's operating expenses beginning this quarter with the full impact of
reducing cash expenditures to an anticipated annual rate of approximately $13M
being realized by the end of the third quarter."
"We are currently evaluating three options, all of which are intended to
preserve the ongoing gene therapy efforts, including our clinical program,
AV201, for Parkinson's disease," added Chahine. Chahine concluded, "All of us at Avigen would like to extend our
heart-felt gratitude to all of the scientists, medical institutions and
collaborators who have assisted in moving the frontiers of gene therapy
science forward and bringing our programs into clinical trials. Patients with severe neuropathic conditions
must often rely on increasing doses of morphine for pain relief. Of the fifty per cent of
individuals with chronic severe pain not associated with cancer, fewer than
half reported that pain medication controlled the problem (American Pain
Society, 1999.

ABOUT PC TOOLS

PC Tools is a global leader in innovative software products to protect the
privacy and security of Windows computer users.

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com

About The eLearning Guild
The eLearning Guild is a global Community of Practice for e-Learning
professionals and provides learning opportunities, networking services,
resources, and publications for almost 20,000 members.com for more information. (Nasdaq: WEBX) is the leading provider of on-
demand collaboration applications. These savings will help to preserve Avigen's cash for the development
and commercialization of its internal preclinical programs in neuropathic pain
and the acquisition or in-license of later -stage clinical products.D.
This presentation will be webcast live from the Millennium Broadway Hotel
in New York City and may be accessed by following the link below. More information about PC Tools
can be found at www.

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Please call toll free +1. Parkinson's Program Will Continue Through External Funding

ALAMEDA, Calif."

Looking Ahead
"I am enthusiastic about Avigen's future," said Chahine.

PRESS RELEASE Resolve to Start the New Year With a Clean Registry and Boost Your Computer's Performance

"This latest upgrade to Registry Mechanic not only improves upon
our industry-leading position, but helps ensure that computers across the
world are functioning as efficiently as possible.

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WebEx Communications is Exclusive Sponsor

SANTA ROSA, Calif." The tips were compiled from a survey the Guild conducted in 2005
that resulted in the submission from 336 e-Learning professionals.
(Nasdaq: AVGN) announced today it will exclusively focus on the development of
traditional pharmaceutical products, particularly small molecules and
biologics.
Under certain strategic options, this facility would be available for
sublease.

veracast. In addition, there are many other risks and
uncertainties inherent in the development of drug products.

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WebEx Communications is based in Santa Clara, California. "Although Avigen is a leader in the AAV
field, when the challenges ahead are viewed objectively, we believe that
focusing our existing resources on traditional pharmaceuticals offers a
greater potential to increase shareholder value than staying the course and
investing our existing capital in viral-based gene therapy programs . Linda Watkins, a
world leader in the field and Professor of Psychology and Director,
Interdepartmental Neuroscience Program at CU - Boulder.

Considerable AAV Asset Value
Avigen will consider a number of possible deal structures. patents and
29 issued foreign patents, Avigen has the largest and broadest patent
portfolio related to AAV technologies.
http://www.

The updated registry cleaner is now also capable of scanning all user
profile sections of the Windows registry, which ensures an error-free
computer for users.

Other enhancements to the award-winning software include:

-- New results screen which classifies registry errors (low, medium &
high) , for quick and easy identification of critical items.

"Computers were a popular, great gift over the holidays, and it's important
that consumers have the most effective tools available to keep their PCs
working like new in the years to come," said Simon Clausen, CEO of PC
Tools.pctools.

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The eLearning Guild Publishes e-Book: '834 Tips for Successful Online Instruction'

3239 or visit http://www.webex .)
Avigen is working on a new and exiting class of molecules for the
treatment of chronic pain . In
addition, Avigen has established a collaboration with Dr. In addition, on April
2, 2005 Dr .
Avigen has a dominant intellectual property portfolio related to AAV
technologies.

Avigen to Present at CIBC Biotechnology Conference Today
Ken Chahine will present more information on Avigen's new strategic
initiative at the CIBC World Markets Biotechnology and Specialty
Pharmaceuticals Conference today, April 5, 2005 at 10:00 a.1 features a significantly redesigned scanning engine
to provide scanning speeds up to four times faster than its previous
version, along with more comprehensive scanning of the Windows registry.pctools.

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"For example, contributors identified four
instructor skills as critical to success; as far as I am aware, no individual
writer or consultant has previously highlighted just these four skills. As part of the decision, Avigen will discontinue funding its
proprietary AAV technology while ensuring that its ongoing clinical programs
continue. "Avigen will
focus on developing and commercializing innovative drugs for the treatment of
neurological conditions.

Pain accounts
for over 70 million doctor's visits per year in the U., according the
International Association for the Study of Pain.
Avigen and its collaborators at CU-Boulder have focused on the
effectiveness of one of the most powerful naturally occurring
anti-inflammatory proteins, interleukin-10 (IL-10). Among these
options are out-licensing, joint ventures or complete divestiture of assets.

New tweaks have also been added to the "Optimize Your System" feature to
further improve system performance and ensure a smooth running of the
Windows operating system.

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.

877. Kerr Basic Science Award at
the Annual American Pain Society Meeting. These facilities can be used to produce commercial scale
quantities of AAV but could also be used to manufacture other biologics ,
including cell therapeutics, recombinant proteins and monoclonal antibodies.

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---

- - kjjkjk

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